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Protein

Protein-associating with the carboxyl-terminal domain of ezrin

Gene

SCYL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulating cell adhesion/migration complexes in migrating cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • protein phosphorylation Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8IZE3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-associating with the carboxyl-terminal domain of ezrin
Alternative name(s):
Ezrin-binding protein PACE-1
SCY1-like protein 3
Gene namesi
Name:SCYL3
Synonyms:PACE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19285. SCYL3.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Golgi apparatus 1 Publication
  • Cell projectionlamellipodium 1 Publication

  • Note: Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • lamellipodium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2 – 6GSENS → M: No Golgi targeting, accumulates in the cytoplasm. 1 Publication5

Organism-specific databases

DisGeNETi57147.
OpenTargetsiENSG00000000457.
PharmGKBiPA142670945.

Polymorphism and mutation databases

BioMutaiSCYL3.
DMDMi61214481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00000581672 – 742Protein-associating with the carboxyl-terminal domain of ezrinAdd BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei439PhosphoserineBy similarity1
Modified residuei707PhosphoserineCombined sources1

Post-translational modificationi

May be myristoylated; myristoylation may target it to Golgi compartment.1 Publication
Phosphorylated.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ8IZE3.
PaxDbiQ8IZE3.
PeptideAtlasiQ8IZE3.
PRIDEiQ8IZE3.

PTM databases

iPTMnetiQ8IZE3.
PhosphoSitePlusiQ8IZE3.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000000457.
CleanExiHS_SCYL3.
ExpressionAtlasiQ8IZE3. baseline and differential.
GenevisibleiQ8IZE3. HS.

Organism-specific databases

HPAiHPA005624.

Interactioni

Subunit structurei

Interacts with EZR/VIL2 C-terminal domain.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EZRP153114EBI-1380680,EBI-1056902
GABARAPL1Q9H0R83EBI-1380680,EBI-746969
LHX8Q68G743EBI-1380680,EBI-8474075
TXN2Q997573EBI-1380680,EBI-2932492

Protein-protein interaction databases

BioGridi121404. 9 interactors.
IntActiQ8IZE3. 13 interactors.
MINTiMINT-262276.
STRINGi9606.ENSP00000356744.

Structurei

3D structure databases

ProteinModelPortaliQ8IZE3.
SMRiQ8IZE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 245Protein kinasePROSITE-ProRule annotationAdd BLAST244
Repeati199 – 238HEAT 1Add BLAST40
Repeati285 – 323HEAT 2Add BLAST39
Repeati333 – 370HEAT 3Add BLAST38
Repeati372 – 409HEAT 4Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 742Interaction with EZR1 PublicationAdd BLAST195

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 4 HEAT repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
GeneTreeiENSGT00860000133812.
HOVERGENiHBG053485.
InParanoidiQ8IZE3.
KOiK17542.
OMAiQFSSKFA.
OrthoDBiEOG091G0B8M.
PhylomeDBiQ8IZE3.
TreeFamiTF313435.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV
60 70 80 90 100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV
110 120 130 140 150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCKVS
160 170 180 190 200
QATPEFLRSI QSIRDPASIP PEEMSPEFTT LPECHGHARD AFSFGTLVES
210 220 230 240 250
LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL SHDFFRNDFL
260 270 280 290 300
EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF
310 320 330 340 350
AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE
360 370 380 390 400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL
410 420 430 440 450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK NTDLSLEDSP MCVVCSHHSQ
460 470 480 490 500
ISPILENPFS SIFPKCFFSG STPINSKKHI QRDYYNTLLQ TGDPFSQPIK
510 520 530 540 550
FPINGLSDVK NTSEDSENFP SSSKKSEEWP DWSEPEEPEN QTVNIQIWPR
560 570 580 590 600
EPCDDVKSQC TTLDVEESSW DDCEPSSLDT KVNPGGGITA TKPVTSGEQK
610 620 630 640 650
PIPALLSLTE ESMPWKSSLP QKISLVQRGD DADQIEPPKV SSQERPLKVP
660 670 680 690 700
SELGLGEEFT IQVKKKPVKD PEMDWFADMI PEIKPSAAFL ILPELRTEMV
710 720 730 740
PKKDDVSPVM QFSSKFAAAE ITEGEAEGWE EEGELNWEDN NW
Length:742
Mass (Da):82,857
Last modified:January 23, 2007 - v3
Checksum:i2F7D03681A4F641B
GO
Isoform 2 (identifier: Q8IZE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-491: Missing.

Show »
Length:688
Mass (Da):76,731
Checksum:i96DCB00F38A7F928
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti613M → T in AAN23123 (PubMed:12651155).Curated1
Sequence conflicti613M → T in AAN41656 (PubMed:12651155).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051690597G → A.1 PublicationCorresponds to variant rs12143301dbSNPEnsembl.1
Natural variantiVAR_051691621Q → R.3 PublicationsCorresponds to variant rs4656197dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013125438 – 491Missing in isoform 2. 3 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540957 mRNA. Translation: AAN23123.1.
AY144493 mRNA. Translation: AAN41656.1.
AL117233 mRNA. Translation: CAB55300.1.
AK292507 mRNA. Translation: BAF85196.1.
AL031297 Genomic DNA. Translation: CAB52564.2.
AL031297 Genomic DNA. Translation: CAI23517.1.
AL031297 Genomic DNA. Translation: CAI23518.1.
CH471067 Genomic DNA. Translation: EAW90867.1.
BC014662 mRNA. Translation: AAH14662.1.
CCDSiCCDS1286.1. [Q8IZE3-2]
CCDS1287.1. [Q8IZE3-1]
RefSeqiNP_065156.5. NM_020423.6. [Q8IZE3-2]
NP_851607.2. NM_181093.3. [Q8IZE3-1]
XP_006711528.1. XM_006711465.1. [Q8IZE3-1]
XP_011508103.1. XM_011509801.1. [Q8IZE3-1]
XP_016857351.1. XM_017001862.1. [Q8IZE3-2]
XP_016857352.1. XM_017001863.1. [Q8IZE3-2]
UniGeneiHs.435560.
Hs.443551.

Genome annotation databases

EnsembliENST00000367770; ENSP00000356744; ENSG00000000457. [Q8IZE3-1]
ENST00000367771; ENSP00000356745; ENSG00000000457. [Q8IZE3-2]
ENST00000367772; ENSP00000356746; ENSG00000000457. [Q8IZE3-1]
GeneIDi57147.
KEGGihsa:57147.
UCSCiuc001ggs.5. human. [Q8IZE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540957 mRNA. Translation: AAN23123.1.
AY144493 mRNA. Translation: AAN41656.1.
AL117233 mRNA. Translation: CAB55300.1.
AK292507 mRNA. Translation: BAF85196.1.
AL031297 Genomic DNA. Translation: CAB52564.2.
AL031297 Genomic DNA. Translation: CAI23517.1.
AL031297 Genomic DNA. Translation: CAI23518.1.
CH471067 Genomic DNA. Translation: EAW90867.1.
BC014662 mRNA. Translation: AAH14662.1.
CCDSiCCDS1286.1. [Q8IZE3-2]
CCDS1287.1. [Q8IZE3-1]
RefSeqiNP_065156.5. NM_020423.6. [Q8IZE3-2]
NP_851607.2. NM_181093.3. [Q8IZE3-1]
XP_006711528.1. XM_006711465.1. [Q8IZE3-1]
XP_011508103.1. XM_011509801.1. [Q8IZE3-1]
XP_016857351.1. XM_017001862.1. [Q8IZE3-2]
XP_016857352.1. XM_017001863.1. [Q8IZE3-2]
UniGeneiHs.435560.
Hs.443551.

3D structure databases

ProteinModelPortaliQ8IZE3.
SMRiQ8IZE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121404. 9 interactors.
IntActiQ8IZE3. 13 interactors.
MINTiMINT-262276.
STRINGi9606.ENSP00000356744.

PTM databases

iPTMnetiQ8IZE3.
PhosphoSitePlusiQ8IZE3.

Polymorphism and mutation databases

BioMutaiSCYL3.
DMDMi61214481.

Proteomic databases

MaxQBiQ8IZE3.
PaxDbiQ8IZE3.
PeptideAtlasiQ8IZE3.
PRIDEiQ8IZE3.

Protocols and materials databases

DNASUi57147.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367770; ENSP00000356744; ENSG00000000457. [Q8IZE3-1]
ENST00000367771; ENSP00000356745; ENSG00000000457. [Q8IZE3-2]
ENST00000367772; ENSP00000356746; ENSG00000000457. [Q8IZE3-1]
GeneIDi57147.
KEGGihsa:57147.
UCSCiuc001ggs.5. human. [Q8IZE3-1]

Organism-specific databases

CTDi57147.
DisGeNETi57147.
GeneCardsiSCYL3.
HGNCiHGNC:19285. SCYL3.
HPAiHPA005624.
MIMi608192. gene.
neXtProtiNX_Q8IZE3.
OpenTargetsiENSG00000000457.
PharmGKBiPA142670945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
GeneTreeiENSGT00860000133812.
HOVERGENiHBG053485.
InParanoidiQ8IZE3.
KOiK17542.
OMAiQFSSKFA.
OrthoDBiEOG091G0B8M.
PhylomeDBiQ8IZE3.
TreeFamiTF313435.

Enzyme and pathway databases

SignaLinkiQ8IZE3.

Miscellaneous databases

GeneWikiiSCYL3.
GenomeRNAii57147.
PROiQ8IZE3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000000457.
CleanExiHS_SCYL3.
ExpressionAtlasiQ8IZE3. baseline and differential.
GenevisibleiQ8IZE3. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPACE1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZE3
Secondary accession number(s): A8K8Z2
, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.