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Protein

Protein-associating with the carboxyl-terminal domain of ezrin

Gene

SCYL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in regulating cell adhesion/migration complexes in migrating cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • protein phosphorylation Source: InterPro

Enzyme and pathway databases

SignaLinkiQ8IZE3

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-associating with the carboxyl-terminal domain of ezrin
Alternative name(s):
Ezrin-binding protein PACE-1
SCY1-like protein 3
Gene namesi
Name:SCYL3
Synonyms:PACE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000000457.13
HGNCiHGNC:19285 SCYL3
MIMi608192 gene
neXtProtiNX_Q8IZE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2 – 6GSENS → M: No Golgi targeting, accumulates in the cytoplasm. 1 Publication5

Organism-specific databases

DisGeNETi57147
OpenTargetsiENSG00000000457
PharmGKBiPA142670945

Polymorphism and mutation databases

BioMutaiSCYL3
DMDMi61214481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00000581672 – 742Protein-associating with the carboxyl-terminal domain of ezrinAdd BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei439PhosphoserineBy similarity1
Modified residuei707PhosphoserineCombined sources1

Post-translational modificationi

May be myristoylated; myristoylation may target it to Golgi compartment.1 Publication
Phosphorylated.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ8IZE3
MaxQBiQ8IZE3
PaxDbiQ8IZE3
PeptideAtlasiQ8IZE3
PRIDEiQ8IZE3

PTM databases

iPTMnetiQ8IZE3
PhosphoSitePlusiQ8IZE3

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000000457
CleanExiHS_SCYL3
ExpressionAtlasiQ8IZE3 baseline and differential
GenevisibleiQ8IZE3 HS

Organism-specific databases

HPAiHPA005624

Interactioni

Subunit structurei

Interacts with EZR/VIL2 C-terminal domain.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121404, 10 interactors
IntActiQ8IZE3, 15 interactors
STRINGi9606.ENSP00000356744

Structurei

3D structure databases

ProteinModelPortaliQ8IZE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 245Protein kinasePROSITE-ProRule annotationAdd BLAST244
Repeati199 – 238HEAT 1Add BLAST40
Repeati285 – 323HEAT 2Add BLAST39
Repeati333 – 370HEAT 3Add BLAST38
Repeati372 – 409HEAT 4Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 742Interaction with EZR1 PublicationAdd BLAST195

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1243 Eukaryota
ENOG410XQTG LUCA
GeneTreeiENSGT00890000139451
HOVERGENiHBG053485
InParanoidiQ8IZE3
KOiK17542
OMAiEWPDWSE
OrthoDBiEOG091G0B8M
PhylomeDBiQ8IZE3
TreeFamiTF313435

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV
60 70 80 90 100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV
110 120 130 140 150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCKVS
160 170 180 190 200
QATPEFLRSI QSIRDPASIP PEEMSPEFTT LPECHGHARD AFSFGTLVES
210 220 230 240 250
LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL SHDFFRNDFL
260 270 280 290 300
EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF
310 320 330 340 350
AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE
360 370 380 390 400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL
410 420 430 440 450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK NTDLSLEDSP MCVVCSHHSQ
460 470 480 490 500
ISPILENPFS SIFPKCFFSG STPINSKKHI QRDYYNTLLQ TGDPFSQPIK
510 520 530 540 550
FPINGLSDVK NTSEDSENFP SSSKKSEEWP DWSEPEEPEN QTVNIQIWPR
560 570 580 590 600
EPCDDVKSQC TTLDVEESSW DDCEPSSLDT KVNPGGGITA TKPVTSGEQK
610 620 630 640 650
PIPALLSLTE ESMPWKSSLP QKISLVQRGD DADQIEPPKV SSQERPLKVP
660 670 680 690 700
SELGLGEEFT IQVKKKPVKD PEMDWFADMI PEIKPSAAFL ILPELRTEMV
710 720 730 740
PKKDDVSPVM QFSSKFAAAE ITEGEAEGWE EEGELNWEDN NW
Length:742
Mass (Da):82,857
Last modified:January 23, 2007 - v3
Checksum:i2F7D03681A4F641B
GO
Isoform 2 (identifier: Q8IZE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-491: Missing.

Show »
Length:688
Mass (Da):76,731
Checksum:i96DCB00F38A7F928
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti613M → T in AAN23123 (PubMed:12651155).Curated1
Sequence conflicti613M → T in AAN41656 (PubMed:12651155).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051690597G → A1 PublicationCorresponds to variant dbSNP:rs12143301Ensembl.1
Natural variantiVAR_051691621Q → R3 PublicationsCorresponds to variant dbSNP:rs4656197Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013125438 – 491Missing in isoform 2. 3 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540957 mRNA Translation: AAN23123.1
AY144493 mRNA Translation: AAN41656.1
AL117233 mRNA Translation: CAB55300.1
AK292507 mRNA Translation: BAF85196.1
AL031297 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90867.1
BC014662 mRNA Translation: AAH14662.1
CCDSiCCDS1286.1 [Q8IZE3-2]
CCDS1287.1 [Q8IZE3-1]
RefSeqiNP_065156.5, NM_020423.6 [Q8IZE3-2]
NP_851607.2, NM_181093.3 [Q8IZE3-1]
XP_006711528.1, XM_006711465.1 [Q8IZE3-1]
XP_011508103.1, XM_011509801.1 [Q8IZE3-1]
XP_016857351.1, XM_017001862.1 [Q8IZE3-2]
XP_016857352.1, XM_017001863.1 [Q8IZE3-2]
UniGeneiHs.435560
Hs.443551

Genome annotation databases

EnsembliENST00000367770; ENSP00000356744; ENSG00000000457 [Q8IZE3-1]
ENST00000367771; ENSP00000356745; ENSG00000000457 [Q8IZE3-2]
ENST00000367772; ENSP00000356746; ENSG00000000457 [Q8IZE3-1]
GeneIDi57147
KEGGihsa:57147
UCSCiuc001ggs.5 human [Q8IZE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPACE1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZE3
Secondary accession number(s): A8K8Z2
, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

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