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Protein

Dedicator of cytokinesis protein 3

Gene

DOCK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 3
Alternative name(s):
Modifier of cell adhesion
Presenilin-binding protein
Short name:
PBP
Gene namesi
Name:DOCK3
Synonyms:KIAA0299, MOCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2989. DOCK3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9.

Organism-specific databases

PharmGKBiPA27455.

Polymorphism and mutation databases

BioMutaiDOCK3.
DMDMi32469734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20302030Dedicator of cytokinesis protein 3PRO_0000189988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1658 – 16581PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZD9.
MaxQBiQ8IZD9.
PaxDbiQ8IZD9.
PeptideAtlasiQ8IZD9.
PRIDEiQ8IZD9.

PTM databases

iPTMnetiQ8IZD9.
PhosphoSiteiQ8IZD9.

Expressioni

Tissue specificityi

In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.1 Publication

Gene expression databases

BgeeiQ8IZD9.
CleanExiHS_DOCK3.
GenevisibleiQ8IZD9. HS.

Organism-specific databases

HPAiHPA037543.
HPA037544.

Interactioni

Subunit structurei

Interacts with presenilin proteins PSEN1 and PSEN2. Interacts with CRK (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1752361,EBI-389883

Protein-protein interaction databases

BioGridi108130. 5 interactions.
IntActiQ8IZD9. 7 interactions.
MINTiMINT-7241019.
STRINGi9606.ENSP00000266037.

Structurei

3D structure databases

ProteinModelPortaliQ8IZD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6762SH3PROSITE-ProRule annotationAdd
BLAST
Domaini421 – 599179DHR-1PROSITE-ProRule annotationAdd
BLAST
Domaini1228 – 1635408DHR-2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1970 – 19767SH3-bindingSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1731 – 176838Ser-richAdd
BLAST

Domaini

The DHR-2 domain may mediate some GEF activity.By similarity

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation
Contains 1 DHR-1 domain.PROSITE-ProRule annotation
Contains 1 DHR-2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
HOGENOMiHOG000006631.
HOVERGENiHBG051389.
InParanoidiQ8IZD9.
KOiK05727.
OMAiIHLKKAI.
OrthoDBiEOG7QNVK8.
PhylomeDBiQ8IZD9.
TreeFamiTF300423.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026800. DOCK3.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF66. PTHR23317:SF66. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK
60 70 80 90 100
PNVKGIFPAN YIHLKKAIVS NRGQYETVVP LEDSIVTEVT ATLQEWASLW
110 120 130 140 150
KQLYVKHKVD LFYKLRHVMN ELIDLRRQLL SGHLTQDQVR EVKRHITVRL
160 170 180 190 200
DWGNEHLGLD LVPRKDFEVV DSDQISVSDL YKMHLSSRQS VQQSTSQVDT
210 220 230 240 250
MRPRHGETCR MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY DMREGKQISE
260 270 280 290 300
RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML
310 320 330 340 350
LNDSKKGPPH LHYRRPYGCA VLSILDVLQS LTEVKEEKDF VLKVYTCNNE
360 370 380 390 400
SEWSQIHENI IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ IRRENPMIFN
410 420 430 440 450
RGLAITRKLG FPDVIMPGDI RNDLYLTLEK GDFERGGKSV QKNIEVTMYV
460 470 480 490 500
LYADGEILKD CISLGSGEPN RSSYHSFVLY HSNSPRWGEI IKLPIPIDRF
510 520 530 540 550
RGSHLRFEFR HCSTKDKGEK KLFGFAFSTL MRDDGTTLSD DIHELYVYKC
560 570 580 590 600
DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSTKE SFFISTQLSS
610 620 630 640 650
TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR HVSGEEIVKF LQDILDTLFV
660 670 680 690 700
ILDDNTEKYG LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY
710 720 730 740 750
KELIRCLKWY MDCSAELIRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG
760 770 780 790 800
MEEEQFRSSI QELFQSIRFV LSLDSRNSET LLFTQAALLN SFPTIFDELL
810 820 830 840 850
QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART VDSRLFSFSE
860 870 880 890 900
SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV
910 920 930 940 950
EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS
960 970 980 990 1000
LLRQMCDTHF QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM
1010 1020 1030 1040 1050
RLLTSNIIVT TVQYLSSALH KNFTETDFDF KVWNSYFSLA VLFINQPSLQ
1060 1070 1080 1090 1100
LEIITSAKRK KILDKYGDMR VMMAYELFSM WQNLGEHKIH FIPGMIGPFL
1110 1120 1130 1140 1150
GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI DKLDSMVSEG
1160 1170 1180 1190 1200
KGDESYRELF SLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL
1210 1220 1230 1240 1250
LDYRDCMKGE ETENKKIGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ
1260 1270 1280 1290 1300
AENYTEAAFT LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY
1310 1320 1330 1340 1350
FNKGKSWEFG IPLCRELACQ YESLYDYQSL SWIRKMEASY YDNIMEQQRL
1360 1370 1380 1390 1400
EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY ERLEAFQQRM LSEFPQAVAM
1410 1420 1430 1440 1450
QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD RVKSFYRVNN
1460 1470 1480 1490 1500
VRKFRYDRPF HKGPKDKENE FKSLWIERTT LTLTHSLPGI SRWFEVERRE
1510 1520 1530 1540 1550
LVEVSPLENA IQVVENKNQE LRSLISQYQH KQVHGNINLL SMCLNGVIDA
1560 1570 1580 1590 1600
AVNGGIARYQ EAFFDKDYIN KHPGDAEKIT QLKELMQEQV HVLGVGLAVH
1610 1620 1630 1640 1650
EKFVHPEMRP LHKKLIDQFQ MMRASLYHEF PGLDKLSPAC SGTSTPRGNV
1660 1670 1680 1690 1700
LASHSPMSPE SIKMTHRHSP MNLMGTGRHS SSSLSSHASS EAGNMVMLGD
1710 1720 1730 1740 1750
GSMGDAPEDL YHHMQLAYPN PRYQGSVTNV SVLSSSQASP SSSSLSSTHS
1760 1770 1780 1790 1800
APSQMITSAP SSARGSPSLP DKYRHAREMM LLLPTYRDRP SSAMYPAAIL
1810 1820 1830 1840 1850
ENGQPPNFQR ALFQQVVGAC KPCSDPNLSV AEKGHYSLHF DAFHHPLGDT
1860 1870 1880 1890 1900
PPALPARTLR KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN
1910 1920 1930 1940 1950
FGHSSEAPPR TDTMDSMPSQ AWNADEDLEP PYLPVHYSLS ESAVLDSIKA
1960 1970 1980 1990 2000
QPCRSHSAPG CVIPQDPMDP PALPPKPYHP RLPALEHDEG VLLREETERP
2010 2020 2030
RGLHRKAPLP PGSAKEEQAR MAWEHGRGEQ
Length:2,030
Mass (Da):233,103
Last modified:March 1, 2003 - v1
Checksum:iFF87E874B926C1C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145303 mRNA. Translation: AAN12301.1.
AY254099 mRNA. Translation: AAP80572.1.
AB002297 mRNA. Translation: BAA20759.1.
CCDSiCCDS46835.1.
RefSeqiNP_004938.1. NM_004947.4.
UniGeneiHs.476284.

Genome annotation databases

EnsembliENST00000266037; ENSP00000266037; ENSG00000088538.
GeneIDi1795.
KEGGihsa:1795.
UCSCiuc011bds.2. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145303 mRNA. Translation: AAN12301.1.
AY254099 mRNA. Translation: AAP80572.1.
AB002297 mRNA. Translation: BAA20759.1.
CCDSiCCDS46835.1.
RefSeqiNP_004938.1. NM_004947.4.
UniGeneiHs.476284.

3D structure databases

ProteinModelPortaliQ8IZD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108130. 5 interactions.
IntActiQ8IZD9. 7 interactions.
MINTiMINT-7241019.
STRINGi9606.ENSP00000266037.

PTM databases

iPTMnetiQ8IZD9.
PhosphoSiteiQ8IZD9.

Polymorphism and mutation databases

BioMutaiDOCK3.
DMDMi32469734.

Proteomic databases

EPDiQ8IZD9.
MaxQBiQ8IZD9.
PaxDbiQ8IZD9.
PeptideAtlasiQ8IZD9.
PRIDEiQ8IZD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266037; ENSP00000266037; ENSG00000088538.
GeneIDi1795.
KEGGihsa:1795.
UCSCiuc011bds.2. human.

Organism-specific databases

CTDi1795.
GeneCardsiDOCK3.
HGNCiHGNC:2989. DOCK3.
HPAiHPA037543.
HPA037544.
MIMi603123. gene.
neXtProtiNX_Q8IZD9.
PharmGKBiPA27455.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1998. Eukaryota.
ENOG410XQH7. LUCA.
GeneTreeiENSGT00610000085806.
HOGENOMiHOG000006631.
HOVERGENiHBG051389.
InParanoidiQ8IZD9.
KOiK05727.
OMAiIHLKKAI.
OrthoDBiEOG7QNVK8.
PhylomeDBiQ8IZD9.
TreeFamiTF300423.

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSiDOCK3. human.
GeneWikiiDock3.
GenomeRNAii1795.
PROiQ8IZD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZD9.
CleanExiHS_DOCK3.
GenevisibleiQ8IZD9. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026800. DOCK3.
IPR010703. DOCK_C.
IPR032376. DOCK_N.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF66. PTHR23317:SF66. 1 hit.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF16172. DOCK_N. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of novel presenilin binding protein."
    Kashiwa A., Yoshida H., Lee S., Paladino T., Liu Y., Chen Q., Dargusch R., Schubert D., Kimura H.
    J. Neurochem. 75:109-116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype."
    De Silva M.G., Elliott K., Dahl H.-H.M., Fitzpatrick E., Wilcox S., Delatycki M., Williamson R., Efron D., Lynch M., Forrest S.
    J. Med. Genet. 40:733-740(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL REARRANGEMENT.
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-2030.
    Tissue: Brain.
  4. "Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation."
    Chen Q., Yoshida H., Schubert D., Maher P., Mallory M., Masliah E.
    Am. J. Pathol. 159:1597-1602(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
    Cote J.-F., Vuori K.
    J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiDOCK3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZD9
Secondary accession number(s): O15017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.