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Protein

Solute carrier family 22 member 15

Gene

SLC22A15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.32. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 15
Alternative name(s):
Fly-like putative transporter 1
Short name:
Flipt 1
Gene namesi
Name:SLC22A15
Synonyms:FLIPT1
ORF Names:UNQ9429/PRO34686
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20301. SLC22A15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Transmembranei165 – 18723HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST
Transmembranei401 – 42020HelicalSequence analysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence analysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870374.

Polymorphism and mutation databases

BioMutaiSLC22A15.
DMDMi74750790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Solute carrier family 22 member 15PRO_0000338619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZD6.
PRIDEiQ8IZD6.

PTM databases

iPTMnetiQ8IZD6.
PhosphoSiteiQ8IZD6.

Expressioni

Tissue specificityi

Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.2 Publications

Developmental stagei

Expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

BgeeiQ8IZD6.
CleanExiHS_SLC22A15.
GenevisibleiQ8IZD6. HS.

Organism-specific databases

HPAiHPA019785.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358515.

Structurei

3D structure databases

ProteinModelPortaliQ8IZD6.
SMRiQ8IZD6. Positions 112-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi529 – 5357Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI2. Eukaryota.
ENOG4110YHH. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG108435.
InParanoidiQ8IZD6.
KOiK08211.
OMAiEFFAVTR.
OrthoDBiEOG7JDQX7.
PhylomeDBiQ8IZD6.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW
60 70 80 90 100
DLAELLPNQS HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE
110 120 130 140 150
WFLIANRSYK VSAASSFFFS GVFVGVISFG QLSDRFGRKK VYLTGFALDI
160 170 180 190 200
LFAIANGFSP SYEFFAVTRF LVGMMNGGMS LVAFVLLNEC VGTAYWALAG
210 220 230 240 250
SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL LSLFIPESPR
260 270 280 290 300
WLYSQGRLSE AEEALYLIAK RNRKLKCTFS LTHPANRSCR ETGSFLDLFR
310 320 330 340 350
YRVLLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS
360 370 380 390 400
YPLCIYLINQ KWFGRKRTLS AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS
410 420 430 440 450
HSLSLLGKLT ISAAFNIVYI YTSELYPTVI RNVGLGTCSM FSRVGGIIAP
460 470 480 490 500
FIPSLKYVQW SLPFIVFGAT GLTSGLLSLL LPETLNSPLL ETFSDLQVYS
510 520 530 540
YRRLGEEALS LQALDPQQCV DKESSLGSES EEEEEFYDAD EETQMIK
Length:547
Mass (Da):60,540
Last modified:March 1, 2003 - v1
Checksum:iAFE2EEA64B7FFDBC
GO
Isoform 2 (identifier: Q8IZD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-245: FI → VD
     246-547: Missing.

Show »
Length:245
Mass (Da):26,794
Checksum:i628B254C0C1C95FD
GO

Sequence cautioni

The sequence AAH26358.1 differs from that shown. Reason: Frameshift at position 7. Curated
The sequence AAH26358.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti349 – 3491P → Q.1 Publication
Corresponds to variant rs17852419 [ dbSNP | Ensembl ].
VAR_043813

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei244 – 2452FI → VD in isoform 2. 1 PublicationVSP_034059
Alternative sequencei246 – 547302Missing in isoform 2. 1 PublicationVSP_034060Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145501 mRNA. Translation: AAN52927.1.
AY358258 mRNA. Translation: AAQ88625.1.
AL357137, AL365318 Genomic DNA. Translation: CAH70379.1.
AL365318, AL357137 Genomic DNA. Translation: CAH70685.1.
AL357137, AL365318 Genomic DNA. Translation: CAH70380.1.
AL365318, AL357137 Genomic DNA. Translation: CAH70686.1.
CH471122 Genomic DNA. Translation: EAW56640.1.
BC026358 mRNA. Translation: AAH26358.1. Sequence problems.
AL353933 mRNA. Translation: CAB89246.1.
CCDSiCCDS44198.1. [Q8IZD6-1]
PIRiT48683.
RefSeqiNP_060890.2. NM_018420.2. [Q8IZD6-1]
XP_005271063.1. XM_005271006.2. [Q8IZD6-2]
UniGeneiHs.125482.

Genome annotation databases

EnsembliENST00000369502; ENSP00000358514; ENSG00000163393. [Q8IZD6-2]
ENST00000369503; ENSP00000358515; ENSG00000163393. [Q8IZD6-1]
GeneIDi55356.
KEGGihsa:55356.
UCSCiuc001ega.3. human. [Q8IZD6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145501 mRNA. Translation: AAN52927.1.
AY358258 mRNA. Translation: AAQ88625.1.
AL357137, AL365318 Genomic DNA. Translation: CAH70379.1.
AL365318, AL357137 Genomic DNA. Translation: CAH70685.1.
AL357137, AL365318 Genomic DNA. Translation: CAH70380.1.
AL365318, AL357137 Genomic DNA. Translation: CAH70686.1.
CH471122 Genomic DNA. Translation: EAW56640.1.
BC026358 mRNA. Translation: AAH26358.1. Sequence problems.
AL353933 mRNA. Translation: CAB89246.1.
CCDSiCCDS44198.1. [Q8IZD6-1]
PIRiT48683.
RefSeqiNP_060890.2. NM_018420.2. [Q8IZD6-1]
XP_005271063.1. XM_005271006.2. [Q8IZD6-2]
UniGeneiHs.125482.

3D structure databases

ProteinModelPortaliQ8IZD6.
SMRiQ8IZD6. Positions 112-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358515.

Protein family/group databases

TCDBi2.A.1.19.32. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8IZD6.
PhosphoSiteiQ8IZD6.

Polymorphism and mutation databases

BioMutaiSLC22A15.
DMDMi74750790.

Proteomic databases

PaxDbiQ8IZD6.
PRIDEiQ8IZD6.

Protocols and materials databases

DNASUi55356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369502; ENSP00000358514; ENSG00000163393. [Q8IZD6-2]
ENST00000369503; ENSP00000358515; ENSG00000163393. [Q8IZD6-1]
GeneIDi55356.
KEGGihsa:55356.
UCSCiuc001ega.3. human. [Q8IZD6-1]

Organism-specific databases

CTDi55356.
GeneCardsiSLC22A15.
HGNCiHGNC:20301. SLC22A15.
HPAiHPA019785.
MIMi608275. gene.
neXtProtiNX_Q8IZD6.
PharmGKBiPA134870374.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRI2. Eukaryota.
ENOG4110YHH. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG108435.
InParanoidiQ8IZD6.
KOiK08211.
OMAiEFFAVTR.
OrthoDBiEOG7JDQX7.
PhylomeDBiQ8IZD6.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-HSA-549127. Organic cation transport.

Miscellaneous databases

GenomeRNAii55356.
PROiQ8IZD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZD6.
CleanExiHS_SLC22A15.
GenevisibleiQ8IZD6. HS.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters."
    Eraly S.A., Nigam S.K.
    Biochem. Biophys. Res. Commun. 297:1159-1166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-349.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-547 (ISOFORM 1).
    Tissue: Amygdala.
  7. "Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines."
    Molderings G.J., Bruss M., Bonisch H., Gothert M.
    Ann. N. Y. Acad. Sci. 1009:75-81(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS22AF_HUMAN
AccessioniPrimary (citable) accession number: Q8IZD6
Secondary accession number(s): A8MUR3
, Q6UXP5, Q8TAL9, Q9NSH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.