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Protein

mRNA-decapping enzyme 1B

Gene

DCP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme 1B (EC:3.-.-.-)
Gene namesi
Name:DCP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24451. DCP1B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • P-body Source: GO_Central

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi196513.
OpenTargetsiENSG00000151065.
PharmGKBiPA134889143.

Polymorphism and mutation databases

BioMutaiDCP1B.
DMDMi317373353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004027992 – 617mRNA-decapping enzyme 1BAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei191PhosphotyrosineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei392PhosphothreonineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IZD4.
MaxQBiQ8IZD4.
PaxDbiQ8IZD4.
PeptideAtlasiQ8IZD4.
PRIDEiQ8IZD4.

PTM databases

iPTMnetiQ8IZD4.
PhosphoSitePlusiQ8IZD4.

Expressioni

Gene expression databases

BgeeiENSG00000151065.
CleanExiHS_DCP1B.
ExpressionAtlasiQ8IZD4. baseline and differential.
GenevisibleiQ8IZD4. HS.

Organism-specific databases

HPAiHPA039709.
HPA058778.

Interactioni

Subunit structurei

Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128216. 43 interactors.
DIPiDIP-31289N.
IntActiQ8IZD4. 17 interactors.
MINTiMINT-1190113.
STRINGi9606.ENSP00000280665.

Structurei

3D structure databases

ProteinModelPortaliQ8IZD4.
SMRiQ8IZD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi252 – 261Poly-Gln10

Sequence similaritiesi

Belongs to the DCP1 family.Curated

Phylogenomic databases

eggNOGiKOG2868. Eukaryota.
ENOG410XRY6. LUCA.
GeneTreeiENSGT00390000014855.
HOGENOMiHOG000090228.
HOVERGENiHBG103159.
InParanoidiQ8IZD4.
KOiK12611.
OMAiDEYTKCK.
OrthoDBiEOG091G0JB7.
PhylomeDBiQ8IZD4.
TreeFamiTF320504.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR010334. Dcp1.
IPR031953. mRNA_decap_C.
IPR011993. PH_dom-like.
PANTHERiPTHR16290. PTHR16290. 1 hit.
PfamiView protein in Pfam
PF06058. DCP1. 1 hit.
PF16741. mRNA_decap_C. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAAGGLV GKGRDISLAA LQRHDPYINR IVDVASQVAL YTFGHRANEW
60 70 80 90 100
EKTDVEGTLF VYTRSASPKH GFTIMNRLSM ENRTEPITKD LDFQLQDPFL
110 120 130 140 150
LYRNARLSIY GIWFYDKEEC QRIAELMKNL TQYEQLKAHQ GTGAGISPVI
160 170 180 190 200
LNSGEGKEVD ILRMLIKAKD EYTKCKTCSE PKKITSSSAI YDNPNLIKPI
210 220 230 240 250
PVKPSENQQQ RIPQPNQTLD PEPQHLSLTA LFGKQDKATC QETVEPPQTL
260 270 280 290 300
HQQQQQQQQQ QEKLPIRQGV VRSLSYEEPR RHSPPIEKQL CPAIQKLMVR
310 320 330 340 350
SADLHPLSEL PENRPCENGS THSAGEFFTG PVQPGSPHNI GTSRGVQNAS
360 370 380 390 400
RTQNLFEKLQ STPGAANKCD PSTPAPASSA ALNRSRAPTS VTPVAPGKGL
410 420 430 440 450
AQPPQAYFNG SLPPQTVGHQ AHGREQSTLP RQTLPISGSQ TGSSGVISPQ
460 470 480 490 500
ELLKKLQIVQ QEQQLHASNR PALAAKFPVL AQSSGTGKPL ESWINKTPNT
510 520 530 540 550
EQQTPLFQVI SPQRIPATAA PSLLMSPMVF AQPTSVPPKE RESGLLPVGG
560 570 580 590 600
QEPPAAATSL LLPIQSPEPS VITSSPLTKL QLQEALLYLI QNDDNFLNII
610
YEAYLFSMTQ AAMKKTM
Length:617
Mass (Da):67,723
Last modified:January 11, 2011 - v2
Checksum:i00B9D9592BAC3B64
GO
Isoform 2 (identifier: Q8IZD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MAAVAAGGLV...PFLLYRNARL → MQIKV

Note: No experimental confirmation available.
Show »
Length:515
Mass (Da):56,273
Checksum:i200E0AAD38984003
GO

Sequence cautioni

The sequence AAH15368 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251H → HQ in AAN62764 (PubMed:12417715).Curated1
Sequence conflicti251H → HQ in BAB71118 (PubMed:14702039).Curated1
Sequence conflicti251H → HQ in AAH15368 (PubMed:15489334).Curated1
Sequence conflicti251H → HQ in AAH43437 (PubMed:15489334).Curated1
Sequence conflicti426Q → R in BAB71118 (PubMed:14702039).Curated1
Sequence conflicti435P → A in AAH43437 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047395195N → D. Corresponds to variant dbSNP:rs12423058Ensembl.1
Natural variantiVAR_047396216N → S. Corresponds to variant dbSNP:rs34730825Ensembl.1
Natural variantiVAR_047397301S → T. Corresponds to variant dbSNP:rs2470449Ensembl.1
Natural variantiVAR_047398344R → H. Corresponds to variant dbSNP:rs715146Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560441 – 107MAAVA…RNARL → MQIKV in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146652 mRNA. Translation: AAN62764.1.
AK056200 mRNA. Translation: BAB71118.1.
AK299203 mRNA. Translation: BAG61243.1.
AC005342 Genomic DNA. No translation available.
BC015368 mRNA. Translation: AAH15368.2. Different initiation.
BC043437 mRNA. Translation: AAH43437.1.
CCDSiCCDS31727.1. [Q8IZD4-1]
RefSeqiNP_689853.3. NM_152640.4. [Q8IZD4-1]
XP_011519229.1. XM_011520927.2. [Q8IZD4-2]
UniGeneiHs.130934.
Hs.657746.

Genome annotation databases

EnsembliENST00000280665; ENSP00000280665; ENSG00000151065. [Q8IZD4-1]
GeneIDi196513.
KEGGihsa:196513.
UCSCiuc001qjx.2. human. [Q8IZD4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDCP1B_HUMAN
AccessioniPrimary (citable) accession number: Q8IZD4
Secondary accession number(s): B4DRD1
, Q86XH9, Q96BP8, Q96MZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 11, 2011
Last modified: August 30, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families