Reviewed, UniProtKB/Swiss-Prot Q8IZD2 (MLL5_HUMAN)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase MLL5
    EC=2.1.1.43
Alternative name(s):
    Myeloid/lymphoid or mixed-lineage leukemia protein 5
    Lysine N-methyltransferase 2E
      Short name=KMT2E

Gene names

Name:	MLL5
Synonyms:	KMT2E

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1858 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Ref.7 Ref.9 Ref.10
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subunit structure	Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with RARA. Ref.10
Subcellular location	Nucleus speckle. Note: Absent from the nucleolus. Ref.7
Tissue specificity	Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum. Ref.1
Post-translational modification	O-glycosylation at Thr-440 in the SET domain by OGT is essential for the histone methyltransferase and the coactivator activity toward RARA in granulopoiesis. The absence of Thr-440 glycosylation in assays done in vitro may explain why some authors did not detected any histone methyltransferase activity for this protein.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 PHD-type zinc finger. Contains 1 SET domain.
Sequence caution	The sequence AAH01296.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence starting in position 492. The sequence AAH40004.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence starting in position 227. The sequence AAH53906.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence starting in position 227. The sequence AAI42988.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence starting in position 492.

Ontologies

Keywords
Biological process	Cell cycle Growth arrest Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Chromatin regulator Methyltransferase Transferase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA methylation Inferred from sequence or structural similarity. Source: UniProtKB cell cycle arrest Inferred from electronic annotation. Source: UniProtKB-KW erythrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB histone methylation Ref.10 Inferred from direct assay. Source: UniProtKB neutrophil activation Inferred from sequence or structural similarity. Source: UniProtKB neutrophil mediated immunity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Ref.10 Inferred from mutant phenotype. Source: UniProtKB response to retinoic acid Ref.10 Inferred from mutant phenotype. Source: UniProtKB retinoic acid receptor signaling pathway Ref.10 Inferred from mutant phenotype. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MLL5-L complex Ref.10 Inferred from direct assay. Source: UniProtKB nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	enzyme binding Ref.10 Inferred from physical interaction. Source: UniProtKB histone methyltransferase activity (H3-K4 specific) Ref.10 Inferred from direct assay. Source: UniProtKB transcription coactivator activity Ref.10 Inferred from mutant phenotype. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.2 (identifier: Q8IZD2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.2 (identifier: Q8IZD2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     494-573: Missing.

Note: No experimental confirmation available.

Isoform 3 Ref.3 Ref.5 (identifier: Q8IZD2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     575-609: TREERKMEAILQAFARLEKREKRREQALERISTAK → VSWEASSLGLVTAALHMVIVAAFTWAFTLFFEVSE
     610-1858: Missing.

Isoform 4 Ref.2 (identifier: Q8IZD2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     850-865: GENKSPLLLNDSCSLP → EYFFPRKFSRNKETHL
     866-1858: Missing.

Note: No experimental confirmation available.

Isoform 5 Ref.2 (identifier: Q8IZD2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1508-1653: ANTQQATSGT...PNSHQQHSVA → VFWLLGIIPH...DSKNIFLNVL
     1654-1858: Missing.

Isoform 6 Ref.2 (identifier: Q8IZD2-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1443-1621: PSPHLENPPK...SQNPTIHHQT → SSPSTTPSIH...ALKWTPKTFF
     1622-1858: Missing.

Isoform 7 Ref.2 (identifier: Q8IZD2-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1282-1323: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1858	1858	Histone-lysine N-methyltransferase MLL5		PRO_0000341419
Regions
	Domain	328 – 451	124	SET
	Zinc finger	118 – 166	49	PHD-type
	Coiled coil	559 – 615	57	Potential
	Compositional bias	1433 – 1846	414	Pro-rich
Amino acid modifications
	Modified residue	1405	1	Phosphoserine Ref.8
	Glycosylation	440	1	O-linked (GalNAc...) Ref.10
Natural variations
	Alternative sequence	494 – 573	80	Missing in isoform 2. Ref.2		VSP_052803
	Alternative sequence	575 – 609	35	TREER…ISTAK → VSWEASSLGLVTAALHMVIV AAFTWAFTLFFEVSE in isoform 3. Ref.3 Ref.5		VSP_052804
	Alternative sequence	610 – 1858	1249	Missing in isoform 3. Ref.3 Ref.5		VSP_052805
	Alternative sequence	850 – 865	16	GENKS…SCSLP → EYFFPRKFSRNKETHL in isoform 4. Ref.2		VSP_052806
	Alternative sequence	866 – 1858	993	Missing in isoform 4. Ref.2		VSP_052807
	Alternative sequence	1282 – 1323	42	Missing in isoform 7. Ref.2		VSP_052808
	Alternative sequence	1443 – 1621	179	PSPHL…IHHQT → SSPSTTPSIHRTPRSTSTTP ACCKFSTPTTPSAATFQCFG FWASYHISSSLTPPTSSRTS TFSFECSSNCTTVSLTSYTS YHFGTGTPAPAFWNRATLSI TCHRSSSPAPRTKQYSNTYC FRVLSSSWLCGPATWGSRTS AGISSAWTDSNSQSTGATNI SKQLPWVRVALKWTPKTFF in isoform 6. Ref.2		VSP_052809
	Alternative sequence	1508 – 1653	146	ANTQQ…QHSVA → VFWLLGIIPHQLKPYTTHLI KDLHFFLRVLIQLYHRIPHK LHIIPLWDRDPSTSLLEQGH IVHYLSQVLISSPKDQTVFQ HLLLQGSVLILALWPCHMGF KDLSRHLQCLDRFQFTEHRC HQHFKTITMGQGGIKMDSKN IFLNVL in isoform 5. Ref.2		VSP_052810
	Alternative sequence	1622 – 1858	237	Missing in isoform 6. Ref.2		VSP_052811
	Alternative sequence	1654 – 1858	205	Missing in isoform 5. Ref.2		VSP_052812
	Natural variant	1424	1	S → P: dbSNP rs35605511.		VAR_052656
Experimental info
	Mutagenesis	334	1	S → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	345	1	S → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	358	1	Y → A: Loss of methyltransferase activity. Ref.10
	Mutagenesis	386	1	S → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	399	1	T → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	410	1	S → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	412	1	T → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	425	1	T → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	432	1	S → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	435	1	S → A: Does not affect O-glycosylation by OGT. Ref.10
	Mutagenesis	440	1	T → A: Abbolishes O-glycosylation by OGT and prevents coactivator activity toward RARA in granulopoiesis. Ref.10
	Mutagenesis	441	1	E → A: Loss of methyltransferase activity. Ref.10
	Mutagenesis	443	1	T → A: Does not affect O-glycosylation by OGT. Ref.10
	Sequence conflict	496	1	K → E in AAM74947. Ref.1
	Sequence conflict	496	1	K → E in AK000940. Ref.6
	Sequence conflict	516	1	T → A in AAM74947. Ref.1
	Sequence conflict	516	1	T → A in AK000940. Ref.6
	Sequence conflict	594	1	R → K in AK000940. Ref.6
	Sequence conflict	1020	1	V → A in AAM74947. Ref.1
	Sequence conflict	1073	1	R → S in AAM74947. Ref.1
	Sequence conflict	1090	1	S → P in AAM74947. Ref.1
	Sequence conflict	1099	1	F → S in AAM74947. Ref.1
	Sequence conflict	1168	1	E → K in AAM74947. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 8ACCB3CDB5BFCEFA	FASTA	1,858	204,965
	10 20 30 40 50 60 MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 70 80 90 100 110 120 YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 130 140 150 160 170 180 CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 190 200 210 220 230 240 RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 250 260 270 280 290 300 CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 310 320 330 340 350 360 QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 370 380 390 400 410 420 KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 430 440 450 460 470 480 IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 490 500 510 520 530 540 INSGYETRRK KGKKDKDISK EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN 550 560 570 580 590 600 QEPDFIDDIE EKTPISNEVE MESEEQIAER KRKMTREERK MEAILQAFAR LEKREKRREQ 610 620 630 640 650 660 ALERISTAKT EVKTECKDTQ IVSDAEVIQE QAKEENASKP TPAKVNRTKQ RKSFSRSRTH 670 680 690 700 710 720 IGQQRRRHRT VSMCSDIQPS SPDIEVTSQQ NDIENTVLTI EPETETALAE IITETEVPAL 730 740 750 760 770 780 NKCPTKYPKT KKHLVNEWLS EKNEKTGKPS DGLSERPLRI TTDPEVLATQ LNSLPGLTYS 790 800 810 820 830 840 PHVYSTPKHY IRFTSPFLSE KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ 850 860 870 880 890 900 ERSRSPAVNG ENKSPLLLND SCSLPDLTTP LKKRRFYQLL DSVYSETSTP TPSPYATPTH 910 920 930 940 950 960 TDITPMDPSF ATPPRIKSDD ETCRNGYKPI YSPVTPVTPG TPGNTMHFEN ISSPESSPEI 970 980 990 1000 1010 1020 KRRTYSQEGY DRSSTMLTLG PFRNSNLTEL GLQEIKTIGY TSPRSRTEVN RQCPGEKEPV 1030 1040 1050 1060 1070 1080 SDLQLGLDAV EPTALHKTLE TPAHDRAEPN SQLDSTHSGR GTMYSSWVKS PDRTGVNFSV 1090 1100 1110 1120 1130 1140 NSNLRDLTPS HQLEVGGGFR ISESKCLMQD DTRGMFMETT VFCTSEDGLV SGFGRTVNDN 1150 1160 1170 1180 1190 1200 LIDGNCTPQN PPQKKKVSLL EYRKRQREAR KSGSKTENFP LISVSPHASG SLSNNGDGCA 1210 1220 1230 1240 1250 1260 SSNDNGEQVD HTASLPLPTP ATVYNATSEE TSNNCPVKDA TASEKNEPEV QWTASTSVEQ 1270 1280 1290 1300 1310 1320 VRERSYQRAL LLSDHRKDKD SGGESPCVSC SPSHVQSSPS SHSNHIPQLQ AKGPVPSFSE 1330 1340 1350 1360 1370 1380 LMEDPDPENP EPTTTNECPS PDTSQNTCKS PPKMSKPGSP GSVIPAQAHG KIFTKPDPQW 1390 1400 1410 1420 1430 1440 DSTVSASEAE NGVHLKTELQ QKQLSNNNQA LSKNHPPQTH VRNSSEQLSQ KLPSVPTKLH 1450 1460 1470 1480 1490 1500 CPPSPHLENP PKSSTPHTPV QHGYLSPKPP SQQLGSPYRP HHSQSPQVGT PQREPQRNFY 1510 1520 1530 1540 1550 1560 PAAQNLPANT QQATSGTLFT QTPSGQSSAT YSQFNQQSLN STAPPPPPPP PPSSSYYQNQ 1570 1580 1590 1600 1610 1620 QPSANFQNYN QLKGSLSQQT VFTSGPNQAL PGTTSQQTVP GHHVTPGHFL PSQNPTIHHQ 1630 1640 1650 1660 1670 1680 TAAAVVPPPP PPPPAPGPHL VQQPNSHQQH SVAHVVGPVH AVTPGSHIHS QTAGHHLPPP 1690 1700 1710 1720 1730 1740 PPPPGPAPHH HPPPHPSTGL QGLQAQHQHV VNSAPPPPPP PPPSSVLASG HHTTSAQALH 1750 1760 1770 1780 1790 1800 HPPHQGPPLF PSSAHPTVPP YPSQATHHTT LGPGPQHQPS GTGPHCPLPV TGPHLQPQGP 1810 1820 1830 1840 1850 NSIPTPTASG FCPHPGSVAL PHGVQGPQQA SPVPGQIPIH RAQVPPTFQN NYHGSGWH
	Isoform 2. Checksum: AEA0E38D5D008BE7	FASTA	1,778	195,675
	10 20 30 40 50 60 MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 70 80 90 100 110 120 YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 130 140 150 160 170 180 CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 190 200 210 220 230 240 RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 250 260 270 280 290 300 CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 310 320 330 340 350 360 QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 370 380 390 400 410 420 KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 430 440 450 460 470 480 IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 490 500 510 520 530 540 INSGYETRRK KGKMTREERK MEAILQAFAR LEKREKRREQ ALERISTAKT EVKTECKDTQ 550 560 570 580 590 600 IVSDAEVIQE QAKEENASKP TPAKVNRTKQ RKSFSRSRTH IGQQRRRHRT VSMCSDIQPS 610 620 630 640 650 660 SPDIEVTSQQ NDIENTVLTI EPETETALAE IITETEVPAL NKCPTKYPKT KKHLVNEWLS 670 680 690 700 710 720 EKNEKTGKPS DGLSERPLRI TTDPEVLATQ LNSLPGLTYS PHVYSTPKHY IRFTSPFLSE 730 740 750 760 770 780 KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ ERSRSPAVNG ENKSPLLLND 790 800 810 820 830 840 SCSLPDLTTP LKKRRFYQLL DSVYSETSTP TPSPYATPTH TDITPMDPSF ATPPRIKSDD 850 860 870 880 890 900 ETCRNGYKPI YSPVTPVTPG TPGNTMHFEN ISSPESSPEI KRRTYSQEGY DRSSTMLTLG 910 920 930 940 950 960 PFRNSNLTEL GLQEIKTIGY TSPRSRTEVN RQCPGEKEPV SDLQLGLDAV EPTALHKTLE 970 980 990 1000 1010 1020 TPAHDRAEPN SQLDSTHSGR GTMYSSWVKS PDRTGVNFSV NSNLRDLTPS HQLEVGGGFR 1030 1040 1050 1060 1070 1080 ISESKCLMQD DTRGMFMETT VFCTSEDGLV SGFGRTVNDN LIDGNCTPQN PPQKKKVSLL 1090 1100 1110 1120 1130 1140 EYRKRQREAR KSGSKTENFP LISVSPHASG SLSNNGDGCA SSNDNGEQVD HTASLPLPTP 1150 1160 1170 1180 1190 1200 ATVYNATSEE TSNNCPVKDA TASEKNEPEV QWTASTSVEQ VRERSYQRAL LLSDHRKDKD 1210 1220 1230 1240 1250 1260 SGGESPCVSC SPSHVQSSPS SHSNHIPQLQ AKGPVPSFSE LMEDPDPENP EPTTTNECPS 1270 1280 1290 1300 1310 1320 PDTSQNTCKS PPKMSKPGSP GSVIPAQAHG KIFTKPDPQW DSTVSASEAE NGVHLKTELQ 1330 1340 1350 1360 1370 1380 QKQLSNNNQA LSKNHPPQTH VRNSSEQLSQ KLPSVPTKLH CPPSPHLENP PKSSTPHTPV 1390 1400 1410 1420 1430 1440 QHGYLSPKPP SQQLGSPYRP HHSQSPQVGT PQREPQRNFY PAAQNLPANT QQATSGTLFT 1450 1460 1470 1480 1490 1500 QTPSGQSSAT YSQFNQQSLN STAPPPPPPP PPSSSYYQNQ QPSANFQNYN QLKGSLSQQT 1510 1520 1530 1540 1550 1560 VFTSGPNQAL PGTTSQQTVP GHHVTPGHFL PSQNPTIHHQ TAAAVVPPPP PPPPAPGPHL 1570 1580 1590 1600 1610 1620 VQQPNSHQQH SVAHVVGPVH AVTPGSHIHS QTAGHHLPPP PPPPGPAPHH HPPPHPSTGL 1630 1640 1650 1660 1670 1680 QGLQAQHQHV VNSAPPPPPP PPPSSVLASG HHTTSAQALH HPPHQGPPLF PSSAHPTVPP 1690 1700 1710 1720 1730 1740 YPSQATHHTT LGPGPQHQPS GTGPHCPLPV TGPHLQPQGP NSIPTPTASG FCPHPGSVAL 1750 1760 1770 PHGVQGPQQA SPVPGQIPIH RAQVPPTFQN NYHGSGWH
	Isoform 3. Checksum: CAC22E252873885E	FASTA	609	68,926
	10 20 30 40 50 60 MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 70 80 90 100 110 120 YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 130 140 150 160 170 180 CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 190 200 210 220 230 240 RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 250 260 270 280 290 300 CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 310 320 330 340 350 360 QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 370 380 390 400 410 420 KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 430 440 450 460 470 480 IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 490 500 510 520 530 540 INSGYETRRK KGKKDKDISK EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN 550 560 570 580 590 600 QEPDFIDDIE EKTPISNEVE MESEEQIAER KRKMVSWEAS SLGLVTAALH MVIVAAFTWA FTLFFEVSE
	Isoform 4. Checksum: 7E1470684F22660D	FASTA	865	98,795
	10 20 30 40 50 60 MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 70 80 90 100 110 120 YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 130 140 150 160 170 180 CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 190 200 210 220 230 240 RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 250 260 270 280 290 300 CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 310 320 330 340 350 360 QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 370 380 390 400 410 420 KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 430 440 450 460 470 480 IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 490 500 510 520 530 540 INSGYETRRK KGKKDKDISK EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN 550 560 570 580 590 600 QEPDFIDDIE EKTPISNEVE MESEEQIAER KRKMTREERK MEAILQAFAR LEKREKRREQ 610 620 630 640 650 660 ALERISTAKT EVKTECKDTQ IVSDAEVIQE QAKEENASKP TPAKVNRTKQ RKSFSRSRTH 670 680 690 700 710 720 IGQQRRRHRT VSMCSDIQPS SPDIEVTSQQ NDIENTVLTI EPETETALAE IITETEVPAL 730 740 750 760 770 780 NKCPTKYPKT KKHLVNEWLS EKNEKTGKPS DGLSERPLRI TTDPEVLATQ LNSLPGLTYS 790 800 810 820 830 840 PHVYSTPKHY IRFTSPFLSE KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ 850 860 ERSRSPAVNE YFFPRKFSRN KETHL
	Isoform 5. Checksum: 6AF69A147E64F516	FASTA	1,653	185,802
	10 20 30 40 50 60 MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 70 80 90 100 110 120 YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 130 140 150 160 170 180 CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 190 200 210 220 230 240 RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 250 260 270 280 290 300 CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 310 320 330 340 350 360 QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 370 380 390 400 410 420 KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 430 440 450 460 470 480 IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 490 500 510 520 530 540 INSGYETRRK KGKKDKDISK EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN 550 560 570 580 590 600 QEPDFIDDIE EKTPISNEVE MESEEQIAER KRKMTREERK MEAILQAFAR LEKREKRREQ 610 620 630 640 650 660 ALERISTAKT EVKTECKDTQ IVSDAEVIQE QAKEENASKP TPAKVNRTKQ RKSFSRSRTH 670 680 690 700 710 720 IGQQRRRHRT VSMCSDIQPS SPDIEVTSQQ NDIENTVLTI EPETETALAE IITETEVPAL 730 740 750 760 770 780 NKCPTKYPKT KKHLVNEWLS EKNEKTGKPS DGLSERPLRI TTDPEVLATQ LNSLPGLTYS 790 800 810 820 830 840 PHVYSTPKHY IRFTSPFLSE KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ 850 860 870 880 890 900 ERSRSPAVNG ENKSPLLLND SCSLPDLTTP LKKRRFYQLL DSVYSETSTP TPSPYATPTH 910 920 930 940 950 960 TDITPMDPSF ATPPRIKSDD ETCRNGYKPI YSPVTPVTPG TPGNTMHFEN ISSPESSPEI 970 980 990 1000 1010 1020 KRRTYSQEGY DRSSTMLTLG PFRNSNLTEL GLQEIKTIGY TSPRSRTEVN RQCPGEKEPV 1030 1040 1050 1060 1070 1080 SDLQLGLDAV EPTALHKTLE TPAHDRAEPN SQLDSTHSGR GTMYSSWVKS PDRTGVNFSV 1090 1100 1110 1120 1130 1140 NSNLRDLTPS HQLEVGGGFR ISESKCLMQD DTRGMFMETT VFCTSEDGLV SGFGRTVNDN 1150 1160 1170 1180 1190 1200 LIDGNCTPQN PPQKKKVSLL EYRKRQREAR KSGSKTENFP LISVSPHASG SLSNNGDGCA 1210 1220 1230 1240 1250 1260 SSNDNGEQVD HTASLPLPTP ATVYNATSEE TSNNCPVKDA TASEKNEPEV QWTASTSVEQ 1270 1280 1290 1300 1310 1320 VRERSYQRAL LLSDHRKDKD SGGESPCVSC SPSHVQSSPS SHSNHIPQLQ AKGPVPSFSE 1330 1340 1350 1360 1370 1380 LMEDPDPENP EPTTTNECPS PDTSQNTCKS PPKMSKPGSP GSVIPAQAHG KIFTKPDPQW 1390 1400 1410 1420 1430 1440 DSTVSASEAE NGVHLKTELQ QKQLSNNNQA LSKNHPPQTH VRNSSEQLSQ KLPSVPTKLH 1450 1460 1470 1480 1490 1500 CPPSPHLENP PKSSTPHTPV QHGYLSPKPP SQQLGSPYRP HHSQSPQVGT PQREPQRNFY 1510 1520 1530 1540 1550 1560 PAAQNLPVFW LLGIIPHQLK PYTTHLIKDL HFFLRVLIQL YHRIPHKLHI IPLWDRDPST 1570 1580 1590 1600 1610 1620 SLLEQGHIVH YLSQVLISSP KDQTVFQHLL LQGSVLILAL WPCHMGFKDL SRHLQCLDRF 1630 1640 1650 QFTEHRCHQH FKTITMGQGG IKMDSKNIFL NVL
	Isoform 6. Checksum: 97E5EB49B9961FEA	FASTA	1,621	180,779
	10 20 30 40 50 60 MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 70 80 90 100 110 120 YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 130 140 150 160 170 180 CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 190 200 210 220 230 240 RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 250 260 270 280 290 300 CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 310 320 330 340 350 360 QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 370 380 390 400 410 420 KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 430 440 450 460 470 480 IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 490 500 510 520 530 540 INSGYETRRK KGKKDKDISK EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN 550 560 570 580 590 600 QEPDFIDDIE EKTPISNEVE MESEEQIAER KRKMTREERK MEAILQAFAR LEKREKRREQ 610 620 630 640 650 660 ALERISTAKT EVKTECKDTQ IVSDAEVIQE QAKEENASKP TPAKVNRTKQ RKSFSRSRTH 670 680 690 700 710 720 IGQQRRRHRT VSMCSDIQPS SPDIEVTSQQ NDIENTVLTI EPETETALAE IITETEVPAL 730 740 750 760 770 780 NKCPTKYPKT KKHLVNEWLS EKNEKTGKPS DGLSERPLRI TTDPEVLATQ LNSLPGLTYS 790 800 810 820 830 840 PHVYSTPKHY IRFTSPFLSE KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ 850 860 870 880 890 900 ERSRSPAVNG ENKSPLLLND SCSLPDLTTP LKKRRFYQLL DSVYSETSTP TPSPYATPTH 910 920 930 940 950 960 TDITPMDPSF ATPPRIKSDD ETCRNGYKPI YSPVTPVTPG TPGNTMHFEN ISSPESSPEI 970 980 990 1000 1010 1020 KRRTYSQEGY DRSSTMLTLG PFRNSNLTEL GLQEIKTIGY TSPRSRTEVN RQCPGEKEPV 1030 1040 1050 1060 1070 1080 SDLQLGLDAV EPTALHKTLE TPAHDRAEPN SQLDSTHSGR GTMYSSWVKS PDRTGVNFSV 1090 1100 1110 1120 1130 1140 NSNLRDLTPS HQLEVGGGFR ISESKCLMQD DTRGMFMETT VFCTSEDGLV SGFGRTVNDN 1150 1160 1170 1180 1190 1200 LIDGNCTPQN PPQKKKVSLL EYRKRQREAR KSGSKTENFP LISVSPHASG SLSNNGDGCA 1210 1220 1230 1240 1250 1260 SSNDNGEQVD HTASLPLPTP ATVYNATSEE TSNNCPVKDA TASEKNEPEV QWTASTSVEQ 1270 1280 1290 1300 1310 1320 VRERSYQRAL LLSDHRKDKD SGGESPCVSC SPSHVQSSPS SHSNHIPQLQ AKGPVPSFSE 1330 1340 1350 1360 1370 1380 LMEDPDPENP EPTTTNECPS PDTSQNTCKS PPKMSKPGSP GSVIPAQAHG KIFTKPDPQW 1390 1400 1410 1420 1430 1440 DSTVSASEAE NGVHLKTELQ QKQLSNNNQA LSKNHPPQTH VRNSSEQLSQ KLPSVPTKLH 1450 1460 1470 1480 1490 1500 CPSSPSTTPS IHRTPRSTST TPACCKFSTP TTPSAATFQC FGFWASYHIS SSLTPPTSSR 1510 1520 1530 1540 1550 1560 TSTFSFECSS NCTTVSLTSY TSYHFGTGTP APAFWNRATL SITCHRSSSP APRTKQYSNT 1570 1580 1590 1600 1610 1620 YCFRVLSSSW LCGPATWGSR TSAGISSAWT DSNSQSTGAT NISKQLPWVR VALKWTPKTF F
	Isoform 7. Checksum: 16311FD3AC2DC1EF	FASTA	1,816	200,635
	10 20 30 40 50 60 MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 70 80 90 100 110 120 YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 130 140 150 160 170 180 CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 190 200 210 220 230 240 RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 250 260 270 280 290 300 CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 310 320 330 340 350 360 QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 370 380 390 400 410 420 KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 430 440 450 460 470 480 IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 490 500 510 520 530 540 INSGYETRRK KGKKDKDISK EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN 550 560 570 580 590 600 QEPDFIDDIE EKTPISNEVE MESEEQIAER KRKMTREERK MEAILQAFAR LEKREKRREQ 610 620 630 640 650 660 ALERISTAKT EVKTECKDTQ IVSDAEVIQE QAKEENASKP TPAKVNRTKQ RKSFSRSRTH 670 680 690 700 710 720 IGQQRRRHRT VSMCSDIQPS SPDIEVTSQQ NDIENTVLTI EPETETALAE IITETEVPAL 730 740 750 760 770 780 NKCPTKYPKT KKHLVNEWLS EKNEKTGKPS DGLSERPLRI TTDPEVLATQ LNSLPGLTYS 790 800 810 820 830 840 PHVYSTPKHY IRFTSPFLSE KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ 850 860 870 880 890 900 ERSRSPAVNG ENKSPLLLND SCSLPDLTTP LKKRRFYQLL DSVYSETSTP TPSPYATPTH 910 920 930 940 950 960 TDITPMDPSF ATPPRIKSDD ETCRNGYKPI YSPVTPVTPG TPGNTMHFEN ISSPESSPEI 970 980 990 1000 1010 1020 KRRTYSQEGY DRSSTMLTLG PFRNSNLTEL GLQEIKTIGY TSPRSRTEVN RQCPGEKEPV 1030 1040 1050 1060 1070 1080 SDLQLGLDAV EPTALHKTLE TPAHDRAEPN SQLDSTHSGR GTMYSSWVKS PDRTGVNFSV 1090 1100 1110 1120 1130 1140 NSNLRDLTPS HQLEVGGGFR ISESKCLMQD DTRGMFMETT VFCTSEDGLV SGFGRTVNDN 1150 1160 1170 1180 1190 1200 LIDGNCTPQN PPQKKKVSLL EYRKRQREAR KSGSKTENFP LISVSPHASG SLSNNGDGCA 1210 1220 1230 1240 1250 1260 SSNDNGEQVD HTASLPLPTP ATVYNATSEE TSNNCPVKDA TASEKNEPEV QWTASTSVEQ 1270 1280 1290 1300 1310 1320 VRERSYQRAL LLSDHRKDKD SDPDPENPEP TTTNECPSPD TSQNTCKSPP KMSKPGSPGS 1330 1340 1350 1360 1370 1380 VIPAQAHGKI FTKPDPQWDS TVSASEAENG VHLKTELQQK QLSNNNQALS KNHPPQTHVR 1390 1400 1410 1420 1430 1440 NSSEQLSQKL PSVPTKLHCP PSPHLENPPK SSTPHTPVQH GYLSPKPPSQ QLGSPYRPHH 1450 1460 1470 1480 1490 1500 SQSPQVGTPQ REPQRNFYPA AQNLPANTQQ ATSGTLFTQT PSGQSSATYS QFNQQSLNST 1510 1520 1530 1540 1550 1560 APPPPPPPPP SSSYYQNQQP SANFQNYNQL KGSLSQQTVF TSGPNQALPG TTSQQTVPGH 1570 1580 1590 1600 1610 1620 HVTPGHFLPS QNPTIHHQTA AAVVPPPPPP PPAPGPHLVQ QPNSHQQHSV AHVVGPVHAV 1630 1640 1650 1660 1670 1680 TPGSHIHSQT AGHHLPPPPP PPGPAPHHHP PPHPSTGLQG LQAQHQHVVN SAPPPPPPPP 1690 1700 1710 1720 1730 1740 PSSVLASGHH TTSAQALHHP PHQGPPLFPS SAHPTVPPYP SQATHHTTLG PGPQHQPSGT 1750 1760 1770 1780 1790 1800 GPHCPLPVTG PHLQPQGPNS IPTPTASGFC PHPGSVALPH GVQGPQQASP VPGQIPIHRA 1810 QVPPTFQNNY HGSGWH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia." Emerling B.M., Bonifas J., Kratz C.P., Donovan S., Taylor B.R., Green E.D., Le Beau M.M., Shannon K.M. Oncogene 21:4849-4854(2002) [PubMed: 12101424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Identification and characterization of a novel gene located in the commonly deleted region 7q22-q31.1 in myeloid leukemias." Dohner K., Obermiller R.T., Lipka D.B., Hofmann K., Habdank M., Fazekas G., Frohling S., Lichter P., Scherer S.W., Dohner H. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 624-1858 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 1149-1251 (ISOFORMS 1/2/4/6/7), NUCLEOTIDE SEQUENCE [MRNA] OF 1190-1355 (ISOFORM 7), NUCLEOTIDE SEQUENCE [MRNA] OF 1415-1858 (ISOFORMS 5 AND 6). Tissue: Brain and Peripheral blood leukocyte.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-491. Tissue: Choriocarcinoma, Liver and Uterus.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-594. Tissue: Embryo.
[7]	"MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression." Deng L.-W., Chiu I., Strominger J.L. Proc. Natl. Acad. Sci. U.S.A. 101:757-762(2004) [PubMed: 14718661] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1405, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"RNA interference against mixed lineage leukemia 5 resulted in cell cycle arrest." Cheng F., Liu J., Zhou S.H., Wang X.N., Chew J.F., Deng L.-W. Int. J. Biochem. Cell Biol. 40:2472-2481(2008) [PubMed: 18573682] [Abstract] Cited for: FUNCTION.
[10]	"GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis." Fujiki R., Chikanishi T., Hashiba W., Ito H., Takada I., Roeder R.G., Kitagawa H., Kato S. Nature 459:455-459(2009) [PubMed: 19377461] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY, IDENTIFICATION IN THE MLL5-L COMPLEX, GLYCOSYLATION AT THR-440, INTERACTION WITH RARA, MUTAGENESIS OF SER-334; SER-345; TYR-358; SER-386; THR-399; SER-410; THR-412; THR-425; SER-432; SER-435; THR-440; GLU-441 AND THR-443.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF519459 mRNA. Translation: AAM74947.1. AY147037 mRNA. Translation: AAN17675.1. AY157990 mRNA. Translation: AAN76325.1. AY195568 mRNA. Translation: AAO47009.1. AY195569 mRNA. Translation: AAO47010.1. AY222296 mRNA. Translation: AAO64395.1. AY234382 mRNA. Translation: AAO89072.1. AY438698 mRNA. Translation: AAR13893.1. AC005065 Genomic DNA. No translation available. AC005070 Genomic DNA. No translation available. AC007384 Genomic DNA. No translation available. CH471070 Genomic DNA. Translation: EAW83356.1. BC001296 mRNA. Translation: AAH01296.1. Sequence problems. BC040004 mRNA. Translation: AAH40004.1. Sequence problems. BC053906 mRNA. Translation: AAH53906.1. Sequence problems. BC062583 mRNA. Translation: AAH62583.1. BC142987 mRNA. Translation: AAI42988.1. Sequence problems. AK000940 mRNA. No translation available.
IPI	IPI00337726. IPI00383482. IPI00384449. IPI00647901. IPI00895774. IPI00895784. IPI00895932.
RefSeq	NP_061152.3. NP_891847.1.
UniGene	Hs.592262
3D structure databases
HSSP	HSSP built from PDB template 1WEM based on UniProtKB Q8C9B9.
SMR	Q8IZD2. Positions 107-165, 312-466, 341-469.
ModBase	Search...
PTM databases
PhosphoSite	Q8IZD2.
Proteomic databases
PRIDE	Q8IZD2.
Genome annotation databases
Ensembl	ENST00000257745; ENSP00000257745; ENSG00000005483; Homo sapiens. [Genome view] ENST00000311117; ENSP00000312379; ENSG00000005483; Homo sapiens. [Genome view]
GeneID	55904.
KEGG	hsa:55904.
UCSC	uc003vcl.2. human. uc003vcm.1. human.
Organism-specific databases
CTD	55904.
GeneCards	GC07P104441.
HGNC	HGNC:18541. MLL5.
MIM	608444. gene.
PharmGKB	PA38568.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IZD2.
InParanoid	Q8IZD2.
OMA	PGHHVTP.
OrthoDB	EOG96Q9BT.
PhylomeDB	Q8IZD2.
Gene expression databases
ArrayExpress	Q8IZD2.
Bgee	Q8IZD2.
Genevestigator	Q8IZD2.
Family and domain databases
InterPro	IPR001214. SET_dom. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view]
Pfam	PF00628. PHD. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	61277.
SOURCE	Search...

Entry information

Entry name

MLL5_HUMAN

Accession

Primary (citable) accession number: Q8IZD2
Secondary accession number(s): B6ZDE4 , B6ZDM3, Q6P5Y2, Q6PKG4, Q6T316, Q86TI3, Q86W12, Q86WG0, Q86WL2, Q8IV78, Q8IWR5, Q8NFF8, Q9NWE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.