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Protein

Sterile alpha motif domain-containing protein 14

Gene

SAMD14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 14
Short name:
SAM domain-containing protein 14
Gene namesi
Name:SAMD14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:27312. SAMD14.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670953.

Polymorphism and mutation databases

BioMutaiSAMD14.
DMDMi115502829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Sterile alpha motif domain-containing protein 14PRO_0000250563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei108 – 1081PhosphoserineBy similarity
Modified residuei173 – 1731PhosphoserineBy similarity
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei279 – 2791PhosphoserineBy similarity
Modified residuei283 – 2831PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiQ8IZD0.
PRIDEiQ8IZD0.

PTM databases

iPTMnetiQ8IZD0.
PhosphoSiteiQ8IZD0.

Expressioni

Gene expression databases

BgeeiENSG00000167100.
CleanExiHS_SAMD14.
ExpressionAtlasiQ8IZD0. baseline and differential.
GenevisibleiQ8IZD0. HS.

Organism-specific databases

HPAiHPA051916.

Structurei

3D structure databases

ProteinModelPortaliQ8IZD0.
SMRiQ8IZD0. Positions 323-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini326 – 38964SAMPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili377 – 41741Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000010033.
HOVERGENiHBG093931.
InParanoidiQ8IZD0.
OMAiQWLESLN.
OrthoDBiEOG091G0MB9.
PhylomeDBiQ8IZD0.
TreeFamiTF331870.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSKLREPV DEVFDLDLAV PETARLDSSL HKARAQLLAK GRRHRPSRSR
60 70 80 90 100
LRDSASSAED GEGSDGPGGK VTDGCGSPLH RLRSPLHSGP GSPAGGSFCL
110 120 130 140 150
DPPGLRRSLD EDEPPPSPLT RYRPLHNAAS HEGLAAASCS PPRSAPSSDS
160 170 180 190 200
SPSFVRRHPR AEPHSEDDSR DASPPEPASP TIGLDKKTRR KFLDLGVTLR
210 220 230 240 250
RASTGKSRKE KGSNRLSMGS RESVEGSGRS GGSPFLPFSW FTDSGKGSAS
260 270 280 290 300
SGSTTSPTCS PKHEGFSPKK SASQESTLSD DSTPPSSSPK IPSGPWQEAK
310 320 330 340 350
CSYPYHTLSQ SSDEFLDEPL PPVHHWTSQQ VGQWLQSLNL EQYAAEFAAR
360 370 380 390 400
QVDGPQLLQL DGSKLKSLGL SNSHDRALVK RKLKEMAAAA EKERKAQEKA
410
ARQREKLRRR EQEAKKS
Length:417
Mass (Da):45,056
Last modified:October 3, 2006 - v2
Checksum:iAC180362D67F4400
GO
Isoform 2 (identifier: Q8IZD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: Q → QAQLLAHAQEALSNSWCLVQDFGSTQIGM

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):48,057
Checksum:i2005CD6F6502C502
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei274 – 2741Q → QAQLLAHAQEALSNSWCLVQ DFGSTQIGM in isoform 2. 1 PublicationVSP_020659

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY148482 mRNA. Translation: AAN71008.1.
AK094209 mRNA. Translation: BAG52844.1.
CH471109 Genomic DNA. Translation: EAW94641.1.
BC029872 mRNA. Translation: AAH29872.1.
BC136485 mRNA. Translation: AAI36486.1.
BC141822 mRNA. Translation: AAI41823.1.
BC142728 mRNA. Translation: AAI42729.1.
CCDSiCCDS11560.1. [Q8IZD0-2]
CCDS58562.1. [Q8IZD0-1]
RefSeqiNP_001244288.1. NM_001257359.1. [Q8IZD0-1]
NP_777580.1. NM_174920.3. [Q8IZD0-2]
UniGeneiHs.567769.

Genome annotation databases

EnsembliENST00000330175; ENSP00000329144; ENSG00000167100. [Q8IZD0-1]
ENST00000503131; ENSP00000424474; ENSG00000167100. [Q8IZD0-2]
GeneIDi201191.
KEGGihsa:201191.
UCSCiuc002iqf.5. human. [Q8IZD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY148482 mRNA. Translation: AAN71008.1.
AK094209 mRNA. Translation: BAG52844.1.
CH471109 Genomic DNA. Translation: EAW94641.1.
BC029872 mRNA. Translation: AAH29872.1.
BC136485 mRNA. Translation: AAI36486.1.
BC141822 mRNA. Translation: AAI41823.1.
BC142728 mRNA. Translation: AAI42729.1.
CCDSiCCDS11560.1. [Q8IZD0-2]
CCDS58562.1. [Q8IZD0-1]
RefSeqiNP_001244288.1. NM_001257359.1. [Q8IZD0-1]
NP_777580.1. NM_174920.3. [Q8IZD0-2]
UniGeneiHs.567769.

3D structure databases

ProteinModelPortaliQ8IZD0.
SMRiQ8IZD0. Positions 323-392.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8IZD0.
PhosphoSiteiQ8IZD0.

Polymorphism and mutation databases

BioMutaiSAMD14.
DMDMi115502829.

Proteomic databases

PeptideAtlasiQ8IZD0.
PRIDEiQ8IZD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330175; ENSP00000329144; ENSG00000167100. [Q8IZD0-1]
ENST00000503131; ENSP00000424474; ENSG00000167100. [Q8IZD0-2]
GeneIDi201191.
KEGGihsa:201191.
UCSCiuc002iqf.5. human. [Q8IZD0-1]

Organism-specific databases

CTDi201191.
GeneCardsiSAMD14.
HGNCiHGNC:27312. SAMD14.
HPAiHPA051916.
neXtProtiNX_Q8IZD0.
PharmGKBiPA142670953.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000010033.
HOVERGENiHBG093931.
InParanoidiQ8IZD0.
OMAiQWLESLN.
OrthoDBiEOG091G0MB9.
PhylomeDBiQ8IZD0.
TreeFamiTF331870.

Miscellaneous databases

ChiTaRSiSAMD14. human.
GenomeRNAii201191.
PROiQ8IZD0.

Gene expression databases

BgeeiENSG00000167100.
CleanExiHS_SAMD14.
ExpressionAtlasiQ8IZD0. baseline and differential.
GenevisibleiQ8IZD0. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAM14_HUMAN
AccessioniPrimary (citable) accession number: Q8IZD0
Secondary accession number(s): A5D8V1, Q8N2X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.