Q8IZD0 (SAM14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sterile alpha motif domain-containing protein 14
Short name=SAM domain-containing protein 14

Gene names

Name:

SAMD14

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZD0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZD0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: Q → QAQLLAHAQEALSNSWCLVQDFGSTQIGM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Sterile alpha motif domain-containing protein 14		PRO_0000250563
Regions
	Domain	326 – 389	64	SAM
	Coiled coil	377 – 417	41	Potential
Amino acid modifications
	Modified residue	108	1	Phosphoserine By similarity
	Modified residue	173	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	274	1	Q → QAQLLAHAQEALSNSWCLVQ DFGSTQIGM in isoform 2.		VSP_020659

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: AC180362D67F4400	FASTA	417	45,056
	10 20 30 40 50 60 MASSKLREPV DEVFDLDLAV PETARLDSSL HKARAQLLAK GRRHRPSRSR LRDSASSAED 70 80 90 100 110 120 GEGSDGPGGK VTDGCGSPLH RLRSPLHSGP GSPAGGSFCL DPPGLRRSLD EDEPPPSPLT 130 140 150 160 170 180 RYRPLHNAAS HEGLAAASCS PPRSAPSSDS SPSFVRRHPR AEPHSEDDSR DASPPEPASP 190 200 210 220 230 240 TIGLDKKTRR KFLDLGVTLR RASTGKSRKE KGSNRLSMGS RESVEGSGRS GGSPFLPFSW 250 260 270 280 290 300 FTDSGKGSAS SGSTTSPTCS PKHEGFSPKK SASQESTLSD DSTPPSSSPK IPSGPWQEAK 310 320 330 340 350 360 CSYPYHTLSQ SSDEFLDEPL PPVHHWTSQQ VGQWLQSLNL EQYAAEFAAR QVDGPQLLQL 370 380 390 400 410 DGSKLKSLGL SNSHDRALVK RKLKEMAAAA EKERKAQEKA ARQREKLRRR EQEAKKS
	Isoform 2 [UniParc]. Checksum: 2005CD6F6502C502	FASTA	445	48,057
	10 20 30 40 50 60 MASSKLREPV DEVFDLDLAV PETARLDSSL HKARAQLLAK GRRHRPSRSR LRDSASSAED 70 80 90 100 110 120 GEGSDGPGGK VTDGCGSPLH RLRSPLHSGP GSPAGGSFCL DPPGLRRSLD EDEPPPSPLT 130 140 150 160 170 180 RYRPLHNAAS HEGLAAASCS PPRSAPSSDS SPSFVRRHPR AEPHSEDDSR DASPPEPASP 190 200 210 220 230 240 TIGLDKKTRR KFLDLGVTLR RASTGKSRKE KGSNRLSMGS RESVEGSGRS GGSPFLPFSW 250 260 270 280 290 300 FTDSGKGSAS SGSTTSPTCS PKHEGFSPKK SASQAQLLAH AQEALSNSWC LVQDFGSTQI 310 320 330 340 350 360 GMESTLSDDS TPPSSSPKIP SGPWQEAKCS YPYHTLSQSS DEFLDEPLPP VHHWTSQQVG 370 380 390 400 410 420 QWLQSLNLEQ YAAEFAARQV DGPQLLQLDG SKLKSLGLSN SHDRALVKRK LKEMAAAAEK 430 440 ERKAQEKAAR QREKLRRREQ EAKKS

References

[1]	Guo J.H., Yu L. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY148482 mRNA. Translation: AAN71008.1. AK094209 mRNA. Translation: BAG52844.1. CH471109 Genomic DNA. Translation: EAW94641.1. BC029872 mRNA. Translation: AAH29872.1. BC136485 mRNA. Translation: AAI36486.1. BC141822 mRNA. Translation: AAI41823.1. BC142728 mRNA. Translation: AAI42729.1.
IPI	IPI00217977. IPI00333788.
RefSeq	NP_777580.1. NM_174920.2.
UniGene	Hs.567769.
3D structure databases
ProteinModelPortal	Q8IZD0.
SMR	Q8IZD0. Positions 323-392.
ModBase	Search...
PTM databases
PhosphoSite	Q8IZD0.
Polymorphism databases
DMDM	115502829.
Proteomic databases
PRIDE	Q8IZD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285206; ENSP00000285206; ENSG00000167100.
GeneID	201191.
KEGG	hsa:201191.
UCSC	uc002iqf.1. human. uc002iqg.1. human.
Organism-specific databases
CTD	201191.
GeneCards	GC17M048188.
HGNC	HGNC:27312. SAMD14.
neXtProt	NX_Q8IZD0.
PharmGKB	PA142670953.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000010033.
HOVERGEN	HBG093931.
OMA	HPRAEPH.
Gene expression databases
ArrayExpress	Q8IZD0.
Bgee	Q8IZD0.
CleanEx	HS_SAMD14.
Genevestigator	Q8IZD0.
GermOnline	ENSG00000167100. Homo sapiens.
Family and domain databases
InterPro	IPR001660. SAM. IPR013761. SAM/pointed. IPR021129. SAM_type1. [Graphical view]
Gene3D	G3DSA:1.10.150.50. SAM_type. 1 hit.
Pfam	PF00536. SAM_1. 1 hit. [Graphical view]
SMART	SM00454. SAM. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
PROSITE	PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	90080.

Entry information

Entry name

SAM14_HUMAN

Accession

Primary (citable) accession number: Q8IZD0
Secondary accession number(s): A5D8V1, Q8N2X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.