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Protein

Zinc finger protein 101

Gene

ZNF101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri102 – 12423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27624C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 101
Alternative name(s):
Zinc finger protein HZF12
Gene namesi
Name:ZNF101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12881. ZNF101.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37470.

Polymorphism and mutation databases

BioMutaiZNF101.
DMDMi55976740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Zinc finger protein 101PRO_0000047406Add
BLAST

Proteomic databases

EPDiQ8IZC7.
MaxQBiQ8IZC7.
PaxDbiQ8IZC7.
PeptideAtlasiQ8IZC7.
PRIDEiQ8IZC7.

PTM databases

iPTMnetiQ8IZC7.
PhosphoSiteiQ8IZC7.

Expressioni

Tissue specificityi

Expressed in a variety of adult and fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000181896.
CleanExiHS_ZNF101.
ExpressionAtlasiQ8IZC7. baseline and differential.
GenevisibleiQ8IZC7. HS.

Organism-specific databases

HPAiHPA023449.
HPA055486.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-5278328,EBI-10171697
KRTAP10-7P604093EBI-5278328,EBI-10172290
MDFIQ997503EBI-5278328,EBI-724076
ZNF16P170203EBI-5278328,EBI-3921553

Protein-protein interaction databases

BioGridi125102. 14 interactions.
IntActiQ8IZC7. 6 interactions.
MINTiMINT-1479229.
STRINGi9606.ENSP00000319716.

Structurei

3D structure databases

ProteinModelPortaliQ8IZC7.
SMRiQ8IZC7. Positions 4-53, 81-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8279KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri102 – 12423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27624C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IZC7.
KOiK09228.
OMAiLCGRKEG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IZC7.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LSPSQKNLYR DVTLETFRNL ASVGIQWKDQ
60 70 80 90 100
DIENLYQNLG IKLRSLVERL CGRKEGNEHR ETFSQIPDCH LNKKSQTGVK
110 120 130 140 150
PCKCSVCGKV FLRHSFLDRH MRAHAGHKRS ECGGEWRETP RKQKQHGKAS
160 170 180 190 200
ISPSSGARRT VTPTRKRPYE CKVCGKAFNS PNLFQIHQRT HTGKRSYKCR
210 220 230 240 250
EIVRAFTVSS FFRKHGKMHT GEKRYECKYC GKPIDYPSLF QIHVRTHTGE
260 270 280 290 300
KPYKCKQCGK AFISAGYLRT HEIRSHALEK SHQCQECGKK LSCSSSLHRH
310 320 330 340 350
ERTHSGGKLY ECQKCAKVFR CPTSLQAHER AHTGERPYEC NKCGKTFNYP
360 370 380 390 400
SCFRRHKKTH SGEKPYECTR CGKAFGWCSS LRRHEMTHTG EKPFDCKQCG
410 420 430
KVFTFSNYLR LHERTHLAGR SQCFGRRQGD HLSPGV
Length:436
Mass (Da):50,339
Last modified:March 1, 2003 - v1
Checksum:i48EEA2EEA86212B3
GO
Isoform 2 (identifier: Q8IZC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):36,473
Checksum:iD09DCD06780FF3A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211M → L.
Corresponds to variant rs4808209 [ dbSNP | Ensembl ].
VAR_024197

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform 2. 1 PublicationVSP_055937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149174 mRNA. Translation: AAN46749.1.
AC011458 Genomic DNA. No translation available.
BC119680 mRNA. Translation: AAI19681.1.
CCDSiCCDS32971.1. [Q8IZC7-1]
CCDS77271.1. [Q8IZC7-2]
RefSeqiNP_001287878.1. NM_001300949.1. [Q8IZC7-2]
NP_149981.2. NM_033204.3. [Q8IZC7-1]
UniGeneiHs.631642.
Hs.63187.

Genome annotation databases

EnsembliENST00000318110; ENSP00000319716; ENSG00000181896. [Q8IZC7-1]
ENST00000415784; ENSP00000400952; ENSG00000181896. [Q8IZC7-2]
ENST00000592502; ENSP00000468049; ENSG00000181896. [Q8IZC7-1]
GeneIDi94039.
KEGGihsa:94039.
UCSCiuc002nni.3. human. [Q8IZC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149174 mRNA. Translation: AAN46749.1.
AC011458 Genomic DNA. No translation available.
BC119680 mRNA. Translation: AAI19681.1.
CCDSiCCDS32971.1. [Q8IZC7-1]
CCDS77271.1. [Q8IZC7-2]
RefSeqiNP_001287878.1. NM_001300949.1. [Q8IZC7-2]
NP_149981.2. NM_033204.3. [Q8IZC7-1]
UniGeneiHs.631642.
Hs.63187.

3D structure databases

ProteinModelPortaliQ8IZC7.
SMRiQ8IZC7. Positions 4-53, 81-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125102. 14 interactions.
IntActiQ8IZC7. 6 interactions.
MINTiMINT-1479229.
STRINGi9606.ENSP00000319716.

PTM databases

iPTMnetiQ8IZC7.
PhosphoSiteiQ8IZC7.

Polymorphism and mutation databases

BioMutaiZNF101.
DMDMi55976740.

Proteomic databases

EPDiQ8IZC7.
MaxQBiQ8IZC7.
PaxDbiQ8IZC7.
PeptideAtlasiQ8IZC7.
PRIDEiQ8IZC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318110; ENSP00000319716; ENSG00000181896. [Q8IZC7-1]
ENST00000415784; ENSP00000400952; ENSG00000181896. [Q8IZC7-2]
ENST00000592502; ENSP00000468049; ENSG00000181896. [Q8IZC7-1]
GeneIDi94039.
KEGGihsa:94039.
UCSCiuc002nni.3. human. [Q8IZC7-1]

Organism-specific databases

CTDi94039.
GeneCardsiZNF101.
HGNCiHGNC:12881. ZNF101.
HPAiHPA023449.
HPA055486.
MIMi603983. gene.
neXtProtiNX_Q8IZC7.
PharmGKBiPA37470.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IZC7.
KOiK09228.
OMAiLCGRKEG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IZC7.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii94039.
PROiQ8IZC7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181896.
CleanExiHS_ZNF101.
ExpressionAtlasiQ8IZC7. baseline and differential.
GenevisibleiQ8IZC7. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN101_HUMAN
AccessioniPrimary (citable) accession number: Q8IZC7
Secondary accession number(s): C9JU83, Q0VDG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.