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Q8IZC6

- CORA1_HUMAN

UniProt

Q8IZC6 - CORA1_HUMAN

Protein

Collagen alpha-1(XXVII) chain

Gene

COL27A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Plays a role during the calcification of cartilage and the transition of cartilage to bone.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1708 – 17081CalciumBy similarity
    Metal bindingi1710 – 17101CalciumBy similarity
    Metal bindingi1713 – 17131Calcium; via carbonyl oxygenBy similarity
    Metal bindingi1716 – 17161CalciumBy similarity

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. extracellular matrix organization Source: Reactome

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_150180. Assembly of collagen fibrils and other multimeric structures.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XXVII) chain
    Gene namesi
    Name:COL27A1
    Synonyms:KIAA1870
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:22986. COL27A1.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix
    Note: Found on some small banded collagen fibrils and meshworks.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. extracellular region Source: Reactome
    3. fibrillar collagen trimer Source: Ensembl

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134990818.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Propeptidei42 – 624583N-terminal propeptidePRO_0000314667Add
    BLAST
    Chaini625 – 1621997Collagen alpha-1(XXVII) chainPRO_5000089163Add
    BLAST
    Propeptidei1622 – 1860239C-terminal propeptidePRO_0000314668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1690 ↔ 1722PROSITE-ProRule annotation
    Disulfide bondi1696 – 1696Interchain (with C-1285)PROSITE-ProRule annotation
    Disulfide bondi1713 – 1713Interchain (with C-1268)PROSITE-ProRule annotation
    Disulfide bondi1731 ↔ 1858PROSITE-ProRule annotation
    Disulfide bondi1767 ↔ 1811PROSITE-ProRule annotation
    Glycosylationi1769 – 17691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IZC6.
    PRIDEiQ8IZC6.

    PTM databases

    PhosphoSiteiQ8IZC6.

    Expressioni

    Developmental stagei

    Detected at E67 in the primary ossification center and is tightly restricted to the pericellular region of the hypertrophic chondrocytes and lacunae at the very center of the future diaphysis. At fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction. Weakly detected around cells in the resting and proliferative zone of the cartilaginous plate, but the intense detection occurred deep in the hypertrophic zone near the newly formed bone. Detected throughout the extracellular matrix (ECM) in this zone it is also closely situated around hypertrophic chondrocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ8IZC6.
    BgeeiQ8IZC6.
    CleanExiHS_COL27A1.
    GenevestigatoriQ8IZC6.

    Organism-specific databases

    HPAiHPA021884.
    HPA048471.

    Interactioni

    Protein-protein interaction databases

    BioGridi124464. 1 interaction.
    IntActiQ8IZC6. 1 interaction.
    MINTiMINT-7970406.
    STRINGi9606.ENSP00000348385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZC6.
    SMRiQ8IZC6. Positions 1678-1860.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 236166Laminin G-likeAdd
    BLAST
    Domaini625 – 67955Collagen-like 1Add
    BLAST
    Domaini688 – 74760Collagen-like 2Add
    BLAST
    Domaini748 – 80760Collagen-like 3Add
    BLAST
    Domaini808 – 86760Collagen-like 4Add
    BLAST
    Domaini871 – 93060Collagen-like 5Add
    BLAST
    Domaini931 – 99060Collagen-like 6Add
    BLAST
    Domaini1003 – 106260Collagen-like 7Add
    BLAST
    Domaini1066 – 112560Collagen-like 8Add
    BLAST
    Domaini1126 – 118560Collagen-like 9Add
    BLAST
    Domaini1192 – 125160Collagen-like 10Add
    BLAST
    Domaini1258 – 131760Collagen-like 11Add
    BLAST
    Domaini1318 – 137861Collagen-like 12Add
    BLAST
    Domaini1382 – 144160Collagen-like 13Add
    BLAST
    Domaini1442 – 150160Collagen-like 14Add
    BLAST
    Domaini1502 – 156160Collagen-like 15Add
    BLAST
    Domaini1562 – 162160Collagen-like 16Add
    BLAST
    Domaini1660 – 1860201Fibrillar collagen NC1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni625 – 1618994Triple-helical regionAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi283 – 16211339Pro-richAdd
    BLAST

    Domaini

    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.By similarity

    Sequence similaritiesi

    Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
    Contains 16 collagen-like domains.Curated
    Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000085654.
    HOVERGENiHBG098141.
    KOiK06236.
    OMAiYSYPDRL.
    OrthoDBiEOG7Q5HCC.
    PhylomeDBiQ8IZC6.
    TreeFamiTF344135.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000885. Fib_collagen_C.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF01410. COLFI. 2 hits.
    PF01391. Collagen. 13 hits.
    [Graphical view]
    ProDomiPD002078. Fib_collagen_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00038. COLFI. 1 hit.
    SM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS51461. NC1_FIB. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZC6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAGSARGAR GTAAAAAARG GGFLFSWILV SFACHLASTQ GAPEDVDILQ     50
    RLGLSWTKAG SPAPPGVIPF QSGFIFTQRA RLQAPTGTVI PAALGTELAL 100
    VLSLCSHRVN HAFLFAVRSQ KRKLQLGLQF LPGKTVVHLG SRRSVAFDLD 150
    MHDGRWHHLA LELRGRTVTL VTACGQRRVP VLLPFHRDPA LDPGGSFLFG 200
    KMNPHAVQFE GALCQFSIYP VTQVAHNYCT HLRKQCGQAD TYQSPLGPLF 250
    SQDSGRPFTF QSDLALLGLE NLTTATPALG SLPAGRGPRG TVAPATPTKP 300
    QRTSPTNPHQ HMAVGGPAQT PLLPAKLSAS NALDPMLPAS VGGSTRTPRP 350
    AAAQPSQKIT ATKIPKSLPT KPSAPSTSIV PIKSPHPTQK TAPSSFTKSA 400
    LPTQKQVPPT SRPVPARVSR PAEKPIQRNP GMPRPPPPST RPLPPTTSSS 450
    KKPIPTLART EAKITSHASK PASARTSTHK PPPFTALSSS PAPTPGSTRS 500
    TRPPATMVPP TSGTSTPRTA PAVPTPGSAP TGSKKPIGSE ASKKAGPKSS 550
    PRKPVPLRPG KAARDVPLSD LTTRPSPRQP QPSQQTTPAL VLAPAQFLSS 600
    SPRPTSSGYS IFHLAGSTPF PLLMGPPGPK GDCGLPGPPG LPGLPGIPGA 650
    RGPRGPPGPY GNPGLPGPPG AKGQKGDPGL SPGKAHDGAK GDMGLPGLSG 700
    NPGPPGRKGH KGYPGPAGHP GEQGQPGPEG SPGAKGYPGR QGLPGPVGDP 750
    GPKGSRGYIG LPGLFGLPGS DGERGLPGVP GKRGKMGMPG FPGVFGERGP 800
    PGLDGNPGEL GLPGPPGVPG LIGDLGVLGP IGYPGPKGMK GLMGSVGEPG 850
    LKGDKGEQGV PGVSGDPGFQ GDKGSQGLPG FPGARGKPGP LGKVGDKGSI 900
    GFPGPPGPEG FPGDIGPPGD NGPEGMKGKP GARGLPGPRG QLGPEGDEGP 950
    MGPPGAPGLE GQPGRKGFPG RPGLDGVKGE PGDPGRPGPV GEQGFMGFIG 1000
    LVGEPGIVGE KGDRGMMGPP GVPGPKGSMG HPGMPGGMGT PGEPGPQGPP 1050
    GSRGPPGMRG AKGRRGPRGP DGPAGEQGSR GLKGPPGPQG RPGRPGQQGV 1100
    AGERGHLGSR GFPGIPGPSG PPGTKGLPGE PGPQGPQGPI GPPGEMGPKG 1150
    PPGAVGEPGL PGEAGMKGDL GPLGTPGEQG LIGQRGEPGL EGDSGPMGPD 1200
    GLKGDRGDPG PDGEHGEKGQ EGLMGEDGPP GPPGVTGVRG PEGKSGKQGE 1250
    KGRTGAKGAK GYQGQLGEMG VPGDPGPPGT PGPKGSRGSL GPTGAPGRMG 1300
    AQGEPGLAGY DGHKGIVGPL GPPGPKGEKG EQGEDGKAEG PPGPPGDRGP 1350
    VGDRGDRGEP GDPGYPGQEG VQGLRGKPGQ QGQPGHPGPR GWPGPKGSKG 1400
    AEGPKGKQGK AGAPGRRGVQ GLQGLPGPRG VVGRQGLEGI AGPDGLPGRD 1450
    GQAGQQGEQG DDGDPGPMGP AGKRGNPGVA GLPGAQGPPG FKGESGLPGQ 1500
    LGPPGKRGTE GRTGLPGNQG EPGSKGQPGD SGEMGFPGMA GLFGPKGPPG 1550
    DIGFKGIQGP RGPPGLMGKE GIVGPLGILG PSGLPGPKGD KGSRGDWGLQ 1600
    GPRGPPGPRG RPGPPGPPGG PIQLQQDDLG AAFQTWMDTS GALRPESYSY 1650
    PDRLVLDQGG EIFKTLHYLS NLIQSIKTPL GTKENPARVC RDLMDCEQKM 1700
    VDGTYWVDPN LGCSSDTIEV SCNFTHGGQT CLKPITASKV EFAISRVQMN 1750
    FLHLLSSEVT QHITIHCLNM TVWQEGTGQT PAKQAVRFRA WNGQIFEAGG 1800
    QFRPEVSMDG CKVQDGRWHQ TLFTFRTQDP QQLPIISVDN LPPASSGKQY 1850
    RLEVGPACFL 1860
    Length:1,860
    Mass (Da):186,892
    Last modified:March 1, 2003 - v1
    Checksum:i5F8CDFAF4B6014EC
    GO
    Isoform 2 (identifier: Q8IZC6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1033: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:827
    Mass (Da):82,801
    Checksum:i3941B3A8696704BB
    GO
    Isoform 3 (identifier: Q8IZC6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         637-703: GPPGLPGLPG...GLPGLSGNPG → VRLSGVCMLL...CIIAHPAPDS
         704-1860: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:703
    Mass (Da):73,105
    Checksum:i9D3751FE90AE9E0D
    GO

    Sequence cautioni

    The sequence BAB47499.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti89 – 891V → I.
    Corresponds to variant rs2567707 [ dbSNP | Ensembl ].
    VAR_048784
    Natural varianti120 – 1201Q → R.
    Corresponds to variant rs2567706 [ dbSNP | Ensembl ].
    VAR_048785
    Natural varianti265 – 2651A → T.
    Corresponds to variant rs34578955 [ dbSNP | Ensembl ].
    VAR_048786
    Natural varianti349 – 3491R → C.
    Corresponds to variant rs34973417 [ dbSNP | Ensembl ].
    VAR_048787
    Natural varianti422 – 4221A → T.1 Publication
    Corresponds to variant rs2241671 [ dbSNP | Ensembl ].
    VAR_048788
    Natural varianti537 – 5371I → T.1 Publication
    Corresponds to variant rs2808770 [ dbSNP | Ensembl ].
    VAR_048789
    Natural varianti611 – 6111I → F.1 Publication
    Corresponds to variant rs2567705 [ dbSNP | Ensembl ].
    VAR_048790
    Natural varianti720 – 7201P → R.
    Corresponds to variant rs35446342 [ dbSNP | Ensembl ].
    VAR_048791
    Natural varianti1116 – 11161P → Q.
    Corresponds to variant rs7048607 [ dbSNP | Ensembl ].
    VAR_048792
    Natural varianti1348 – 13481R → Q.
    Corresponds to variant rs1631319 [ dbSNP | Ensembl ].
    VAR_048793
    Natural varianti1354 – 13541R → Q.
    Corresponds to variant rs10982134 [ dbSNP | Ensembl ].
    VAR_048794
    Natural varianti1808 – 18081M → V.
    Corresponds to variant rs3736252 [ dbSNP | Ensembl ].
    VAR_048795

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 10331033Missing in isoform 2. 1 PublicationVSP_030347Add
    BLAST
    Alternative sequencei637 – 70367GPPGL…SGNPG → VRLSGVCMLLGAPVGDWGIG QVVAPSKDRKRSSLEQGAGY GYILGSSQAPGSSGSAKCII AHPAPDS in isoform 3. 1 PublicationVSP_030348Add
    BLAST
    Alternative sequencei704 – 18601157Missing in isoform 3. 1 PublicationVSP_030349Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY149237 mRNA. Translation: AAN41263.1.
    AB058773 mRNA. Translation: BAB47499.1. Different initiation.
    AL445543, AL356796 Genomic DNA. Translation: CAI14772.1.
    AL356796, AL445543 Genomic DNA. Translation: CAI16857.1.
    BC080610 mRNA. Translation: AAH80610.1.
    CCDSiCCDS6802.1. [Q8IZC6-1]
    RefSeqiNP_116277.2. NM_032888.2. [Q8IZC6-1]
    UniGeneiHs.494892.

    Genome annotation databases

    EnsembliENST00000356083; ENSP00000348385; ENSG00000196739. [Q8IZC6-1]
    GeneIDi85301.
    KEGGihsa:85301.
    UCSCiuc011lxl.2. human. [Q8IZC6-1]

    Polymorphism databases

    DMDMi74762504.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY149237 mRNA. Translation: AAN41263.1 .
    AB058773 mRNA. Translation: BAB47499.1 . Different initiation.
    AL445543 , AL356796 Genomic DNA. Translation: CAI14772.1 .
    AL356796 , AL445543 Genomic DNA. Translation: CAI16857.1 .
    BC080610 mRNA. Translation: AAH80610.1 .
    CCDSi CCDS6802.1. [Q8IZC6-1 ]
    RefSeqi NP_116277.2. NM_032888.2. [Q8IZC6-1 ]
    UniGenei Hs.494892.

    3D structure databases

    ProteinModelPortali Q8IZC6.
    SMRi Q8IZC6. Positions 1678-1860.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124464. 1 interaction.
    IntActi Q8IZC6. 1 interaction.
    MINTi MINT-7970406.
    STRINGi 9606.ENSP00000348385.

    Chemistry

    ChEMBLi CHEMBL2364188.

    PTM databases

    PhosphoSitei Q8IZC6.

    Polymorphism databases

    DMDMi 74762504.

    Proteomic databases

    PaxDbi Q8IZC6.
    PRIDEi Q8IZC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356083 ; ENSP00000348385 ; ENSG00000196739 . [Q8IZC6-1 ]
    GeneIDi 85301.
    KEGGi hsa:85301.
    UCSCi uc011lxl.2. human. [Q8IZC6-1 ]

    Organism-specific databases

    CTDi 85301.
    GeneCardsi GC09P116917.
    HGNCi HGNC:22986. COL27A1.
    HPAi HPA021884.
    HPA048471.
    MIMi 608461. gene.
    neXtProti NX_Q8IZC6.
    PharmGKBi PA134990818.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000085654.
    HOVERGENi HBG098141.
    KOi K06236.
    OMAi YSYPDRL.
    OrthoDBi EOG7Q5HCC.
    PhylomeDBi Q8IZC6.
    TreeFami TF344135.

    Enzyme and pathway databases

    Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_150180. Assembly of collagen fibrils and other multimeric structures.

    Miscellaneous databases

    GeneWikii Collagen,_type_XXVII,_alpha_1.
    GenomeRNAii 85301.
    NextBioi 75783.
    PROi Q8IZC6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZC6.
    Bgeei Q8IZC6.
    CleanExi HS_COL27A1.
    Genevestigatori Q8IZC6.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000885. Fib_collagen_C.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF01410. COLFI. 2 hits.
    PF01391. Collagen. 13 hits.
    [Graphical view ]
    ProDomi PD002078. Fib_collagen_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00038. COLFI. 1 hit.
    SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS51461. NC1_FIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1."
      Pace J.M., Corrado M., Missero C., Byers P.H.
      Matrix Biol. 22:3-14(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Cartilage.
    2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-1860 (ISOFORM 3), VARIANTS THR-422; THR-537 AND PHE-611.
      Tissue: Skin.
    5. Cited for: FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCORA1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZC6
    Secondary accession number(s): Q66K43, Q96JF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3