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Q8IZC6

- CORA1_HUMAN

UniProt

Q8IZC6 - CORA1_HUMAN

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Protein

Collagen alpha-1(XXVII) chain

Gene

COL27A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role during the calcification of cartilage and the transition of cartilage to bone.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1708 – 17081CalciumBy similarity
Metal bindingi1710 – 17101CalciumBy similarity
Metal bindingi1713 – 17131Calcium; via carbonyl oxygenBy similarity
Metal bindingi1716 – 17161CalciumBy similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. extracellular matrix organization Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150180. Assembly of collagen fibrils and other multimeric structures.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVII) chain
Gene namesi
Name:COL27A1
Synonyms:KIAA1870
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:22986. COL27A1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix
Note: Found on some small banded collagen fibrils and meshworks.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. extracellular region Source: Reactome
  3. fibrillar collagen trimer Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134990818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence AnalysisAdd
BLAST
Propeptidei42 – 624583N-terminal propeptidePRO_0000314667Add
BLAST
Chaini625 – 1621997Collagen alpha-1(XXVII) chainPRO_5000089163Add
BLAST
Propeptidei1622 – 1860239C-terminal propeptidePRO_0000314668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1690 ↔ 1722PROSITE-ProRule annotation
Disulfide bondi1696 – 1696Interchain (with C-1285)PROSITE-ProRule annotation
Disulfide bondi1713 – 1713Interchain (with C-1268)PROSITE-ProRule annotation
Disulfide bondi1731 ↔ 1858PROSITE-ProRule annotation
Disulfide bondi1767 ↔ 1811PROSITE-ProRule annotation
Glycosylationi1769 – 17691N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IZC6.
PRIDEiQ8IZC6.

PTM databases

PhosphoSiteiQ8IZC6.

Expressioni

Developmental stagei

Detected at E67 in the primary ossification center and is tightly restricted to the pericellular region of the hypertrophic chondrocytes and lacunae at the very center of the future diaphysis. At fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction. Weakly detected around cells in the resting and proliferative zone of the cartilaginous plate, but the intense detection occurred deep in the hypertrophic zone near the newly formed bone. Detected throughout the extracellular matrix (ECM) in this zone it is also closely situated around hypertrophic chondrocytes.1 Publication

Gene expression databases

BgeeiQ8IZC6.
CleanExiHS_COL27A1.
ExpressionAtlasiQ8IZC6. baseline and differential.
GenevestigatoriQ8IZC6.

Organism-specific databases

HPAiHPA021884.
HPA048471.

Interactioni

Protein-protein interaction databases

BioGridi124464. 1 interaction.
IntActiQ8IZC6. 1 interaction.
MINTiMINT-7970406.
STRINGi9606.ENSP00000348385.

Structurei

3D structure databases

ProteinModelPortaliQ8IZC6.
SMRiQ8IZC6. Positions 1678-1860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 236166Laminin G-likeAdd
BLAST
Domaini625 – 67955Collagen-like 1Add
BLAST
Domaini688 – 74760Collagen-like 2Add
BLAST
Domaini748 – 80760Collagen-like 3Add
BLAST
Domaini808 – 86760Collagen-like 4Add
BLAST
Domaini871 – 93060Collagen-like 5Add
BLAST
Domaini931 – 99060Collagen-like 6Add
BLAST
Domaini1003 – 106260Collagen-like 7Add
BLAST
Domaini1066 – 112560Collagen-like 8Add
BLAST
Domaini1126 – 118560Collagen-like 9Add
BLAST
Domaini1192 – 125160Collagen-like 10Add
BLAST
Domaini1258 – 131760Collagen-like 11Add
BLAST
Domaini1318 – 137861Collagen-like 12Add
BLAST
Domaini1382 – 144160Collagen-like 13Add
BLAST
Domaini1442 – 150160Collagen-like 14Add
BLAST
Domaini1502 – 156160Collagen-like 15Add
BLAST
Domaini1562 – 162160Collagen-like 16Add
BLAST
Domaini1660 – 1860201Fibrillar collagen NC1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni625 – 1618994Triple-helical regionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi283 – 16211339Pro-richAdd
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
Contains 16 collagen-like domains.Curated
Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00770000120467.
HOGENOMiHOG000085654.
HOVERGENiHBG098141.
InParanoidiQ8IZC6.
KOiK06236.
OMAiYSYPDRL.
OrthoDBiEOG7Q5HCC.
PhylomeDBiQ8IZC6.
TreeFamiTF344135.

Family and domain databases

InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01410. COLFI. 2 hits.
PF01391. Collagen. 13 hits.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZC6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAGSARGAR GTAAAAAARG GGFLFSWILV SFACHLASTQ GAPEDVDILQ
60 70 80 90 100
RLGLSWTKAG SPAPPGVIPF QSGFIFTQRA RLQAPTGTVI PAALGTELAL
110 120 130 140 150
VLSLCSHRVN HAFLFAVRSQ KRKLQLGLQF LPGKTVVHLG SRRSVAFDLD
160 170 180 190 200
MHDGRWHHLA LELRGRTVTL VTACGQRRVP VLLPFHRDPA LDPGGSFLFG
210 220 230 240 250
KMNPHAVQFE GALCQFSIYP VTQVAHNYCT HLRKQCGQAD TYQSPLGPLF
260 270 280 290 300
SQDSGRPFTF QSDLALLGLE NLTTATPALG SLPAGRGPRG TVAPATPTKP
310 320 330 340 350
QRTSPTNPHQ HMAVGGPAQT PLLPAKLSAS NALDPMLPAS VGGSTRTPRP
360 370 380 390 400
AAAQPSQKIT ATKIPKSLPT KPSAPSTSIV PIKSPHPTQK TAPSSFTKSA
410 420 430 440 450
LPTQKQVPPT SRPVPARVSR PAEKPIQRNP GMPRPPPPST RPLPPTTSSS
460 470 480 490 500
KKPIPTLART EAKITSHASK PASARTSTHK PPPFTALSSS PAPTPGSTRS
510 520 530 540 550
TRPPATMVPP TSGTSTPRTA PAVPTPGSAP TGSKKPIGSE ASKKAGPKSS
560 570 580 590 600
PRKPVPLRPG KAARDVPLSD LTTRPSPRQP QPSQQTTPAL VLAPAQFLSS
610 620 630 640 650
SPRPTSSGYS IFHLAGSTPF PLLMGPPGPK GDCGLPGPPG LPGLPGIPGA
660 670 680 690 700
RGPRGPPGPY GNPGLPGPPG AKGQKGDPGL SPGKAHDGAK GDMGLPGLSG
710 720 730 740 750
NPGPPGRKGH KGYPGPAGHP GEQGQPGPEG SPGAKGYPGR QGLPGPVGDP
760 770 780 790 800
GPKGSRGYIG LPGLFGLPGS DGERGLPGVP GKRGKMGMPG FPGVFGERGP
810 820 830 840 850
PGLDGNPGEL GLPGPPGVPG LIGDLGVLGP IGYPGPKGMK GLMGSVGEPG
860 870 880 890 900
LKGDKGEQGV PGVSGDPGFQ GDKGSQGLPG FPGARGKPGP LGKVGDKGSI
910 920 930 940 950
GFPGPPGPEG FPGDIGPPGD NGPEGMKGKP GARGLPGPRG QLGPEGDEGP
960 970 980 990 1000
MGPPGAPGLE GQPGRKGFPG RPGLDGVKGE PGDPGRPGPV GEQGFMGFIG
1010 1020 1030 1040 1050
LVGEPGIVGE KGDRGMMGPP GVPGPKGSMG HPGMPGGMGT PGEPGPQGPP
1060 1070 1080 1090 1100
GSRGPPGMRG AKGRRGPRGP DGPAGEQGSR GLKGPPGPQG RPGRPGQQGV
1110 1120 1130 1140 1150
AGERGHLGSR GFPGIPGPSG PPGTKGLPGE PGPQGPQGPI GPPGEMGPKG
1160 1170 1180 1190 1200
PPGAVGEPGL PGEAGMKGDL GPLGTPGEQG LIGQRGEPGL EGDSGPMGPD
1210 1220 1230 1240 1250
GLKGDRGDPG PDGEHGEKGQ EGLMGEDGPP GPPGVTGVRG PEGKSGKQGE
1260 1270 1280 1290 1300
KGRTGAKGAK GYQGQLGEMG VPGDPGPPGT PGPKGSRGSL GPTGAPGRMG
1310 1320 1330 1340 1350
AQGEPGLAGY DGHKGIVGPL GPPGPKGEKG EQGEDGKAEG PPGPPGDRGP
1360 1370 1380 1390 1400
VGDRGDRGEP GDPGYPGQEG VQGLRGKPGQ QGQPGHPGPR GWPGPKGSKG
1410 1420 1430 1440 1450
AEGPKGKQGK AGAPGRRGVQ GLQGLPGPRG VVGRQGLEGI AGPDGLPGRD
1460 1470 1480 1490 1500
GQAGQQGEQG DDGDPGPMGP AGKRGNPGVA GLPGAQGPPG FKGESGLPGQ
1510 1520 1530 1540 1550
LGPPGKRGTE GRTGLPGNQG EPGSKGQPGD SGEMGFPGMA GLFGPKGPPG
1560 1570 1580 1590 1600
DIGFKGIQGP RGPPGLMGKE GIVGPLGILG PSGLPGPKGD KGSRGDWGLQ
1610 1620 1630 1640 1650
GPRGPPGPRG RPGPPGPPGG PIQLQQDDLG AAFQTWMDTS GALRPESYSY
1660 1670 1680 1690 1700
PDRLVLDQGG EIFKTLHYLS NLIQSIKTPL GTKENPARVC RDLMDCEQKM
1710 1720 1730 1740 1750
VDGTYWVDPN LGCSSDTIEV SCNFTHGGQT CLKPITASKV EFAISRVQMN
1760 1770 1780 1790 1800
FLHLLSSEVT QHITIHCLNM TVWQEGTGQT PAKQAVRFRA WNGQIFEAGG
1810 1820 1830 1840 1850
QFRPEVSMDG CKVQDGRWHQ TLFTFRTQDP QQLPIISVDN LPPASSGKQY
1860
RLEVGPACFL
Length:1,860
Mass (Da):186,892
Last modified:March 1, 2003 - v1
Checksum:i5F8CDFAF4B6014EC
GO
Isoform 2 (identifier: Q8IZC6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1033: Missing.

Note: No experimental confirmation available.

Show »
Length:827
Mass (Da):82,801
Checksum:i3941B3A8696704BB
GO
Isoform 3 (identifier: Q8IZC6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-703: GPPGLPGLPG...GLPGLSGNPG → VRLSGVCMLL...CIIAHPAPDS
     704-1860: Missing.

Note: No experimental confirmation available.

Show »
Length:703
Mass (Da):73,105
Checksum:i9D3751FE90AE9E0D
GO

Sequence cautioni

The sequence BAB47499.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891V → I.
Corresponds to variant rs2567707 [ dbSNP | Ensembl ].
VAR_048784
Natural varianti120 – 1201Q → R.
Corresponds to variant rs2567706 [ dbSNP | Ensembl ].
VAR_048785
Natural varianti265 – 2651A → T.
Corresponds to variant rs34578955 [ dbSNP | Ensembl ].
VAR_048786
Natural varianti349 – 3491R → C.
Corresponds to variant rs34973417 [ dbSNP | Ensembl ].
VAR_048787
Natural varianti422 – 4221A → T.1 Publication
Corresponds to variant rs2241671 [ dbSNP | Ensembl ].
VAR_048788
Natural varianti537 – 5371I → T.1 Publication
Corresponds to variant rs2808770 [ dbSNP | Ensembl ].
VAR_048789
Natural varianti611 – 6111I → F.1 Publication
Corresponds to variant rs2567705 [ dbSNP | Ensembl ].
VAR_048790
Natural varianti720 – 7201P → R.
Corresponds to variant rs35446342 [ dbSNP | Ensembl ].
VAR_048791
Natural varianti1116 – 11161P → Q.
Corresponds to variant rs7048607 [ dbSNP | Ensembl ].
VAR_048792
Natural varianti1348 – 13481R → Q.
Corresponds to variant rs1631319 [ dbSNP | Ensembl ].
VAR_048793
Natural varianti1354 – 13541R → Q.
Corresponds to variant rs10982134 [ dbSNP | Ensembl ].
VAR_048794
Natural varianti1808 – 18081M → V.
Corresponds to variant rs3736252 [ dbSNP | Ensembl ].
VAR_048795

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10331033Missing in isoform 2. 1 PublicationVSP_030347Add
BLAST
Alternative sequencei637 – 70367GPPGL…SGNPG → VRLSGVCMLLGAPVGDWGIG QVVAPSKDRKRSSLEQGAGY GYILGSSQAPGSSGSAKCII AHPAPDS in isoform 3. 1 PublicationVSP_030348Add
BLAST
Alternative sequencei704 – 18601157Missing in isoform 3. 1 PublicationVSP_030349Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149237 mRNA. Translation: AAN41263.1.
AB058773 mRNA. Translation: BAB47499.1. Different initiation.
AL445543, AL356796 Genomic DNA. Translation: CAI14772.1.
AL356796, AL445543 Genomic DNA. Translation: CAI16857.1.
BC080610 mRNA. Translation: AAH80610.1.
CCDSiCCDS6802.1. [Q8IZC6-1]
RefSeqiNP_116277.2. NM_032888.3. [Q8IZC6-1]
UniGeneiHs.494892.

Genome annotation databases

EnsembliENST00000356083; ENSP00000348385; ENSG00000196739. [Q8IZC6-1]
GeneIDi85301.
KEGGihsa:85301.
UCSCiuc011lxl.2. human. [Q8IZC6-1]

Polymorphism databases

DMDMi74762504.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149237 mRNA. Translation: AAN41263.1 .
AB058773 mRNA. Translation: BAB47499.1 . Different initiation.
AL445543 , AL356796 Genomic DNA. Translation: CAI14772.1 .
AL356796 , AL445543 Genomic DNA. Translation: CAI16857.1 .
BC080610 mRNA. Translation: AAH80610.1 .
CCDSi CCDS6802.1. [Q8IZC6-1 ]
RefSeqi NP_116277.2. NM_032888.3. [Q8IZC6-1 ]
UniGenei Hs.494892.

3D structure databases

ProteinModelPortali Q8IZC6.
SMRi Q8IZC6. Positions 1678-1860.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124464. 1 interaction.
IntActi Q8IZC6. 1 interaction.
MINTi MINT-7970406.
STRINGi 9606.ENSP00000348385.

Chemistry

ChEMBLi CHEMBL2364188.

PTM databases

PhosphoSitei Q8IZC6.

Polymorphism databases

DMDMi 74762504.

Proteomic databases

PaxDbi Q8IZC6.
PRIDEi Q8IZC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356083 ; ENSP00000348385 ; ENSG00000196739 . [Q8IZC6-1 ]
GeneIDi 85301.
KEGGi hsa:85301.
UCSCi uc011lxl.2. human. [Q8IZC6-1 ]

Organism-specific databases

CTDi 85301.
GeneCardsi GC09P116917.
HGNCi HGNC:22986. COL27A1.
HPAi HPA021884.
HPA048471.
MIMi 608461. gene.
neXtProti NX_Q8IZC6.
PharmGKBi PA134990818.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00770000120467.
HOGENOMi HOG000085654.
HOVERGENi HBG098141.
InParanoidi Q8IZC6.
KOi K06236.
OMAi YSYPDRL.
OrthoDBi EOG7Q5HCC.
PhylomeDBi Q8IZC6.
TreeFami TF344135.

Enzyme and pathway databases

Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150180. Assembly of collagen fibrils and other multimeric structures.

Miscellaneous databases

ChiTaRSi COL27A1. human.
GeneWikii Collagen,_type_XXVII,_alpha_1.
GenomeRNAii 85301.
NextBioi 75783.
PROi Q8IZC6.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZC6.
CleanExi HS_COL27A1.
ExpressionAtlasi Q8IZC6. baseline and differential.
Genevestigatori Q8IZC6.

Family and domain databases

InterProi IPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF01410. COLFI. 2 hits.
PF01391. Collagen. 13 hits.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51461. NC1_FIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1."
    Pace J.M., Corrado M., Missero C., Byers P.H.
    Matrix Biol. 22:3-14(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Cartilage.
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-1860 (ISOFORM 3), VARIANTS THR-422; THR-537 AND PHE-611.
    Tissue: Skin.
  5. Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCORA1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZC6
Secondary accession number(s): Q66K43, Q96JF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3