Q8IZC6 (CORA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(XXVII) chain

Gene names

Name:	COL27A1
Synonyms:	KIAA1870

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1860 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role during the calcification of cartilage and the transition of cartilage to bone. Ref.5
Subcellular location	Secreted › extracellular space › extracellular matrix. Note: Found on some small banded collagen fibrils and meshworks By similarity.
Developmental stage	Detected at E67 in the primary ossification center and is tightly restricted to the pericellular region of the hypertrophic chondrocytes and lacunae at the very center of the future diaphysis. At fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction. Weakly detected around cells in the resting and proliferative zone of the cartilaginous plate, but the intense detection occurred deep in the hypertrophic zone near the newly formed bone. Detected throughout the extracellular matrix (ECM) in this zone it is also closely situated around hypertrophic chondrocytes. Ref.5
Domain	The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.
Sequence similarities	Belongs to the fibrillar collagen family. Contains 16 collagen-like domains. Contains 1 fibrillar collagen NC1 domain. Contains 1 laminin G-like domain.
Sequence caution	The sequence BAB47499.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Collagen Repeat Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	extracellular matrix organization Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum lumen Traceable author statement. Source: Reactome extracellular region Traceable author statement. Source: Reactome fibrillar collagen Inferred from electronic annotation. Source: Compara
Molecular_function	extracellular matrix structural constituent Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZC6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZC6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1033: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8IZC6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     637-703: GPPGLPGLPG...GLPGLSGNPG → VRLSGVCMLL...CIIAHPAPDS
     704-1860: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 41	41	Potential
	Propeptide	42 – 624	583	N-terminal propeptide		PRO_0000314667
	Chain	625 – 1621	997	Collagen alpha-1(XXVII) chain		PRO_5000089163
	Propeptide	1622 – 1860	239	C-terminal propeptide		PRO_0000314668
Regions
	Domain	71 – 236	166	Laminin G-like
	Domain	625 – 679	55	Collagen-like 1
	Domain	688 – 747	60	Collagen-like 2
	Domain	748 – 807	60	Collagen-like 3
	Domain	808 – 867	60	Collagen-like 4
	Domain	871 – 930	60	Collagen-like 5
	Domain	931 – 990	60	Collagen-like 6
	Domain	1003 – 1062	60	Collagen-like 7
	Domain	1066 – 1125	60	Collagen-like 8
	Domain	1126 – 1185	60	Collagen-like 9
	Domain	1192 – 1251	60	Collagen-like 10
	Domain	1258 – 1317	60	Collagen-like 11
	Domain	1318 – 1378	61	Collagen-like 12
	Domain	1382 – 1441	60	Collagen-like 13
	Domain	1442 – 1501	60	Collagen-like 14
	Domain	1502 – 1561	60	Collagen-like 15
	Domain	1562 – 1621	60	Collagen-like 16
	Domain	1660 – 1860	201	Fibrillar collagen NC1
	Region	625 – 1618	994	Triple-helical region
	Compositional bias	283 – 1621	1339	Pro-rich
Sites
	Metal binding	1708	1	Calcium By similarity
	Metal binding	1710	1	Calcium By similarity
	Metal binding	1713	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1716	1	Calcium By similarity
Amino acid modifications
	Glycosylation	271	1	N-linked (GlcNAc...) Potential
	Glycosylation	1769	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1690 ↔ 1722		By similarity
	Disulfide bond	1696		Interchain (with C-1285) By similarity
	Disulfide bond	1713		Interchain (with C-1268) By similarity
	Disulfide bond	1731 ↔ 1858		By similarity
	Disulfide bond	1767 ↔ 1811		By similarity
Natural variations
	Alternative sequence	1 – 1033	1033	Missing in isoform 2.		VSP_030347
	Alternative sequence	637 – 703	67	GPPGL…SGNPG → VRLSGVCMLLGAPVGDWGIG QVVAPSKDRKRSSLEQGAGY GYILGSSQAPGSSGSAKCII AHPAPDS in isoform 3.		VSP_030348
	Alternative sequence	704 – 1860	1157	Missing in isoform 3.		VSP_030349
	Natural variant	89	1	V → I. Corresponds to variant rs2567707 [ dbSNP | Ensembl ].		VAR_048784
	Natural variant	120	1	Q → R. Corresponds to variant rs2567706 [ dbSNP | Ensembl ].		VAR_048785
	Natural variant	265	1	A → T. Corresponds to variant rs34578955 [ dbSNP | Ensembl ].		VAR_048786
	Natural variant	349	1	R → C. Corresponds to variant rs34973417 [ dbSNP | Ensembl ].		VAR_048787
	Natural variant	422	1	A → T. Ref.4 Corresponds to variant rs2241671 [ dbSNP | Ensembl ].		VAR_048788
	Natural variant	537	1	I → T. Ref.4 Corresponds to variant rs2808770 [ dbSNP | Ensembl ].		VAR_048789
	Natural variant	611	1	I → F. Ref.4 Corresponds to variant rs2567705 [ dbSNP | Ensembl ].		VAR_048790
	Natural variant	720	1	P → R. Corresponds to variant rs35446342 [ dbSNP | Ensembl ].		VAR_048791
	Natural variant	1116	1	P → Q. Corresponds to variant rs7048607 [ dbSNP | Ensembl ].		VAR_048792
	Natural variant	1348	1	R → Q. Corresponds to variant rs1631319 [ dbSNP | Ensembl ].		VAR_048793
	Natural variant	1354	1	R → Q. Corresponds to variant rs10982134 [ dbSNP | Ensembl ].		VAR_048794
	Natural variant	1808	1	M → V. Corresponds to variant rs3736252 [ dbSNP | Ensembl ].		VAR_048795

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5F8CDFAF4B6014EC	FASTA	1,860	186,892
	10 20 30 40 50 60 MGAGSARGAR GTAAAAAARG GGFLFSWILV SFACHLASTQ GAPEDVDILQ RLGLSWTKAG 70 80 90 100 110 120 SPAPPGVIPF QSGFIFTQRA RLQAPTGTVI PAALGTELAL VLSLCSHRVN HAFLFAVRSQ 130 140 150 160 170 180 KRKLQLGLQF LPGKTVVHLG SRRSVAFDLD MHDGRWHHLA LELRGRTVTL VTACGQRRVP 190 200 210 220 230 240 VLLPFHRDPA LDPGGSFLFG KMNPHAVQFE GALCQFSIYP VTQVAHNYCT HLRKQCGQAD 250 260 270 280 290 300 TYQSPLGPLF SQDSGRPFTF QSDLALLGLE NLTTATPALG SLPAGRGPRG TVAPATPTKP 310 320 330 340 350 360 QRTSPTNPHQ HMAVGGPAQT PLLPAKLSAS NALDPMLPAS VGGSTRTPRP AAAQPSQKIT 370 380 390 400 410 420 ATKIPKSLPT KPSAPSTSIV PIKSPHPTQK TAPSSFTKSA LPTQKQVPPT SRPVPARVSR 430 440 450 460 470 480 PAEKPIQRNP GMPRPPPPST RPLPPTTSSS KKPIPTLART EAKITSHASK PASARTSTHK 490 500 510 520 530 540 PPPFTALSSS PAPTPGSTRS TRPPATMVPP TSGTSTPRTA PAVPTPGSAP TGSKKPIGSE 550 560 570 580 590 600 ASKKAGPKSS PRKPVPLRPG KAARDVPLSD LTTRPSPRQP QPSQQTTPAL VLAPAQFLSS 610 620 630 640 650 660 SPRPTSSGYS IFHLAGSTPF PLLMGPPGPK GDCGLPGPPG LPGLPGIPGA RGPRGPPGPY 670 680 690 700 710 720 GNPGLPGPPG AKGQKGDPGL SPGKAHDGAK GDMGLPGLSG NPGPPGRKGH KGYPGPAGHP 730 740 750 760 770 780 GEQGQPGPEG SPGAKGYPGR QGLPGPVGDP GPKGSRGYIG LPGLFGLPGS DGERGLPGVP 790 800 810 820 830 840 GKRGKMGMPG FPGVFGERGP PGLDGNPGEL GLPGPPGVPG LIGDLGVLGP IGYPGPKGMK 850 860 870 880 890 900 GLMGSVGEPG LKGDKGEQGV PGVSGDPGFQ GDKGSQGLPG FPGARGKPGP LGKVGDKGSI 910 920 930 940 950 960 GFPGPPGPEG FPGDIGPPGD NGPEGMKGKP GARGLPGPRG QLGPEGDEGP MGPPGAPGLE 970 980 990 1000 1010 1020 GQPGRKGFPG RPGLDGVKGE PGDPGRPGPV GEQGFMGFIG LVGEPGIVGE KGDRGMMGPP 1030 1040 1050 1060 1070 1080 GVPGPKGSMG HPGMPGGMGT PGEPGPQGPP GSRGPPGMRG AKGRRGPRGP DGPAGEQGSR 1090 1100 1110 1120 1130 1140 GLKGPPGPQG RPGRPGQQGV AGERGHLGSR GFPGIPGPSG PPGTKGLPGE PGPQGPQGPI 1150 1160 1170 1180 1190 1200 GPPGEMGPKG PPGAVGEPGL PGEAGMKGDL GPLGTPGEQG LIGQRGEPGL EGDSGPMGPD 1210 1220 1230 1240 1250 1260 GLKGDRGDPG PDGEHGEKGQ EGLMGEDGPP GPPGVTGVRG PEGKSGKQGE KGRTGAKGAK 1270 1280 1290 1300 1310 1320 GYQGQLGEMG VPGDPGPPGT PGPKGSRGSL GPTGAPGRMG AQGEPGLAGY DGHKGIVGPL 1330 1340 1350 1360 1370 1380 GPPGPKGEKG EQGEDGKAEG PPGPPGDRGP VGDRGDRGEP GDPGYPGQEG VQGLRGKPGQ 1390 1400 1410 1420 1430 1440 QGQPGHPGPR GWPGPKGSKG AEGPKGKQGK AGAPGRRGVQ GLQGLPGPRG VVGRQGLEGI 1450 1460 1470 1480 1490 1500 AGPDGLPGRD GQAGQQGEQG DDGDPGPMGP AGKRGNPGVA GLPGAQGPPG FKGESGLPGQ 1510 1520 1530 1540 1550 1560 LGPPGKRGTE GRTGLPGNQG EPGSKGQPGD SGEMGFPGMA GLFGPKGPPG DIGFKGIQGP 1570 1580 1590 1600 1610 1620 RGPPGLMGKE GIVGPLGILG PSGLPGPKGD KGSRGDWGLQ GPRGPPGPRG RPGPPGPPGG 1630 1640 1650 1660 1670 1680 PIQLQQDDLG AAFQTWMDTS GALRPESYSY PDRLVLDQGG EIFKTLHYLS NLIQSIKTPL 1690 1700 1710 1720 1730 1740 GTKENPARVC RDLMDCEQKM VDGTYWVDPN LGCSSDTIEV SCNFTHGGQT CLKPITASKV 1750 1760 1770 1780 1790 1800 EFAISRVQMN FLHLLSSEVT QHITIHCLNM TVWQEGTGQT PAKQAVRFRA WNGQIFEAGG 1810 1820 1830 1840 1850 1860 QFRPEVSMDG CKVQDGRWHQ TLFTFRTQDP QQLPIISVDN LPPASSGKQY RLEVGPACFL
	Isoform 2 [UniParc]. Checksum: 3941B3A8696704BB	FASTA	827	82,801
	10 20 30 40 50 60 MPGGMGTPGE PGPQGPPGSR GPPGMRGAKG RRGPRGPDGP AGEQGSRGLK GPPGPQGRPG 70 80 90 100 110 120 RPGQQGVAGE RGHLGSRGFP GIPGPSGPPG TKGLPGEPGP QGPQGPIGPP GEMGPKGPPG 130 140 150 160 170 180 AVGEPGLPGE AGMKGDLGPL GTPGEQGLIG QRGEPGLEGD SGPMGPDGLK GDRGDPGPDG 190 200 210 220 230 240 EHGEKGQEGL MGEDGPPGPP GVTGVRGPEG KSGKQGEKGR TGAKGAKGYQ GQLGEMGVPG 250 260 270 280 290 300 DPGPPGTPGP KGSRGSLGPT GAPGRMGAQG EPGLAGYDGH KGIVGPLGPP GPKGEKGEQG 310 320 330 340 350 360 EDGKAEGPPG PPGDRGPVGD RGDRGEPGDP GYPGQEGVQG LRGKPGQQGQ PGHPGPRGWP 370 380 390 400 410 420 GPKGSKGAEG PKGKQGKAGA PGRRGVQGLQ GLPGPRGVVG RQGLEGIAGP DGLPGRDGQA 430 440 450 460 470 480 GQQGEQGDDG DPGPMGPAGK RGNPGVAGLP GAQGPPGFKG ESGLPGQLGP PGKRGTEGRT 490 500 510 520 530 540 GLPGNQGEPG SKGQPGDSGE MGFPGMAGLF GPKGPPGDIG FKGIQGPRGP PGLMGKEGIV 550 560 570 580 590 600 GPLGILGPSG LPGPKGDKGS RGDWGLQGPR GPPGPRGRPG PPGPPGGPIQ LQQDDLGAAF 610 620 630 640 650 660 QTWMDTSGAL RPESYSYPDR LVLDQGGEIF KTLHYLSNLI QSIKTPLGTK ENPARVCRDL 670 680 690 700 710 720 MDCEQKMVDG TYWVDPNLGC SSDTIEVSCN FTHGGQTCLK PITASKVEFA ISRVQMNFLH 730 740 750 760 770 780 LLSSEVTQHI TIHCLNMTVW QEGTGQTPAK QAVRFRAWNG QIFEAGGQFR PEVSMDGCKV 790 800 810 820 QDGRWHQTLF TFRTQDPQQL PIISVDNLPP ASSGKQYRLE VGPACFL
	Isoform 3 [UniParc]. Checksum: 9D3751FE90AE9E0D	FASTA	703	73,105
	10 20 30 40 50 60 MGAGSARGAR GTAAAAAARG GGFLFSWILV SFACHLASTQ GAPEDVDILQ RLGLSWTKAG 70 80 90 100 110 120 SPAPPGVIPF QSGFIFTQRA RLQAPTGTVI PAALGTELAL VLSLCSHRVN HAFLFAVRSQ 130 140 150 160 170 180 KRKLQLGLQF LPGKTVVHLG SRRSVAFDLD MHDGRWHHLA LELRGRTVTL VTACGQRRVP 190 200 210 220 230 240 VLLPFHRDPA LDPGGSFLFG KMNPHAVQFE GALCQFSIYP VTQVAHNYCT HLRKQCGQAD 250 260 270 280 290 300 TYQSPLGPLF SQDSGRPFTF QSDLALLGLE NLTTATPALG SLPAGRGPRG TVAPATPTKP 310 320 330 340 350 360 QRTSPTNPHQ HMAVGGPAQT PLLPAKLSAS NALDPMLPAS VGGSTRTPRP AAAQPSQKIT 370 380 390 400 410 420 ATKIPKSLPT KPSAPSTSIV PIKSPHPTQK TAPSSFTKSA LPTQKQVPPT SRPVPARVSR 430 440 450 460 470 480 PAEKPIQRNP GMPRPPPPST RPLPPTTSSS KKPIPTLART EAKITSHASK PASARTSTHK 490 500 510 520 530 540 PPPFTALSSS PAPTPGSTRS TRPPATMVPP TSGTSTPRTA PAVPTPGSAP TGSKKPIGSE 550 560 570 580 590 600 ASKKAGPKSS PRKPVPLRPG KAARDVPLSD LTTRPSPRQP QPSQQTTPAL VLAPAQFLSS 610 620 630 640 650 660 SPRPTSSGYS IFHLAGSTPF PLLMGPPGPK GDCGLPVRLS GVCMLLGAPV GDWGIGQVVA 670 680 690 700 PSKDRKRSSL EQGAGYGYIL GSSQAPGSSG SAKCIIAHPA PDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1." Pace J.M., Corrado M., Missero C., Byers P.H. Matrix Biol. 22:3-14(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Cartilage.
[2]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-1860 (ISOFORM 3), VARIANTS THR-422; THR-537 AND PHE-611. Tissue: Skin.
[5]	"Type XXVII collagen at the transition of cartilage to bone during skeletogenesis." Hjorten R., Hansen U., Underwood R.A., Telfer H.E., Fernandes R.J., Krakow D., Sebald E., Wachsmann-Hogiu S., Bruckner P., Jacquet R., Landis W.J., Byers P.H., Pace J.M. Bone 41:535-542(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY149237 mRNA. Translation: AAN41263.1. AB058773 mRNA. Translation: BAB47499.1. Different initiation. AL445543, AL356796 Genomic DNA. Translation: CAI14772.1. AL356796, AL445543 Genomic DNA. Translation: CAI16857.1. BC080610 mRNA. Translation: AAH80610.1.
IPI	IPI00844557. IPI00878670. IPI00878879.
RefSeq	NP_116277.2. NM_032888.2.
UniGene	Hs.494892.
3D structure databases
HSSP	HSSP built from PDB template 1Q7D based on UniProtKB Q15201.
ProteinModelPortal	Q8IZC6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000348385.
PTM databases
PhosphoSite	Q8IZC6.
Polymorphism databases
DMDM	74762504.
Proteomic databases
PaxDb	Q8IZC6.
PRIDE	Q8IZC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356083; ENSP00000348385; ENSG00000196739.
GeneID	85301.
KEGG	hsa:85301.
UCSC	uc011lxl.2. human.
Organism-specific databases
CTD	85301.
GeneCards	GC09P116917.
HGNC	HGNC:22986. COL27A1.
HPA	HPA021884. HPA048471.
MIM	608461. gene.
neXtProt	NX_Q8IZC6.
PharmGKB	PA134990818.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000085654.
HOVERGEN	HBG098141.
KO	K06236.
OrthoDB	EOG4FBHSB.
PhylomeDB	Q8IZC6.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	Q8IZC6.
Bgee	Q8IZC6.
CleanEx	HS_COL27A1.
Genevestigator	Q8IZC6.
Family and domain databases
InterPro	IPR008160. Collagen. IPR008985. ConA-like_lec_gl_sf. IPR000885. Fib_collagen_C. IPR001791. Laminin_G. [Graphical view]
Pfam	PF01410. COLFI. 2 hits. PF01391. Collagen. 13 hits. [Graphical view]
ProDom	PD002078. Fib_collagen_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00038. COLFI. 1 hit. SM00210. TSPN. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50025. LAM_G_DOMAIN. False negative. PS51461. NC1_FIB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	85301.
NextBio	75783.
SOURCE	Search...

Entry information

Entry name

CORA1_HUMAN

Accession

Primary (citable) accession number: Q8IZC6
Secondary accession number(s): Q66K43, Q96JF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.