Q8IZA3 (H1FOO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone H1oo

Alternative name(s):
Oocyte-specific histone H1
Oocyte-specific linker histone H1
Short name=osH1

Gene names

Name:	H1FOO
Synonyms:	H1OO, OSH1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Chromosome By similarity.
Tissue specificity	Oocyte-specific. Ref.1
Sequence similarities	Belongs to the histone H1/H5 family. Contains 1 H15 (linker histone H1/H5 globular) domain.

Ontologies

Keywords
Biological process	Meiosis
Cellular component	Chromosome Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	meiosis Inferred from electronic annotation. Source: UniProtKB-KW nucleosome assembly Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleosome Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZA3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZA3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Histone H1oo		PRO_0000343412
Regions
	Domain	51 – 129	79	H15
	Motif	164 – 179	16	Nuclear localization signal Potential
Natural variations
	Alternative sequence	1 – 139	139	Missing in isoform 2.		VSP_034592
	Natural variant	296	1	N → S. Corresponds to variant rs59415528 [ dbSNP | Ensembl ].		VAR_061208

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 666964009BE6F4AC	FASTA	346	35,813
	10 20 30 40 50 60 MAPGSVTSDI SPSSTSTAGS SRSPESEKPG PSHGGVPPGG PSHSSLPVGR RHPPVLRMVL 70 80 90 100 110 120 EALQAGEQRR GTSVAAIKLY ILHKYPTVDV LRFKYLLKQA LATGMRRGLL ARPLNSKARG 130 140 150 160 170 180 ATGSFKLVPK HKKKIQPRKM APATAPRRAG EAKGKGPKKP SEAKEDPPNV GKVKKAAKRP 190 200 210 220 230 240 AKVQKPPPKP GAATEKARKQ GGAAKDTRAQ SGEARKVPPK PDKAMRAPSS AGGLSRKAKA 250 260 270 280 290 300 KGSRSSQGDA EAYRKTKAES KSSKPTASKV KNGAASPTKK KVVAKAKAPK AGQGPNTKAA 310 320 330 340 APAKGSGSKV VPAHLSRKTE APKGPRKAGL PIKASSSKVS SQRAEA
	Isoform 2 [UniParc]. Checksum: F70644D8CCD87E9B	FASTA	207	21,010
	10 20 30 40 50 60 MAPATAPRRA GEAKGKGPKK PSEAKEDPPN VGKVKKAAKR PAKVQKPPPK PGAATEKARK 70 80 90 100 110 120 QGGAAKDTRA QSGEARKVPP KPDKAMRAPS SAGGLSRKAK AKGSRSSQGD AEAYRKTKAE 130 140 150 160 170 180 SKSSKPTASK VKNGAASPTK KKVVAKAKAP KAGQGPNTKA AAPAKGSGSK VVPAHLSRKT 190 200 EAPKGPRKAG LPIKASSSKV SSQRAEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte." Tanaka Y., Kato S., Tanaka M., Kuji N., Yoshimura Y. Biochem. Biophys. Res. Commun. 304:351-357(2003) [PubMed: 12711322] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY158091 mRNA. Translation: AAN46899.1. CH471052 Genomic DNA. Translation: EAW79242.1. CH471052 Genomic DNA. Translation: EAW79243.1. BC047943 mRNA. Translation: AAH47943.1.
IPI	IPI00217955. IPI00790076.
RefSeq	NP_722575.1. NM_153833.1.
UniGene	Hs.97358.
3D structure databases
HSSP	HSSP built from PDB template 1HST based on UniProtKB P02259.
ProteinModelPortal	Q8IZA3.
SMR	Q8IZA3. Positions 47-133.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IZA3.
Polymorphism databases
DMDM	74762503.
Proteomic databases
PRIDE	Q8IZA3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000324382; ENSP00000319799; ENSG00000178804.
GeneID	132243.
KEGG	hsa:132243.
UCSC	uc003emu.1. human. uc003emv.1. human.
Organism-specific databases
CTD	132243.
GeneCards	GC03P129262.
HGNC	HGNC:18463. H1FOO.
HPA	HPA037992.
neXtProt	NX_Q8IZA3.
PharmGKB	PA134958422.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17754.
GeneTree	ENSGT00550000074201.
HOGENOM	HBG267901.
HOVERGEN	HBG096668.
InParanoid	Q8IZA3.
OMA	EKPGPSH.
OrthoDB	EOG4NCMFC.
PhylomeDB	Q8IZA3.
Gene expression databases
ArrayExpress	Q8IZA3.
Bgee	Q8IZA3.
CleanEx	HS_H1FOO.
Genevestigator	Q8IZA3.
Family and domain databases
InterPro	IPR005818. Histone_H1/H5. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00538. Linker_histone. 1 hit. [Graphical view]
SMART	SM00526. H15. 1 hit. [Graphical view]
PROSITE	PS51504. H15. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	83068.

Entry information

Entry name

H1FOO_HUMAN

Accession

Primary (citable) accession number: Q8IZA3
Secondary accession number(s): Q86WT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.