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Protein

Histone H1oo

Gene

H1FOO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1oo
Alternative name(s):
Oocyte-specific histone H1
Oocyte-specific linker histone H1
Short name:
osH1
Gene namesi
Name:H1FOO
Synonyms:H1OO, OSH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18463. H1FOO.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus PROSITE-ProRule annotation
  • Chromosome PROSITE-ProRule annotation

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • female germ cell nucleus Source: Ensembl
  • nucleosome Source: InterPro
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958422.

Polymorphism and mutation databases

BioMutaiH1FOO.
DMDMi74762503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Histone H1ooPRO_0000343412Add
BLAST

Proteomic databases

PaxDbiQ8IZA3.
PRIDEiQ8IZA3.

PTM databases

iPTMnetiQ8IZA3.
PhosphoSiteiQ8IZA3.

Expressioni

Tissue specificityi

Oocyte-specific.1 Publication

Gene expression databases

BgeeiQ8IZA3.
CleanExiHS_H1FOO.
GenevisibleiQ8IZA3. HS.

Organism-specific databases

HPAiHPA037992.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319799.

Structurei

3D structure databases

ProteinModelPortaliQ8IZA3.
SMRiQ8IZA3. Positions 40-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12979H15PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi164 – 17916Nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00720000108877.
HOGENOMiHOG000112841.
HOVERGENiHBG096668.
InParanoidiQ8IZA3.
OMAiKEDPPNV.
OrthoDBiEOG75QR72.
PhylomeDBiQ8IZA3.
TreeFamiTF333386.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZA3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPGSVTSDI SPSSTSTAGS SRSPESEKPG PSHGGVPPGG PSHSSLPVGR
60 70 80 90 100
RHPPVLRMVL EALQAGEQRR GTSVAAIKLY ILHKYPTVDV LRFKYLLKQA
110 120 130 140 150
LATGMRRGLL ARPLNSKARG ATGSFKLVPK HKKKIQPRKM APATAPRRAG
160 170 180 190 200
EAKGKGPKKP SEAKEDPPNV GKVKKAAKRP AKVQKPPPKP GAATEKARKQ
210 220 230 240 250
GGAAKDTRAQ SGEARKVPPK PDKAMRAPSS AGGLSRKAKA KGSRSSQGDA
260 270 280 290 300
EAYRKTKAES KSSKPTASKV KNGAASPTKK KVVAKAKAPK AGQGPNTKAA
310 320 330 340
APAKGSGSKV VPAHLSRKTE APKGPRKAGL PIKASSSKVS SQRAEA
Length:346
Mass (Da):35,813
Last modified:March 1, 2003 - v1
Checksum:i666964009BE6F4AC
GO
Isoform 2 (identifier: Q8IZA3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.

Show »
Length:207
Mass (Da):21,010
Checksum:iF70644D8CCD87E9B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti296 – 2961N → S.
Corresponds to variant rs59415528 [ dbSNP | Ensembl ].
VAR_061208

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 139139Missing in isoform 2. 1 PublicationVSP_034592Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158091 mRNA. Translation: AAN46899.1.
CH471052 Genomic DNA. Translation: EAW79242.1.
CH471052 Genomic DNA. Translation: EAW79243.1.
BC047943 mRNA. Translation: AAH47943.1.
CCDSiCCDS3064.1. [Q8IZA3-1]
CCDS77815.1. [Q8IZA3-2]
RefSeqiNP_001295191.1. NM_001308262.1. [Q8IZA3-2]
NP_722575.1. NM_153833.2. [Q8IZA3-1]
UniGeneiHs.97358.

Genome annotation databases

EnsembliENST00000324382; ENSP00000319799; ENSG00000178804. [Q8IZA3-1]
ENST00000503977; ENSP00000422964; ENSG00000178804. [Q8IZA3-2]
GeneIDi132243.
KEGGihsa:132243.
UCSCiuc003emu.3. human. [Q8IZA3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158091 mRNA. Translation: AAN46899.1.
CH471052 Genomic DNA. Translation: EAW79242.1.
CH471052 Genomic DNA. Translation: EAW79243.1.
BC047943 mRNA. Translation: AAH47943.1.
CCDSiCCDS3064.1. [Q8IZA3-1]
CCDS77815.1. [Q8IZA3-2]
RefSeqiNP_001295191.1. NM_001308262.1. [Q8IZA3-2]
NP_722575.1. NM_153833.2. [Q8IZA3-1]
UniGeneiHs.97358.

3D structure databases

ProteinModelPortaliQ8IZA3.
SMRiQ8IZA3. Positions 40-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319799.

PTM databases

iPTMnetiQ8IZA3.
PhosphoSiteiQ8IZA3.

Polymorphism and mutation databases

BioMutaiH1FOO.
DMDMi74762503.

Proteomic databases

PaxDbiQ8IZA3.
PRIDEiQ8IZA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324382; ENSP00000319799; ENSG00000178804. [Q8IZA3-1]
ENST00000503977; ENSP00000422964; ENSG00000178804. [Q8IZA3-2]
GeneIDi132243.
KEGGihsa:132243.
UCSCiuc003emu.3. human. [Q8IZA3-1]

Organism-specific databases

CTDi132243.
GeneCardsiH1FOO.
HGNCiHGNC:18463. H1FOO.
HPAiHPA037992.
neXtProtiNX_Q8IZA3.
PharmGKBiPA134958422.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00720000108877.
HOGENOMiHOG000112841.
HOVERGENiHBG096668.
InParanoidiQ8IZA3.
OMAiKEDPPNV.
OrthoDBiEOG75QR72.
PhylomeDBiQ8IZA3.
TreeFamiTF333386.

Miscellaneous databases

GeneWikiiH1FOO.
GenomeRNAii132243.
NextBioi83068.
PROiQ8IZA3.

Gene expression databases

BgeeiQ8IZA3.
CleanExiHS_H1FOO.
GenevisibleiQ8IZA3. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte."
    Tanaka Y., Kato S., Tanaka M., Kuji N., Yoshimura Y.
    Biochem. Biophys. Res. Commun. 304:351-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiH1FOO_HUMAN
AccessioniPrimary (citable) accession number: Q8IZA3
Secondary accession number(s): Q86WT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.