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Q8IZA0

- K319L_HUMAN

UniProt

Q8IZA0 - K319L_HUMAN

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Protein

Dyslexia-associated protein KIAA0319-like protein

Gene
KIAA0319L, KIAA1837, PP791
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possible role in axon guidance through interaction with RTN4R.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dyslexia-associated protein KIAA0319-like protein
Gene namesi
Synonyms:KIAA1837
ORF Names:PP791
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30071. KIAA0319L.

Subcellular locationi

Cytoplasmic granule membrane; Multi-pass membrane protein Reviewed prediction 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei30 – 5021Helical; Reviewed predictionAdd
BLAST
Topological domaini51 – 932882Extracellular Reviewed predictionAdd
BLAST
Transmembranei933 – 95321Helical; Reviewed predictionAdd
BLAST
Topological domaini954 – 104996Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti220402. Limited cutaneous systemic sclerosis.
536. Systemic lupus erythematosus.
PharmGKBiPA142671625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10491049Dyslexia-associated protein KIAA0319-like proteinPRO_0000329064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi247 – 2471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...)1 Publication
Glycosylationi487 – 4871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi525 – 5251N-linked (GlcNAc...)1 Publication
Modified residuei1037 – 10371Phosphothreonine1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IZA0.
PaxDbiQ8IZA0.
PRIDEiQ8IZA0.

Expressioni

Tissue specificityi

Expressed in cortical neurons in the brain cortex (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ8IZA0.
BgeeiQ8IZA0.
CleanExiHS_KIAA0319L.
GenevestigatoriQ8IZA0.

Organism-specific databases

HPAiHPA011169.

Interactioni

Subunit structurei

Interacts with RTN4R.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RTN4RQ9BZR64EBI-5240269,EBI-5240240

Protein-protein interaction databases

IntActiQ8IZA0. 1 interaction.

Structurei

Secondary structure

1
1049
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi607 – 6104
Beta strandi615 – 6195
Beta strandi625 – 6273
Beta strandi634 – 6396
Beta strandi644 – 6474
Beta strandi650 – 6578
Beta strandi660 – 67112
Beta strandi676 – 68611

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YRLNMR-A600-688[»]
ProteinModelPortaliQ8IZA0.
SMRiQ8IZA0. Positions 298-400, 417-497, 505-595, 600-688, 703-785.

Miscellaneous databases

EvolutionaryTraceiQ8IZA0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12779MANSCAdd
BLAST
Domaini312 – 40190PKD 1Add
BLAST
Domaini409 – 49890PKD 2Add
BLAST
Domaini504 – 59491PKD 3Add
BLAST
Domaini600 – 68889PKD 4Add
BLAST
Domaini694 – 78592PKD 5Add
BLAST

Sequence similaritiesi

Contains 1 MANSC domain.
Contains 5 PKD domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3291.
HOVERGENiHBG057130.
OMAiDSNCEWS.
OrthoDBiEOG79PJNJ.
PhylomeDBiQ8IZA0.
TreeFamiTF323356.

Family and domain databases

Gene3Di2.60.40.670. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013980. MANSC.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF02010. REJ. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00089. PKD. 5 hits.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 4 hits.
PROSITEiPS50986. MANSC. 1 hit.
PS50093. PKD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZA0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEKRLGVKPN PASWILSGYY WQTSAKWLRS LYLFYTCFCF SVLWLSTDAS     50
ESRCQQGKTQ FGVGLRSGGE NHLWLLEGTP SLQSCWAACC QDSACHVFWW 100
LEGMCIQADC SRPQSCRAFR THSSNSMLVF LKKFQTADDL GFLPEDDVPH 150
LLGLGWNWAS WRQSPPRAAL RPAVSSSDQQ SLIRKLQKRG SPSDVVTPIV 200
TQHSKVNDSN ELGGLTTSGS AEVHKAITIS SPLTTDLTAE LSGGPKNVSV 250
QPEISEGLAT TPSTQQVKSS EKTQIAVPQP VAPSYSYATP TPQASFQSTS 300
APYPVIKELV VSAGESVQIT LPKNEVQLNA YVLQEPPKGE TYTYDWQLIT 350
HPRDYSGEME GKHSQILKLS KLTPGLYEFK VIVEGQNAHG EGYVNVTVKP 400
EPRKNRPPIA IVSPQFQEIS LPTTSTVIDG SQSTDDDKIV QYHWEELKGP 450
LREEKISEDT AILKLSKLVP GNYTFSLTVV DSDGATNSTT ANLTVNKAVD 500
YPPVANAGPN QVITLPQNSI TLFGNQSTDD HGITSYEWSL SPSSKGKVVE 550
MQGVRTPTLQ LSAMQEGDYT YQLTVTDTIG QQATAQVTVI VQPENNKPPQ 600
ADAGPDKELT LPVDSTTLDG SKSSDDQKII SYLWEKTQGP DGVQLENANS 650
SVATVTGLQV GTYVFTLTVK DERNLQSQSS VNVIVKEEIN KPPIAKITGN 700
VVITLPTSTA ELDGSKSSDD KGIVSYLWTR DEGSPAAGEV LNHSDHHPIL 750
FLSNLVEGTY TFHLKVTDAK GESDTDRTTV EVKPDPRKNN LVEIILDINV 800
SQLTERLKGM FIRQIGVLLG VLDSDIIVQK IQPYTEQSTK MVFFVQNEPP 850
HQIFKGHEVA AMLKSELRKQ KADFLIFRAL EVNTVTCQLN CSDHGHCDSF 900
TKRCICDPFW MENFIKVQLR DGDSNCEWSV LYVIIATFVI VVALGILSWT 950
VICCCKRQKG KPKRKSKYKI LDATDQESLE LKPTSRAGIK QKGLLLSSSL 1000
MHSESELDSD DAIFTWPDRE KGKLLHGQNG SVPNGQTPLK ARSPREEIL 1049
Length:1,049
Mass (Da):115,658
Last modified:April 29, 2008 - v2
Checksum:iFD81BFCA3D38D106
GO
Isoform 2 (identifier: Q8IZA0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1049: IKQKGLLLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL → RGPGCQSF

Note: No experimental confirmation available.

Show »
Length:996
Mass (Da):109,752
Checksum:iE4D2181467A9353C
GO
Isoform 3 (identifier: Q8IZA0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     638-638: Q → HFFFCR

Note: No experimental confirmation available.

Show »
Length:491
Mass (Da):54,656
Checksum:iD920F8CBB52D3CC9
GO

Sequence cautioni

The sequence BAB47466.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
The sequence AAL55781.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14874.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAD05028.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI22688.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI23123.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti243 – 2431G → D.
Corresponds to variant rs1635712 [ dbSNP | Ensembl ].
VAR_042644
Natural varianti837 – 8371Q → H.
Corresponds to variant rs1361040 [ dbSNP | Ensembl ].
VAR_042645

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 563563Missing in isoform 3. VSP_032953Add
BLAST
Alternative sequencei638 – 6381Q → HFFFCR in isoform 3. VSP_032954
Alternative sequencei989 – 104961IKQKG…REEIL → RGPGCQSF in isoform 2. VSP_032955Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371C → Y in AAN61054. 1 Publication
Sequence conflicti37 – 371C → Y in AAG24389. 1 Publication
Sequence conflicti86 – 861W → L in AAH14530. 1 Publication
Sequence conflicti203 – 2031H → Y in AAG24389. 1 Publication
Sequence conflicti520 – 5201I → T in AAG24389. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY163234 mRNA. Translation: AAN61054.1.
AF275679 mRNA. Translation: AAG24389.2.
AF289597 mRNA. Translation: AAL55781.1. Different initiation.
AL356362, AC004865, AL445211 Genomic DNA. Translation: CAI22688.1. Sequence problems.
AL445211, AC004865, AL356362 Genomic DNA. Translation: CAI23123.1. Sequence problems.
AC004865 Genomic DNA. Translation: AAD05028.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX07415.1.
CH471059 Genomic DNA. Translation: EAX07416.1.
BC001858 mRNA. Translation: AAH01858.2.
BC007645 mRNA. Translation: AAH07645.1.
BC014530 mRNA. Translation: AAH14530.1.
BC031672 mRNA. Translation: AAH31672.2.
AL834315 mRNA. Translation: CAD38985.1.
AK024287 mRNA. Translation: BAB14874.1. Different initiation.
AK090878 mRNA. Translation: BAC03536.1.
AB058740 mRNA. Translation: BAB47466.1. Sequence problems.
CCDSiCCDS390.1. [Q8IZA0-1]
RefSeqiNP_079150.3. NM_024874.4. [Q8IZA0-1]
XP_006710970.1. XM_006710907.1. [Q8IZA0-1]
XP_006710971.1. XM_006710908.1. [Q8IZA0-1]
XP_006710972.1. XM_006710909.1. [Q8IZA0-1]
XP_006710973.1. XM_006710910.1.
XP_006710974.1. XM_006710911.1.
UniGeneiHs.456507.
Hs.683078.

Genome annotation databases

EnsembliENST00000325722; ENSP00000318406; ENSG00000142687. [Q8IZA0-1]
GeneIDi79932.
KEGGihsa:79932.
UCSCiuc001byw.3. human. [Q8IZA0-3]
uc001byx.3. human. [Q8IZA0-1]
uc010ohv.1. human. [Q8IZA0-2]

Polymorphism databases

DMDMi187609609.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY163234 mRNA. Translation: AAN61054.1 .
AF275679 mRNA. Translation: AAG24389.2 .
AF289597 mRNA. Translation: AAL55781.1 . Different initiation.
AL356362 , AC004865 , AL445211 Genomic DNA. Translation: CAI22688.1 . Sequence problems.
AL445211 , AC004865 , AL356362 Genomic DNA. Translation: CAI23123.1 . Sequence problems.
AC004865 Genomic DNA. Translation: AAD05028.1 . Sequence problems.
CH471059 Genomic DNA. Translation: EAX07415.1 .
CH471059 Genomic DNA. Translation: EAX07416.1 .
BC001858 mRNA. Translation: AAH01858.2 .
BC007645 mRNA. Translation: AAH07645.1 .
BC014530 mRNA. Translation: AAH14530.1 .
BC031672 mRNA. Translation: AAH31672.2 .
AL834315 mRNA. Translation: CAD38985.1 .
AK024287 mRNA. Translation: BAB14874.1 . Different initiation.
AK090878 mRNA. Translation: BAC03536.1 .
AB058740 mRNA. Translation: BAB47466.1 . Sequence problems.
CCDSi CCDS390.1. [Q8IZA0-1 ]
RefSeqi NP_079150.3. NM_024874.4. [Q8IZA0-1 ]
XP_006710970.1. XM_006710907.1. [Q8IZA0-1 ]
XP_006710971.1. XM_006710908.1. [Q8IZA0-1 ]
XP_006710972.1. XM_006710909.1. [Q8IZA0-1 ]
XP_006710973.1. XM_006710910.1.
XP_006710974.1. XM_006710911.1.
UniGenei Hs.456507.
Hs.683078.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YRL NMR - A 600-688 [» ]
ProteinModelPortali Q8IZA0.
SMRi Q8IZA0. Positions 298-400, 417-497, 505-595, 600-688, 703-785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8IZA0. 1 interaction.

Polymorphism databases

DMDMi 187609609.

Proteomic databases

MaxQBi Q8IZA0.
PaxDbi Q8IZA0.
PRIDEi Q8IZA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325722 ; ENSP00000318406 ; ENSG00000142687 . [Q8IZA0-1 ]
GeneIDi 79932.
KEGGi hsa:79932.
UCSCi uc001byw.3. human. [Q8IZA0-3 ]
uc001byx.3. human. [Q8IZA0-1 ]
uc010ohv.1. human. [Q8IZA0-2 ]

Organism-specific databases

CTDi 79932.
GeneCardsi GC01M035899.
HGNCi HGNC:30071. KIAA0319L.
HPAi HPA011169.
MIMi 613535. gene.
neXtProti NX_Q8IZA0.
Orphaneti 220402. Limited cutaneous systemic sclerosis.
536. Systemic lupus erythematosus.
PharmGKBi PA142671625.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3291.
HOVERGENi HBG057130.
OMAi DSNCEWS.
OrthoDBi EOG79PJNJ.
PhylomeDBi Q8IZA0.
TreeFami TF323356.

Miscellaneous databases

ChiTaRSi KIAA0319L. human.
EvolutionaryTracei Q8IZA0.
GenomeRNAii 79932.
NextBioi 69860.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IZA0.
Bgeei Q8IZA0.
CleanExi HS_KIAA0319L.
Genevestigatori Q8IZA0.

Family and domain databases

Gene3Di 2.60.40.670. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013980. MANSC.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR000601. PKD_dom.
[Graphical view ]
Pfami PF02010. REJ. 2 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00089. PKD. 5 hits.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 4 hits.
PROSITEi PS50986. MANSC. 1 hit.
PS50093. PKD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hao D., Hooi S.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney, Lung, Muscle and Placenta.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-1049 (ISOFORM 1).
    Tissue: Testis.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-1049 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Amygdala.
  8. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-1049 (ISOFORM 2).
    Tissue: Brain.
  9. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-472 AND ASN-525.
    Tissue: Liver.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1037, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1."
    Poon M.W., Tsang W.H., Chan S.O., Li H.M., Ng H.K., Waye M.M.
    Cell. Mol. Neurobiol. 31:27-35(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RTN4R, GLYCOSYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  14. "Solution structure of the PKD domain from KIAA1837 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 600-688.

Entry informationi

Entry nameiK319L_HUMAN
AccessioniPrimary (citable) accession number: Q8IZA0
Secondary accession number(s): B1AN13
, D3DPR8, O95010, Q6PJJ7, Q7L1C9, Q8N2B3, Q8NDA0, Q8WY39, Q8WYZ5, Q96IC3, Q96JJ0, Q9BUW6, Q9H7V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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