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Q8IZA0

- K319L_HUMAN

UniProt

Q8IZA0 - K319L_HUMAN

Protein

Dyslexia-associated protein KIAA0319-like protein

Gene

KIAA0319L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Possible role in axon guidance through interaction with RTN4R.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dyslexia-associated protein KIAA0319-like protein
    Gene namesi
    Name:KIAA0319L
    Synonyms:KIAA1837
    ORF Names:PP791
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30071. KIAA0319L.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti220402. Limited cutaneous systemic sclerosis.
    536. Systemic lupus erythematosus.
    PharmGKBiPA142671625.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10491049Dyslexia-associated protein KIAA0319-like proteinPRO_0000329064Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)2 Publications
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi525 – 5251N-linked (GlcNAc...)2 Publications
    Modified residuei1037 – 10371Phosphothreonine1 Publication

    Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8IZA0.
    PaxDbiQ8IZA0.
    PRIDEiQ8IZA0.

    Expressioni

    Tissue specificityi

    Expressed in cortical neurons in the brain cortex (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ8IZA0.
    BgeeiQ8IZA0.
    CleanExiHS_KIAA0319L.
    GenevestigatoriQ8IZA0.

    Organism-specific databases

    HPAiHPA011169.

    Interactioni

    Subunit structurei

    Interacts with RTN4R.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RTN4RQ9BZR64EBI-5240269,EBI-5240240

    Protein-protein interaction databases

    IntActiQ8IZA0. 1 interaction.

    Structurei

    Secondary structure

    1
    1049
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi607 – 6104
    Beta strandi615 – 6195
    Beta strandi625 – 6273
    Beta strandi634 – 6396
    Beta strandi644 – 6474
    Beta strandi650 – 6578
    Beta strandi660 – 67112
    Beta strandi676 – 68611

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YRLNMR-A600-688[»]
    ProteinModelPortaliQ8IZA0.
    SMRiQ8IZA0. Positions 298-400, 417-497, 505-595, 600-688, 703-785.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8IZA0.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini51 – 932882ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini954 – 104996CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei933 – 95321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 12779MANSCPROSITE-ProRule annotationAdd
    BLAST
    Domaini312 – 40190PKD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini409 – 49890PKD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini504 – 59491PKD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini600 – 68889PKD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini694 – 78592PKD 5PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MANSC domain.PROSITE-ProRule annotation
    Contains 5 PKD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3291.
    HOVERGENiHBG057130.
    OMAiDSNCEWS.
    OrthoDBiEOG79PJNJ.
    PhylomeDBiQ8IZA0.
    TreeFamiTF323356.

    Family and domain databases

    Gene3Di2.60.40.670. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013980. MANSC.
    IPR022409. PKD/Chitinase_dom.
    IPR002859. PKD/REJ-like.
    IPR000601. PKD_dom.
    [Graphical view]
    PfamiPF02010. REJ. 2 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    SM00089. PKD. 5 hits.
    [Graphical view]
    SUPFAMiSSF49299. SSF49299. 4 hits.
    PROSITEiPS50986. MANSC. 1 hit.
    PS50093. PKD. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZA0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKRLGVKPN PASWILSGYY WQTSAKWLRS LYLFYTCFCF SVLWLSTDAS     50
    ESRCQQGKTQ FGVGLRSGGE NHLWLLEGTP SLQSCWAACC QDSACHVFWW 100
    LEGMCIQADC SRPQSCRAFR THSSNSMLVF LKKFQTADDL GFLPEDDVPH 150
    LLGLGWNWAS WRQSPPRAAL RPAVSSSDQQ SLIRKLQKRG SPSDVVTPIV 200
    TQHSKVNDSN ELGGLTTSGS AEVHKAITIS SPLTTDLTAE LSGGPKNVSV 250
    QPEISEGLAT TPSTQQVKSS EKTQIAVPQP VAPSYSYATP TPQASFQSTS 300
    APYPVIKELV VSAGESVQIT LPKNEVQLNA YVLQEPPKGE TYTYDWQLIT 350
    HPRDYSGEME GKHSQILKLS KLTPGLYEFK VIVEGQNAHG EGYVNVTVKP 400
    EPRKNRPPIA IVSPQFQEIS LPTTSTVIDG SQSTDDDKIV QYHWEELKGP 450
    LREEKISEDT AILKLSKLVP GNYTFSLTVV DSDGATNSTT ANLTVNKAVD 500
    YPPVANAGPN QVITLPQNSI TLFGNQSTDD HGITSYEWSL SPSSKGKVVE 550
    MQGVRTPTLQ LSAMQEGDYT YQLTVTDTIG QQATAQVTVI VQPENNKPPQ 600
    ADAGPDKELT LPVDSTTLDG SKSSDDQKII SYLWEKTQGP DGVQLENANS 650
    SVATVTGLQV GTYVFTLTVK DERNLQSQSS VNVIVKEEIN KPPIAKITGN 700
    VVITLPTSTA ELDGSKSSDD KGIVSYLWTR DEGSPAAGEV LNHSDHHPIL 750
    FLSNLVEGTY TFHLKVTDAK GESDTDRTTV EVKPDPRKNN LVEIILDINV 800
    SQLTERLKGM FIRQIGVLLG VLDSDIIVQK IQPYTEQSTK MVFFVQNEPP 850
    HQIFKGHEVA AMLKSELRKQ KADFLIFRAL EVNTVTCQLN CSDHGHCDSF 900
    TKRCICDPFW MENFIKVQLR DGDSNCEWSV LYVIIATFVI VVALGILSWT 950
    VICCCKRQKG KPKRKSKYKI LDATDQESLE LKPTSRAGIK QKGLLLSSSL 1000
    MHSESELDSD DAIFTWPDRE KGKLLHGQNG SVPNGQTPLK ARSPREEIL 1049
    Length:1,049
    Mass (Da):115,658
    Last modified:April 29, 2008 - v2
    Checksum:iFD81BFCA3D38D106
    GO
    Isoform 2 (identifier: Q8IZA0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         989-1049: IKQKGLLLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL → RGPGCQSF

    Note: No experimental confirmation available.

    Show »
    Length:996
    Mass (Da):109,752
    Checksum:iE4D2181467A9353C
    GO
    Isoform 3 (identifier: Q8IZA0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-563: Missing.
         638-638: Q → HFFFCR

    Note: No experimental confirmation available.

    Show »
    Length:491
    Mass (Da):54,656
    Checksum:iD920F8CBB52D3CC9
    GO

    Sequence cautioni

    The sequence BAB47466.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
    The sequence AAL55781.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14874.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAD05028.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI22688.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI23123.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371C → Y in AAN61054. 1 PublicationCurated
    Sequence conflicti37 – 371C → Y in AAG24389. (PubMed:15498874)Curated
    Sequence conflicti86 – 861W → L in AAH14530. (PubMed:15489334)Curated
    Sequence conflicti203 – 2031H → Y in AAG24389. (PubMed:15498874)Curated
    Sequence conflicti520 – 5201I → T in AAG24389. (PubMed:15498874)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti243 – 2431G → D.
    Corresponds to variant rs1635712 [ dbSNP | Ensembl ].
    VAR_042644
    Natural varianti837 – 8371Q → H.
    Corresponds to variant rs1361040 [ dbSNP | Ensembl ].
    VAR_042645

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 563563Missing in isoform 3. 1 PublicationVSP_032953Add
    BLAST
    Alternative sequencei638 – 6381Q → HFFFCR in isoform 3. 1 PublicationVSP_032954
    Alternative sequencei989 – 104961IKQKG…REEIL → RGPGCQSF in isoform 2. 1 PublicationVSP_032955Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY163234 mRNA. Translation: AAN61054.1.
    AF275679 mRNA. Translation: AAG24389.2.
    AF289597 mRNA. Translation: AAL55781.1. Different initiation.
    AL356362, AC004865, AL445211 Genomic DNA. Translation: CAI22688.1. Sequence problems.
    AL445211, AC004865, AL356362 Genomic DNA. Translation: CAI23123.1. Sequence problems.
    AC004865 Genomic DNA. Translation: AAD05028.1. Sequence problems.
    CH471059 Genomic DNA. Translation: EAX07415.1.
    CH471059 Genomic DNA. Translation: EAX07416.1.
    BC001858 mRNA. Translation: AAH01858.2.
    BC007645 mRNA. Translation: AAH07645.1.
    BC014530 mRNA. Translation: AAH14530.1.
    BC031672 mRNA. Translation: AAH31672.2.
    AL834315 mRNA. Translation: CAD38985.1.
    AK024287 mRNA. Translation: BAB14874.1. Different initiation.
    AK090878 mRNA. Translation: BAC03536.1.
    AB058740 mRNA. Translation: BAB47466.1. Sequence problems.
    CCDSiCCDS390.1. [Q8IZA0-1]
    RefSeqiNP_079150.3. NM_024874.4. [Q8IZA0-1]
    XP_006710970.1. XM_006710907.1. [Q8IZA0-1]
    XP_006710971.1. XM_006710908.1. [Q8IZA0-1]
    XP_006710972.1. XM_006710909.1. [Q8IZA0-1]
    XP_006710973.1. XM_006710910.1.
    XP_006710974.1. XM_006710911.1.
    UniGeneiHs.456507.
    Hs.683078.

    Genome annotation databases

    EnsembliENST00000325722; ENSP00000318406; ENSG00000142687. [Q8IZA0-1]
    GeneIDi79932.
    KEGGihsa:79932.
    UCSCiuc001byw.3. human. [Q8IZA0-3]
    uc001byx.3. human. [Q8IZA0-1]
    uc010ohv.1. human. [Q8IZA0-2]

    Polymorphism databases

    DMDMi187609609.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY163234 mRNA. Translation: AAN61054.1 .
    AF275679 mRNA. Translation: AAG24389.2 .
    AF289597 mRNA. Translation: AAL55781.1 . Different initiation.
    AL356362 , AC004865 , AL445211 Genomic DNA. Translation: CAI22688.1 . Sequence problems.
    AL445211 , AC004865 , AL356362 Genomic DNA. Translation: CAI23123.1 . Sequence problems.
    AC004865 Genomic DNA. Translation: AAD05028.1 . Sequence problems.
    CH471059 Genomic DNA. Translation: EAX07415.1 .
    CH471059 Genomic DNA. Translation: EAX07416.1 .
    BC001858 mRNA. Translation: AAH01858.2 .
    BC007645 mRNA. Translation: AAH07645.1 .
    BC014530 mRNA. Translation: AAH14530.1 .
    BC031672 mRNA. Translation: AAH31672.2 .
    AL834315 mRNA. Translation: CAD38985.1 .
    AK024287 mRNA. Translation: BAB14874.1 . Different initiation.
    AK090878 mRNA. Translation: BAC03536.1 .
    AB058740 mRNA. Translation: BAB47466.1 . Sequence problems.
    CCDSi CCDS390.1. [Q8IZA0-1 ]
    RefSeqi NP_079150.3. NM_024874.4. [Q8IZA0-1 ]
    XP_006710970.1. XM_006710907.1. [Q8IZA0-1 ]
    XP_006710971.1. XM_006710908.1. [Q8IZA0-1 ]
    XP_006710972.1. XM_006710909.1. [Q8IZA0-1 ]
    XP_006710973.1. XM_006710910.1.
    XP_006710974.1. XM_006710911.1.
    UniGenei Hs.456507.
    Hs.683078.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YRL NMR - A 600-688 [» ]
    ProteinModelPortali Q8IZA0.
    SMRi Q8IZA0. Positions 298-400, 417-497, 505-595, 600-688, 703-785.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IZA0. 1 interaction.

    Polymorphism databases

    DMDMi 187609609.

    Proteomic databases

    MaxQBi Q8IZA0.
    PaxDbi Q8IZA0.
    PRIDEi Q8IZA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325722 ; ENSP00000318406 ; ENSG00000142687 . [Q8IZA0-1 ]
    GeneIDi 79932.
    KEGGi hsa:79932.
    UCSCi uc001byw.3. human. [Q8IZA0-3 ]
    uc001byx.3. human. [Q8IZA0-1 ]
    uc010ohv.1. human. [Q8IZA0-2 ]

    Organism-specific databases

    CTDi 79932.
    GeneCardsi GC01M035899.
    HGNCi HGNC:30071. KIAA0319L.
    HPAi HPA011169.
    MIMi 613535. gene.
    neXtProti NX_Q8IZA0.
    Orphaneti 220402. Limited cutaneous systemic sclerosis.
    536. Systemic lupus erythematosus.
    PharmGKBi PA142671625.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3291.
    HOVERGENi HBG057130.
    OMAi DSNCEWS.
    OrthoDBi EOG79PJNJ.
    PhylomeDBi Q8IZA0.
    TreeFami TF323356.

    Miscellaneous databases

    ChiTaRSi KIAA0319L. human.
    EvolutionaryTracei Q8IZA0.
    GenomeRNAii 79932.
    NextBioi 69860.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZA0.
    Bgeei Q8IZA0.
    CleanExi HS_KIAA0319L.
    Genevestigatori Q8IZA0.

    Family and domain databases

    Gene3Di 2.60.40.670. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013980. MANSC.
    IPR022409. PKD/Chitinase_dom.
    IPR002859. PKD/REJ-like.
    IPR000601. PKD_dom.
    [Graphical view ]
    Pfami PF02010. REJ. 2 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    SM00089. PKD. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49299. SSF49299. 4 hits.
    PROSITEi PS50986. MANSC. 1 hit.
    PS50093. PKD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hao D., Hooi S.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney, Lung, Muscle and Placenta.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-1049 (ISOFORM 1).
      Tissue: Testis.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-1049 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Amygdala.
    8. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-1049 (ISOFORM 2).
      Tissue: Brain.
    9. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-472 AND ASN-525.
      Tissue: Liver.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1037, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1."
      Poon M.W., Tsang W.H., Chan S.O., Li H.M., Ng H.K., Waye M.M.
      Cell. Mol. Neurobiol. 31:27-35(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RTN4R, GLYCOSYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    14. "Solution structure of the PKD domain from KIAA1837 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 600-688.

    Entry informationi

    Entry nameiK319L_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZA0
    Secondary accession number(s): B1AN13
    , D3DPR8, O95010, Q6PJJ7, Q7L1C9, Q8N2B3, Q8NDA0, Q8WY39, Q8WYZ5, Q96IC3, Q96JJ0, Q9BUW6, Q9H7V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3