Q8IZA0 (K319L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dyslexia-associated protein KIAA0319-like protein

Gene names

Name:	KIAA0319L
Synonyms:	KIAA1837
ORF Names:	PP791

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1049 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possible role in axon guidance through interaction with RTN4R. Ref.13
Subunit structure	Interacts with RTN4R. Ref.13
Subcellular location	Cytoplasmic granule membrane; Multi-pass membrane protein Potential Ref.13.
Tissue specificity	Expressed in cortical neurons in the brain cortex (at protein level). Ref.13
Post-translational modification	N-glycosylated. Ref.13
Sequence similarities	Contains 1 MANSC domain. Contains 5 PKD domains.
Sequence caution	The sequence AAD05028.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAL55781.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14874.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB47466.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part. The sequence CAI22688.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23123.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasmic vesicle part Inferred from direct assay Ref.13. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RTN4R	Q9BZR6	4	EBI-5240269,EBI-5240240

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZA0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZA0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     989-1049: IKQKGLLLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL → RGPGCQSF

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8IZA0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     638-638: Q → HFFFCR

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1049

1049

Dyslexia-associated protein KIAA0319-like protein

PRO_0000329064

Regions

Topological domain

1 – 29

29

Cytoplasmic Potential

Transmembrane

30 – 50

21

Helical; Potential

Topological domain

51 – 932

882

Extracellular Potential

Transmembrane

933 – 953

21

Helical; Potential

Topological domain

954 – 1049

96

Cytoplasmic Potential

Domain

49 – 127

79

MANSC

Domain

312 – 401

90

PKD 1

Domain

409 – 498

90

PKD 2

Domain

504 – 594

91

PKD 3

Domain

600 – 688

89

PKD 4

Domain

694 – 785

92

PKD 5

Amino acid modifications

Modified residue

974

1

Phosphothreonine By similarity

Modified residue

978

1

Phosphoserine By similarity

Modified residue

1037

1

Phosphothreonine Ref.11

Glycosylation

247

1

N-linked (GlcNAc...) Potential

Glycosylation

395

1

N-linked (GlcNAc...) Potential

Glycosylation

472

1

N-linked (GlcNAc...) Ref.10

Glycosylation

487

1

N-linked (GlcNAc...) Potential

Glycosylation

525

1

N-linked (GlcNAc...) Ref.10

Natural variations

Alternative sequence

1 – 563

563

Missing in isoform 3.

VSP_032953

Alternative sequence

638

1

Q → HFFFCR in isoform 3.

VSP_032954

Alternative sequence

989 – 1049

61

IKQKG…REEIL → RGPGCQSF in isoform 2.

VSP_032955

Natural variant

243

1

G → D.
Corresponds to variant rs1635712 [ dbSNP | Ensembl ].

VAR_042644

Natural variant

837

1

Q → H.
Corresponds to variant rs1361040 [ dbSNP | Ensembl ].

VAR_042645

Experimental info

Sequence conflict

37

1

C → Y in AAN61054. Ref.1

Sequence conflict

37

1

C → Y in AAG24389. Ref.2

Sequence conflict

86

1

W → L in AAH14530. Ref.5

Sequence conflict

203

1

H → Y in AAG24389. Ref.2

Sequence conflict

520

1

I → T in AAG24389. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1049

Helix Strand Turn

Details...

Beta strand

607 – 610

4

Beta strand

615 – 619

5

Beta strand

625 – 627

3

Beta strand

634 – 639

6

Beta strand

644 – 647

4

Beta strand

650 – 657

8

Beta strand

660 – 671

12

Beta strand

676 – 686

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: FD81BFCA3D38D106	FASTA	1,049	115,658
	10 20 30 40 50 60 MEKRLGVKPN PASWILSGYY WQTSAKWLRS LYLFYTCFCF SVLWLSTDAS ESRCQQGKTQ 70 80 90 100 110 120 FGVGLRSGGE NHLWLLEGTP SLQSCWAACC QDSACHVFWW LEGMCIQADC SRPQSCRAFR 130 140 150 160 170 180 THSSNSMLVF LKKFQTADDL GFLPEDDVPH LLGLGWNWAS WRQSPPRAAL RPAVSSSDQQ 190 200 210 220 230 240 SLIRKLQKRG SPSDVVTPIV TQHSKVNDSN ELGGLTTSGS AEVHKAITIS SPLTTDLTAE 250 260 270 280 290 300 LSGGPKNVSV QPEISEGLAT TPSTQQVKSS EKTQIAVPQP VAPSYSYATP TPQASFQSTS 310 320 330 340 350 360 APYPVIKELV VSAGESVQIT LPKNEVQLNA YVLQEPPKGE TYTYDWQLIT HPRDYSGEME 370 380 390 400 410 420 GKHSQILKLS KLTPGLYEFK VIVEGQNAHG EGYVNVTVKP EPRKNRPPIA IVSPQFQEIS 430 440 450 460 470 480 LPTTSTVIDG SQSTDDDKIV QYHWEELKGP LREEKISEDT AILKLSKLVP GNYTFSLTVV 490 500 510 520 530 540 DSDGATNSTT ANLTVNKAVD YPPVANAGPN QVITLPQNSI TLFGNQSTDD HGITSYEWSL 550 560 570 580 590 600 SPSSKGKVVE MQGVRTPTLQ LSAMQEGDYT YQLTVTDTIG QQATAQVTVI VQPENNKPPQ 610 620 630 640 650 660 ADAGPDKELT LPVDSTTLDG SKSSDDQKII SYLWEKTQGP DGVQLENANS SVATVTGLQV 670 680 690 700 710 720 GTYVFTLTVK DERNLQSQSS VNVIVKEEIN KPPIAKITGN VVITLPTSTA ELDGSKSSDD 730 740 750 760 770 780 KGIVSYLWTR DEGSPAAGEV LNHSDHHPIL FLSNLVEGTY TFHLKVTDAK GESDTDRTTV 790 800 810 820 830 840 EVKPDPRKNN LVEIILDINV SQLTERLKGM FIRQIGVLLG VLDSDIIVQK IQPYTEQSTK 850 860 870 880 890 900 MVFFVQNEPP HQIFKGHEVA AMLKSELRKQ KADFLIFRAL EVNTVTCQLN CSDHGHCDSF 910 920 930 940 950 960 TKRCICDPFW MENFIKVQLR DGDSNCEWSV LYVIIATFVI VVALGILSWT VICCCKRQKG 970 980 990 1000 1010 1020 KPKRKSKYKI LDATDQESLE LKPTSRAGIK QKGLLLSSSL MHSESELDSD DAIFTWPDRE 1030 1040 KGKLLHGQNG SVPNGQTPLK ARSPREEIL
	Isoform 2 [UniParc]. Checksum: E4D2181467A9353C	FASTA	996	109,752
	10 20 30 40 50 60 MEKRLGVKPN PASWILSGYY WQTSAKWLRS LYLFYTCFCF SVLWLSTDAS ESRCQQGKTQ 70 80 90 100 110 120 FGVGLRSGGE NHLWLLEGTP SLQSCWAACC QDSACHVFWW LEGMCIQADC SRPQSCRAFR 130 140 150 160 170 180 THSSNSMLVF LKKFQTADDL GFLPEDDVPH LLGLGWNWAS WRQSPPRAAL RPAVSSSDQQ 190 200 210 220 230 240 SLIRKLQKRG SPSDVVTPIV TQHSKVNDSN ELGGLTTSGS AEVHKAITIS SPLTTDLTAE 250 260 270 280 290 300 LSGGPKNVSV QPEISEGLAT TPSTQQVKSS EKTQIAVPQP VAPSYSYATP TPQASFQSTS 310 320 330 340 350 360 APYPVIKELV VSAGESVQIT LPKNEVQLNA YVLQEPPKGE TYTYDWQLIT HPRDYSGEME 370 380 390 400 410 420 GKHSQILKLS KLTPGLYEFK VIVEGQNAHG EGYVNVTVKP EPRKNRPPIA IVSPQFQEIS 430 440 450 460 470 480 LPTTSTVIDG SQSTDDDKIV QYHWEELKGP LREEKISEDT AILKLSKLVP GNYTFSLTVV 490 500 510 520 530 540 DSDGATNSTT ANLTVNKAVD YPPVANAGPN QVITLPQNSI TLFGNQSTDD HGITSYEWSL 550 560 570 580 590 600 SPSSKGKVVE MQGVRTPTLQ LSAMQEGDYT YQLTVTDTIG QQATAQVTVI VQPENNKPPQ 610 620 630 640 650 660 ADAGPDKELT LPVDSTTLDG SKSSDDQKII SYLWEKTQGP DGVQLENANS SVATVTGLQV 670 680 690 700 710 720 GTYVFTLTVK DERNLQSQSS VNVIVKEEIN KPPIAKITGN VVITLPTSTA ELDGSKSSDD 730 740 750 760 770 780 KGIVSYLWTR DEGSPAAGEV LNHSDHHPIL FLSNLVEGTY TFHLKVTDAK GESDTDRTTV 790 800 810 820 830 840 EVKPDPRKNN LVEIILDINV SQLTERLKGM FIRQIGVLLG VLDSDIIVQK IQPYTEQSTK 850 860 870 880 890 900 MVFFVQNEPP HQIFKGHEVA AMLKSELRKQ KADFLIFRAL EVNTVTCQLN CSDHGHCDSF 910 920 930 940 950 960 TKRCICDPFW MENFIKVQLR DGDSNCEWSV LYVIIATFVI VVALGILSWT VICCCKRQKG 970 980 990 KPKRKSKYKI LDATDQESLE LKPTSRAGRG PGCQSF
	Isoform 3 [UniParc]. Checksum: D920F8CBB52D3CC9	FASTA	491	54,656
	10 20 30 40 50 60 MQEGDYTYQL TVTDTIGQQA TAQVTVIVQP ENNKPPQADA GPDKELTLPV DSTTLDGSKS 70 80 90 100 110 120 SDDQKIISYL WEKTHFFFCR GPDGVQLENA NSSVATVTGL QVGTYVFTLT VKDERNLQSQ 130 140 150 160 170 180 SSVNVIVKEE INKPPIAKIT GNVVITLPTS TAELDGSKSS DDKGIVSYLW TRDEGSPAAG 190 200 210 220 230 240 EVLNHSDHHP ILFLSNLVEG TYTFHLKVTD AKGESDTDRT TVEVKPDPRK NNLVEIILDI 250 260 270 280 290 300 NVSQLTERLK GMFIRQIGVL LGVLDSDIIV QKIQPYTEQS TKMVFFVQNE PPHQIFKGHE 310 320 330 340 350 360 VAAMLKSELR KQKADFLIFR ALEVNTVTCQ LNCSDHGHCD SFTKRCICDP FWMENFIKVQ 370 380 390 400 410 420 LRDGDSNCEW SVLYVIIATF VIVVALGILS WTVICCCKRQ KGKPKRKSKY KILDATDQES 430 440 450 460 470 480 LELKPTSRAG IKQKGLLLSS SLMHSESELD SDDAIFTWPD REKGKLLHGQ NGSVPNGQTP 490 LKARSPREEI L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Hao D., Hooi S. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney, Lung, Muscle and Placenta.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-1049 (ISOFORM 1). Tissue: Testis.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-1049 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Amygdala.
[8]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-1049 (ISOFORM 2). Tissue: Brain.
[9]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[10]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-472 AND ASN-525, MASS SPECTROMETRY. Tissue: Liver.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1037, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1." Poon M.W., Tsang W.H., Chan S.O., Li H.M., Ng H.K., Waye M.M. Cell. Mol. Neurobiol. 31:27-35(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RTN4R, GLYCOSYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[14]	"Solution structure of the PKD domain from KIAA1837 protein." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 600-688.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY163234 mRNA. Translation: AAN61054.1.
AF275679 mRNA. Translation: AAG24389.2.
AF289597 mRNA. Translation: AAL55781.1. Different initiation.
AL356362, AC004865, AL445211 Genomic DNA. Translation: CAI22688.1. Sequence problems.
AL445211, AC004865, AL356362 Genomic DNA. Translation: CAI23123.1. Sequence problems.
AC004865 Genomic DNA. Translation: AAD05028.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX07415.1.
CH471059 Genomic DNA. Translation: EAX07416.1.
BC001858 mRNA. Translation: AAH01858.2.
BC007645 mRNA. Translation: AAH07645.1.
BC014530 mRNA. Translation: AAH14530.1.
BC031672 mRNA. Translation: AAH31672.2.
AL834315 mRNA. Translation: CAD38985.1.
AK024287 mRNA. Translation: BAB14874.1. Different initiation.
AK090878 mRNA. Translation: BAC03536.1.
AB058740 mRNA. Translation: BAB47466.1. Sequence problems.

IPI

IPI00472754.
IPI00844309.
IPI00936149.

RefSeq

NP_079150.3. NM_024874.4.

UniGene

Hs.456507.
Hs.683078.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YRL	NMR	-	A	600-688	[»]

ProteinModelPortal

Q8IZA0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IZA0. 1 interaction.

Polymorphism databases

DMDM

187609609.

Proteomic databases

PaxDb

Q8IZA0.

PRIDE

Q8IZA0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000325722; ENSP00000318406; ENSG00000142687.

GeneID

79932.

KEGG

hsa:79932.

UCSC

uc001byw.3. human.
uc001byx.3. human.
uc010ohv.1. human.

Organism-specific databases

CTD

79932.

GeneCards

GC01M035899.

HGNC

HGNC:30071. KIAA0319L.

HPA

HPA011169.

MIM

613535. gene.

neXtProt

NX_Q8IZA0.

PharmGKB

PA142671625.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG3291.

HOVERGEN

HBG057130.

OMA

DSNCEWS.

OrthoDB

EOG4B8JC7.

PhylomeDB

Q8IZA0.

Gene expression databases

ArrayExpress

Q8IZA0.

Bgee

Q8IZA0.

CleanEx

HS_KIAA0319L.

Genevestigator

Q8IZA0.

Family and domain databases

Gene3D

2.60.40.670. 2 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR013980. MANSC.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR000601. PKD_dom.
[Graphical view]

Pfam

PF02010. REJ. 2 hits.
[Graphical view]

SMART

SM00060. FN3. 4 hits.
SM00089. PKD. 5 hits.
[Graphical view]

SUPFAM

SSF49299. PKD. 4 hits.

PROSITE

PS50986. MANSC. 1 hit.
PS50093. PKD. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

KIAA0319L. human.

EvolutionaryTrace

Q8IZA0.

GenomeRNAi

79932.

NextBio

69860.

SOURCE

Search...

Entry information

Entry name

K319L_HUMAN

Accession

Primary (citable) accession number: Q8IZA0
Secondary accession number(s): B1AN13 , D3DPR8, O95010, Q6PJJ7, Q7L1C9, Q8N2B3, Q8NDA0, Q8WY39, Q8WYZ5, Q96IC3, Q96JJ0, Q9BUW6, Q9H7V0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.