Q8IZ96 (CKLF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 78.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: CKLF-like MARVEL transmembrane domain-containing protein 1 Alternative name(s): Chemokine-like factor superfamily member 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 169 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Subcellular location | |
| Tissue specificity | |
| Sequence similarities | Belongs to the chemokine-like factor family. Contains 1 MARVEL domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Chemotaxis |
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Cytokine |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 17 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8IZ96-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 1a (identifier: Q8IZ96-2) Also known as: 17; The sequence of this isoform differs from the canonical sequence as follows: 1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR | ||||||
| Isoform 1b (identifier: Q8IZ96-3) The sequence of this isoform differs from the canonical sequence as follows: 1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR 115-169: Missing. | ||||||
| Isoform 2 (identifier: Q8IZ96-4) The sequence of this isoform differs from the canonical sequence as follows: 114-114: S → R 115-169: Missing. | ||||||
| Isoform 3 (identifier: Q8IZ96-5) The sequence of this isoform differs from the canonical sequence as follows: 28-33: SLILGA → ASSGSV 34-80: Missing. | ||||||
| Isoform 4 (identifier: Q8IZ96-6) The sequence of this isoform differs from the canonical sequence as follows: 28-80: Missing. | ||||||
| Isoform 5 (identifier: Q8IZ96-7) The sequence of this isoform differs from the canonical sequence as follows: 28-80: Missing. 114-114: S → R 115-169: Missing. | ||||||
| Isoform 6 (identifier: Q8IZ96-8) Also known as: 7; The sequence of this isoform differs from the canonical sequence as follows: 28-92: SLILGALACF...TNSIITAVFL → ASSGSVVSSV...TVSLQLCSFQ 93-169: Missing. | ||||||
| Isoform 8 (identifier: Q8IZ96-9) Also known as: 9; The sequence of this isoform differs from the canonical sequence as follows: 81-91: DLTNSIITAVF → NAEYRKQTKQI 92-169: Missing. | ||||||
| Isoform 10 (identifier: Q8IZ96-10) The sequence of this isoform differs from the canonical sequence as follows: 28-65: SLILGALACF...IVVFFILIYV → ASSGSVVSSV...TGPDAPQRPA 66-169: Missing. | ||||||
| Isoform 11 (identifier: Q8IZ96-11) The sequence of this isoform differs from the canonical sequence as follows: 28-33: SLILGA → EAYNSK 34-169: Missing. | ||||||
| Isoform 12 (identifier: Q8IZ96-12) The sequence of this isoform differs from the canonical sequence as follows: 8-65: Missing. 77-77: W → R 81-103: DLTNSIITAVFLSVVAILAMQEK → AAELSLSHRMPSTGSRQSKYEQL 104-169: Missing. | ||||||
| Isoform 13 (identifier: Q8IZ96-13) The sequence of this isoform differs from the canonical sequence as follows: 28-38: SLILGALACFI → EADKANMSNFN 39-169: Missing. | ||||||
| Isoform 14 (identifier: Q8IZ96-14) Also known as: 15; The sequence of this isoform differs from the canonical sequence as follows: 28-32: SLILG → LCSFQ 33-169: Missing. | ||||||
| Isoform 16 (identifier: Q8IZ96-15) The sequence of this isoform differs from the canonical sequence as follows: 28-28: S → R 29-169: Missing. | ||||||
| Isoform 19 (identifier: Q8IZ96-16) Also known as: 20,21,22,23; The sequence of this isoform differs from the canonical sequence as follows: 1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR 81-91: DLTNSIITAVF → NAEYRKQTKQI 92-169: Missing. | ||||||
| Isoform 24 (identifier: Q8IZ96-17) The sequence of this isoform differs from the canonical sequence as follows: 26-26: A → ALASSGSVVS...SPTGMLKILR | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 169 | 169 | CKLF-like MARVEL transmembrane domain-containing protein 1 | PRO_0000186097 | |||||
Regions | |||||||||
| Transmembrane | 22 – 42 | 21 | Helical; Potential | ||||||
| Transmembrane | 46 – 66 | 21 | Helical; Potential | ||||||
| Transmembrane | 79 – 99 | 21 | Helical; Potential | ||||||
| Transmembrane | 110 – 130 | 21 | Helical; Potential | ||||||
| Domain | 17 – 135 | 119 | MARVEL | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 26 | 26 | MDPEH…ETAAA → MLKILR in isoform 1a, isoform 1b and isoform 19. | VSP_008229 | |||||
| Alternative sequence | 8 – 65 | 58 | Missing in isoform 12. | VSP_008230 | |||||
| Alternative sequence | 26 | 1 | A → ALASSGSVVSSVPKAQRNIS AKTAPRKHPAVSIRSAQSAA AARPQGSEGTAPSRKATTRP PPKPTLPPPTPSAHTESKLL NEMAIKERVEGRAKVPYKFR DSLKRFSFSPTGMLKILR in isoform 24. | VSP_043579 | |||||
| Alternative sequence | 28 – 92 | 65 | SLILG…TAVFL → ASSGSVVSSVPKAQRNISAK TAPRKHPAVSIRSAQSAAAA RPQGSEGTAPSRILPTVSLQ LCSFQ in isoform 6. | VSP_008238 | |||||
| Alternative sequence | 28 – 80 | 53 | Missing in isoform 4 and isoform 5. | VSP_008237 | |||||
| Alternative sequence | 28 – 65 | 38 | SLILG…ILIYV → ASSGSVVSSVPKAQRNISAK TAPRKHPETGPDAPQRPA in isoform 10. | VSP_008236 | |||||
| Alternative sequence | 28 – 38 | 11 | SLILGALACFI → EADKANMSNFN in isoform 13. | VSP_008235 | |||||
| Alternative sequence | 28 – 33 | 6 | SLILGA → EAYNSK in isoform 11. | VSP_008233 | |||||
| Alternative sequence | 28 – 33 | 6 | SLILGA → ASSGSV in isoform 3. | VSP_008234 | |||||
| Alternative sequence | 28 – 32 | 5 | SLILG → LCSFQ in isoform 14. | VSP_008232 | |||||
| Alternative sequence | 28 | 1 | S → R in isoform 16. | VSP_008231 | |||||
| Alternative sequence | 29 – 169 | 141 | Missing in isoform 16. | VSP_008239 | |||||
| Alternative sequence | 33 – 169 | 137 | Missing in isoform 14. | VSP_008240 | |||||
| Alternative sequence | 34 – 169 | 136 | Missing in isoform 11. | VSP_008241 | |||||
| Alternative sequence | 34 – 80 | 47 | Missing in isoform 3. | VSP_008242 | |||||
| Alternative sequence | 39 – 169 | 131 | Missing in isoform 13. | VSP_008243 | |||||
| Alternative sequence | 66 – 169 | 104 | Missing in isoform 10. | VSP_008244 | |||||
| Alternative sequence | 77 | 1 | W → R in isoform 12. | VSP_008245 | |||||
| Alternative sequence | 81 – 103 | 23 | DLTNS…AMQEK → AAELSLSHRMPSTGSRQSKY EQL in isoform 12. | VSP_008246 | |||||
| Alternative sequence | 81 – 91 | 11 | DLTNSIITAVF → NAEYRKQTKQI in isoform 8 and isoform 19. | VSP_008247 | |||||
| Alternative sequence | 92 – 169 | 78 | Missing in isoform 8 and isoform 19. | VSP_008248 | |||||
| Alternative sequence | 93 – 169 | 77 | Missing in isoform 6. | VSP_008249 | |||||
| Alternative sequence | 104 – 169 | 66 | Missing in isoform 12. | VSP_008250 | |||||
| Alternative sequence | 114 | 1 | S → R in isoform 2 and isoform 5. | VSP_008251 | |||||
| Alternative sequence | 115 – 169 | 55 | Missing in isoform 1b, isoform 2 and isoform 5. | VSP_008252 | |||||
| Natural variant | 10 | 1 | S → T. Corresponds to variant rs16956746 [ dbSNP | Ensembl ]. | VAR_053039 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation." Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D. Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Testis. |
| [2] | "Molecular cloning and characterization of chemokine-like factor super family member 1 (CKLFSF1), a novel human gene with at least 23 alternative splicing isoforms in testis tissue." Wang L., Wu C., Zheng Y., Qiu X., Wang L., Fan H., Han W., Lv B., Wang Y., Zhu X., Xu M., Ding P., Cheng S., Zhang Y., Song Q., Ma D. Int. J. Biochem. Cell Biol. 36:1492-1501(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 2; 3; 4; 5; 6; 8; 10; 11; 12; 13; 14; 16 AND 19), TISSUE SPECIFICITY. Tissue: Testis. |
| [3] | "Homo sapiens chemokine-like factor superfamily 1 (CKLFSF1), transcript variant 24." Wang J., Wang L. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 19). |
| [4] | "The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A.Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 24). Tissue: Testis. |
Cross-references
Entry information
| Entry name | CKLF1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8IZ96 Secondary accession number(s): Q2PPY5 Q96JC3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
