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Q8IZ96 (CKLF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CKLF-like MARVEL transmembrane domain-containing protein 1
Alternative name(s):
Chemokine-like factor superfamily member 1
Gene names
Name:CMTM1
Synonyms:CKLFSF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in testis. Ref.1 Ref.2

Sequence similarities

Belongs to the chemokine-like factor family.

Contains 1 MARVEL domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionCytokine
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 17 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IZ96-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1a (identifier: Q8IZ96-2)

Also known as: 17;

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR
Isoform 1b (identifier: Q8IZ96-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR
     115-169: Missing.
Isoform 2 (identifier: Q8IZ96-4)

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: S → R
     115-169: Missing.
Isoform 3 (identifier: Q8IZ96-5)

The sequence of this isoform differs from the canonical sequence as follows:
     28-33: SLILGA → ASSGSV
     34-80: Missing.
Isoform 4 (identifier: Q8IZ96-6)

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.
Isoform 5 (identifier: Q8IZ96-7)

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.
     114-114: S → R
     115-169: Missing.
Isoform 6 (identifier: Q8IZ96-8)

Also known as: 7;

The sequence of this isoform differs from the canonical sequence as follows:
     28-92: SLILGALACF...TNSIITAVFL → ASSGSVVSSV...TVSLQLCSFQ
     93-169: Missing.
Isoform 8 (identifier: Q8IZ96-9)

Also known as: 9;

The sequence of this isoform differs from the canonical sequence as follows:
     81-91: DLTNSIITAVF → NAEYRKQTKQI
     92-169: Missing.
Isoform 10 (identifier: Q8IZ96-10)

The sequence of this isoform differs from the canonical sequence as follows:
     28-65: SLILGALACF...IVVFFILIYV → ASSGSVVSSV...TGPDAPQRPA
     66-169: Missing.
Isoform 11 (identifier: Q8IZ96-11)

The sequence of this isoform differs from the canonical sequence as follows:
     28-33: SLILGA → EAYNSK
     34-169: Missing.
Isoform 12 (identifier: Q8IZ96-12)

The sequence of this isoform differs from the canonical sequence as follows:
     8-65: Missing.
     77-77: W → R
     81-103: DLTNSIITAVFLSVVAILAMQEK → AAELSLSHRMPSTGSRQSKYEQL
     104-169: Missing.
Isoform 13 (identifier: Q8IZ96-13)

The sequence of this isoform differs from the canonical sequence as follows:
     28-38: SLILGALACFI → EADKANMSNFN
     39-169: Missing.
Isoform 14 (identifier: Q8IZ96-14)

Also known as: 15;

The sequence of this isoform differs from the canonical sequence as follows:
     28-32: SLILG → LCSFQ
     33-169: Missing.
Isoform 16 (identifier: Q8IZ96-15)

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: S → R
     29-169: Missing.
Isoform 19 (identifier: Q8IZ96-16)

Also known as: 20,21,22,23;

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR
     81-91: DLTNSIITAVF → NAEYRKQTKQI
     92-169: Missing.
Isoform 24 (identifier: Q8IZ96-17)

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: A → ALASSGSVVS...SPTGMLKILR
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169CKLF-like MARVEL transmembrane domain-containing protein 1
PRO_0000186097

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane110 – 13021Helical; Potential
Domain17 – 135119MARVEL

Natural variations

Alternative sequence1 – 2626MDPEH…ETAAA → MLKILR in isoform 1a, isoform 1b and isoform 19.
VSP_008229
Alternative sequence8 – 6558Missing in isoform 12.
VSP_008230
Alternative sequence261A → ALASSGSVVSSVPKAQRNIS AKTAPRKHPAVSIRSAQSAA AARPQGSEGTAPSRKATTRP PPKPTLPPPTPSAHTESKLL NEMAIKERVEGRAKVPYKFR DSLKRFSFSPTGMLKILR in isoform 24.
VSP_043579
Alternative sequence28 – 9265SLILG…TAVFL → ASSGSVVSSVPKAQRNISAK TAPRKHPAVSIRSAQSAAAA RPQGSEGTAPSRILPTVSLQ LCSFQ in isoform 6.
VSP_008238
Alternative sequence28 – 8053Missing in isoform 4 and isoform 5.
VSP_008237
Alternative sequence28 – 6538SLILG…ILIYV → ASSGSVVSSVPKAQRNISAK TAPRKHPETGPDAPQRPA in isoform 10.
VSP_008236
Alternative sequence28 – 3811SLILGALACFI → EADKANMSNFN in isoform 13.
VSP_008235
Alternative sequence28 – 336SLILGA → EAYNSK in isoform 11.
VSP_008233
Alternative sequence28 – 336SLILGA → ASSGSV in isoform 3.
VSP_008234
Alternative sequence28 – 325SLILG → LCSFQ in isoform 14.
VSP_008232
Alternative sequence281S → R in isoform 16.
VSP_008231
Alternative sequence29 – 169141Missing in isoform 16.
VSP_008239
Alternative sequence33 – 169137Missing in isoform 14.
VSP_008240
Alternative sequence34 – 169136Missing in isoform 11.
VSP_008241
Alternative sequence34 – 8047Missing in isoform 3.
VSP_008242
Alternative sequence39 – 169131Missing in isoform 13.
VSP_008243
Alternative sequence66 – 169104Missing in isoform 10.
VSP_008244
Alternative sequence771W → R in isoform 12.
VSP_008245
Alternative sequence81 – 10323DLTNS…AMQEK → AAELSLSHRMPSTGSRQSKY EQL in isoform 12.
VSP_008246
Alternative sequence81 – 9111DLTNSIITAVF → NAEYRKQTKQI in isoform 8 and isoform 19.
VSP_008247
Alternative sequence92 – 16978Missing in isoform 8 and isoform 19.
VSP_008248
Alternative sequence93 – 16977Missing in isoform 6.
VSP_008249
Alternative sequence104 – 16966Missing in isoform 12.
VSP_008250
Alternative sequence1141S → R in isoform 2 and isoform 5.
VSP_008251
Alternative sequence115 – 16955Missing in isoform 1b, isoform 2 and isoform 5.
VSP_008252
Natural variant101S → T.
Corresponds to variant rs16956746 [ dbSNP | Ensembl ].
VAR_053039

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 72F3C2E26D738E76

FASTA16918,576
        10         20         30         40         50         60 
MDPEHAKPES SEAPSGNLKQ PETAAALSLI LGALACFIIT QANESFITIT SLEICIVVFF 

        70         80         90        100        110        120 
ILIYVLTLHH LLTYLHWPLL DLTNSIITAV FLSVVAILAM QEKKRRHLLY VGGSLCLTAV 

       130        140        150        160 
IVCCIDAFVV TTKMRTNLKR FLGVEVERKL SPAKDAYPET GPDAPQRPA 

« Hide

Isoform 1a (17) [UniParc].

Checksum: 49B9A541A50808A4
Show »

FASTA14916,656
Isoform 1b [UniParc].

Checksum: 191F4C3E3CAC7D90
Show »

FASTA9410,640
Isoform 2 [UniParc].

Checksum: F50DA17544F24B18
Show »

FASTA11412,629
Isoform 3 [UniParc].

Checksum: 3F2C56CEBC3F3146
Show »

FASTA12213,037
Isoform 4 [UniParc].

Checksum: F641CD1FB1E06E98
Show »

FASTA11612,549
Isoform 5 [UniParc].

Checksum: FD45F64EAC5105D7
Show »

FASTA616,602
Isoform 6 (7) [UniParc].

Checksum: 73AF83CE10165410
Show »

FASTA929,389
Isoform 8 (9) [UniParc].

Checksum: 7124F06BA1F1E5A1
Show »

FASTA9110,194
Isoform 10 [UniParc].

Checksum: FEC634E7970EA7DB
Show »

FASTA656,669
Isoform 11 [UniParc].

Checksum: 0AA27266266CA05B
Show »

FASTA333,499
Isoform 12 [UniParc].

Checksum: C680DB671BC002BB
Show »

FASTA455,208
Isoform 13 [UniParc].

Checksum: 60F335FBCEADCA15
Show »

FASTA384,028
Isoform 14 (15) [UniParc].

Checksum: 511FE8C500905B46
Show »

FASTA323,385
Isoform 16 [UniParc].

Checksum: 43B05B463D202C28
Show »

FASTA282,962
Isoform 19 (20,21,22,23) [UniParc].

Checksum: 8F60080E17B7AC10
Show »

FASTA718,274
Isoform 24 [UniParc].

Checksum: 72C6D584CB10DEEC
Show »

FASTA28631,068

References

« Hide 'large scale' references
[1]"Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Molecular cloning and characterization of chemokine-like factor super family member 1 (CKLFSF1), a novel human gene with at least 23 alternative splicing isoforms in testis tissue."
Wang L., Wu C., Zheng Y., Qiu X., Wang L., Fan H., Han W., Lv B., Wang Y., Zhu X., Xu M., Ding P., Cheng S., Zhang Y., Song Q., Ma D.
Int. J. Biochem. Cell Biol. 36:1492-1501(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 2; 3; 4; 5; 6; 8; 10; 11; 12; 13; 14; 16 AND 19), TISSUE SPECIFICITY.
Tissue: Testis.
[3]"Homo sapiens chemokine-like factor superfamily 1 (CKLFSF1), transcript variant 24."
Wang J., Wang L.
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 19).
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 24).
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF278576 mRNA. Translation: AAK73015.1.
AF278577 mRNA. Translation: AAK73016.1.
AY174118 mRNA. Translation: AAN73227.1.
AY174119 mRNA. Translation: AAN73228.1.
AY174120 mRNA. Translation: AAN73229.1.
AY174121 mRNA. Translation: AAN73230.1.
AY174122 mRNA. Translation: AAN73231.1.
AY174123 mRNA. Translation: AAN73232.1.
AY174124 mRNA. Translation: AAN73233.1.
AY174125 mRNA. Translation: AAN73234.1.
AY174126 mRNA. Translation: AAN73235.1.
AY174127 mRNA. Translation: AAN73236.1.
AY174128 mRNA. Translation: AAN73237.1.
AY174129 mRNA. Translation: AAN73238.1.
AY174130 mRNA. Translation: AAN73239.1.
AY174131 mRNA. Translation: AAN73240.1.
AY174132 mRNA. Translation: AAN73241.1.
AY174133 mRNA. Translation: AAN73242.1.
AY174134 mRNA. Translation: AAN73243.1.
AY174135 mRNA. Translation: AAN73244.1.
AY174136 mRNA. Translation: AAN73245.1.
AY174137 mRNA. Translation: AAN73246.1.
AY174138 mRNA. Translation: AAN73247.1.
DQ309766 mRNA. Translation: ABC33727.2.
AC010542 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83023.1.
BC057852 mRNA. Translation: AAH57852.2.
RefSeqNP_443725.3. NM_052999.3.
NP_851785.2. NM_181268.2.
NP_851786.1. NM_181269.2.
NP_851787.1. NM_181270.2.
NP_851788.1. NM_181271.2.
NP_851789.1. NM_181272.2.
NP_851800.1. NM_181283.2.
NP_851813.1. NM_181296.2.
UniGeneHs.15159.
Hs.698621.
Hs.722591.

3D structure databases

ProteinModelPortalQ8IZ96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125251. 1 interaction.

PTM databases

PhosphoSiteQ8IZ96.

Polymorphism databases

DMDM34921810.

Proteomic databases

PaxDbQ8IZ96.
PRIDEQ8IZ96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332695; ENSP00000331428; ENSG00000089505. [Q8IZ96-5]
ENST00000333001; ENSP00000331494; ENSG00000089505. [Q8IZ96-9]
ENST00000336328; ENSP00000337119; ENSG00000089505. [Q8IZ96-6]
ENST00000379500; ENSP00000368814; ENSG00000089505. [Q8IZ96-17]
ENST00000457188; ENSP00000405729; ENSG00000089505. [Q8IZ96-1]
ENST00000528324; ENSP00000432398; ENSG00000089505. [Q8IZ96-4]
ENST00000528484; ENSP00000437079; ENSG00000089505. [Q8IZ96-13]
ENST00000529386; ENSP00000431303; ENSG00000089505. [Q8IZ96-13]
ENST00000531885; ENSP00000432687; ENSG00000089505. [Q8IZ96-7]
ENST00000533078; ENSP00000432387; ENSG00000089505. [Q8IZ96-14]
ENST00000533666; ENSP00000435020; ENSG00000089505. [Q8IZ96-15]
ENST00000533915; ENSP00000435755; ENSG00000089505. [Q8IZ96-9]
ENST00000535705; ENSP00000443374; ENSG00000089505. [Q8IZ96-13]
GeneID113540.
KEGGhsa:113540.
UCSCuc002epa.4. human. [Q8IZ96-15]
uc002eph.4. human. [Q8IZ96-4]
uc002epi.4. human. [Q8IZ96-1]
uc002epj.4. human. [Q8IZ96-7]
uc002epk.4. human. [Q8IZ96-6]
uc002epl.4. human. [Q8IZ96-5]
uc002epr.4. human. [Q8IZ96-17]

Organism-specific databases

CTD113540.
GeneCardsGC16P066600.
HGNCHGNC:19172. CMTM1.
HPAHPA013801.
HPA017136.
MIM607884. gene.
neXtProtNX_Q8IZ96.
PharmGKBPA38811.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG290806.
HOGENOMHOG000143431.
HOVERGENHBG050979.
OMAITILEIF.
OrthoDBEOG7JMGF9.
PhylomeDBQ8IZ96.
TreeFamTF338711.

Gene expression databases

ArrayExpressQ8IZ96.
BgeeQ8IZ96.
GenevestigatorQ8IZ96.

Family and domain databases

InterProIPR008253. Marvel.
[Graphical view]
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi113540.
NextBio78856.
PROQ8IZ96.
SOURCESearch...

Entry information

Entry nameCKLF1_HUMAN
AccessionPrimary (citable) accession number: Q8IZ96
Secondary accession number(s): Q2PPY5 expand/collapse secondary AC list , Q6PEV5, Q8IU76, Q8IU83, Q8IU86, Q8IU93, Q8IZ87, Q8IZ88, Q8IZ89, Q8IZ90, Q8IZ91, Q8IZ92, Q8IZ93, Q8IZ94, Q8IZ95, Q96JC2, Q96JC3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM