ID   A16A1_HUMAN             Reviewed;         802 AA.
AC   Q8IZ83; Q86YF0; Q8IYL4; Q8TEI8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   07-JUL-2009, entry version 48.
DE   RecName: Full=Aldehyde dehydrogenase family 16 member A1;
GN   Name=ALDH16A1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Spleen;
RA   Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT   "The nucleotide sequence of a long cDNA clone isolated from human
RT   spleen.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lymph, Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- INTERACTION:
CC       Q9BRP4:PAAF1; NbExp=1; IntAct=EBI-1044483, EBI-1056358;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8IZ83-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IZ83-2; Sequence=VSP_029982, VSP_029983;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC   -!- CAUTION: The active site cysteine and glutamate residues are not
CC       conserved in this protein. Its activity is therefore unsure.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB84962.1; Type=Erroneous translation; Note=Wrong choice of frame;
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DR   EMBL; AK074136; BAB84962.1; ALT_SEQ; mRNA.
DR   EMBL; BC014895; AAH14895.2; -; mRNA.
DR   EMBL; BC035641; AAH35641.1; ALT_INIT; mRNA.
DR   EMBL; BC042142; AAH42142.1; -; mRNA.
DR   IPI; IPI00217920; -.
DR   IPI; IPI00646424; -.
DR   RefSeq; NP_699160.2; -.
DR   UniGene; Hs.355398; -.
DR   IntAct; Q8IZ83; 1.
DR   PRIDE; Q8IZ83; -.
DR   Ensembl; ENSG00000161618; Homo sapiens.
DR   GeneID; 126133; -.
DR   KEGG; hsa:126133; -.
DR   UCSC; uc002pnt.1; human.
DR   GeneCards; GC19P054649; -.
DR   HGNC; HGNC:28114; ALDH16A1.
DR   PharmGKB; PA134903503; -.
DR   HOGENOM; Q8IZ83; -.
DR   HOVERGEN; Q8IZ83; -.
DR   NextBio; 81700; -.
DR   ArrayExpress; Q8IZ83; -.
DR   Bgee; Q8IZ83; -.
DR   CleanEx; HS_ALDH16A1; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR011408; ADH_dupl.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 2.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 2.
DR   PIRSF; PIRSF036490; Aldedh_dupl; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Polymorphism.
FT   CHAIN         1    802       Aldehyde dehydrogenase family 16 member
FT                                A1.
FT                                /FTId=PRO_0000312986.
FT   VAR_SEQ     254    308       EGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGV
FT                                VDAAWSDRGPGGLR -> VPSGQGSWRNAAGGRKAPPAAEL
FT                                GGVPRKGVPFDGAWRESVRSWAWRWGRSRCCC (in
FT                                isoform 2).
FT                                /FTId=VSP_029982.
FT   VAR_SEQ     309    802       Missing (in isoform 2).
FT                                /FTId=VSP_029983.
FT   VARIANT     110    110       E -> K (in dbSNP:rs3745312).
FT                                /FTId=VAR_037638.
FT   VARIANT     227    227       V -> L (in dbSNP:rs1320303).
FT                                /FTId=VAR_037639.
SQ   SEQUENCE   802 AA;  85113 MW;  E2DD75662DFEB827 CRC64;
     MAATRAGPRA REIFTSLEYG PVPESHACAL AWLDTQDRCL GHYVNGKWLK PEHRNSVPCQ
     DPITGENLAS CLQAQAEDVA AAVEAARMAF KGWSAHPGVV RAQHLTRLAE VIQKHQRLLW
     TLESLVTGRA VREVRDGDVQ LAQQLLHYHA IQASTQEEAL AGWEPMGVIG LILPPTFSFL
     EMMWRICPAL AVGCTVVALV PPASPAPLLL AQLAGELGPF PGILNVVSGP ASLVPILASQ
     PGIRKVAFCG APEEGRALRR SLAGECAELG LALGTESLLL LTDTADVDSA VEGVVDAAWS
     DRGPGGLRLL IQESVWDEAM RRLQERMGRL RSGRGLDGAV DMGARGAAAC DLVQRFVREA
     QSQGAQVFQA GDVPSERPFY PPTLVSNLPP ASPCAQVEVP WPVVVASPFR TAKEALLVAN
     GTPRGGSASV WSERLGQALE LGYGLQVGTV WINAHGLRDP SVPTGGCKES GCSWHGGPDG
     LYEYLRPSGT PARLSCLSKN LNYDTFGLAV PSTLPAGPEI GPSPAPPYGL FVGGRFQAPG
     ARSSRPIRDS SGNLHGYVAE GGAKDIRGAV EAAHQAFPGW AGQSPGARAA LLWALAAALE
     RRKSTLASRL ERQGAELKAA EAEVELSARR LRAWGARVQA QGHTLQVAGL RGPVLRLREP
     LGVLAVVCPD EWPLLAFVSL LAPALAYGNT VVMVPSAACP LLALEVCQDM ATVFPAGLAN
     VVTGDRDHLT RCLALHQDVQ AMWYFGSAQG SQFVEWASAG NLKPVWASRG CPRAWDQEAE
     GAGPELGLRV ARTKALWLPM GD
//