Reviewed, UniProtKB/Swiss-Prot Q8IZ83 (A16A1_HUMAN)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase family 16 member A1

Gene names

Name:

ALDH16A1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	802 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Caution	The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.
Sequence caution	The sequence BAB84962.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PAAF1	Q9BRP4	1	EBI-1044483,EBI-1056358

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZ83-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZ83-2)

The sequence of this isoform differs from the canonical sequence as follows:
     254-308: EGRALRRSLA...WSDRGPGGLR → VPSGQGSWRN...WRWGRSRCCC
     309-802: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 802	802	Aldehyde dehydrogenase family 16 member A1		PRO_0000312986
Natural variations
	Alternative sequence	254 – 308	55	EGRAL…PGGLR → VPSGQGSWRNAAGGRKAPPA AELGGVPRKGVPFDGAWRES VRSWAWRWGRSRCCC in isoform 2.		VSP_029982
	Alternative sequence	309 – 802	494	Missing in isoform 2.		VSP_029983
	Natural variant	110	1	E → K: dbSNP rs3745312.		VAR_037638
	Natural variant	227	1	V → L: dbSNP rs1320303.		VAR_037639

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E2DD75662DFEB827	FASTA	802	85,113
	10 20 30 40 50 60 MAATRAGPRA REIFTSLEYG PVPESHACAL AWLDTQDRCL GHYVNGKWLK PEHRNSVPCQ 70 80 90 100 110 120 DPITGENLAS CLQAQAEDVA AAVEAARMAF KGWSAHPGVV RAQHLTRLAE VIQKHQRLLW 130 140 150 160 170 180 TLESLVTGRA VREVRDGDVQ LAQQLLHYHA IQASTQEEAL AGWEPMGVIG LILPPTFSFL 190 200 210 220 230 240 EMMWRICPAL AVGCTVVALV PPASPAPLLL AQLAGELGPF PGILNVVSGP ASLVPILASQ 250 260 270 280 290 300 PGIRKVAFCG APEEGRALRR SLAGECAELG LALGTESLLL LTDTADVDSA VEGVVDAAWS 310 320 330 340 350 360 DRGPGGLRLL IQESVWDEAM RRLQERMGRL RSGRGLDGAV DMGARGAAAC DLVQRFVREA 370 380 390 400 410 420 QSQGAQVFQA GDVPSERPFY PPTLVSNLPP ASPCAQVEVP WPVVVASPFR TAKEALLVAN 430 440 450 460 470 480 GTPRGGSASV WSERLGQALE LGYGLQVGTV WINAHGLRDP SVPTGGCKES GCSWHGGPDG 490 500 510 520 530 540 LYEYLRPSGT PARLSCLSKN LNYDTFGLAV PSTLPAGPEI GPSPAPPYGL FVGGRFQAPG 550 560 570 580 590 600 ARSSRPIRDS SGNLHGYVAE GGAKDIRGAV EAAHQAFPGW AGQSPGARAA LLWALAAALE 610 620 630 640 650 660 RRKSTLASRL ERQGAELKAA EAEVELSARR LRAWGARVQA QGHTLQVAGL RGPVLRLREP 670 680 690 700 710 720 LGVLAVVCPD EWPLLAFVSL LAPALAYGNT VVMVPSAACP LLALEVCQDM ATVFPAGLAN 730 740 750 760 770 780 VVTGDRDHLT RCLALHQDVQ AMWYFGSAQG SQFVEWASAG NLKPVWASRG CPRAWDQEAE 790 800 GAGPELGLRV ARTKALWLPM GD
	Isoform 2. Checksum: 7D12E423B16610C7	FASTA	308	33,114
	10 20 30 40 50 60 MAATRAGPRA REIFTSLEYG PVPESHACAL AWLDTQDRCL GHYVNGKWLK PEHRNSVPCQ 70 80 90 100 110 120 DPITGENLAS CLQAQAEDVA AAVEAARMAF KGWSAHPGVV RAQHLTRLAE VIQKHQRLLW 130 140 150 160 170 180 TLESLVTGRA VREVRDGDVQ LAQQLLHYHA IQASTQEEAL AGWEPMGVIG LILPPTFSFL 190 200 210 220 230 240 EMMWRICPAL AVGCTVVALV PPASPAPLLL AQLAGELGPF PGILNVVSGP ASLVPILASQ 250 260 270 280 290 300 PGIRKVAFCG APEVPSGQGS WRNAAGGRKA PPAAELGGVP RKGVPFDGAW RESVRSWAWR WGRSRCCC

References

[1]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph, Skin and Uterus.
[3]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK074136 mRNA. Translation: BAB84962.1. Sequence problems. BC014895 mRNA. Translation: AAH14895.2. BC035641 mRNA. Translation: AAH35641.1. Different initiation. BC042142 mRNA. Translation: AAH42142.1.
IPI	IPI00217920. IPI00646424.
RefSeq	NP_699160.2.
UniGene	Hs.355398
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZ83. 1 interaction.
Proteomic databases
PRIDE	Q8IZ83.
Genome annotation databases
Ensembl	ENSG00000161618. Homo sapiens. [Contig view]
GeneID	126133.
KEGG	hsa:126133.
Organism-specific databases
GeneCards	GC19P054649.
HGNC	HGNC:28114. ALDH16A1.
PharmGKB	PA134903503.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8IZ83.
HOVERGEN	Q8IZ83.
Gene expression databases
ArrayExpress	Q8IZ83.
Bgee	Q8IZ83.
CleanEx	HS_ALDH16A1.
Family and domain databases
InterPro	IPR011408. ADH_dupl. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 2 hits. [Graphical view]
PIRSF	PIRSF036490. Aldedh_dupl. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	81700.

Entry information

Entry name

A16A1_HUMAN

Accession

Primary (citable) accession number: Q8IZ83
Secondary accession number(s): Q86YF0, Q8IYL4, Q8TEI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)