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Q8IZ81 (ELMD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ELMO domain-containing protein 2
Gene names
Name:ELMOD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses. Ref.5 Ref.6

Tissue specificity

Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls. Ref.4 Ref.5

Sequence similarities

Contains 1 ELMO domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293ELMO domain-containing protein 2
PRO_0000225017

Regions

Domain126 – 282157ELMO

Sequences

Sequence LengthMass (Da)Tools
Q8IZ81 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 339CD216FC46ADD2

FASTA29334,961
        10         20         30         40         50         60 
MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS LTYSKNKVLQ 

        70         80         90        100        110        120 
KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL QITGYKQLYL DVESVRKRPY 

       130        140        150        160        170        180 
DSDNLQHEEL LMKLWNLLMP TKKLNARISK QWAEIGFQGD DPKTDFRGMG ILGLINLVYF 

       190        200        210        220        230        240 
SENYTSEAHQ ILSRSNHPKL GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH 

       250        260        270        280        290 
FHQFYCYLVY EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[4]"ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis."
Hodgson U., Pulkkinen V., Dixon M., Peyrard-Janvid M., Rehn M., Lahermo P., Ollikainen V., Salmenkivi K., Kinnula V., Kere J., Tukiainen P., Laitinen T.
Am. J. Hum. Genet. 79:149-154(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs."
Bowzard J.B., Cheng D., Peng J., Kahn R.A.
J. Biol. Chem. 282:17568-17580(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses."
Pulkkinen V., Bruce S., Rintahaka J., Hodgson U., Laitinen T., Alenius H., Kinnula V.L., Myllaerniemi M., Matikainen S., Kere J.
FASEB J. 24:1167-1177(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK312800 mRNA. Translation: BAG35659.1.
CH471056 Genomic DNA. Translation: EAX05096.1.
CH471056 Genomic DNA. Translation: EAX05097.1.
BC015168 mRNA. Translation: AAH15168.2.
RefSeqNP_714913.1. NM_153702.3.
XP_005262943.1. XM_005262886.1.
UniGeneHs.450105.

3D structure databases

ProteinModelPortalQ8IZ81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129109. 3 interactions.
IntActQ8IZ81. 2 interactions.
STRING9606.ENSP00000326342.

PTM databases

PhosphoSiteQ8IZ81.

Polymorphism databases

DMDM74728441.

Proteomic databases

PaxDbQ8IZ81.
PeptideAtlasQ8IZ81.
PRIDEQ8IZ81.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323570; ENSP00000326342; ENSG00000179387.
GeneID255520.
KEGGhsa:255520.
UCSCuc003iik.3. human.

Organism-specific databases

CTD255520.
GeneCardsGC04P141445.
HGNCHGNC:28111. ELMOD2.
HPAHPA047600.
MIM610196. gene.
neXtProtNX_Q8IZ81.
PharmGKBPA134984145.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317117.
HOGENOMHOG000007810.
HOVERGENHBG056692.
InParanoidQ8IZ81.
OMASFKICMK.
OrthoDBEOG712TWN.
PhylomeDBQ8IZ81.
TreeFamTF323472.

Gene expression databases

ArrayExpressQ8IZ81.
BgeeQ8IZ81.
CleanExHS_ELMOD2.
GenevestigatorQ8IZ81.

Family and domain databases

InterProIPR006816. Engulfment_cell_motility_ELMO.
[Graphical view]
PfamPF04727. ELMO_CED12. 1 hit.
[Graphical view]
PROSITEPS51335. ELMO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi255520.
NextBio92603.
PROQ8IZ81.
SOURCESearch...

Entry information

Entry nameELMD2_HUMAN
AccessionPrimary (citable) accession number: Q8IZ81
Secondary accession number(s): B2R712, D3DNZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM