Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ELMO domain-containing protein 2

Gene

ELMOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

  • defense response to virus Source: UniProtKB-KW
  • regulation of defense response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
ELMO domain-containing protein 2
Gene namesi
Name:ELMOD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28111. ELMOD2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984145.

Polymorphism and mutation databases

BioMutaiELMOD2.
DMDMi74728441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293ELMO domain-containing protein 2PRO_0000225017Add
BLAST

Proteomic databases

MaxQBiQ8IZ81.
PaxDbiQ8IZ81.
PeptideAtlasiQ8IZ81.
PRIDEiQ8IZ81.

PTM databases

PhosphoSiteiQ8IZ81.

Expressioni

Tissue specificityi

Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls.2 Publications

Gene expression databases

BgeeiQ8IZ81.
CleanExiHS_ELMOD2.
ExpressionAtlasiQ8IZ81. baseline and differential.
GenevisibleiQ8IZ81. HS.

Organism-specific databases

HPAiHPA047600.

Interactioni

Protein-protein interaction databases

BioGridi129109. 3 interactions.
IntActiQ8IZ81. 2 interactions.
STRINGi9606.ENSP00000326342.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 282157ELMOPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ELMO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG317117.
GeneTreeiENSGT00390000006017.
HOGENOMiHOG000007810.
HOVERGENiHBG056692.
InParanoidiQ8IZ81.
OMAiMFISLWE.
OrthoDBiEOG712TWN.
PhylomeDBiQ8IZ81.
TreeFamiTF323472.

Family and domain databases

InterProiIPR030724. ELMOD2.
IPR006816. Engulfment_cell_motility_ELMO.
[Graphical view]
PANTHERiPTHR12771:SF21. PTHR12771:SF21. 1 hit.
PfamiPF04727. ELMO_CED12. 1 hit.
[Graphical view]
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZ81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS
60 70 80 90 100
LTYSKNKVLQ KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL
110 120 130 140 150
QITGYKQLYL DVESVRKRPY DSDNLQHEEL LMKLWNLLMP TKKLNARISK
160 170 180 190 200
QWAEIGFQGD DPKTDFRGMG ILGLINLVYF SENYTSEAHQ ILSRSNHPKL
210 220 230 240 250
GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH FHQFYCYLVY
260 270 280 290
EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV
Length:293
Mass (Da):34,961
Last modified:March 1, 2003 - v1
Checksum:i339CD216FC46ADD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312800 mRNA. Translation: BAG35659.1.
CH471056 Genomic DNA. Translation: EAX05096.1.
CH471056 Genomic DNA. Translation: EAX05097.1.
BC015168 mRNA. Translation: AAH15168.2.
CCDSiCCDS3752.1.
RefSeqiNP_714913.1. NM_153702.3.
XP_005262943.1. XM_005262886.1.
UniGeneiHs.450105.
Hs.677038.

Genome annotation databases

EnsembliENST00000323570; ENSP00000326342; ENSG00000179387.
GeneIDi255520.
KEGGihsa:255520.
UCSCiuc003iik.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312800 mRNA. Translation: BAG35659.1.
CH471056 Genomic DNA. Translation: EAX05096.1.
CH471056 Genomic DNA. Translation: EAX05097.1.
BC015168 mRNA. Translation: AAH15168.2.
CCDSiCCDS3752.1.
RefSeqiNP_714913.1. NM_153702.3.
XP_005262943.1. XM_005262886.1.
UniGeneiHs.450105.
Hs.677038.

3D structure databases

ProteinModelPortaliQ8IZ81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129109. 3 interactions.
IntActiQ8IZ81. 2 interactions.
STRINGi9606.ENSP00000326342.

PTM databases

PhosphoSiteiQ8IZ81.

Polymorphism and mutation databases

BioMutaiELMOD2.
DMDMi74728441.

Proteomic databases

MaxQBiQ8IZ81.
PaxDbiQ8IZ81.
PeptideAtlasiQ8IZ81.
PRIDEiQ8IZ81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323570; ENSP00000326342; ENSG00000179387.
GeneIDi255520.
KEGGihsa:255520.
UCSCiuc003iik.3. human.

Organism-specific databases

CTDi255520.
GeneCardsiGC04P141445.
HGNCiHGNC:28111. ELMOD2.
HPAiHPA047600.
MIMi610196. gene.
neXtProtiNX_Q8IZ81.
PharmGKBiPA134984145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317117.
GeneTreeiENSGT00390000006017.
HOGENOMiHOG000007810.
HOVERGENiHBG056692.
InParanoidiQ8IZ81.
OMAiMFISLWE.
OrthoDBiEOG712TWN.
PhylomeDBiQ8IZ81.
TreeFamiTF323472.

Miscellaneous databases

ChiTaRSiELMOD2. human.
GenomeRNAii255520.
NextBioi92603.
PROiQ8IZ81.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZ81.
CleanExiHS_ELMOD2.
ExpressionAtlasiQ8IZ81. baseline and differential.
GenevisibleiQ8IZ81. HS.

Family and domain databases

InterProiIPR030724. ELMOD2.
IPR006816. Engulfment_cell_motility_ELMO.
[Graphical view]
PANTHERiPTHR12771:SF21. PTHR12771:SF21. 1 hit.
PfamiPF04727. ELMO_CED12. 1 hit.
[Graphical view]
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. Cited for: TISSUE SPECIFICITY.
  5. "ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs."
    Bowzard J.B., Cheng D., Peng J., Kahn R.A.
    J. Biol. Chem. 282:17568-17580(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses."
    Pulkkinen V., Bruce S., Rintahaka J., Hodgson U., Laitinen T., Alenius H., Kinnula V.L., Myllaerniemi M., Matikainen S., Kere J.
    FASEB J. 24:1167-1177(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiELMD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ81
Secondary accession number(s): B2R712, D3DNZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.