Q8IZ81 (ELMD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ELMO domain-containing protein 2

Gene names

Name:

ELMOD2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses. Ref.5 Ref.6
Tissue specificity	Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls. Ref.4 Ref.5
Sequence similarities	Contains 1 ELMO domain.

Ontologies

Keywords
Biological process	Antiviral defense
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW phagocytosis Inferred from electronic annotation. Source: InterPro regulation of defense response to virus Inferred from direct assay Ref.5. Source: UniProtKB
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: InterPro
Molecular_function	GTPase activator activity Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	ELMO domain-containing protein 2		PRO_0000225017
Regions
	Domain	126 – 282	157	ELMO

Sequences

	Sequence		Length	Mass (Da)
	Q8IZ81 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 339CD216FC46ADD2	FASTA	293	34,961
	10 20 30 40 50 60 MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS LTYSKNKVLQ 70 80 90 100 110 120 KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL QITGYKQLYL DVESVRKRPY 130 140 150 160 170 180 DSDNLQHEEL LMKLWNLLMP TKKLNARISK QWAEIGFQGD DPKTDFRGMG ILGLINLVYF 190 200 210 220 230 240 SENYTSEAHQ ILSRSNHPKL GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH 250 260 270 280 290 FHQFYCYLVY EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[4]	"ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis." Hodgson U., Pulkkinen V., Dixon M., Peyrard-Janvid M., Rehn M., Lahermo P., Ollikainen V., Salmenkivi K., Kinnula V., Kere J., Tukiainen P., Laitinen T. Am. J. Hum. Genet. 79:149-154(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[5]	"ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs." Bowzard J.B., Cheng D., Peng J., Kahn R.A. J. Biol. Chem. 282:17568-17580(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
[6]	"ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses." Pulkkinen V., Bruce S., Rintahaka J., Hodgson U., Laitinen T., Alenius H., Kinnula V.L., Myllaerniemi M., Matikainen S., Kere J. FASEB J. 24:1167-1177(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK312800 mRNA. Translation: BAG35659.1. CH471056 Genomic DNA. Translation: EAX05096.1. CH471056 Genomic DNA. Translation: EAX05097.1. BC015168 mRNA. Translation: AAH15168.2.
IPI	IPI00217918.
RefSeq	NP_714913.1. NM_153702.3.
UniGene	Hs.450105.
3D structure databases
ProteinModelPortal	Q8IZ81.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZ81. 2 interactions.
STRING	9606.ENSP00000326342.
PTM databases
PhosphoSite	Q8IZ81.
Polymorphism databases
DMDM	74728441.
Proteomic databases
PaxDb	Q8IZ81.
PeptideAtlas	Q8IZ81.
PRIDE	Q8IZ81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323570; ENSP00000326342; ENSG00000179387.
GeneID	255520.
KEGG	hsa:255520.
UCSC	uc003iik.3. human.
Organism-specific databases
CTD	255520.
GeneCards	GC04P141445.
HGNC	HGNC:28111. ELMOD2.
HPA	HPA047600.
MIM	610196. gene.
neXtProt	NX_Q8IZ81.
PharmGKB	PA134984145.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317117.
HOGENOM	HOG000007810.
HOVERGEN	HBG056692.
InParanoid	Q8IZ81.
OMA	SFKICMK.
OrthoDB	EOG4ZCT4Z.
PhylomeDB	Q8IZ81.
Gene expression databases
ArrayExpress	Q8IZ81.
Bgee	Q8IZ81.
CleanEx	HS_ELMOD2.
Genevestigator	Q8IZ81.
GermOnline	ENSG00000179387. Homo sapiens.
Family and domain databases
InterPro	IPR006816. Engulfment_cell_motility_ELMO. [Graphical view]
Pfam	PF04727. ELMO_CED12. 1 hit. [Graphical view]
PROSITE	PS51335. ELMO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	255520.
NextBio	92603.
SOURCE	Search...

Entry information

Entry name

ELMD2_HUMAN

Accession

Primary (citable) accession number: Q8IZ81
Secondary accession number(s): B2R712, D3DNZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.