Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8IZ81

- ELMD2_HUMAN

UniProt

Q8IZ81 - ELMD2_HUMAN

Protein

ELMO domain-containing protein 2

Gene

ELMOD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.2 Publications

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB

    GO - Biological processi

    1. defense response to virus Source: UniProtKB-KW
    2. phagocytosis Source: InterPro
    3. positive regulation of GTPase activity Source: GOC
    4. regulation of defense response to virus Source: UniProtKB

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Biological processi

    Antiviral defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ELMO domain-containing protein 2
    Gene namesi
    Name:ELMOD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:28111. ELMOD2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: InterPro
    2. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984145.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293ELMO domain-containing protein 2PRO_0000225017Add
    BLAST

    Proteomic databases

    MaxQBiQ8IZ81.
    PaxDbiQ8IZ81.
    PeptideAtlasiQ8IZ81.
    PRIDEiQ8IZ81.

    PTM databases

    PhosphoSiteiQ8IZ81.

    Expressioni

    Tissue specificityi

    Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls.2 Publications

    Gene expression databases

    ArrayExpressiQ8IZ81.
    BgeeiQ8IZ81.
    CleanExiHS_ELMOD2.
    GenevestigatoriQ8IZ81.

    Organism-specific databases

    HPAiHPA047600.

    Interactioni

    Protein-protein interaction databases

    BioGridi129109. 3 interactions.
    IntActiQ8IZ81. 2 interactions.
    STRINGi9606.ENSP00000326342.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZ81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini126 – 282157ELMOPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ELMO domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG317117.
    HOGENOMiHOG000007810.
    HOVERGENiHBG056692.
    InParanoidiQ8IZ81.
    OMAiSFKICMK.
    OrthoDBiEOG712TWN.
    PhylomeDBiQ8IZ81.
    TreeFamiTF323472.

    Family and domain databases

    InterProiIPR006816. Engulfment_cell_motility_ELMO.
    [Graphical view]
    PfamiPF04727. ELMO_CED12. 1 hit.
    [Graphical view]
    PROSITEiPS51335. ELMO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZ81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS    50
    LTYSKNKVLQ KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL 100
    QITGYKQLYL DVESVRKRPY DSDNLQHEEL LMKLWNLLMP TKKLNARISK 150
    QWAEIGFQGD DPKTDFRGMG ILGLINLVYF SENYTSEAHQ ILSRSNHPKL 200
    GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH FHQFYCYLVY 250
    EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV 293
    Length:293
    Mass (Da):34,961
    Last modified:March 1, 2003 - v1
    Checksum:i339CD216FC46ADD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312800 mRNA. Translation: BAG35659.1.
    CH471056 Genomic DNA. Translation: EAX05096.1.
    CH471056 Genomic DNA. Translation: EAX05097.1.
    BC015168 mRNA. Translation: AAH15168.2.
    CCDSiCCDS3752.1.
    RefSeqiNP_714913.1. NM_153702.3.
    XP_005262943.1. XM_005262886.1.
    UniGeneiHs.450105.

    Genome annotation databases

    EnsembliENST00000323570; ENSP00000326342; ENSG00000179387.
    GeneIDi255520.
    KEGGihsa:255520.
    UCSCiuc003iik.3. human.

    Polymorphism databases

    DMDMi74728441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312800 mRNA. Translation: BAG35659.1 .
    CH471056 Genomic DNA. Translation: EAX05096.1 .
    CH471056 Genomic DNA. Translation: EAX05097.1 .
    BC015168 mRNA. Translation: AAH15168.2 .
    CCDSi CCDS3752.1.
    RefSeqi NP_714913.1. NM_153702.3.
    XP_005262943.1. XM_005262886.1.
    UniGenei Hs.450105.

    3D structure databases

    ProteinModelPortali Q8IZ81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129109. 3 interactions.
    IntActi Q8IZ81. 2 interactions.
    STRINGi 9606.ENSP00000326342.

    PTM databases

    PhosphoSitei Q8IZ81.

    Polymorphism databases

    DMDMi 74728441.

    Proteomic databases

    MaxQBi Q8IZ81.
    PaxDbi Q8IZ81.
    PeptideAtlasi Q8IZ81.
    PRIDEi Q8IZ81.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323570 ; ENSP00000326342 ; ENSG00000179387 .
    GeneIDi 255520.
    KEGGi hsa:255520.
    UCSCi uc003iik.3. human.

    Organism-specific databases

    CTDi 255520.
    GeneCardsi GC04P141445.
    HGNCi HGNC:28111. ELMOD2.
    HPAi HPA047600.
    MIMi 610196. gene.
    neXtProti NX_Q8IZ81.
    PharmGKBi PA134984145.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317117.
    HOGENOMi HOG000007810.
    HOVERGENi HBG056692.
    InParanoidi Q8IZ81.
    OMAi SFKICMK.
    OrthoDBi EOG712TWN.
    PhylomeDBi Q8IZ81.
    TreeFami TF323472.

    Miscellaneous databases

    GenomeRNAii 255520.
    NextBioi 92603.
    PROi Q8IZ81.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZ81.
    Bgeei Q8IZ81.
    CleanExi HS_ELMOD2.
    Genevestigatori Q8IZ81.

    Family and domain databases

    InterProi IPR006816. Engulfment_cell_motility_ELMO.
    [Graphical view ]
    Pfami PF04727. ELMO_CED12. 1 hit.
    [Graphical view ]
    PROSITEi PS51335. ELMO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    4. Cited for: TISSUE SPECIFICITY.
    5. "ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs."
      Bowzard J.B., Cheng D., Peng J., Kahn R.A.
      J. Biol. Chem. 282:17568-17580(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses."
      Pulkkinen V., Bruce S., Rintahaka J., Hodgson U., Laitinen T., Alenius H., Kinnula V.L., Myllaerniemi M., Matikainen S., Kere J.
      FASEB J. 24:1167-1177(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiELMD2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZ81
    Secondary accession number(s): B2R712, D3DNZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3