Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IZ81

- ELMD2_HUMAN

UniProt

Q8IZ81 - ELMD2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ELMO domain-containing protein 2

Gene

ELMOD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.2 Publications

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. phagocytosis Source: InterPro
  3. positive regulation of GTPase activity Source: GOC
  4. regulation of defense response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
ELMO domain-containing protein 2
Gene namesi
Name:ELMOD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:28111. ELMOD2.

Subcellular locationi

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
  2. membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293ELMO domain-containing protein 2PRO_0000225017Add
BLAST

Proteomic databases

MaxQBiQ8IZ81.
PaxDbiQ8IZ81.
PeptideAtlasiQ8IZ81.
PRIDEiQ8IZ81.

PTM databases

PhosphoSiteiQ8IZ81.

Expressioni

Tissue specificityi

Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls.2 Publications

Gene expression databases

BgeeiQ8IZ81.
CleanExiHS_ELMOD2.
ExpressionAtlasiQ8IZ81. baseline and differential.
GenevestigatoriQ8IZ81.

Organism-specific databases

HPAiHPA047600.

Interactioni

Protein-protein interaction databases

BioGridi129109. 3 interactions.
IntActiQ8IZ81. 2 interactions.
STRINGi9606.ENSP00000326342.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 282157ELMOPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ELMO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG317117.
GeneTreeiENSGT00390000006017.
HOGENOMiHOG000007810.
HOVERGENiHBG056692.
InParanoidiQ8IZ81.
OMAiSFKICMK.
OrthoDBiEOG712TWN.
PhylomeDBiQ8IZ81.
TreeFamiTF323472.

Family and domain databases

InterProiIPR006816. Engulfment_cell_motility_ELMO.
[Graphical view]
PfamiPF04727. ELMO_CED12. 1 hit.
[Graphical view]
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZ81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS
60 70 80 90 100
LTYSKNKVLQ KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL
110 120 130 140 150
QITGYKQLYL DVESVRKRPY DSDNLQHEEL LMKLWNLLMP TKKLNARISK
160 170 180 190 200
QWAEIGFQGD DPKTDFRGMG ILGLINLVYF SENYTSEAHQ ILSRSNHPKL
210 220 230 240 250
GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH FHQFYCYLVY
260 270 280 290
EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV
Length:293
Mass (Da):34,961
Last modified:March 1, 2003 - v1
Checksum:i339CD216FC46ADD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312800 mRNA. Translation: BAG35659.1.
CH471056 Genomic DNA. Translation: EAX05096.1.
CH471056 Genomic DNA. Translation: EAX05097.1.
BC015168 mRNA. Translation: AAH15168.2.
CCDSiCCDS3752.1.
RefSeqiNP_714913.1. NM_153702.3.
XP_005262943.1. XM_005262886.1.
UniGeneiHs.450105.

Genome annotation databases

EnsembliENST00000323570; ENSP00000326342; ENSG00000179387.
GeneIDi255520.
KEGGihsa:255520.
UCSCiuc003iik.3. human.

Polymorphism databases

DMDMi74728441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312800 mRNA. Translation: BAG35659.1 .
CH471056 Genomic DNA. Translation: EAX05096.1 .
CH471056 Genomic DNA. Translation: EAX05097.1 .
BC015168 mRNA. Translation: AAH15168.2 .
CCDSi CCDS3752.1.
RefSeqi NP_714913.1. NM_153702.3.
XP_005262943.1. XM_005262886.1.
UniGenei Hs.450105.

3D structure databases

ProteinModelPortali Q8IZ81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129109. 3 interactions.
IntActi Q8IZ81. 2 interactions.
STRINGi 9606.ENSP00000326342.

PTM databases

PhosphoSitei Q8IZ81.

Polymorphism databases

DMDMi 74728441.

Proteomic databases

MaxQBi Q8IZ81.
PaxDbi Q8IZ81.
PeptideAtlasi Q8IZ81.
PRIDEi Q8IZ81.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323570 ; ENSP00000326342 ; ENSG00000179387 .
GeneIDi 255520.
KEGGi hsa:255520.
UCSCi uc003iik.3. human.

Organism-specific databases

CTDi 255520.
GeneCardsi GC04P141445.
HGNCi HGNC:28111. ELMOD2.
HPAi HPA047600.
MIMi 610196. gene.
neXtProti NX_Q8IZ81.
PharmGKBi PA134984145.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317117.
GeneTreei ENSGT00390000006017.
HOGENOMi HOG000007810.
HOVERGENi HBG056692.
InParanoidi Q8IZ81.
OMAi SFKICMK.
OrthoDBi EOG712TWN.
PhylomeDBi Q8IZ81.
TreeFami TF323472.

Miscellaneous databases

GenomeRNAii 255520.
NextBioi 92603.
PROi Q8IZ81.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZ81.
CleanExi HS_ELMOD2.
ExpressionAtlasi Q8IZ81. baseline and differential.
Genevestigatori Q8IZ81.

Family and domain databases

InterProi IPR006816. Engulfment_cell_motility_ELMO.
[Graphical view ]
Pfami PF04727. ELMO_CED12. 1 hit.
[Graphical view ]
PROSITEi PS51335. ELMO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. Cited for: TISSUE SPECIFICITY.
  5. "ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs."
    Bowzard J.B., Cheng D., Peng J., Kahn R.A.
    J. Biol. Chem. 282:17568-17580(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses."
    Pulkkinen V., Bruce S., Rintahaka J., Hodgson U., Laitinen T., Alenius H., Kinnula V.L., Myllaerniemi M., Matikainen S., Kere J.
    FASEB J. 24:1167-1177(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiELMD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ81
Secondary accession number(s): B2R712, D3DNZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3