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Q8IZ73

- RUSD2_HUMAN

UniProt

Q8IZ73 - RUSD2_HUMAN

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Protein
RNA pseudouridylate synthase domain-containing protein 2
Gene
RPUSD2, C15orf19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei274 – 2741 By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
  3. pseudouridine synthase activity Source: InterPro

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pseudouridylate synthase domain-containing protein 2
Gene namesi
Name:RPUSD2
Synonyms:C15orf19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:24180. RPUSD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545RNA pseudouridylate synthase domain-containing protein 2
PRO_0000300819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IZ73.
PaxDbiQ8IZ73.
PeptideAtlasiQ8IZ73.
PRIDEiQ8IZ73.

PTM databases

PhosphoSiteiQ8IZ73.

Expressioni

Gene expression databases

ArrayExpressiQ8IZ73.
BgeeiQ8IZ73.
CleanExiHS_RPUSD2.
GenevestigatoriQ8IZ73.

Organism-specific databases

HPAiHPA042079.
HPA042194.

Interactioni

Protein-protein interaction databases

BioGridi117987. 16 interactions.
IntActiQ8IZ73. 1 interaction.
STRINGi9606.ENSP00000323288.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ73.
SMRiQ8IZ73. Positions 225-389.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi458 – 4614Poly-Ala

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000167783.
HOVERGENiHBG103625.
InParanoidiQ8IZ73.
OMAiSYNGHSS.
OrthoDBiEOG7JDQX4.
PhylomeDBiQ8IZ73.
TreeFamiTF323255.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZ73-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWLDRRGWLR VLGHWRYDLR RPSFTRTWSG DKGPMAETVS TQVGTEGGLR    50
ASHQQNGDAG GDAKVELSPG PPKPAGREVE PAPVGGEHPS AAAPGPGKHK 100
KRRGATRERV VPPPKKRRTG VSFGDEHFAE TSYYFEGGLR KVRPYYFDFR 150
TYCKGRWVGH SLLHVFSTEF RAQPLAYYEA AVRAGRLQLN EKPVQDLNIV 200
LKDNDFLRNT VHRHEPPVTA EPIRLLAENE DVVVVDKPSS IPVHPCGRFR 250
HNTVIFILGK EHQLKELHPL HRLDRLTSGV LMFAKTAAVS ERIHEQVRDR 300
QLEKEYVCRV EGEFPTEEVT CKEPILVVSY KVGVCRVDPR GKPCETVFQR 350
LSYNGQSSVV RCRPLTGRTH QIRVHLQFLG HPILNDPIYN SVAWGPSRGR 400
GGYIPKTNEE LLRDLVAEHQ AKQSLDVLDL CEGDLSPGLT DSTAPSSELG 450
KDDLEELAAA AQKMEEVAEA APQELDTIAL ASEKAVETDV MNQETDPLCA 500
ECRLVRQDPL PQDLVMFLHA LRYKGPGFEY FSPMPAWAQD DWQKD 545
Length:545
Mass (Da):61,311
Last modified:April 3, 2007 - v2
Checksum:i16E8B71918A6E0B7
GO
Isoform 2 (identifier: Q8IZ73-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-201: Missing.

Note: No experimental confirmation available.

Show »
Length:484
Mass (Da):54,097
Checksum:i5E8139769C17ADF8
GO

Sequence cautioni

The sequence AAB07777.1 differs from that shown. Reason: Frameshift at positions 494 and 497.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei141 – 20161Missing in isoform 2.
VSP_055372Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti336 – 3361R → L in AAB07777. 1 Publication
Sequence conflicti492 – 4921N → H in AAB07777. 1 Publication
Sequence conflicti499 – 4991C → S in AAB07777. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055971 mRNA. Translation: BAB71059.1.
AK293145 mRNA. Translation: BAG56692.1.
AC091045 Genomic DNA. No translation available.
BC007697 mRNA. Translation: AAH07697.1.
BC016967 mRNA. Translation: AAH16967.2.
U67934 Genomic DNA. Translation: AAB07777.1. Frameshift.
CCDSiCCDS10061.1. [Q8IZ73-1]
RefSeqiNP_001273336.1. NM_001286407.1.
NP_689473.1. NM_152260.2.
UniGeneiHs.173311.

Genome annotation databases

EnsembliENST00000315616; ENSP00000323288; ENSG00000166133.
ENST00000559271; ENSP00000453036; ENSG00000166133.
GeneIDi27079.
KEGGihsa:27079.
UCSCiuc001zmd.1. human. [Q8IZ73-1]

Polymorphism databases

DMDMi158563848.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055971 mRNA. Translation: BAB71059.1 .
AK293145 mRNA. Translation: BAG56692.1 .
AC091045 Genomic DNA. No translation available.
BC007697 mRNA. Translation: AAH07697.1 .
BC016967 mRNA. Translation: AAH16967.2 .
U67934 Genomic DNA. Translation: AAB07777.1 . Frameshift.
CCDSi CCDS10061.1. [Q8IZ73-1 ]
RefSeqi NP_001273336.1. NM_001286407.1.
NP_689473.1. NM_152260.2.
UniGenei Hs.173311.

3D structure databases

ProteinModelPortali Q8IZ73.
SMRi Q8IZ73. Positions 225-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117987. 16 interactions.
IntActi Q8IZ73. 1 interaction.
STRINGi 9606.ENSP00000323288.

PTM databases

PhosphoSitei Q8IZ73.

Polymorphism databases

DMDMi 158563848.

Proteomic databases

MaxQBi Q8IZ73.
PaxDbi Q8IZ73.
PeptideAtlasi Q8IZ73.
PRIDEi Q8IZ73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315616 ; ENSP00000323288 ; ENSG00000166133 .
ENST00000559271 ; ENSP00000453036 ; ENSG00000166133 .
GeneIDi 27079.
KEGGi hsa:27079.
UCSCi uc001zmd.1. human. [Q8IZ73-1 ]

Organism-specific databases

CTDi 27079.
GeneCardsi GC15P040861.
HGNCi HGNC:24180. RPUSD2.
HPAi HPA042079.
HPA042194.
neXtProti NX_Q8IZ73.
PharmGKBi PA134866412.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0564.
HOGENOMi HOG000167783.
HOVERGENi HBG103625.
InParanoidi Q8IZ73.
OMAi SYNGHSS.
OrthoDBi EOG7JDQX4.
PhylomeDBi Q8IZ73.
TreeFami TF323255.

Miscellaneous databases

GenomeRNAii 27079.
NextBioi 35470905.
PROi Q8IZ73.

Gene expression databases

ArrayExpressi Q8IZ73.
Bgeei Q8IZ73.
CleanExi HS_RPUSD2.
Genevestigatori Q8IZ73.

Family and domain databases

InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view ]
Pfami PF00849. PseudoU_synth_2. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 2 hits.
TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
PROSITEi PS01129. PSI_RLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  4. Sampson M., McClendon D., Wiley K., Barlow C.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-545.
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRUSD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ73
Secondary accession number(s): B4DDD1
, Q7L989, Q92939, Q96IA7, Q96N50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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