ID   NRSN1_HUMAN             Reviewed;         195 AA.
AC   Q8IZ57; B2RAV4; Q8N8R6; Q96P21;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 133.
DE   RecName: Full=Neurensin-1;
DE   AltName: Full=Neuro-p24;
DE   AltName: Full=Vesicular membrane protein of 24 kDa;
DE            Short=Vesicular membrane protein p24;
GN   Name=NRSN1 {ECO:0000312|HGNC:HGNC:17881}; Synonyms=VMP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAL14639.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Fetal brain {ECO:0000269|PubMed:12463420};
RX   PubMed=12463420; DOI=10.1023/a:1020402410522;
RA   Cheng C., Xu J., Ye X., Dai J., Wu Q., Zeng L., Wang L., Zhao W., Ji C.,
RA   Gu S., Xie Y., Mao Y.;
RT   "Cloning, expression and characterization of a novel human VMP gene.";
RL   Mol. Biol. Rep. 29:281-286(2002).
RN   [2] {ECO:0000312|EMBL:BAC04748.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Teratocarcinoma {ECO:0000269|PubMed:14702039};
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000312|EMBL:AAH23514.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH23514.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play an important role in neural organelle transport, and
CC       in transduction of nerve signals or in nerve growth. May play a role in
CC       neurite extension. May play a role in memory consolidation (By
CC       similarity). {ECO:0000250|UniProtKB:P97799,
CC       ECO:0000269|PubMed:12463420}.
CC   -!- INTERACTION:
CC       Q8IZ57; Q969F0: FATE1; NbExp=3; IntAct=EBI-10264528, EBI-743099;
CC       Q8IZ57; P12314: FCGR1A; NbExp=3; IntAct=EBI-10264528, EBI-2869867;
CC       Q8IZ57; Q99795: GPA33; NbExp=3; IntAct=EBI-10264528, EBI-4289554;
CC       Q8IZ57; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-10264528, EBI-10329546;
CC       Q8IZ57; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-10264528, EBI-13044680;
CC       Q8IZ57; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-10264528, EBI-17498703;
CC       Q8IZ57; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-10264528, EBI-2821497;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell projection, neuron projection
CC       {ECO:0000250|UniProtKB:P97799}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain. Not detectable in other tissues
CC       tested. {ECO:0000269|PubMed:12463420}.
CC   -!- SIMILARITY: Belongs to the VMP family. {ECO:0000255}.
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DR   EMBL; AF418980; AAL14639.1; -; mRNA.
DR   EMBL; AK096290; BAC04748.1; -; mRNA.
DR   EMBL; AK314373; BAG37001.1; -; mRNA.
DR   EMBL; FO393410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471087; EAW55439.1; -; Genomic_DNA.
DR   EMBL; BC023514; AAH23514.1; -; mRNA.
DR   CCDS; CCDS4549.1; -.
DR   RefSeq; NP_542454.3; NM_080723.4.
DR   AlphaFoldDB; Q8IZ57; -.
DR   BioGRID; 126698; 181.
DR   IntAct; Q8IZ57; 7.
DR   STRING; 9606.ENSP00000367739; -.
DR   TCDB; 8.A.122.1.1; the vesicular membrane neurensin/tmem74 (neurensin/tmem74) family.
DR   PhosphoSitePlus; Q8IZ57; -.
DR   BioMuta; NRSN1; -.
DR   DMDM; 74750784; -.
DR   MassIVE; Q8IZ57; -.
DR   PaxDb; 9606-ENSP00000367739; -.
DR   PeptideAtlas; Q8IZ57; -.
DR   ProteomicsDB; 71280; -.
DR   Antibodypedia; 58910; 119 antibodies from 20 providers.
DR   DNASU; 140767; -.
DR   Ensembl; ENST00000378478.5; ENSP00000367739.2; ENSG00000152954.12.
DR   Ensembl; ENST00000378491.9; ENSP00000367752.4; ENSG00000152954.12.
DR   GeneID; 140767; -.
DR   KEGG; hsa:140767; -.
DR   MANE-Select; ENST00000378491.9; ENSP00000367752.4; NM_080723.5; NP_542454.3.
DR   UCSC; uc010jpq.1; human.
DR   AGR; HGNC:17881; -.
DR   CTD; 140767; -.
DR   DisGeNET; 140767; -.
DR   GeneCards; NRSN1; -.
DR   HGNC; HGNC:17881; NRSN1.
DR   HPA; ENSG00000152954; Group enriched (brain, pituitary gland, retina).
DR   MIM; 616630; gene.
DR   neXtProt; NX_Q8IZ57; -.
DR   OpenTargets; ENSG00000152954; -.
DR   PharmGKB; PA38254; -.
DR   VEuPathDB; HostDB:ENSG00000152954; -.
DR   eggNOG; ENOG502QRNK; Eukaryota.
DR   GeneTree; ENSGT00530000063877; -.
DR   InParanoid; Q8IZ57; -.
DR   OMA; ASIWEHE; -.
DR   OrthoDB; 5398558at2759; -.
DR   PhylomeDB; Q8IZ57; -.
DR   TreeFam; TF332090; -.
DR   PathwayCommons; Q8IZ57; -.
DR   SignaLink; Q8IZ57; -.
DR   BioGRID-ORCS; 140767; 11 hits in 1143 CRISPR screens.
DR   GeneWiki; NRSN1; -.
DR   GenomeRNAi; 140767; -.
DR   Pharos; Q8IZ57; Tbio.
DR   PRO; PR:Q8IZ57; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q8IZ57; Protein.
DR   Bgee; ENSG00000152954; Expressed in dorsolateral prefrontal cortex and 124 other cell types or tissues.
DR   ExpressionAtlas; Q8IZ57; baseline and differential.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR   GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR   GO; GO:0030133; C:transport vesicle; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   InterPro; IPR024883; Neurensin.
DR   PANTHER; PTHR14796; NEURENSIN 1-RELATED; 1.
DR   PANTHER; PTHR14796:SF6; NEURENSIN-1; 1.
DR   Pfam; PF14927; Neurensin; 1.
DR   Genevisible; Q8IZ57; HS.
PE   1: Evidence at protein level;
KW   Cell projection; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Neurensin-1"
FT                   /id="PRO_0000270583"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         41
FT                   /note="I -> V (in dbSNP:rs17299946)"
FT                   /id="VAR_029816"
FT   VARIANT         104
FT                   /note="H -> Y (in dbSNP:rs11544636)"
FT                   /id="VAR_053737"
FT   CONFLICT        138
FT                   /note="V -> A (in Ref. 1; AAL14639)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        161
FT                   /note="I -> T (in Ref. 2; BAC04748)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   195 AA;  21475 MW;  BFADD774F04279D6 CRC64;
     MSSCSNVCGS RQAQAAAEGG YQRYGVRSYL HQFYEDCTAS IWEYEDDFQI QRSPNRWSSV
     FWKVGLISGT VFVILGLTVL AVGFLVPPKI EAFGEADFVV VDTHAVQFNS ALDMYKLAGA
     VLFCIGGTSM AGCLLMSVFV KSYSKEEKFL QQKFKERIAD IKAHTQPVTK APGPGETKIP
     VTLSRVQNVQ PLLAT
//