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Q8IZ57

- NRSN1_HUMAN

UniProt

Q8IZ57 - NRSN1_HUMAN

Protein

Neurensin-1

Gene

NRSN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension.By similarity1 Publication

    GO - Biological processi

    1. nervous system development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurensin-1
    Alternative name(s):
    Neuro-p24
    Vesicular membrane protein of 24 kDa
    Short name:
    Vesicular membrane protein p24
    Gene namesi
    Name:NRSN1Imported
    Synonyms:VMP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17881. NRSN1.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated
    Note: Localizes mainly to neurites.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    2. growth cone Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: UniProtKB
    5. neuron projection Source: UniProtKB
    6. transport vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38254.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 195195Neurensin-1PRO_0000270583Add
    BLAST

    Proteomic databases

    PaxDbiQ8IZ57.
    PRIDEiQ8IZ57.

    Expressioni

    Tissue specificityi

    Expressed in brain. Not detectable in other tissues tested.1 Publication

    Gene expression databases

    ArrayExpressiQ8IZ57.
    BgeeiQ8IZ57.
    CleanExiHS_NRSN1.
    GenevestigatoriQ8IZ57.

    Organism-specific databases

    HPAiHPA061006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZ57.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the VMP family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44987.
    HOGENOMiHOG000231873.
    HOVERGENiHBG053471.
    InParanoidiQ8IZ57.
    OMAiWLESTRI.
    OrthoDBiEOG73BVG9.
    PhylomeDBiQ8IZ57.
    TreeFamiTF332090.

    Family and domain databases

    InterProiIPR024883. Neurensin.
    [Graphical view]
    PANTHERiPTHR14796. PTHR14796. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8IZ57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSCSNVCGS RQAQAAAEGG YQRYGVRSYL HQFYEDCTAS IWEYEDDFQI    50
    QRSPNRWSSV FWKVGLISGT VFVILGLTVL AVGFLVPPKI EAFGEADFVV 100
    VDTHAVQFNS ALDMYKLAGA VLFCIGGTSM AGCLLMSVFV KSYSKEEKFL 150
    QQKFKERIAD IKAHTQPVTK APGPGETKIP VTLSRVQNVQ PLLAT 195
    Length:195
    Mass (Da):21,475
    Last modified:March 1, 2003 - v1
    Checksum:iBFADD774F04279D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381V → A in AAL14639. (PubMed:12463420)Curated
    Sequence conflicti161 – 1611I → T in BAC04748. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 411I → V.
    Corresponds to variant rs17299946 [ dbSNP | Ensembl ].
    VAR_029816
    Natural varianti104 – 1041H → Y.
    Corresponds to variant rs11544636 [ dbSNP | Ensembl ].
    VAR_053737

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418980 mRNA. Translation: AAL14639.1.
    AK096290 mRNA. Translation: BAC04748.1.
    AK314373 mRNA. Translation: BAG37001.1.
    FO393410 Genomic DNA. No translation available.
    CH471087 Genomic DNA. Translation: EAW55439.1.
    BC023514 mRNA. Translation: AAH23514.1.
    CCDSiCCDS4549.1.
    RefSeqiNP_542454.3. NM_080723.4.
    UniGeneiHs.726270.

    Genome annotation databases

    EnsembliENST00000378491; ENSP00000367752; ENSG00000152954.
    GeneIDi140767.
    KEGGihsa:140767.
    UCSCiuc010jpq.1. human.

    Polymorphism databases

    DMDMi74750784.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418980 mRNA. Translation: AAL14639.1 .
    AK096290 mRNA. Translation: BAC04748.1 .
    AK314373 mRNA. Translation: BAG37001.1 .
    FO393410 Genomic DNA. No translation available.
    CH471087 Genomic DNA. Translation: EAW55439.1 .
    BC023514 mRNA. Translation: AAH23514.1 .
    CCDSi CCDS4549.1.
    RefSeqi NP_542454.3. NM_080723.4.
    UniGenei Hs.726270.

    3D structure databases

    ProteinModelPortali Q8IZ57.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74750784.

    Proteomic databases

    PaxDbi Q8IZ57.
    PRIDEi Q8IZ57.

    Protocols and materials databases

    DNASUi 140767.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378491 ; ENSP00000367752 ; ENSG00000152954 .
    GeneIDi 140767.
    KEGGi hsa:140767.
    UCSCi uc010jpq.1. human.

    Organism-specific databases

    CTDi 140767.
    GeneCardsi GC06P024126.
    HGNCi HGNC:17881. NRSN1.
    HPAi HPA061006.
    neXtProti NX_Q8IZ57.
    PharmGKBi PA38254.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44987.
    HOGENOMi HOG000231873.
    HOVERGENi HBG053471.
    InParanoidi Q8IZ57.
    OMAi WLESTRI.
    OrthoDBi EOG73BVG9.
    PhylomeDBi Q8IZ57.
    TreeFami TF332090.

    Miscellaneous databases

    GeneWikii NRSN1.
    GenomeRNAii 140767.
    NextBioi 84371.
    PROi Q8IZ57.

    Gene expression databases

    ArrayExpressi Q8IZ57.
    Bgeei Q8IZ57.
    CleanExi HS_NRSN1.
    Genevestigatori Q8IZ57.

    Family and domain databases

    InterProi IPR024883. Neurensin.
    [Graphical view ]
    PANTHERi PTHR14796. PTHR14796. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and characterization of a novel human VMP gene."
      Cheng C., Xu J., Ye X., Dai J., Wu Q., Zeng L., Wang L., Zhao W., Ji C., Gu S., Xie Y., Mao Y.
      Mol. Biol. Rep. 29:281-286(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Fetal brain1 Publication.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Teratocarcinoma1 Publication.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiNRSN1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZ57
    Secondary accession number(s): B2RAV4, Q8N8R6, Q96P21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3