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Q8IZ57 (NRSN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurensin-1
Alternative name(s):
Neuro-p24
Vesicular membrane protein of 24 kDa
Short name=Vesicular membrane protein p24
Gene names
Name:NRSN1
Synonyms:VMP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. Ref.1 UniProtKB P97799

Subcellular location

Membrane; Multi-pass membrane protein Potential. Note: Localizes mainly to neurites.

Tissue specificity

Expressed in brain. Not detectable in other tissues tested. Ref.1

Sequence similarities

Belongs to the VMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 195195Neurensin-1
PRO_0000270583

Regions

Transmembrane66 – 8621Helical; Potential
Transmembrane120 – 14021Helical; Potential

Natural variations

Natural variant411I → V.
Corresponds to variant rs17299946 [ dbSNP | Ensembl ].
VAR_029816
Natural variant1041H → Y.
Corresponds to variant rs11544636 [ dbSNP | Ensembl ].
VAR_053737

Experimental info

Sequence conflict1381V → A in AAL14639. Ref.1
Sequence conflict1611I → T in BAC04748. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8IZ57 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: BFADD774F04279D6

FASTA19521,475
        10         20         30         40         50         60 
MSSCSNVCGS RQAQAAAEGG YQRYGVRSYL HQFYEDCTAS IWEYEDDFQI QRSPNRWSSV 

        70         80         90        100        110        120 
FWKVGLISGT VFVILGLTVL AVGFLVPPKI EAFGEADFVV VDTHAVQFNS ALDMYKLAGA 

       130        140        150        160        170        180 
VLFCIGGTSM AGCLLMSVFV KSYSKEEKFL QQKFKERIAD IKAHTQPVTK APGPGETKIP 

       190 
VTLSRVQNVQ PLLAT 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression and characterization of a novel human VMP gene."
Cheng C., Xu J., Ye X., Dai J., Wu Q., Zeng L., Wang L., Zhao W., Ji C., Gu S., Xie Y., Mao Y.
Mol. Biol. Rep. 29:281-286(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Teratocarcinoma.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF418980 mRNA. Translation: AAL14639.1.
AK096290 mRNA. Translation: BAC04748.1.
AK314373 mRNA. Translation: BAG37001.1.
FO393410 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55439.1.
BC023514 mRNA. Translation: AAH23514.1.
CCDSCCDS4549.1.
RefSeqNP_542454.3. NM_080723.4.
UniGeneHs.726270.

3D structure databases

ProteinModelPortalQ8IZ57.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74750784.

Proteomic databases

PaxDbQ8IZ57.
PRIDEQ8IZ57.

Protocols and materials databases

DNASU140767.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378491; ENSP00000367752; ENSG00000152954.
GeneID140767.
KEGGhsa:140767.
UCSCuc010jpq.1. human.

Organism-specific databases

CTD140767.
GeneCardsGC06P024126.
HGNCHGNC:17881. NRSN1.
HPAHPA061006.
neXtProtNX_Q8IZ57.
PharmGKBPA38254.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44987.
HOGENOMHOG000231873.
HOVERGENHBG053471.
InParanoidQ8IZ57.
OMAWLESTRI.
OrthoDBEOG73BVG9.
PhylomeDBQ8IZ57.
TreeFamTF332090.

Gene expression databases

ArrayExpressQ8IZ57.
BgeeQ8IZ57.
CleanExHS_NRSN1.
GenevestigatorQ8IZ57.

Family and domain databases

InterProIPR024883. Neurensin.
[Graphical view]
PANTHERPTHR14796. PTHR14796. 1 hit.
ProtoNetSearch...

Other

GeneWikiNRSN1.
GenomeRNAi140767.
NextBio84371.
PROQ8IZ57.

Entry information

Entry nameNRSN1_HUMAN
AccessionPrimary (citable) accession number: Q8IZ57
Secondary accession number(s): B2RAV4, Q8N8R6, Q96P21
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM