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Protein

Neurensin-1

Gene

NRSN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension.By similarity1 Publication

GO - Biological processi

  1. nervous system development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurensin-1
Alternative name(s):
Neuro-p24
Vesicular membrane protein of 24 kDa
Short name:
Vesicular membrane protein p24
Gene namesi
Name:NRSN1Imported
Synonyms:VMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17881. NRSN1.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated
Note: Localizes mainly to neurites.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  2. growth cone Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: UniProtKB
  5. neuron projection Source: UniProtKB
  6. transport vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Neurensin-1PRO_0000270583Add
BLAST

Proteomic databases

PaxDbiQ8IZ57.
PRIDEiQ8IZ57.

Expressioni

Tissue specificityi

Expressed in brain. Not detectable in other tissues tested.1 Publication

Gene expression databases

BgeeiQ8IZ57.
CleanExiHS_NRSN1.
ExpressionAtlasiQ8IZ57. baseline and differential.
GenevestigatoriQ8IZ57.

Organism-specific databases

HPAiHPA061006.

Interactioni

Protein-protein interaction databases

BioGridi126698. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44987.
GeneTreeiENSGT00530000063877.
HOGENOMiHOG000231873.
HOVERGENiHBG053471.
InParanoidiQ8IZ57.
OMAiTSIWEYE.
OrthoDBiEOG73BVG9.
PhylomeDBiQ8IZ57.
TreeFamiTF332090.

Family and domain databases

InterProiIPR024883. Neurensin.
IPR029698. Nrsn1.
[Graphical view]
PANTHERiPTHR14796. PTHR14796. 1 hit.
PTHR14796:SF2. PTHR14796:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IZ57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSCSNVCGS RQAQAAAEGG YQRYGVRSYL HQFYEDCTAS IWEYEDDFQI
60 70 80 90 100
QRSPNRWSSV FWKVGLISGT VFVILGLTVL AVGFLVPPKI EAFGEADFVV
110 120 130 140 150
VDTHAVQFNS ALDMYKLAGA VLFCIGGTSM AGCLLMSVFV KSYSKEEKFL
160 170 180 190
QQKFKERIAD IKAHTQPVTK APGPGETKIP VTLSRVQNVQ PLLAT
Length:195
Mass (Da):21,475
Last modified:March 1, 2003 - v1
Checksum:iBFADD774F04279D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381V → A in AAL14639. (PubMed:12463420)Curated
Sequence conflicti161 – 1611I → T in BAC04748. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411I → V.
Corresponds to variant rs17299946 [ dbSNP | Ensembl ].
VAR_029816
Natural varianti104 – 1041H → Y.
Corresponds to variant rs11544636 [ dbSNP | Ensembl ].
VAR_053737

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418980 mRNA. Translation: AAL14639.1.
AK096290 mRNA. Translation: BAC04748.1.
AK314373 mRNA. Translation: BAG37001.1.
FO393410 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55439.1.
BC023514 mRNA. Translation: AAH23514.1.
CCDSiCCDS4549.1.
RefSeqiNP_542454.3. NM_080723.4.
UniGeneiHs.726270.

Genome annotation databases

EnsembliENST00000378478; ENSP00000367739; ENSG00000152954.
ENST00000378491; ENSP00000367752; ENSG00000152954.
GeneIDi140767.
KEGGihsa:140767.
UCSCiuc010jpq.1. human.

Polymorphism databases

DMDMi74750784.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418980 mRNA. Translation: AAL14639.1.
AK096290 mRNA. Translation: BAC04748.1.
AK314373 mRNA. Translation: BAG37001.1.
FO393410 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55439.1.
BC023514 mRNA. Translation: AAH23514.1.
CCDSiCCDS4549.1.
RefSeqiNP_542454.3. NM_080723.4.
UniGeneiHs.726270.

3D structure databases

ProteinModelPortaliQ8IZ57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126698. 1 interaction.

Polymorphism databases

DMDMi74750784.

Proteomic databases

PaxDbiQ8IZ57.
PRIDEiQ8IZ57.

Protocols and materials databases

DNASUi140767.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378478; ENSP00000367739; ENSG00000152954.
ENST00000378491; ENSP00000367752; ENSG00000152954.
GeneIDi140767.
KEGGihsa:140767.
UCSCiuc010jpq.1. human.

Organism-specific databases

CTDi140767.
GeneCardsiGC06P024126.
HGNCiHGNC:17881. NRSN1.
HPAiHPA061006.
neXtProtiNX_Q8IZ57.
PharmGKBiPA38254.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44987.
GeneTreeiENSGT00530000063877.
HOGENOMiHOG000231873.
HOVERGENiHBG053471.
InParanoidiQ8IZ57.
OMAiTSIWEYE.
OrthoDBiEOG73BVG9.
PhylomeDBiQ8IZ57.
TreeFamiTF332090.

Miscellaneous databases

GeneWikiiNRSN1.
GenomeRNAii140767.
NextBioi84371.
PROiQ8IZ57.

Gene expression databases

BgeeiQ8IZ57.
CleanExiHS_NRSN1.
ExpressionAtlasiQ8IZ57. baseline and differential.
GenevestigatoriQ8IZ57.

Family and domain databases

InterProiIPR024883. Neurensin.
IPR029698. Nrsn1.
[Graphical view]
PANTHERiPTHR14796. PTHR14796. 1 hit.
PTHR14796:SF2. PTHR14796:SF2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and characterization of a novel human VMP gene."
    Cheng C., Xu J., Ye X., Dai J., Wu Q., Zeng L., Wang L., Zhao W., Ji C., Gu S., Xie Y., Mao Y.
    Mol. Biol. Rep. 29:281-286(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Fetal brain1 Publication.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Teratocarcinoma1 Publication.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiNRSN1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ57
Secondary accession number(s): B2RAV4, Q8N8R6, Q96P21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.