Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IZ52

- CHSS2_HUMAN

UniProt

Q8IZ52 - CHSS2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Chondroitin sulfate synthase 2

Gene

CHPF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress.1 Publication

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.

Cofactori

Mn2+. Highest activities are measured with manganese. Can also utilize cobalt.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi617 – 6171Divalent metal cationSequence Analysis

GO - Molecular functioni

  1. glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. chondroitin sulfate biosynthetic process Source: Reactome
  3. chondroitin sulfate metabolic process Source: Reactome
  4. glycosaminoglycan metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS13103-MONOMER.
BRENDAi2.4.1.226. 2681.
ReactomeiREACT_120989. Chondroitin sulfate biosynthesis.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.
GT7. Glycosyltransferase Family 7.

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin sulfate synthase 2 (EC:2.4.1.175, EC:2.4.1.226)
Alternative name(s):
Chondroitin glucuronyltransferase 2
Chondroitin-polymerizing factor
Short name:
ChPF
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
N-acetylgalactosaminyltransferase 2
Gene namesi
Name:CHPF
Synonyms:CSS2
ORF Names:UNQ651/PRO1281
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24291. CHPF.

Subcellular locationi

GO - Cellular componenti

  1. Golgi cisterna membrane Source: InterPro
  2. Golgi membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Chondroitin sulfate synthase 2PRO_0000189560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IZ52.
PaxDbiQ8IZ52.
PRIDEiQ8IZ52.

PTM databases

PhosphoSiteiQ8IZ52.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.3 Publications

Gene expression databases

BgeeiQ8IZ52.
CleanExiHS_CHPF.
ExpressionAtlasiQ8IZ52. baseline and differential.
GenevestigatoriQ8IZ52.

Organism-specific databases

HPAiHPA035123.

Interactioni

Subunit structurei

Binds CHSY1. Isoform 1, isoform 2 and isoform 3 interact with PARK2.

Binary interactionsi

WithEntry#Exp.IntActNotes
PARK2O602605EBI-9029620,EBI-716346

Protein-protein interaction databases

BioGridi122729. 11 interactions.
IntActiQ8IZ52. 8 interactions.
MINTiMINT-1184453.
STRINGi9606.ENSP00000243776.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ52.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini35 – 775741LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3419Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi515 – 57157Ala-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331887.
GeneTreeiENSGT00760000119143.
HOGENOMiHOG000037934.
HOVERGENiHBG050941.
InParanoidiQ8IZ52.
KOiK00747.
OMAiCRNDIVS.
OrthoDBiEOG790G17.
PhylomeDBiQ8IZ52.
TreeFamiTF318303.

Family and domain databases

InterProiIPR008428. Chond_GalNAc.
[Graphical view]
PfamiPF05679. CHGN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZ52-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRASLLLSVL RPAGPVAVGI SLGFTLSLLS VTWVEEPCGP GPPQPGDSEL
60 70 80 90 100
PPRGNTNAAR RPNSVQPGAE REKPGAGEGA GENWEPRVLP YHPAQPGQAA
110 120 130 140 150
KKAVRTRYIS TELGIRQRLL VAVLTSQTTL PTLGVAVNRT LGHRLERVVF
160 170 180 190 200
LTGARGRRAP PGMAVVTLGE ERPIGHLHLA LRHLLEQHGD DFDWFFLVPD
210 220 230 240 250
TTYTEAHGLA RLTGHLSLAS AAHLYLGRPQ DFIGGEPTPG RYCHGGFGVL
260 270 280 290 300
LSRMLLQQLR PHLEGCRNDI VSARPDEWLG RCILDATGVG CTGDHEGVHY
310 320 330 340 350
SHLELSPGEP VQEGDPHFRS ALTAHPVRDP VHMYQLHKAF ARAELERTYQ
360 370 380 390 400
EIQELQWEIQ NTSHLAVDGD QAAAWPVGIP APSRPASRFE VLRWDYFTEQ
410 420 430 440 450
HAFSCADGSP RCPLRGADRA DVADVLGTAL EELNRRYHPA LRLQKQQLVN
460 470 480 490 500
GYRRFDPARG MEYTLDLQLE ALTPQGGRRP LTRRVQLLRP LSRVEILPVP
510 520 530 540 550
YVTEASRLTV LLPLAAAERD LAPGFLEAFA TAALEPGDAA AALTLLLLYE
560 570 580 590 600
PRQAQRVAHA DVFAPVKAHV AELERRFPGA RVPWLSVQTA APSPLRLMDL
610 620 630 640 650
LSKKHPLDTL FLLAGPDTVL TPDFLNRCRM HAISGWQAFF PMHFQAFHPA
660 670 680 690 700
VAPPQGPGPP ELGRDTGRFD RQAASEACFY NSDYVAARGR LAAASEQEEE
710 720 730 740 750
LLESLDVYEL FLHFSSLHVL RAVEPALLQR YRAQTCSARL SEDLYHRCLQ
760 770
SVLEGLGSRT QLAMLLFEQE QGNST
Length:775
Mass (Da):85,467
Last modified:November 2, 2010 - v2
Checksum:i94EDDB2481C97B70
GO
Isoform 2 (identifier: Q8IZ52-2) [UniParc]FASTAAdd to Basket

Also known as: Klokin1

The sequence of this isoform differs from the canonical sequence as follows:
     1-460: Missing.

Show »
Length:315
Mass (Da):34,955
Checksum:iF31E832CBAF52F64
GO
Isoform 3 (identifier: Q8IZ52-4) [UniParc]FASTAAdd to Basket

Also known as: ChPF(D996)

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Show »
Length:613
Mass (Da):68,341
Checksum:iF921806F335177C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti650 – 6501A → G in AAQ88769. (PubMed:12975309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti371 – 3711Q → R Most frequent polymorphism. 7 Publications
Corresponds to variant rs6436155 [ dbSNP | Ensembl ].
VAR_047394

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 460460Missing in isoform 2. 1 PublicationVSP_053433Add
BLAST
Alternative sequencei1 – 162162Missing in isoform 3. 1 PublicationVSP_053434Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB095813 mRNA. Translation: BAC78393.1.
AB086063 mRNA. Translation: BAC81536.1.
AY358403 mRNA. Translation: AAQ88769.1.
AK026331 mRNA. Translation: BAB15449.1.
AK302124 mRNA. Translation: BAG63502.1.
AC009955 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70768.1.
BC008878 mRNA. Translation: AAH08878.2.
BC021223 mRNA. Translation: AAH21223.2.
BC023531 mRNA. Translation: AAH23531.1.
AL136814 mRNA. Translation: CAB66748.2.
CCDSiCCDS2443.1. [Q8IZ52-1]
CCDS56169.1. [Q8IZ52-4]
RefSeqiNP_001182660.1. NM_001195731.1.
NP_078812.2. NM_024536.5.
UniGeneiHs.516711.

Genome annotation databases

EnsembliENST00000243776; ENSP00000243776; ENSG00000123989. [Q8IZ52-1]
ENST00000535926; ENSP00000445571; ENSG00000123989. [Q8IZ52-4]
GeneIDi79586.
KEGGihsa:79586.
UCSCiuc002vmc.4. human. [Q8IZ52-1]
uc010zlh.2. human.

Polymorphism databases

DMDMi311033361.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB095813 mRNA. Translation: BAC78393.1 .
AB086063 mRNA. Translation: BAC81536.1 .
AY358403 mRNA. Translation: AAQ88769.1 .
AK026331 mRNA. Translation: BAB15449.1 .
AK302124 mRNA. Translation: BAG63502.1 .
AC009955 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70768.1 .
BC008878 mRNA. Translation: AAH08878.2 .
BC021223 mRNA. Translation: AAH21223.2 .
BC023531 mRNA. Translation: AAH23531.1 .
AL136814 mRNA. Translation: CAB66748.2 .
CCDSi CCDS2443.1. [Q8IZ52-1 ]
CCDS56169.1. [Q8IZ52-4 ]
RefSeqi NP_001182660.1. NM_001195731.1.
NP_078812.2. NM_024536.5.
UniGenei Hs.516711.

3D structure databases

ProteinModelPortali Q8IZ52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122729. 11 interactions.
IntActi Q8IZ52. 8 interactions.
MINTi MINT-1184453.
STRINGi 9606.ENSP00000243776.

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.
GT7. Glycosyltransferase Family 7.

PTM databases

PhosphoSitei Q8IZ52.

Polymorphism databases

DMDMi 311033361.

Proteomic databases

MaxQBi Q8IZ52.
PaxDbi Q8IZ52.
PRIDEi Q8IZ52.

Protocols and materials databases

DNASUi 79586.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243776 ; ENSP00000243776 ; ENSG00000123989 . [Q8IZ52-1 ]
ENST00000535926 ; ENSP00000445571 ; ENSG00000123989 . [Q8IZ52-4 ]
GeneIDi 79586.
KEGGi hsa:79586.
UCSCi uc002vmc.4. human. [Q8IZ52-1 ]
uc010zlh.2. human.

Organism-specific databases

CTDi 79586.
GeneCardsi GC02M220367.
HGNCi HGNC:24291. CHPF.
HPAi HPA035123.
MIMi 610405. gene.
neXtProti NX_Q8IZ52.
PharmGKBi PA162382245.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331887.
GeneTreei ENSGT00760000119143.
HOGENOMi HOG000037934.
HOVERGENi HBG050941.
InParanoidi Q8IZ52.
KOi K00747.
OMAi CRNDIVS.
OrthoDBi EOG790G17.
PhylomeDBi Q8IZ52.
TreeFami TF318303.

Enzyme and pathway databases

BioCyci MetaCyc:HS13103-MONOMER.
BRENDAi 2.4.1.226. 2681.
Reactomei REACT_120989. Chondroitin sulfate biosynthesis.

Miscellaneous databases

GeneWikii CHPF.
GenomeRNAii 79586.
NextBioi 68587.
PROi Q8IZ52.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZ52.
CleanExi HS_CHPF.
ExpressionAtlasi Q8IZ52. baseline and differential.
Genevestigatori Q8IZ52.

Family and domain databases

InterProi IPR008428. Chond_GalNAc.
[Graphical view ]
Pfami PF05679. CHGN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization."
    Kitagawa H., Izumikawa T., Uyama T., Sugahara K.
    J. Biol. Chem. 278:23666-23671(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CHSY1, TISSUE SPECIFICITY, VARIANT ARG-371.
  2. "Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities."
    Yada T., Gotoh M., Sato T., Shionyu M., Go M., Kaseyama H., Iwasaki H., Kikuchi N., Kwon Y.-D., Togayachi A., Kudo T., Watanabe H., Narimatsu H., Kimata K.
    J. Biol. Chem. 278:30235-30247(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, COFACTOR, TISSUE SPECIFICITY, VARIANT ARG-371.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-371.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-371.
    Tissue: Small intestine.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-371.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-371.
    Tissue: Brain, Muscle and Skin.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 210-775, VARIANT ARG-371.
    Tissue: Testis.
  9. "Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential."
    Kuroda Y., Sako W., Goto S., Sawada T., Uchida D., Izumi Y., Takahashi T., Kagawa N., Matsumoto M., Matsumoto M., Takahashi R., Kaji R., Mitsui T.
    Hum. Mol. Genet. 21:991-1003(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, FUNCTION (ISOFORM 2), INTERACTION WITH PARK2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCHSS2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ52
Secondary accession number(s): B4DXU0
, Q6UXD6, Q7L4G1, Q9H0F8, Q9H618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3