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Protein

REST corepressor 2

Gene

RCOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 2
Gene namesi
Name:RCOR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27455. RCOR2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876257.

Polymorphism and mutation databases

BioMutaiRCOR2.
DMDMi147744586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523REST corepressor 2PRO_0000226776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311PhosphoserineCombined sources
Modified residuei35 – 351PhosphoserineCombined sources
Modified residuei36 – 361PhosphoserineCombined sources
Modified residuei63 – 631PhosphoserineCombined sources
Modified residuei202 – 2021PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZ40.
MaxQBiQ8IZ40.
PaxDbiQ8IZ40.
PeptideAtlasiQ8IZ40.
PRIDEiQ8IZ40.

PTM databases

iPTMnetiQ8IZ40.
PhosphoSiteiQ8IZ40.

Miscellaneous databases

PMAP-CutDBQ8IZ40.

Expressioni

Gene expression databases

BgeeiQ8IZ40.
CleanExiHS_RCOR2.
GenevisibleiQ8IZ40. HS.

Organism-specific databases

HPAiHPA021638.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129510. 8 interactions.
IntActiQ8IZ40. 5 interactions.
MINTiMINT-1387489.
STRINGi9606.ENSP00000301459.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ40.
SMRiQ8IZ40. Positions 46-179, 258-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12986ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 18152SANT 1PROSITE-ProRule annotationAdd
BLAST
Domaini327 – 37852SANT 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili283 – 31432Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi430 – 52192Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CoREST family.Curated
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 2 SANT domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ8IZ40.
OMAiSPARYSN.
OrthoDBiEOG7MWGX1.
PhylomeDBiQ8IZ40.
TreeFamiTF106450.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZ40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVMEKPSA GSGILSRSRA KTVPNGGQPH SEDDSSEEEH SHDSMIRVGT
60 70 80 90 100
NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH
110 120 130 140 150
GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH
160 170 180 190 200
GKCFQRIQQM LPDKLIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE
210 220 230 240 250
DSDELEEGRG GVSEGEPDPA DPKREPLPSR PLNARPGPGK KEVQVSQYRH
260 270 280 290 300
HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS
310 320 330 340 350
MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD
360 370 380 390 400
FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPGAPVPM
410 420 430 440 450
EEARRGAPLP APALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP
460 470 480 490 500
PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAAPRHS
510 520
ARPGPQPPPT LIGTPLEPPA PSL
Length:523
Mass (Da):58,012
Last modified:May 15, 2007 - v2
Checksum:iEA9E53BC578B5A2E
GO

Sequence cautioni

The sequence AAH10608.1 differs from that shown.Chimera.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti422 – 4221I → T in AAH23587 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti514 – 5141T → A.1 Publication
Corresponds to variant rs320108 [ dbSNP | Ensembl ].
VAR_025516

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003780 Genomic DNA. No translation available.
BC010608 mRNA. Translation: AAH10608.1. Sequence problems.
BC023587 mRNA. Translation: AAH23587.1.
CCDSiCCDS8052.1.
RefSeqiNP_775858.2. NM_173587.3.
UniGeneiHs.98788.

Genome annotation databases

EnsembliENST00000301459; ENSP00000301459; ENSG00000167771.
GeneIDi283248.
KEGGihsa:283248.
UCSCiuc001nyc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003780 Genomic DNA. No translation available.
BC010608 mRNA. Translation: AAH10608.1. Sequence problems.
BC023587 mRNA. Translation: AAH23587.1.
CCDSiCCDS8052.1.
RefSeqiNP_775858.2. NM_173587.3.
UniGeneiHs.98788.

3D structure databases

ProteinModelPortaliQ8IZ40.
SMRiQ8IZ40. Positions 46-179, 258-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129510. 8 interactions.
IntActiQ8IZ40. 5 interactions.
MINTiMINT-1387489.
STRINGi9606.ENSP00000301459.

PTM databases

iPTMnetiQ8IZ40.
PhosphoSiteiQ8IZ40.

Polymorphism and mutation databases

BioMutaiRCOR2.
DMDMi147744586.

Proteomic databases

EPDiQ8IZ40.
MaxQBiQ8IZ40.
PaxDbiQ8IZ40.
PeptideAtlasiQ8IZ40.
PRIDEiQ8IZ40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301459; ENSP00000301459; ENSG00000167771.
GeneIDi283248.
KEGGihsa:283248.
UCSCiuc001nyc.3. human.

Organism-specific databases

CTDi283248.
GeneCardsiRCOR2.
HGNCiHGNC:27455. RCOR2.
HPAiHPA021638.
neXtProtiNX_Q8IZ40.
PharmGKBiPA134876257.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ8IZ40.
OMAiSPARYSN.
OrthoDBiEOG7MWGX1.
PhylomeDBiQ8IZ40.
TreeFamiTF106450.

Miscellaneous databases

ChiTaRSiRCOR2. human.
GenomeRNAii283248.
PMAP-CutDBQ8IZ40.
PROiQ8IZ40.

Gene expression databases

BgeeiQ8IZ40.
CleanExiHS_RCOR2.
GenevisibleiQ8IZ40. HS.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-514.
    Tissue: Brain.
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-35 AND SER-36, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiRCOR2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ40
Secondary accession number(s): Q96FP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 15, 2007
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.