ID   ZNF34_HUMAN             Reviewed;         560 AA.
AC   Q8IZ26; D3DWN1; Q9BSZ0;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 3.
DT   27-MAR-2024, entry version 167.
DE   RecName: Full=Zinc finger protein 34;
DE   AltName: Full=Zinc finger protein KOX32;
GN   Name=ZNF34; Synonyms=KOX32;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Substantia nigra;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Blood, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q8IZ26; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10264496, EBI-10172150;
CC       Q8IZ26; Q08AM6: VAC14; NbExp=4; IntAct=EBI-10264496, EBI-2107455;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH04480.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH28136.1; Type=Miscellaneous discrepancy; Note=Codon in position 67 corresponds to a stop codon in genome.; Evidence={ECO:0000305};
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DR   EMBL; AL833814; CAD38677.1; -; mRNA.
DR   EMBL; CH471162; EAW82055.1; -; Genomic_DNA.
DR   EMBL; CH471162; EAW82056.1; -; Genomic_DNA.
DR   EMBL; BC004480; AAH04480.1; ALT_INIT; mRNA.
DR   EMBL; BC028136; AAH28136.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS47945.1; -.
DR   RefSeq; NP_001273698.1; NM_001286769.1.
DR   RefSeq; NP_085057.3; NM_030580.4.
DR   RefSeq; XP_011515616.1; XM_011517314.2.
DR   RefSeq; XP_011515617.1; XM_011517315.2.
DR   RefSeq; XP_011515618.1; XM_011517316.2.
DR   RefSeq; XP_011515620.1; XM_011517318.2.
DR   RefSeq; XP_016869361.1; XM_017013872.1.
DR   RefSeq; XP_016869362.1; XM_017013873.1.
DR   RefSeq; XP_016869363.1; XM_017013874.1.
DR   RefSeq; XP_016869364.1; XM_017013875.1.
DR   AlphaFoldDB; Q8IZ26; -.
DR   SMR; Q8IZ26; -.
DR   BioGRID; 123310; 53.
DR   IntAct; Q8IZ26; 6.
DR   STRING; 9606.ENSP00000341528; -.
DR   iPTMnet; Q8IZ26; -.
DR   PhosphoSitePlus; Q8IZ26; -.
DR   BioMuta; ZNF34; -.
DR   DMDM; 317373492; -.
DR   EPD; Q8IZ26; -.
DR   jPOST; Q8IZ26; -.
DR   MassIVE; Q8IZ26; -.
DR   MaxQB; Q8IZ26; -.
DR   PaxDb; 9606-ENSP00000341528; -.
DR   PeptideAtlas; Q8IZ26; -.
DR   ProteomicsDB; 71275; -.
DR   Antibodypedia; 28631; 133 antibodies from 18 providers.
DR   DNASU; 80778; -.
DR   Ensembl; ENST00000343459.8; ENSP00000341528.4; ENSG00000196378.13.
DR   GeneID; 80778; -.
DR   KEGG; hsa:80778; -.
DR   UCSC; uc003zdx.6; human.
DR   AGR; HGNC:13098; -.
DR   CTD; 80778; -.
DR   DisGeNET; 80778; -.
DR   GeneCards; ZNF34; -.
DR   HGNC; HGNC:13098; ZNF34.
DR   HPA; ENSG00000196378; Low tissue specificity.
DR   MIM; 194526; gene.
DR   neXtProt; NX_Q8IZ26; -.
DR   OpenTargets; ENSG00000196378; -.
DR   PharmGKB; PA37673; -.
DR   VEuPathDB; HostDB:ENSG00000196378; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000154712; -.
DR   HOGENOM; CLU_002678_0_7_1; -.
DR   InParanoid; Q8IZ26; -.
DR   OrthoDB; 5247610at2759; -.
DR   PhylomeDB; Q8IZ26; -.
DR   TreeFam; TF337055; -.
DR   PathwayCommons; Q8IZ26; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q8IZ26; -.
DR   BioGRID-ORCS; 80778; 20 hits in 1177 CRISPR screens.
DR   ChiTaRS; ZNF34; human.
DR   GeneWiki; ZNF34; -.
DR   GenomeRNAi; 80778; -.
DR   Pharos; Q8IZ26; Tdark.
DR   PRO; PR:Q8IZ26; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q8IZ26; Protein.
DR   Bgee; ENSG00000196378; Expressed in tibial artery and 128 other cell types or tissues.
DR   ExpressionAtlas; Q8IZ26; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR   PANTHER; PTHR23232:SF143; ZINC FINGER PROTEIN 747; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 12.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 12.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
DR   Genevisible; Q8IZ26; HS.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..560
FT                   /note="Zinc finger protein 34"
FT                   /id="PRO_0000047365"
FT   DOMAIN          35..108
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         195..217
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         251..273
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         279..301
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         307..329
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         335..357
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         363..385
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         391..413
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         419..441
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         447..469
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         475..497
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         503..525
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         531..553
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          163..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         113
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:20068231,
FT                   ECO:0007744|PubMed:23186163"
SQ   SEQUENCE   560 AA;  64038 MW;  B66056E75C42C324 CRC64;
     MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG RLGPAQRGLY
     RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV QGTSGKEHLR VNSPALGTRT
     EYKELTSQET FGEEDPQGSE PVEACDHISK SEGSLEKLVE QRGPRAVTLT NGESSRESGG
     NLRLLSRPVP DQRPHKCDIC EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE
     DQKIPTGKKL HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM
     HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL IYHQRIHTGE
     KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF TQSSNLIQHQ RIHTGEKPYK
     CNECEKAFIQ KTKLVEHQRS HTGEKPYECN DCGKVFSQST HLIQHQRIHT GEKPYKCSEC
     GKAFHNSSRL IHHQRLHHGE KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF
     RHSSNMCQHQ RIHLREDFSM
//