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Protein

Zinc finger protein 34

Gene

ZNF34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 217C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 34
Alternative name(s):
Zinc finger protein KOX32
Gene namesi
Name:ZNF34
Synonyms:KOX32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000196378.11
HGNCiHGNC:13098 ZNF34
MIMi194526 gene
neXtProtiNX_Q8IZ26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80778
OpenTargetsiENSG00000196378
PharmGKBiPA37673

Polymorphism and mutation databases

BioMutaiZNF34
DMDMi317373492

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473651 – 560Zinc finger protein 34Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZ26
MaxQBiQ8IZ26
PaxDbiQ8IZ26
PeptideAtlasiQ8IZ26
PRIDEiQ8IZ26

PTM databases

iPTMnetiQ8IZ26
PhosphoSitePlusiQ8IZ26

Expressioni

Gene expression databases

BgeeiENSG00000196378
CleanExiHS_ZNF34
ExpressionAtlasiQ8IZ26 baseline and differential
GenevisibleiQ8IZ26 HS

Organism-specific databases

HPAiHPA053925
HPA060755
HPA066805

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123310, 7 interactors
IntActiQ8IZ26, 3 interactors
STRINGi9606.ENSP00000341528

Structurei

3D structure databases

ProteinModelPortaliQ8IZ26
SMRiQ8IZ26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 108KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 217C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144031
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8IZ26
KOiK09228
OMAiIHLREDF
OrthoDBiEOG091G02KC
PhylomeDBiQ8IZ26
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR030753 ZNF34
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR24377:SF717 PTHR24377:SF717, 1 hit
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

Q8IZ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG
60 70 80 90 100
RLGPAQRGLY RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV
110 120 130 140 150
QGTSGKEHLR VNSPALGTRT EYKELTSQET FGEEDPQGSE PVEACDHISK
160 170 180 190 200
SEGSLEKLVE QRGPRAVTLT NGESSRESGG NLRLLSRPVP DQRPHKCDIC
210 220 230 240 250
EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE DQKIPTGKKL
260 270 280 290 300
HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM
310 320 330 340 350
HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL
360 370 380 390 400
IYHQRIHTGE KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF
410 420 430 440 450
TQSSNLIQHQ RIHTGEKPYK CNECEKAFIQ KTKLVEHQRS HTGEKPYECN
460 470 480 490 500
DCGKVFSQST HLIQHQRIHT GEKPYKCSEC GKAFHNSSRL IHHQRLHHGE
510 520 530 540 550
KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF RHSSNMCQHQ
560
RIHLREDFSM
Length:560
Mass (Da):64,038
Last modified:January 11, 2011 - v3
Checksum:iB66056E75C42C324
GO

Sequence cautioni

The sequence AAH04480 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH28136 differs from that shown. Codon in position 67 corresponds to a stop codon in genome.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833814 mRNA Translation: CAD38677.1
CH471162 Genomic DNA Translation: EAW82055.1
CH471162 Genomic DNA Translation: EAW82056.1
BC004480 mRNA Translation: AAH04480.1 Different initiation.
BC028136 mRNA Translation: AAH28136.1 Sequence problems.
CCDSiCCDS47945.1
RefSeqiNP_001273698.1, NM_001286769.1
NP_085057.3, NM_030580.4
XP_011515616.1, XM_011517314.2
XP_011515617.1, XM_011517315.2
XP_011515618.1, XM_011517316.2
XP_011515620.1, XM_011517318.2
XP_016869361.1, XM_017013872.1
XP_016869362.1, XM_017013873.1
XP_016869363.1, XM_017013874.1
XP_016869364.1, XM_017013875.1
UniGeneiHs.631854

Genome annotation databases

EnsembliENST00000343459; ENSP00000341528; ENSG00000196378
GeneIDi80778
KEGGihsa:80778
UCSCiuc003zdx.6 human

Similar proteinsi

Entry informationi

Entry nameiZNF34_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ26
Secondary accession number(s): D3DWN1, Q9BSZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 11, 2011
Last modified: May 23, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health