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Q8IZ26 (ZNF34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 34
Alternative name(s):
Zinc finger protein KOX32
Gene names
Name:ZNF34
Synonyms:KOX32
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAH04480.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH28136.1 differs from that shown. Reason: Codon in position 67 corresponds to a stop codon in genome.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Zinc finger protein 34
PRO_0000047365

Regions

Domain35 – 10874KRAB
Zinc finger195 – 21723C2H2-type 1
Zinc finger251 – 27323C2H2-type 2
Zinc finger279 – 30123C2H2-type 3
Zinc finger307 – 32923C2H2-type 4
Zinc finger335 – 35723C2H2-type 5
Zinc finger363 – 38523C2H2-type 6
Zinc finger391 – 41323C2H2-type 7
Zinc finger419 – 44123C2H2-type 8
Zinc finger447 – 46923C2H2-type 9
Zinc finger475 – 49723C2H2-type 10
Zinc finger503 – 52523C2H2-type 11
Zinc finger531 – 55323C2H2-type 12

Amino acid modifications

Modified residue1131Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8IZ26 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: B66056E75C42C324

FASTA56064,038
        10         20         30         40         50         60 
MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG RLGPAQRGLY 

        70         80         90        100        110        120 
RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV QGTSGKEHLR VNSPALGTRT 

       130        140        150        160        170        180 
EYKELTSQET FGEEDPQGSE PVEACDHISK SEGSLEKLVE QRGPRAVTLT NGESSRESGG 

       190        200        210        220        230        240 
NLRLLSRPVP DQRPHKCDIC EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE 

       250        260        270        280        290        300 
DQKIPTGKKL HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM 

       310        320        330        340        350        360 
HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL IYHQRIHTGE 

       370        380        390        400        410        420 
KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF TQSSNLIQHQ RIHTGEKPYK 

       430        440        450        460        470        480 
CNECEKAFIQ KTKLVEHQRS HTGEKPYECN DCGKVFSQST HLIQHQRIHT GEKPYKCSEC 

       490        500        510        520        530        540 
GKAFHNSSRL IHHQRLHHGE KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF 

       550        560 
RHSSNMCQHQ RIHLREDFSM 

« Hide

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Substantia nigra.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood and Lung.
[4]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL833814 mRNA. Translation: CAD38677.1.
CH471162 Genomic DNA. Translation: EAW82055.1.
CH471162 Genomic DNA. Translation: EAW82056.1.
BC004480 mRNA. Translation: AAH04480.1. Different initiation.
BC028136 mRNA. Translation: AAH28136.1. Sequence problems.
RefSeqNP_001273698.1. NM_001286769.1.
NP_085057.3. NM_030580.4.
XP_005272402.1. XM_005272345.2.
XP_005272403.1. XM_005272346.2.
UniGeneHs.631854.

3D structure databases

ProteinModelPortalQ8IZ26.
SMRQ8IZ26. Positions 30-78, 163-557.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123310. 1 interaction.
MINTMINT-4714311.

PTM databases

PhosphoSiteQ8IZ26.

Polymorphism databases

DMDM317373492.

Proteomic databases

PaxDbQ8IZ26.
PRIDEQ8IZ26.

Protocols and materials databases

DNASU80778.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343459; ENSP00000341528; ENSG00000196378.
ENST00000429371; ENSP00000396894; ENSG00000196378.
GeneID80778.
KEGGhsa:80778.
UCSCuc003zdx.4. human.

Organism-specific databases

CTD80778.
GeneCardsGC08M145969.
HGNCHGNC:13098. ZNF34.
HPAHPA060755.
MIM194526. gene.
neXtProtNX_Q8IZ26.
PharmGKBPA37673.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8IZ26.
KOK09228.
OMAKLHYCSY.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8IZ26.
TreeFamTF337055.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8IZ26.
BgeeQ8IZ26.
CleanExHS_ZNF34.
GenevestigatorQ8IZ26.

Family and domain databases

Gene3D3.30.160.60. 12 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF34.
GenomeRNAi80778.
NextBio71183.
PROQ8IZ26.
SOURCESearch...

Entry information

Entry nameZNF34_HUMAN
AccessionPrimary (citable) accession number: Q8IZ26
Secondary accession number(s): D3DWN1, Q9BSZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM