Q8IZ26 (ZNF34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 34

Alternative name(s):
Zinc finger protein KOX32

Gene names

Name:	ZNF34
Synonyms:	KOX32

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAH04480.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH28136.1 differs from that shown. Reason: Codon in position 67 corresponds to a stop codon in genome.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Zinc finger protein 34		PRO_0000047365
Regions
	Domain	35 – 108	74	KRAB
	Zinc finger	195 – 217	23	C2H2-type 1
	Zinc finger	251 – 273	23	C2H2-type 2
	Zinc finger	279 – 301	23	C2H2-type 3
	Zinc finger	307 – 329	23	C2H2-type 4
	Zinc finger	335 – 357	23	C2H2-type 5
	Zinc finger	363 – 385	23	C2H2-type 6
	Zinc finger	391 – 413	23	C2H2-type 7
	Zinc finger	419 – 441	23	C2H2-type 8
	Zinc finger	447 – 469	23	C2H2-type 9
	Zinc finger	475 – 497	23	C2H2-type 10
	Zinc finger	503 – 525	23	C2H2-type 11
	Zinc finger	531 – 553	23	C2H2-type 12
Amino acid modifications
	Modified residue	113	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8IZ26 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: B66056E75C42C324	FASTA	560	64,038
	10 20 30 40 50 60 MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG RLGPAQRGLY 70 80 90 100 110 120 RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV QGTSGKEHLR VNSPALGTRT 130 140 150 160 170 180 EYKELTSQET FGEEDPQGSE PVEACDHISK SEGSLEKLVE QRGPRAVTLT NGESSRESGG 190 200 210 220 230 240 NLRLLSRPVP DQRPHKCDIC EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE 250 260 270 280 290 300 DQKIPTGKKL HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM 310 320 330 340 350 360 HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL IYHQRIHTGE 370 380 390 400 410 420 KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF TQSSNLIQHQ RIHTGEKPYK 430 440 450 460 470 480 CNECEKAFIQ KTKLVEHQRS HTGEKPYECN DCGKVFSQST HLIQHQRIHT GEKPYKCSEC 490 500 510 520 530 540 GKAFHNSSRL IHHQRLHHGE KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF 550 560 RHSSNMCQHQ RIHLREDFSM

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Substantia nigra.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood and Lung.
[4]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL833814 mRNA. Translation: CAD38677.1. CH471162 Genomic DNA. Translation: EAW82055.1. CH471162 Genomic DNA. Translation: EAW82056.1. BC004480 mRNA. Translation: AAH04480.1. Different initiation. BC028136 mRNA. Translation: AAH28136.1. Sequence problems.
IPI	IPI00941417.
RefSeq	NP_085057.3. NM_030580.3.
UniGene	Hs.631854.
3D structure databases
ProteinModelPortal	Q8IZ26.
SMR	Q8IZ26. Positions 193-557.
ModBase	Search...
PTM databases
PhosphoSite	Q8IZ26.
Polymorphism databases
DMDM	160112323.
Proteomic databases
PaxDb	Q8IZ26.
PRIDE	Q8IZ26.
Protocols and materials databases
DNASU	80778.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343459; ENSP00000341528; ENSG00000196378. ENST00000429371; ENSP00000396894; ENSG00000196378.
GeneID	80778.
KEGG	hsa:80778.
UCSC	uc003zdx.4. human.
Organism-specific databases
CTD	80778.
GeneCards	GC08M145969.
HGNC	HGNC:13098. ZNF34.
MIM	194526. gene.
neXtProt	NX_Q8IZ26.
PharmGKB	PA37673.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q8IZ26.
KO	K09228.
OMA	PWVLDVQ.
OrthoDB	EOG43JC4F.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q8IZ26.
Bgee	Q8IZ26.
CleanEx	HS_ZNF34.
Genevestigator	Q8IZ26.
Family and domain databases
Gene3D	3.30.160.60. 12 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. IPR001878. Znf_CCHC. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 12 hits. SM00343. ZnF_C2HC. 1 hit. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 12 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80778.
NextBio	71183.
SOURCE	Search...

Entry information

Entry name

ZNF34_HUMAN

Accession

Primary (citable) accession number: Q8IZ26
Secondary accession number(s): D3DWN1, Q9BSZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.