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Q8IZ26

- ZNF34_HUMAN

UniProt

Q8IZ26 - ZNF34_HUMAN

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Protein

Zinc finger protein 34

Gene

ZNF34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 21723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 34
Alternative name(s):
Zinc finger protein KOX32
Gene namesi
Name:ZNF34
Synonyms:KOX32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:13098. ZNF34.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Zinc finger protein 34PRO_0000047365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IZ26.
PaxDbiQ8IZ26.
PRIDEiQ8IZ26.

PTM databases

PhosphoSiteiQ8IZ26.

Expressioni

Gene expression databases

BgeeiQ8IZ26.
CleanExiHS_ZNF34.
ExpressionAtlasiQ8IZ26. baseline and differential.
GenevestigatoriQ8IZ26.

Organism-specific databases

HPAiHPA060755.

Interactioni

Protein-protein interaction databases

BioGridi123310. 1 interaction.
MINTiMINT-4714311.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ26.
SMRiQ8IZ26. Positions 193-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10874KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 21723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120488.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IZ26.
KOiK09228.
OMAiKLHYCSY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8IZ26.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZ26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG
60 70 80 90 100
RLGPAQRGLY RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV
110 120 130 140 150
QGTSGKEHLR VNSPALGTRT EYKELTSQET FGEEDPQGSE PVEACDHISK
160 170 180 190 200
SEGSLEKLVE QRGPRAVTLT NGESSRESGG NLRLLSRPVP DQRPHKCDIC
210 220 230 240 250
EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE DQKIPTGKKL
260 270 280 290 300
HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM
310 320 330 340 350
HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL
360 370 380 390 400
IYHQRIHTGE KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF
410 420 430 440 450
TQSSNLIQHQ RIHTGEKPYK CNECEKAFIQ KTKLVEHQRS HTGEKPYECN
460 470 480 490 500
DCGKVFSQST HLIQHQRIHT GEKPYKCSEC GKAFHNSSRL IHHQRLHHGE
510 520 530 540 550
KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF RHSSNMCQHQ
560
RIHLREDFSM
Length:560
Mass (Da):64,038
Last modified:January 11, 2011 - v3
Checksum:iB66056E75C42C324
GO

Sequence cautioni

The sequence AAH04480.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH28136.1 differs from that shown. Reason: Codon in position 67 corresponds to a stop codon in genome.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833814 mRNA. Translation: CAD38677.1.
CH471162 Genomic DNA. Translation: EAW82055.1.
CH471162 Genomic DNA. Translation: EAW82056.1.
BC004480 mRNA. Translation: AAH04480.1. Different initiation.
BC028136 mRNA. Translation: AAH28136.1. Sequence problems.
CCDSiCCDS47945.1.
RefSeqiNP_001273698.1. NM_001286769.1.
NP_085057.3. NM_030580.4.
XP_005272402.1. XM_005272345.2.
XP_005272403.1. XM_005272346.2.
XP_006716725.1. XM_006716662.1.
XP_006716726.1. XM_006716663.1.
UniGeneiHs.631854.

Genome annotation databases

EnsembliENST00000343459; ENSP00000341528; ENSG00000196378.
ENST00000429371; ENSP00000396894; ENSG00000196378.
GeneIDi80778.
KEGGihsa:80778.
UCSCiuc003zdx.4. human.

Polymorphism databases

DMDMi317373492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833814 mRNA. Translation: CAD38677.1 .
CH471162 Genomic DNA. Translation: EAW82055.1 .
CH471162 Genomic DNA. Translation: EAW82056.1 .
BC004480 mRNA. Translation: AAH04480.1 . Different initiation.
BC028136 mRNA. Translation: AAH28136.1 . Sequence problems.
CCDSi CCDS47945.1.
RefSeqi NP_001273698.1. NM_001286769.1.
NP_085057.3. NM_030580.4.
XP_005272402.1. XM_005272345.2.
XP_005272403.1. XM_005272346.2.
XP_006716725.1. XM_006716662.1.
XP_006716726.1. XM_006716663.1.
UniGenei Hs.631854.

3D structure databases

ProteinModelPortali Q8IZ26.
SMRi Q8IZ26. Positions 193-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123310. 1 interaction.
MINTi MINT-4714311.

PTM databases

PhosphoSitei Q8IZ26.

Polymorphism databases

DMDMi 317373492.

Proteomic databases

MaxQBi Q8IZ26.
PaxDbi Q8IZ26.
PRIDEi Q8IZ26.

Protocols and materials databases

DNASUi 80778.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343459 ; ENSP00000341528 ; ENSG00000196378 .
ENST00000429371 ; ENSP00000396894 ; ENSG00000196378 .
GeneIDi 80778.
KEGGi hsa:80778.
UCSCi uc003zdx.4. human.

Organism-specific databases

CTDi 80778.
GeneCardsi GC08M145969.
HGNCi HGNC:13098. ZNF34.
HPAi HPA060755.
MIMi 194526. gene.
neXtProti NX_Q8IZ26.
PharmGKBi PA37673.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120488.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8IZ26.
KOi K09228.
OMAi KLHYCSY.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8IZ26.
TreeFami TF337055.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF34.
GenomeRNAii 80778.
NextBioi 71183.
PROi Q8IZ26.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZ26.
CleanExi HS_ZNF34.
ExpressionAtlasi Q8IZ26. baseline and differential.
Genevestigatori Q8IZ26.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood and Lung.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZNF34_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ26
Secondary accession number(s): D3DWN1, Q9BSZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3