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Q8IZ26

- ZNF34_HUMAN

UniProt

Q8IZ26 - ZNF34_HUMAN

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Protein
Zinc finger protein 34
Gene
ZNF34, KOX32
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 21723C2H2-type 1
Add
BLAST
Zinc fingeri251 – 27323C2H2-type 2
Add
BLAST
Zinc fingeri279 – 30123C2H2-type 3
Add
BLAST
Zinc fingeri307 – 32923C2H2-type 4
Add
BLAST
Zinc fingeri335 – 35723C2H2-type 5
Add
BLAST
Zinc fingeri363 – 38523C2H2-type 6
Add
BLAST
Zinc fingeri391 – 41323C2H2-type 7
Add
BLAST
Zinc fingeri419 – 44123C2H2-type 8
Add
BLAST
Zinc fingeri447 – 46923C2H2-type 9
Add
BLAST
Zinc fingeri475 – 49723C2H2-type 10
Add
BLAST
Zinc fingeri503 – 52523C2H2-type 11
Add
BLAST
Zinc fingeri531 – 55323C2H2-type 12
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 34
Alternative name(s):
Zinc finger protein KOX32
Gene namesi
Name:ZNF34
Synonyms:KOX32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:13098. ZNF34.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Zinc finger protein 34
PRO_0000047365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IZ26.
PRIDEiQ8IZ26.

PTM databases

PhosphoSiteiQ8IZ26.

Expressioni

Gene expression databases

ArrayExpressiQ8IZ26.
BgeeiQ8IZ26.
CleanExiHS_ZNF34.
GenevestigatoriQ8IZ26.

Organism-specific databases

HPAiHPA060755.

Interactioni

Protein-protein interaction databases

BioGridi123310. 1 interaction.
MINTiMINT-4714311.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ26.
SMRiQ8IZ26. Positions 166-557.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10874KRAB
Add
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IZ26.
KOiK09228.
OMAiKLHYCSY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8IZ26.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZ26-1 [UniParc]FASTAAdd to Basket

« Hide

MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG    50
RLGPAQRGLY RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV 100
QGTSGKEHLR VNSPALGTRT EYKELTSQET FGEEDPQGSE PVEACDHISK 150
SEGSLEKLVE QRGPRAVTLT NGESSRESGG NLRLLSRPVP DQRPHKCDIC 200
EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE DQKIPTGKKL 250
HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM 300
HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL 350
IYHQRIHTGE KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF 400
TQSSNLIQHQ RIHTGEKPYK CNECEKAFIQ KTKLVEHQRS HTGEKPYECN 450
DCGKVFSQST HLIQHQRIHT GEKPYKCSEC GKAFHNSSRL IHHQRLHHGE 500
KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF RHSSNMCQHQ 550
RIHLREDFSM 560
Length:560
Mass (Da):64,038
Last modified:January 11, 2011 - v3
Checksum:iB66056E75C42C324
GO

Sequence cautioni

The sequence AAH28136.1 differs from that shown. Reason: Codon in position 67 corresponds to a stop codon in genome.
The sequence AAH04480.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833814 mRNA. Translation: CAD38677.1.
CH471162 Genomic DNA. Translation: EAW82055.1.
CH471162 Genomic DNA. Translation: EAW82056.1.
BC004480 mRNA. Translation: AAH04480.1. Different initiation.
BC028136 mRNA. Translation: AAH28136.1. Sequence problems.
CCDSiCCDS47945.1.
RefSeqiNP_001273698.1. NM_001286769.1.
NP_085057.3. NM_030580.4.
XP_005272402.1. XM_005272345.2.
XP_005272403.1. XM_005272346.2.
XP_006716725.1. XM_006716662.1.
XP_006716726.1. XM_006716663.1.
UniGeneiHs.631854.

Genome annotation databases

EnsembliENST00000343459; ENSP00000341528; ENSG00000196378.
ENST00000429371; ENSP00000396894; ENSG00000196378.
GeneIDi80778.
KEGGihsa:80778.
UCSCiuc003zdx.4. human.

Polymorphism databases

DMDMi317373492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833814 mRNA. Translation: CAD38677.1 .
CH471162 Genomic DNA. Translation: EAW82055.1 .
CH471162 Genomic DNA. Translation: EAW82056.1 .
BC004480 mRNA. Translation: AAH04480.1 . Different initiation.
BC028136 mRNA. Translation: AAH28136.1 . Sequence problems.
CCDSi CCDS47945.1.
RefSeqi NP_001273698.1. NM_001286769.1.
NP_085057.3. NM_030580.4.
XP_005272402.1. XM_005272345.2.
XP_005272403.1. XM_005272346.2.
XP_006716725.1. XM_006716662.1.
XP_006716726.1. XM_006716663.1.
UniGenei Hs.631854.

3D structure databases

ProteinModelPortali Q8IZ26.
SMRi Q8IZ26. Positions 166-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123310. 1 interaction.
MINTi MINT-4714311.

PTM databases

PhosphoSitei Q8IZ26.

Polymorphism databases

DMDMi 317373492.

Proteomic databases

PaxDbi Q8IZ26.
PRIDEi Q8IZ26.

Protocols and materials databases

DNASUi 80778.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343459 ; ENSP00000341528 ; ENSG00000196378 .
ENST00000429371 ; ENSP00000396894 ; ENSG00000196378 .
GeneIDi 80778.
KEGGi hsa:80778.
UCSCi uc003zdx.4. human.

Organism-specific databases

CTDi 80778.
GeneCardsi GC08M145969.
HGNCi HGNC:13098. ZNF34.
HPAi HPA060755.
MIMi 194526. gene.
neXtProti NX_Q8IZ26.
PharmGKBi PA37673.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8IZ26.
KOi K09228.
OMAi KLHYCSY.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8IZ26.
TreeFami TF337055.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF34.
GenomeRNAii 80778.
NextBioi 71183.
PROi Q8IZ26.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IZ26.
Bgeei Q8IZ26.
CleanExi HS_ZNF34.
Genevestigatori Q8IZ26.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood and Lung.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZNF34_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ26
Secondary accession number(s): D3DWN1, Q9BSZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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