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Q8IZ26

- ZNF34_HUMAN

UniProt

Q8IZ26 - ZNF34_HUMAN

Protein

Zinc finger protein 34

Gene

ZNF34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 21723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri251 – 27323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 30123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri307 – 32923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri391 – 41323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 34
    Alternative name(s):
    Zinc finger protein KOX32
    Gene namesi
    Name:ZNF34
    Synonyms:KOX32
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:13098. ZNF34.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37673.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Zinc finger protein 34PRO_0000047365Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei113 – 1131Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8IZ26.
    PRIDEiQ8IZ26.

    PTM databases

    PhosphoSiteiQ8IZ26.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IZ26.
    BgeeiQ8IZ26.
    CleanExiHS_ZNF34.
    GenevestigatoriQ8IZ26.

    Organism-specific databases

    HPAiHPA060755.

    Interactioni

    Protein-protein interaction databases

    BioGridi123310. 1 interaction.
    MINTiMINT-4714311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZ26.
    SMRiQ8IZ26. Positions 166-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 10874KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 21723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri251 – 27323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 30123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri307 – 32923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri391 – 41323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8IZ26.
    KOiK09228.
    OMAiKLHYCSY.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8IZ26.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 12 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZ26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG    50
    RLGPAQRGLY RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV 100
    QGTSGKEHLR VNSPALGTRT EYKELTSQET FGEEDPQGSE PVEACDHISK 150
    SEGSLEKLVE QRGPRAVTLT NGESSRESGG NLRLLSRPVP DQRPHKCDIC 200
    EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE DQKIPTGKKL 250
    HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM 300
    HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL 350
    IYHQRIHTGE KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF 400
    TQSSNLIQHQ RIHTGEKPYK CNECEKAFIQ KTKLVEHQRS HTGEKPYECN 450
    DCGKVFSQST HLIQHQRIHT GEKPYKCSEC GKAFHNSSRL IHHQRLHHGE 500
    KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF RHSSNMCQHQ 550
    RIHLREDFSM 560
    Length:560
    Mass (Da):64,038
    Last modified:January 11, 2011 - v3
    Checksum:iB66056E75C42C324
    GO

    Sequence cautioni

    The sequence AAH28136.1 differs from that shown. Reason: Codon in position 67 corresponds to a stop codon in genome.
    The sequence AAH04480.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833814 mRNA. Translation: CAD38677.1.
    CH471162 Genomic DNA. Translation: EAW82055.1.
    CH471162 Genomic DNA. Translation: EAW82056.1.
    BC004480 mRNA. Translation: AAH04480.1. Different initiation.
    BC028136 mRNA. Translation: AAH28136.1. Sequence problems.
    CCDSiCCDS47945.1.
    RefSeqiNP_001273698.1. NM_001286769.1.
    NP_085057.3. NM_030580.4.
    XP_005272402.1. XM_005272345.2.
    XP_005272403.1. XM_005272346.2.
    XP_006716725.1. XM_006716662.1.
    XP_006716726.1. XM_006716663.1.
    UniGeneiHs.631854.

    Genome annotation databases

    EnsembliENST00000343459; ENSP00000341528; ENSG00000196378.
    ENST00000429371; ENSP00000396894; ENSG00000196378.
    GeneIDi80778.
    KEGGihsa:80778.
    UCSCiuc003zdx.4. human.

    Polymorphism databases

    DMDMi317373492.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833814 mRNA. Translation: CAD38677.1 .
    CH471162 Genomic DNA. Translation: EAW82055.1 .
    CH471162 Genomic DNA. Translation: EAW82056.1 .
    BC004480 mRNA. Translation: AAH04480.1 . Different initiation.
    BC028136 mRNA. Translation: AAH28136.1 . Sequence problems.
    CCDSi CCDS47945.1.
    RefSeqi NP_001273698.1. NM_001286769.1.
    NP_085057.3. NM_030580.4.
    XP_005272402.1. XM_005272345.2.
    XP_005272403.1. XM_005272346.2.
    XP_006716725.1. XM_006716662.1.
    XP_006716726.1. XM_006716663.1.
    UniGenei Hs.631854.

    3D structure databases

    ProteinModelPortali Q8IZ26.
    SMRi Q8IZ26. Positions 166-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123310. 1 interaction.
    MINTi MINT-4714311.

    PTM databases

    PhosphoSitei Q8IZ26.

    Polymorphism databases

    DMDMi 317373492.

    Proteomic databases

    PaxDbi Q8IZ26.
    PRIDEi Q8IZ26.

    Protocols and materials databases

    DNASUi 80778.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343459 ; ENSP00000341528 ; ENSG00000196378 .
    ENST00000429371 ; ENSP00000396894 ; ENSG00000196378 .
    GeneIDi 80778.
    KEGGi hsa:80778.
    UCSCi uc003zdx.4. human.

    Organism-specific databases

    CTDi 80778.
    GeneCardsi GC08M145969.
    HGNCi HGNC:13098. ZNF34.
    HPAi HPA060755.
    MIMi 194526. gene.
    neXtProti NX_Q8IZ26.
    PharmGKBi PA37673.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8IZ26.
    KOi K09228.
    OMAi KLHYCSY.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8IZ26.
    TreeFami TF337055.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF34.
    GenomeRNAii 80778.
    NextBioi 71183.
    PROi Q8IZ26.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZ26.
    Bgeei Q8IZ26.
    CleanExi HS_ZNF34.
    Genevestigatori Q8IZ26.

    Family and domain databases

    Gene3Di 3.30.160.60. 12 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Substantia nigra.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood and Lung.
    4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiZNF34_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZ26
    Secondary accession number(s): D3DWN1, Q9BSZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3