Q8IZ21 (PHAR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatase and actin regulator 4

Gene names

Name:	PHACTR4
ORF Names:	PRO2963

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	702 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway By similarity.
Subunit structure	Binds PPP1CA and actin By similarity.
Subcellular location	Cytoplasm By similarity. Cell projection › lamellipodium By similarity.
Sequence similarities	Belongs to the phosphatase and actin regulator family. Contains 3 RPEL repeats.
Sequence caution	The sequence AAG35507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH68508.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAB14483.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB15130.1 differs from that shown. Reason: Frameshift at position 51. The sequence CAH18286.1 differs from that shown. Reason: Frameshift at position 53.

Ontologies

Keywords
Biological process	Neurogenesis
Cellular component	Cell projection Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Actin-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Rho protein signal transduction Inferred from sequence or structural similarity. Source: UniProtKB actin cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB closure of optic fissure Inferred from sequence or structural similarity. Source: UniProtKB enteric nervous system development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of integrin-mediated signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB neural crest cell migration Inferred from sequence or structural similarity. Source: UniProtKB neural tube closure Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell cycle Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell lamellipodium Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	actin binding Inferred from sequence or structural similarity. Source: UniProtKB protein phosphatase 1 binding Inferred from sequence or structural similarity. Source: UniProtKB protein phosphatase type 1 activator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZ21-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZ21-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MEDPF → MGQADVSRPVNPDAV

Isoform 3 (identifier: Q8IZ21-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Isoform 4 (identifier: Q8IZ21-4)

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: E → DFSREPWNSRGSRPAHYRARHGPGQCGSRRHNTSYQKEEQVLRLWQDLQALEMEEKKK
     7-702: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 702	702	Phosphatase and actin regulator 4		PRO_0000287306
Regions
	Repeat	63 – 88	26	RPEL 1
	Repeat	583 – 608	26	RPEL 2
	Repeat	621 – 646	26	RPEL 3
	Compositional bias	227 – 433	207	Pro-rich
	Compositional bias	478 – 482	5	Poly-Glu
	Compositional bias	508 – 513	6	Poly-Glu
Amino acid modifications
	Modified residue	118	1	Phosphoserine Ref.13
	Modified residue	131	1	Phosphoserine Ref.9
	Modified residue	342	1	Phosphoserine Ref.9
	Modified residue	344	1	Phosphoserine Ref.9
	Modified residue	358	1	Phosphothreonine Ref.9
	Modified residue	427	1	Phosphoserine Ref.9
	Modified residue	432	1	Phosphothreonine Ref.9
	Modified residue	464	1	Phosphoserine Ref.13
	Modified residue	628	1	Phosphoserine Ref.7 Ref.9 Ref.11 Ref.13
Natural variations
	Alternative sequence	1 – 16	16	Missing in isoform 3.		VSP_025436
	Alternative sequence	1 – 5	5	MEDPF → MGQADVSRPVNPDAV in isoform 2.		VSP_025437
	Alternative sequence	6	1	E → DFSREPWNSRGSRPAHYRAR HGPGQCGSRRHNTSYQKEEQ VLRLWQDLQALEMEEKKK in isoform 4.		VSP_039730
	Alternative sequence	7 – 702	696	Missing in isoform 4.		VSP_039731
Experimental info
	Sequence conflict	183	1	E → G in CAH18286. Ref.2
	Sequence conflict	459	1	L → P in BAB14483. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 89AC6A1D08411948	FASTA	702	78,211
	10 20 30 40 50 60 MEDPFEEADQ PTTEPGMVLD SVEAGDTTPP TKRKSKFSGF GKIFKPWKWR KKKSSDKFKE 70 80 90 100 110 120 TSEVLERKIS MRKPREELVK RGVLLEDPEQ GGEDPGKPSD AMLKNGHTTP IGNARSSSPV 130 140 150 160 170 180 QVEEEPVRLA SLRKAIPEED LKKRLGSTGS QPNSEAESVP ENVPKPPLLP PKRPLSSSHE 190 200 210 220 230 240 ASEGQAKDAT SSGGTARFII STSITTAPAA TTAATSLAKT VNLSVTPSPA PRTLPAAPAS 250 260 270 280 290 300 TNTTATPSLT HMVPAKQPPI PPPKPAHRNS NPVIAELSQA INSGTLLSKP SPPLPPKRGI 310 320 330 340 350 360 PSTSVPTLES AAAITTKTPS DEREKSTCSM GSELLPMISP RSPSPPLPTH IPPEPPRTPP 370 380 390 400 410 420 FPAKTFQVVP EIEFPPSLDL HQEIPQQEDQ KKEVPKRILD QNFGEPHIPS RLPPLPLHIR 430 440 450 460 470 480 IQQALTSPLP MTPILEGSHR AHSLLFENSD SFSEDSSTLG RTRSLPITIE MLKVPDDEEE 490 500 510 520 530 540 EEQTCPSTFS EEMTPTSVIP KLPQCLREEE EKESDSDSEG PIQYRDEEDE DESYQSALAN 550 560 570 580 590 600 KVKRKDTLAM KLNHRPSEPE LNLNSWPCKS KEEWNEIRHQ IGNTLIRRLS QRPTPEELEQ 610 620 630 640 650 660 RNILQPKNEA DRQAEKREIK RRLTRKLSQR PTVAELLARK ILRFNEYVEV TDAQDYDRRA 670 680 690 700 DKPWTKLTPA DKAAIRKELN EFKSSEMEVH EESKHFTRYH RP
	Isoform 2 [UniParc]. Checksum: 3F9C6DE318A7B2F0	FASTA	712	79,129
	10 20 30 40 50 60 MGQADVSRPV NPDAVEEADQ PTTEPGMVLD SVEAGDTTPP TKRKSKFSGF GKIFKPWKWR 70 80 90 100 110 120 KKKSSDKFKE TSEVLERKIS MRKPREELVK RGVLLEDPEQ GGEDPGKPSD AMLKNGHTTP 130 140 150 160 170 180 IGNARSSSPV QVEEEPVRLA SLRKAIPEED LKKRLGSTGS QPNSEAESVP ENVPKPPLLP 190 200 210 220 230 240 PKRPLSSSHE ASEGQAKDAT SSGGTARFII STSITTAPAA TTAATSLAKT VNLSVTPSPA 250 260 270 280 290 300 PRTLPAAPAS TNTTATPSLT HMVPAKQPPI PPPKPAHRNS NPVIAELSQA INSGTLLSKP 310 320 330 340 350 360 SPPLPPKRGI PSTSVPTLES AAAITTKTPS DEREKSTCSM GSELLPMISP RSPSPPLPTH 370 380 390 400 410 420 IPPEPPRTPP FPAKTFQVVP EIEFPPSLDL HQEIPQQEDQ KKEVPKRILD QNFGEPHIPS 430 440 450 460 470 480 RLPPLPLHIR IQQALTSPLP MTPILEGSHR AHSLLFENSD SFSEDSSTLG RTRSLPITIE 490 500 510 520 530 540 MLKVPDDEEE EEQTCPSTFS EEMTPTSVIP KLPQCLREEE EKESDSDSEG PIQYRDEEDE 550 560 570 580 590 600 DESYQSALAN KVKRKDTLAM KLNHRPSEPE LNLNSWPCKS KEEWNEIRHQ IGNTLIRRLS 610 620 630 640 650 660 QRPTPEELEQ RNILQPKNEA DRQAEKREIK RRLTRKLSQR PTVAELLARK ILRFNEYVEV 670 680 690 700 710 TDAQDYDRRA DKPWTKLTPA DKAAIRKELN EFKSSEMEVH EESKHFTRYH RP
	Isoform 3 [UniParc]. Checksum: D08F12D5D26DB362	FASTA	686	76,436
	10 20 30 40 50 60 MVLDSVEAGD TTPPTKRKSK FSGFGKIFKP WKWRKKKSSD KFKETSEVLE RKISMRKPRE 70 80 90 100 110 120 ELVKRGVLLE DPEQGGEDPG KPSDAMLKNG HTTPIGNARS SSPVQVEEEP VRLASLRKAI 130 140 150 160 170 180 PEEDLKKRLG STGSQPNSEA ESVPENVPKP PLLPPKRPLS SSHEASEGQA KDATSSGGTA 190 200 210 220 230 240 RFIISTSITT APAATTAATS LAKTVNLSVT PSPAPRTLPA APASTNTTAT PSLTHMVPAK 250 260 270 280 290 300 QPPIPPPKPA HRNSNPVIAE LSQAINSGTL LSKPSPPLPP KRGIPSTSVP TLESAAAITT 310 320 330 340 350 360 KTPSDEREKS TCSMGSELLP MISPRSPSPP LPTHIPPEPP RTPPFPAKTF QVVPEIEFPP 370 380 390 400 410 420 SLDLHQEIPQ QEDQKKEVPK RILDQNFGEP HIPSRLPPLP LHIRIQQALT SPLPMTPILE 430 440 450 460 470 480 GSHRAHSLLF ENSDSFSEDS STLGRTRSLP ITIEMLKVPD DEEEEEQTCP STFSEEMTPT 490 500 510 520 530 540 SVIPKLPQCL REEEEKESDS DSEGPIQYRD EEDEDESYQS ALANKVKRKD TLAMKLNHRP 550 560 570 580 590 600 SEPELNLNSW PCKSKEEWNE IRHQIGNTLI RRLSQRPTPE ELEQRNILQP KNEADRQAEK 610 620 630 640 650 660 REIKRRLTRK LSQRPTVAEL LARKILRFNE YVEVTDAQDY DRRADKPWTK LTPADKAAIR 670 680 KELNEFKSSE MEVHEESKHF TRYHRP
	Isoform 4 [UniParc]. Checksum: C71BB87679575723	FASTA	63	7,586
	10 20 30 40 50 60 MEDPFDFSRE PWNSRGSRPA HYRARHGPGQ CGSRRHNTSY QKEEQVLRLW QDLQALEMEE KKK

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 271-702 (ISOFORM 1).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Fetal brain.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Tissue: Adrenal cortex, Skin and Testis.
[6]	"Functional prediction of the coding sequences of 75 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Bi J., Zhou G., Dong C., Zai Y., Xu W., Gao F., Liu M., He F. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 365-702 (ISOFORM 1). Tissue: Fetal liver.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-628, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-342; SER-344; THR-358; SER-427; THR-432 AND SER-628, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-628, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-464 AND SER-628, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK023233 mRNA. Translation: BAB14483.1. Different initiation. AK025436 mRNA. Translation: BAB15130.1. Frameshift. CR749449 mRNA. Translation: CAH18286.1. Frameshift. AL670471, CR391992, AL360012 Genomic DNA. Translation: CAM12870.1. CR589951, AL360012, CR391992 Genomic DNA. Translation: CAM12871.1. CH471059 Genomic DNA. Translation: EAX07696.1. CH471059 Genomic DNA. Translation: EAX07698.1. BC021247 mRNA. Translation: AAH21247.3. BC029266 mRNA. Translation: AAH29266.1. BC068508 mRNA. Translation: AAH68508.1. Sequence problems. AF130081 mRNA. Translation: AAG35507.1. Different initiation.
IPI	IPI00217851. IPI00432436. IPI00657967. IPI00845221.
RefSeq	NP_001041648.1. NM_001048183.1. NP_076412.3. NM_023923.3.
UniGene	Hs.225641.
3D structure databases
ProteinModelPortal	Q8IZ21.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47323N.
IntAct	Q8IZ21. 1 interaction.
PTM databases
PhosphoSite	Q8IZ21.
Polymorphism databases
DMDM	74728415.
Proteomic databases
PaxDb	Q8IZ21.
PRIDE	Q8IZ21.
Protocols and materials databases
DNASU	65979.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373836; ENSP00000362942; ENSG00000204138. ENST00000373839; ENSP00000362945; ENSG00000204138.
GeneID	65979.
KEGG	hsa:65979.
UCSC	uc001bpw.3. human. uc001bpy.3. human.
Organism-specific databases
CTD	65979.
GeneCards	GC01P028696.
HGNC	HGNC:25793. PHACTR4.
HPA	HPA028985.
MIM	608726. gene.
neXtProt	NX_Q8IZ21.
PharmGKB	PA134959472.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG275065.
HOVERGEN	HBG108247.
OMA	REKSTCS.
OrthoDB	EOG4PNXH9.
Gene expression databases
Bgee	Q8IZ21.
CleanEx	HS_PHACTR4.
Genevestigator	Q8IZ21.
Family and domain databases
InterPro	IPR004018. RPEL_repeat. [Graphical view]
Pfam	PF02755. RPEL. 3 hits. [Graphical view]
SMART	SM00707. RPEL. 3 hits. [Graphical view]
PROSITE	PS51073. RPEL. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PHACTR4. human.
GenomeRNAi	65979.
NextBio	67423.
PMAP-CutDB	Q8IZ21.
SOURCE	Search...

Entry information

Entry name

PHAR4_HUMAN

Accession

Primary (citable) accession number: Q8IZ21
Secondary accession number(s): A2APK6 , B9ZVW0, D3DPM3, Q68DD4, Q6NUN6, Q8N384, Q9H395, Q9H6X0, Q9H8W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.