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Protein

Tissue-resident T-cell transcription regulator protein ZNF683

Gene

ZNF683

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.By similarity
Isoform 1: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8+ T-cells.1 Publication
Isoform 2: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8+ T cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri322 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue-resident T-cell transcription regulator protein ZNF683Curated
Alternative name(s):
Homolog of Blimp-1 in T-cellBy similarity
Short name:
HobitBy similarity
Zinc finger protein 683Imported
Gene namesi
Name:ZNF683Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28495. ZNF683.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi257101.
OpenTargetsiENSG00000176083.
PharmGKBiPA142670484.

Polymorphism and mutation databases

BioMutaiZNF683.
DMDMi205371859.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340021 – 524Tissue-resident T-cell transcription regulator protein ZNF683Add BLAST524

Proteomic databases

PaxDbiQ8IZ20.
PeptideAtlasiQ8IZ20.
PRIDEiQ8IZ20.

PTM databases

iPTMnetiQ8IZ20.
PhosphoSitePlusiQ8IZ20.

Expressioni

Tissue specificityi

Expressed in terminally differentiated effector CD8+ T-cells, but not in naive and central memory cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells and natural killer (NKT) T-cells (at protein level) (PubMed:26179882). Expressed strongly in effector-type CD8+ T-cells and weakly in naive and memory CD8+ T-cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells (PubMed:26179882). Isoform 2 is strongly expressed in effector CD8+ T and natural killer (NK) cells (PubMed:26179882). Isoform 1 is expressed in effector CD8+ T and natural killer (NK) cells (PubMed:26179882).1 Publication
(Microbial infection) Expressed in cytomegalovirus (CMV)-infected effector CD8+ T-cells (at protein level) (PubMed:20921622).1 Publication

Inductioni

(Microbial infection) Up-regulated by cytomegalovirus (CMV) infection in long-lived effector CD8+ T-cells (PubMed:20921622).1 Publication

Gene expression databases

BgeeiENSG00000176083.
CleanExiHS_ZNF683.
ExpressionAtlasiQ8IZ20. baseline and differential.
GenevisibleiQ8IZ20. HS.

Organism-specific databases

HPAiHPA023865.

Interactioni

Protein-protein interaction databases

IntActiQ8IZ20. 1 interactor.
STRINGi9606.ENSP00000344095.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C2H2-type zinc finger are necessary for DNA-binding (PubMed:26179882).1 Publication

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri322 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2461. Eukaryota.
ENOG410ZFVU. LUCA.
GeneTreeiENSGT00830000128336.
HOGENOMiHOG000155807.
InParanoidiQ8IZ20.
OMAiCASWLCP.
OrthoDBiEOG091G0467.
PhylomeDBiQ8IZ20.
TreeFamiTF316545.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZ20-1) [UniParc]FASTAAdd to basket
Also known as: Extra large, XL1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEESAAQLG CCHRPMALGG TGGSLSPSLD FQLFRGDQVF SACRPLPDMV
60 70 80 90 100
DAHGPSCASW LCPLPLAPGR SALLACLQDL DLNLCTPQPA PLGTDLQGLQ
110 120 130 140 150
EDALSMKHEP PGLQASSTDD KKFTVKYPQN KDKLGKQPER AGEGAPCPAF
160 170 180 190 200
SSHNSSSPPP LQNRKSPSPL AFCPCPPVNS ISKELPFLLH AFYPGYPLLL
210 220 230 240 250
PPPHLFTYGA LPSDQCPHLL MLPQDPSYPT MAMPSLLMMV NELGHPSARW
260 270 280 290 300
ETLLPYPGAF QASGQALPSQ ARNPGAGAAP TDSPGLERGG MASPAKRVPL
310 320 330 340 350
SSQTGTAALP YPLKKKNGKI LYECNICGKS FGQLSNLKVH LRVHSGERPF
360 370 380 390 400
QCALCQKSFT QLAHLQKHHL VHTGERPHKC SIPWVPGRNH WKSFQAWRER
410 420 430 440 450
EVCHKRFSSS SNLKTHLRLH SGARPFQCSV CRSRFTQHIH LKLHHRLHAP
460 470 480 490 500
QPCGLVHTQL PLASLACLAQ WHQGALDLMA VASEKHMGYD IDEVKVSSTS
510 520
QGKARAVSLS SAGTPLVMGQ DQNN
Length:524
Mass (Da):56,905
Last modified:September 2, 2008 - v3
Checksum:iF6D800F2A8EE829A
GO
Isoform 2 (identifier: Q8IZ20-2) [UniParc]FASTAAdd to basket
Also known as: Large, L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     382-401: Missing.

Note: No experimental confirmation available.
Show »
Length:504
Mass (Da):54,343
Checksum:iF98ABF65955604E8
GO

Sequence cautioni

The sequence AAH28731 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH29505 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI15857 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI15858 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05744222G → V.Corresponds to variant rs35040247dbSNPEnsembl.1
Natural variantiVAR_05744348D → G.Corresponds to variant rs10794532dbSNPEnsembl.1
Natural variantiVAR_05744453H → R.Corresponds to variant rs10794531dbSNPEnsembl.1
Natural variantiVAR_026155204H → N.1 PublicationCorresponds to variant rs17852672dbSNPEnsembl.1
Natural variantiVAR_057445288R → L.Corresponds to variant rs11247933dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018167382 – 401Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451139 Genomic DNA. Translation: CAI15853.2.
AL451139 Genomic DNA. Translation: CAI15854.2.
AL451139 Genomic DNA. Translation: CAI15855.2.
AL451139 Genomic DNA. Translation: CAI15856.2.
AL451139 Genomic DNA. Translation: CAI15857.2. Different initiation.
AL451139 Genomic DNA. Translation: CAI15858.2. Different initiation.
BC028731 mRNA. Translation: AAH28731.2. Different initiation.
BC029505 mRNA. Translation: AAH29505.1. Different initiation.
CCDSiCCDS279.2. [Q8IZ20-2]
CCDS76126.1. [Q8IZ20-1]
RefSeqiNP_001108231.1. NM_001114759.2. [Q8IZ20-2]
NP_001294854.1. NM_001307925.1. [Q8IZ20-1]
NP_775845.2. NM_173574.3. [Q8IZ20-2]
XP_005245887.1. XM_005245830.3. [Q8IZ20-1]
XP_005245889.1. XM_005245832.3. [Q8IZ20-1]
XP_011539500.1. XM_011541198.2. [Q8IZ20-1]
UniGeneiHs.353208.

Genome annotation databases

EnsembliENST00000349618; ENSP00000344095; ENSG00000176083. [Q8IZ20-2]
ENST00000403843; ENSP00000384782; ENSG00000176083. [Q8IZ20-1]
ENST00000436292; ENSP00000388792; ENSG00000176083. [Q8IZ20-1]
GeneIDi257101.
KEGGihsa:257101.
UCSCiuc001bmg.2. human. [Q8IZ20-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451139 Genomic DNA. Translation: CAI15853.2.
AL451139 Genomic DNA. Translation: CAI15854.2.
AL451139 Genomic DNA. Translation: CAI15855.2.
AL451139 Genomic DNA. Translation: CAI15856.2.
AL451139 Genomic DNA. Translation: CAI15857.2. Different initiation.
AL451139 Genomic DNA. Translation: CAI15858.2. Different initiation.
BC028731 mRNA. Translation: AAH28731.2. Different initiation.
BC029505 mRNA. Translation: AAH29505.1. Different initiation.
CCDSiCCDS279.2. [Q8IZ20-2]
CCDS76126.1. [Q8IZ20-1]
RefSeqiNP_001108231.1. NM_001114759.2. [Q8IZ20-2]
NP_001294854.1. NM_001307925.1. [Q8IZ20-1]
NP_775845.2. NM_173574.3. [Q8IZ20-2]
XP_005245887.1. XM_005245830.3. [Q8IZ20-1]
XP_005245889.1. XM_005245832.3. [Q8IZ20-1]
XP_011539500.1. XM_011541198.2. [Q8IZ20-1]
UniGeneiHs.353208.

3D structure databases

ProteinModelPortaliQ8IZ20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IZ20. 1 interactor.
STRINGi9606.ENSP00000344095.

PTM databases

iPTMnetiQ8IZ20.
PhosphoSitePlusiQ8IZ20.

Polymorphism and mutation databases

BioMutaiZNF683.
DMDMi205371859.

Proteomic databases

PaxDbiQ8IZ20.
PeptideAtlasiQ8IZ20.
PRIDEiQ8IZ20.

Protocols and materials databases

DNASUi257101.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349618; ENSP00000344095; ENSG00000176083. [Q8IZ20-2]
ENST00000403843; ENSP00000384782; ENSG00000176083. [Q8IZ20-1]
ENST00000436292; ENSP00000388792; ENSG00000176083. [Q8IZ20-1]
GeneIDi257101.
KEGGihsa:257101.
UCSCiuc001bmg.2. human. [Q8IZ20-1]

Organism-specific databases

CTDi257101.
DisGeNETi257101.
GeneCardsiZNF683.
HGNCiHGNC:28495. ZNF683.
HPAiHPA023865.
neXtProtiNX_Q8IZ20.
OpenTargetsiENSG00000176083.
PharmGKBiPA142670484.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2461. Eukaryota.
ENOG410ZFVU. LUCA.
GeneTreeiENSGT00830000128336.
HOGENOMiHOG000155807.
InParanoidiQ8IZ20.
OMAiCASWLCP.
OrthoDBiEOG091G0467.
PhylomeDBiQ8IZ20.
TreeFamiTF316545.

Miscellaneous databases

GenomeRNAii257101.
PROiQ8IZ20.

Gene expression databases

BgeeiENSG00000176083.
CleanExiHS_ZNF683.
ExpressionAtlasiQ8IZ20. baseline and differential.
GenevisibleiQ8IZ20. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN683_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ20
Secondary accession number(s): Q5T141
, Q5T146, Q5T147, Q5T149, Q8NEN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.