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Protein

Protein ZBED8

Gene

ZBED8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZBED8
Alternative name(s):
Transposon-derived Buster3 transposase-like protein
Zinc finger BED domain-containing protein 8
Gene namesi
Name:ZBED8
Synonyms:Buster3, C5orf54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30804. ZBED8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717348.

Polymorphism and mutation databases

BioMutaiZBED8.
DMDMi74728411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Protein ZBED8PRO_0000348452Add
BLAST

Proteomic databases

MaxQBiQ8IZ13.
PaxDbiQ8IZ13.
PRIDEiQ8IZ13.

PTM databases

iPTMnetiQ8IZ13.
PhosphoSiteiQ8IZ13.

Expressioni

Gene expression databases

BgeeiQ8IZ13.
GenevisibleiQ8IZ13. HS.

Organism-specific databases

HPAiHPA045445.
HPA055817.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAB2Q157423EBI-7186123,EBI-8641936

Protein-protein interaction databases

BioGridi121989. 13 interactions.
IntActiQ8IZ13. 8 interactions.
MINTiMINT-8247520.
STRINGi9606.ENSP00000386184.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHXC. Eukaryota.
ENOG410ZSKF. LUCA.
GeneTreeiENSGT00760000119070.
HOGENOMiHOG000253000.
InParanoidiQ8IZ13.
OMAiILMEFET.
OrthoDBiEOG75J0M6.
PhylomeDBiQ8IZ13.
TreeFamiTF328297.

Family and domain databases

InterProiIPR012337. RNaseH-like_dom.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IZ13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKRKWDDD YVRYWFTCTT EVDGTQRPQC VLCNSVFSNA DLRPSKLSDH
60 70 80 90 100
FNRQHGGVAG HDLNSLKHMP APSDQSETLK AFGVASHEDT LLQASYQFAY
110 120 130 140 150
LCAKEKNPHT VAEKLVKPCA LEIAQIVLGP DAQKKLQQVP LSDDVIHSRI
160 170 180 190 200
DEMSQDILQQ VLEDIKASPL KVGIQLAETT DMDDCSQLMA FVRYIKEREI
210 220 230 240 250
VEEFLFCEPL QLSMKGIDVF NLFRDFFLKH KIALDVCGSV CTDGASSMLG
260 270 280 290 300
ENSEFVAYVK KEIPHIVVTH CLLNPHALVI KTLPTKLRDA LFTVVRVINF
310 320 330 340 350
IKGRAPNHRL FQAFFEEIGI EYSVLLFHTE MRWLSRGQIL THIFEMYEEI
360 370 380 390 400
NQFLHHKSSN LVDGFENKEF KIHLAYLADL FKHLNELSAS MQRTGMNTVS
410 420 430 440 450
AREKLSAFVR KFPFWQKRIE KRNFTNFPFL EEIIVSDNEG IFIAAEITLH
460 470 480 490 500
LQQLSNFFHG YFSIGDLNEA SKWILDPFLF NIDFVDDSYL MKNDLAELRA
510 520 530 540 550
SGQILMEFET MKLEDFWCAQ FTAFPNLAKT ALEILMPFAT TYLCELGFSS
560 570 580 590
LLHFKTKSRS CFNLSDDIRV AISKKVPRFS DIIEQKLQLQ QKSL
Length:594
Mass (Da):68,327
Last modified:March 1, 2003 - v1
Checksum:iC786B19C80B75263
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631L → F in AAF18452 (PubMed:10607616).Curated
Sequence conflicti556 – 5561T → P in BAB15542 (PubMed:14702039).Curated
Sequence conflicti584 – 5841E → D in BAB15542 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti523 – 5231A → S.
Corresponds to variant rs10515808 [ dbSNP | Ensembl ].
VAR_046179

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205598 Genomic DNA. Translation: AAF18452.1.
AK026754 mRNA. Translation: BAB15542.1.
CH471062 Genomic DNA. Translation: EAW61557.1.
CH471062 Genomic DNA. Translation: EAW61558.1.
CH471062 Genomic DNA. Translation: EAW61559.1.
CH471062 Genomic DNA. Translation: EAW61560.1.
BC032603 mRNA. Translation: AAH32603.1.
BC112128 mRNA. Translation: AAI12129.1.
BC112130 mRNA. Translation: AAI12131.1.
CCDSiCCDS34283.1.
RefSeqiNP_001290180.1. NM_001303251.1.
NP_071373.2. NM_022090.4.
UniGeneiHs.529464.

Genome annotation databases

EnsembliENST00000408953; ENSP00000386184; ENSG00000221886.
ENST00000523213; ENSP00000428831; ENSG00000221886.
GeneIDi63920.
KEGGihsa:63920.
UCSCiuc003lye.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205598 Genomic DNA. Translation: AAF18452.1.
AK026754 mRNA. Translation: BAB15542.1.
CH471062 Genomic DNA. Translation: EAW61557.1.
CH471062 Genomic DNA. Translation: EAW61558.1.
CH471062 Genomic DNA. Translation: EAW61559.1.
CH471062 Genomic DNA. Translation: EAW61560.1.
BC032603 mRNA. Translation: AAH32603.1.
BC112128 mRNA. Translation: AAI12129.1.
BC112130 mRNA. Translation: AAI12131.1.
CCDSiCCDS34283.1.
RefSeqiNP_001290180.1. NM_001303251.1.
NP_071373.2. NM_022090.4.
UniGeneiHs.529464.

3D structure databases

ProteinModelPortaliQ8IZ13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121989. 13 interactions.
IntActiQ8IZ13. 8 interactions.
MINTiMINT-8247520.
STRINGi9606.ENSP00000386184.

PTM databases

iPTMnetiQ8IZ13.
PhosphoSiteiQ8IZ13.

Polymorphism and mutation databases

BioMutaiZBED8.
DMDMi74728411.

Proteomic databases

MaxQBiQ8IZ13.
PaxDbiQ8IZ13.
PRIDEiQ8IZ13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408953; ENSP00000386184; ENSG00000221886.
ENST00000523213; ENSP00000428831; ENSG00000221886.
GeneIDi63920.
KEGGihsa:63920.
UCSCiuc003lye.2. human.

Organism-specific databases

CTDi63920.
GeneCardsiZBED8.
HGNCiHGNC:30804. ZBED8.
HPAiHPA045445.
HPA055817.
MIMi615253. gene.
neXtProtiNX_Q8IZ13.
PharmGKBiPA164717348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHXC. Eukaryota.
ENOG410ZSKF. LUCA.
GeneTreeiENSGT00760000119070.
HOGENOMiHOG000253000.
InParanoidiQ8IZ13.
OMAiILMEFET.
OrthoDBiEOG75J0M6.
PhylomeDBiQ8IZ13.
TreeFamiTF328297.

Miscellaneous databases

ChiTaRSiC5orf54. human.
GenomeRNAii63920.
PROiQ8IZ13.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZ13.
GenevisibleiQ8IZ13. HS.

Family and domain databases

InterProiIPR012337. RNaseH-like_dom.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interspersed repeats and other mementos of transposable elements in mammalian genomes."
    Smit A.F.A.
    Curr. Opin. Genet. Dev. 9:657-663(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Leiomyosarcoma and Lung.
  5. "ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions."
    Hayward A., Ghazal A., Andersson G., Andersson L., Jern P.
    PLoS ONE 8:E59940-E59940(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: EVOLUTIONARY RELATIONSHIP WITH ZBED6, MISCELLANEOUS.

Entry informationi

Entry nameiZBED8_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ13
Secondary accession number(s): D3DQJ9, Q9H5S8, Q9UH87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.