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Protein

Probable G-protein coupled receptor 135

Gene

GPR135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 135
Gene namesi
Name:GPR135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19991. GPR135.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei13 – 3321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini34 – 374CytoplasmicSequence Analysis
Transmembranei38 – 5821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini59 – 8123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini103 – 12523CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini147 – 16418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini186 – 22641CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini248 – 26215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 494211CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863427.

Polymorphism and mutation databases

BioMutaiGPR135.
DMDMi62900365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Probable G-protein coupled receptor 135PRO_0000069612Add
BLAST

Proteomic databases

PaxDbiQ8IZ08.
PRIDEiQ8IZ08.

PTM databases

PhosphoSiteiQ8IZ08.

Expressioni

Gene expression databases

BgeeiQ8IZ08.
CleanExiHS_GPR135.
GenevestigatoriQ8IZ08.

Organism-specific databases

HPAiHPA045337.

Interactioni

Protein-protein interaction databases

BioGridi122207. 3 interactions.
IntActiQ8IZ08. 3 interactions.
MINTiMINT-1400777.
STRINGi9606.ENSP00000352377.

Structurei

3D structure databases

ProteinModelPortaliQ8IZ08.
SMRiQ8IZ08. Positions 109-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282328.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000001555.
HOVERGENiHBG051780.
InParanoidiQ8IZ08.
KOiK08427.
OMAiLGNCAVM.
OrthoDBiEOG7HQN8R.
PhylomeDBiQ8IZ08.
TreeFamiTF333332.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA
60 70 80 90 100
ALGNLSDASG GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG
110 120 130 140 150
AAVAAQALVL LLIFLLSSLG NCAVMGVIVK HRQLRTVTNA FILSLSLSDL
160 170 180 190 200
LTALLCLPAA FLDLFTPPGG SAPAAAAGPW RGFCAASRFF SSCFGIVSTL
210 220 230 240 250
SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF SLPWELLGAP
260 270 280 290 300
RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI
310 320 330 340 350
CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL
360 370 380 390 400
VLLAAARQAQ TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR
410 420 430 440 450
NREEGYRTRN VDAFLPSQGP GLQARSRSRL RNRYANRLGA CNRMSSSNPA
460 470 480 490
SGVAGDVAMW ARKNPVVLFC REGPPEPVTA VTKQPKSEAG DTSL
Length:494
Mass (Da):51,736
Last modified:November 23, 2004 - v2
Checksum:i439A932E2860D4DF
GO

Sequence cautioni

The sequence BAC05800.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51Q → P.
Corresponds to variant rs1752428 [ dbSNP | Ensembl ].
VAR_024259
Natural varianti481 – 4811V → A.
Corresponds to variant rs1752427 [ dbSNP | Ensembl ].
VAR_049402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288418 mRNA. Translation: AAP72127.1.
AB065563 Genomic DNA. Translation: BAC05800.1. Sequence problems.
BC032831 mRNA. Translation: AAH32831.2.
AY255588 mRNA. Translation: AAO85100.1.
CCDSiCCDS9738.1.
RefSeqiNP_072093.2. NM_022571.5.
UniGeneiHs.647573.

Genome annotation databases

EnsembliENST00000395116; ENSP00000378548; ENSG00000181619.
ENST00000481661; ENSP00000432696; ENSG00000181619.
GeneIDi64582.
KEGGihsa:64582.
UCSCiuc010apj.3. human.

Polymorphism and mutation databases

BioMutaiGPR135.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288418 mRNA. Translation: AAP72127.1.
AB065563 Genomic DNA. Translation: BAC05800.1. Sequence problems.
BC032831 mRNA. Translation: AAH32831.2.
AY255588 mRNA. Translation: AAO85100.1.
CCDSiCCDS9738.1.
RefSeqiNP_072093.2. NM_022571.5.
UniGeneiHs.647573.

3D structure databases

ProteinModelPortaliQ8IZ08.
SMRiQ8IZ08. Positions 109-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122207. 3 interactions.
IntActiQ8IZ08. 3 interactions.
MINTiMINT-1400777.
STRINGi9606.ENSP00000352377.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8IZ08.

Polymorphism and mutation databases

BioMutaiGPR135.
DMDMi62900365.

Proteomic databases

PaxDbiQ8IZ08.
PRIDEiQ8IZ08.

Protocols and materials databases

DNASUi64582.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395116; ENSP00000378548; ENSG00000181619.
ENST00000481661; ENSP00000432696; ENSG00000181619.
GeneIDi64582.
KEGGihsa:64582.
UCSCiuc010apj.3. human.

Organism-specific databases

CTDi64582.
GeneCardsiGC14M059895.
HGNCiHGNC:19991. GPR135.
HPAiHPA045337.
MIMi607970. gene.
neXtProtiNX_Q8IZ08.
PharmGKBiPA134863427.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG282328.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000001555.
HOVERGENiHBG051780.
InParanoidiQ8IZ08.
KOiK08427.
OMAiLGNCAVM.
OrthoDBiEOG7HQN8R.
PhylomeDBiQ8IZ08.
TreeFamiTF333332.

Miscellaneous databases

GeneWikiiGPR135.
GenomeRNAii64582.
NextBioi66531.
PROiQ8IZ08.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZ08.
CleanExiHS_GPR135.
GenevestigatoriQ8IZ08.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-280.

Entry informationi

Entry nameiGP135_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ08
Secondary accession number(s): Q7Z604, Q86SM3, Q8NH39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: April 29, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.