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Q8IZ08

- GP135_HUMAN

UniProt

Q8IZ08 - GP135_HUMAN

Protein

Probable G-protein coupled receptor 135

Gene

GPR135

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 135
    Gene namesi
    Name:GPR135
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19991. GPR135.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134863427.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Probable G-protein coupled receptor 135PRO_0000069612Add
    BLAST

    Proteomic databases

    PaxDbiQ8IZ08.
    PRIDEiQ8IZ08.

    PTM databases

    PhosphoSiteiQ8IZ08.

    Expressioni

    Gene expression databases

    BgeeiQ8IZ08.
    CleanExiHS_GPR135.
    GenevestigatoriQ8IZ08.

    Organism-specific databases

    HPAiHPA045337.

    Interactioni

    Protein-protein interaction databases

    BioGridi122207. 2 interactions.
    IntActiQ8IZ08. 3 interactions.
    MINTiMINT-1400777.
    STRINGi9606.ENSP00000352377.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZ08.
    SMRiQ8IZ08. Positions 109-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini34 – 374CytoplasmicSequence Analysis
    Topological domaini59 – 8123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 16418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini186 – 22641CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 494211CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG282328.
    HOGENOMiHOG000001555.
    HOVERGENiHBG051780.
    InParanoidiQ8IZ08.
    KOiK08427.
    OMAiLGNCAVM.
    OrthoDBiEOG7HQN8R.
    PhylomeDBiQ8IZ08.
    TreeFamiTF333332.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZ08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA    50
    ALGNLSDASG GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG 100
    AAVAAQALVL LLIFLLSSLG NCAVMGVIVK HRQLRTVTNA FILSLSLSDL 150
    LTALLCLPAA FLDLFTPPGG SAPAAAAGPW RGFCAASRFF SSCFGIVSTL 200
    SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF SLPWELLGAP 250
    RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI 300
    CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL 350
    VLLAAARQAQ TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR 400
    NREEGYRTRN VDAFLPSQGP GLQARSRSRL RNRYANRLGA CNRMSSSNPA 450
    SGVAGDVAMW ARKNPVVLFC REGPPEPVTA VTKQPKSEAG DTSL 494
    Length:494
    Mass (Da):51,736
    Last modified:November 23, 2004 - v2
    Checksum:i439A932E2860D4DF
    GO

    Sequence cautioni

    The sequence BAC05800.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51Q → P.
    Corresponds to variant rs1752428 [ dbSNP | Ensembl ].
    VAR_024259
    Natural varianti481 – 4811V → A.
    Corresponds to variant rs1752427 [ dbSNP | Ensembl ].
    VAR_049402

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288418 mRNA. Translation: AAP72127.1.
    AB065563 Genomic DNA. Translation: BAC05800.1. Sequence problems.
    BC032831 mRNA. Translation: AAH32831.2.
    AY255588 mRNA. Translation: AAO85100.1.
    CCDSiCCDS9738.1.
    RefSeqiNP_072093.2. NM_022571.5.
    UniGeneiHs.647573.

    Genome annotation databases

    EnsembliENST00000395116; ENSP00000378548; ENSG00000181619.
    ENST00000481661; ENSP00000432696; ENSG00000181619.
    GeneIDi64582.
    KEGGihsa:64582.
    UCSCiuc010apj.3. human.

    Polymorphism databases

    DMDMi62900365.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288418 mRNA. Translation: AAP72127.1 .
    AB065563 Genomic DNA. Translation: BAC05800.1 . Sequence problems.
    BC032831 mRNA. Translation: AAH32831.2 .
    AY255588 mRNA. Translation: AAO85100.1 .
    CCDSi CCDS9738.1.
    RefSeqi NP_072093.2. NM_022571.5.
    UniGenei Hs.647573.

    3D structure databases

    ProteinModelPortali Q8IZ08.
    SMRi Q8IZ08. Positions 109-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122207. 2 interactions.
    IntActi Q8IZ08. 3 interactions.
    MINTi MINT-1400777.
    STRINGi 9606.ENSP00000352377.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IZ08.

    Polymorphism databases

    DMDMi 62900365.

    Proteomic databases

    PaxDbi Q8IZ08.
    PRIDEi Q8IZ08.

    Protocols and materials databases

    DNASUi 64582.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395116 ; ENSP00000378548 ; ENSG00000181619 .
    ENST00000481661 ; ENSP00000432696 ; ENSG00000181619 .
    GeneIDi 64582.
    KEGGi hsa:64582.
    UCSCi uc010apj.3. human.

    Organism-specific databases

    CTDi 64582.
    GeneCardsi GC14M059895.
    HGNCi HGNC:19991. GPR135.
    HPAi HPA045337.
    MIMi 607970. gene.
    neXtProti NX_Q8IZ08.
    PharmGKBi PA134863427.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282328.
    HOGENOMi HOG000001555.
    HOVERGENi HBG051780.
    InParanoidi Q8IZ08.
    KOi K08427.
    OMAi LGNCAVM.
    OrthoDBi EOG7HQN8R.
    PhylomeDBi Q8IZ08.
    TreeFami TF333332.

    Miscellaneous databases

    GeneWikii GPR135.
    GenomeRNAii 64582.
    NextBioi 66531.
    PROi Q8IZ08.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IZ08.
    CleanExi HS_GPR135.
    Genevestigatori Q8IZ08.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-280.

    Entry informationi

    Entry nameiGP135_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZ08
    Secondary accession number(s): Q7Z604, Q86SM3, Q8NH39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3