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Q8IZ08 (GP135_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 135
Gene names
Name:GPR135
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05800.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Probable G-protein coupled receptor 135
PRO_0000069612

Regions

Topological domain1 – 1212Extracellular Potential
Transmembrane13 – 3321Helical; Name=1; Potential
Topological domain34 – 374Cytoplasmic Potential
Transmembrane38 – 5821Helical; Name=2; Potential
Topological domain59 – 8123Extracellular Potential
Transmembrane82 – 10221Helical; Name=3; Potential
Topological domain103 – 12523Cytoplasmic Potential
Transmembrane126 – 14621Helical; Name=4; Potential
Topological domain147 – 16418Extracellular Potential
Transmembrane165 – 18521Helical; Name=5; Potential
Topological domain186 – 22641Cytoplasmic Potential
Transmembrane227 – 24721Helical; Name=6; Potential
Topological domain248 – 26215Extracellular Potential
Transmembrane263 – 28321Helical; Name=7; Potential
Topological domain284 – 494211Cytoplasmic Potential

Natural variations

Natural variant51Q → P.
Corresponds to variant rs1752428 [ dbSNP | Ensembl ].
VAR_024259
Natural variant4811V → A.
Corresponds to variant rs1752427 [ dbSNP | Ensembl ].
VAR_049402

Sequences

Sequence LengthMass (Da)Tools
Q8IZ08 [UniParc].

Last modified November 23, 2004. Version 2.
Checksum: 439A932E2860D4DF

FASTA49451,736
        10         20         30         40         50         60 
MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA ALGNLSDASG 

        70         80         90        100        110        120 
GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG AAVAAQALVL LLIFLLSSLG 

       130        140        150        160        170        180 
NCAVMGVIVK HRQLRTVTNA FILSLSLSDL LTALLCLPAA FLDLFTPPGG SAPAAAAGPW 

       190        200        210        220        230        240 
RGFCAASRFF SSCFGIVSTL SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF 

       250        260        270        280        290        300 
SLPWELLGAP RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI 

       310        320        330        340        350        360 
CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL VLLAAARQAQ 

       370        380        390        400        410        420 
TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR NREEGYRTRN VDAFLPSQGP 

       430        440        450        460        470        480 
GLQARSRSRL RNRYANRLGA CNRMSSSNPA SGVAGDVAMW ARKNPVVLFC REGPPEPVTA 

       490 
VTKQPKSEAG DTSL 

« Hide

References

« Hide 'large scale' references
[1]"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-280.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY288418 mRNA. Translation: AAP72127.1.
AB065563 Genomic DNA. Translation: BAC05800.1. Sequence problems.
BC032831 mRNA. Translation: AAH32831.2.
AY255588 mRNA. Translation: AAO85100.1.
CCDSCCDS9738.1.
RefSeqNP_072093.2. NM_022571.5.
UniGeneHs.647573.

3D structure databases

ProteinModelPortalQ8IZ08.
SMRQ8IZ08. Positions 109-390.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122207. 2 interactions.
IntActQ8IZ08. 3 interactions.
MINTMINT-1400777.
STRING9606.ENSP00000352377.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8IZ08.

Polymorphism databases

DMDM62900365.

Proteomic databases

PaxDbQ8IZ08.
PRIDEQ8IZ08.

Protocols and materials databases

DNASU64582.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395116; ENSP00000378548; ENSG00000181619.
ENST00000481661; ENSP00000432696; ENSG00000181619.
GeneID64582.
KEGGhsa:64582.
UCSCuc010apj.3. human.

Organism-specific databases

CTD64582.
GeneCardsGC14M059895.
HGNCHGNC:19991. GPR135.
HPAHPA045337.
MIM607970. gene.
neXtProtNX_Q8IZ08.
PharmGKBPA134863427.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282328.
HOGENOMHOG000001555.
HOVERGENHBG051780.
InParanoidQ8IZ08.
KOK08427.
OMALGNCAVM.
OrthoDBEOG7HQN8R.
PhylomeDBQ8IZ08.
TreeFamTF333332.

Gene expression databases

BgeeQ8IZ08.
CleanExHS_GPR135.
GenevestigatorQ8IZ08.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR135.
GenomeRNAi64582.
NextBio66531.
PROQ8IZ08.
SOURCESearch...

Entry information

Entry nameGP135_HUMAN
AccessionPrimary (citable) accession number: Q8IZ08
Secondary accession number(s): Q7Z604, Q86SM3, Q8NH39
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries