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Protein

G-protein coupled receptor 135

Gene

GPR135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).1 Publication

GO - Molecular functioni

  • arrestin family protein binding Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 135Curated
Gene namesi
Name:GPR135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000181619.11
HGNCiHGNC:19991 GPR135
MIMi607970 gene
neXtProtiNX_Q8IZ08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12ExtracellularSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini34 – 37CytoplasmicSequence analysis4
Transmembranei38 – 58Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 125CytoplasmicSequence analysisAdd BLAST23
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 164ExtracellularSequence analysisAdd BLAST18
Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini186 – 226CytoplasmicSequence analysisAdd BLAST41
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 262ExtracellularSequence analysisAdd BLAST15
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 494CytoplasmicSequence analysisAdd BLAST211

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64582
OpenTargetsiENSG00000181619
PharmGKBiPA134863427

Chemistry databases

ChEMBLiCHEMBL3309102

Polymorphism and mutation databases

BioMutaiGPR135
DMDMi62900365

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696121 – 494G-protein coupled receptor 135Add BLAST494

Proteomic databases

EPDiQ8IZ08
PaxDbiQ8IZ08
PeptideAtlasiQ8IZ08
PRIDEiQ8IZ08
ProteomicsDBi71266

PTM databases

iPTMnetiQ8IZ08
PhosphoSitePlusiQ8IZ08

Expressioni

Gene expression databases

BgeeiENSG00000181619
CleanExiHS_GPR135
GenevisibleiQ8IZ08 HS

Organism-specific databases

HPAiHPA045337

Interactioni

Subunit structurei

Interacts with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR135 in the endosomal compartment (PubMed:28827538).1 Publication

GO - Molecular functioni

  • arrestin family protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122207, 3 interactors
IntActiQ8IZ08, 3 interactors
STRINGi9606.ENSP00000378548

Chemistry databases

BindingDBiQ8IZ08

Structurei

3D structure databases

ProteinModelPortaliQ8IZ08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000001555
HOVERGENiHBG051780
InParanoidiQ8IZ08
KOiK08427
OMAiLGNCAVM
OrthoDBiEOG091G0FMJ
PhylomeDBiQ8IZ08
TreeFamiTF333332

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IZ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA
60 70 80 90 100
ALGNLSDASG GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG
110 120 130 140 150
AAVAAQALVL LLIFLLSSLG NCAVMGVIVK HRQLRTVTNA FILSLSLSDL
160 170 180 190 200
LTALLCLPAA FLDLFTPPGG SAPAAAAGPW RGFCAASRFF SSCFGIVSTL
210 220 230 240 250
SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF SLPWELLGAP
260 270 280 290 300
RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI
310 320 330 340 350
CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL
360 370 380 390 400
VLLAAARQAQ TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR
410 420 430 440 450
NREEGYRTRN VDAFLPSQGP GLQARSRSRL RNRYANRLGA CNRMSSSNPA
460 470 480 490
SGVAGDVAMW ARKNPVVLFC REGPPEPVTA VTKQPKSEAG DTSL
Length:494
Mass (Da):51,736
Last modified:November 23, 2004 - v2
Checksum:i439A932E2860D4DF
GO

Sequence cautioni

The sequence BAC05800 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0242595Q → P. Corresponds to variant dbSNP:rs1752428Ensembl.1
Natural variantiVAR_049402481V → A. Corresponds to variant dbSNP:rs1752427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288418 mRNA Translation: AAP72127.1
AB065563 Genomic DNA Translation: BAC05800.1 Sequence problems.
AL159140 Genomic DNA No translation available.
BC032831 mRNA Translation: AAH32831.2
AY255588 mRNA Translation: AAO85100.1
CCDSiCCDS9738.1
RefSeqiNP_072093.2, NM_022571.5
XP_016877085.1, XM_017021596.1
XP_016877086.1, XM_017021597.1
XP_016877087.1, XM_017021598.1
XP_016877088.1, XM_017021599.1
UniGeneiHs.647573
Hs.648823

Genome annotation databases

EnsembliENST00000395116; ENSP00000378548; ENSG00000181619
ENST00000481661; ENSP00000432696; ENSG00000181619
GeneIDi64582
KEGGihsa:64582
UCSCiuc001xed.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGP135_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ08
Secondary accession number(s): Q7Z604, Q86SM3, Q8NH39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: June 20, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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