Q8IZ08 (GP135_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 135

Gene names

Name:

GPR135

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAC05800.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Probable G-protein coupled receptor 135		PRO_0000069612
Regions
	Topological domain	1 – 12	12	Extracellular Potential
	Transmembrane	13 – 33	21	Helical; Name=1; Potential
	Topological domain	34 – 37	4	Cytoplasmic Potential
	Transmembrane	38 – 58	21	Helical; Name=2; Potential
	Topological domain	59 – 81	23	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Name=3; Potential
	Topological domain	103 – 125	23	Cytoplasmic Potential
	Transmembrane	126 – 146	21	Helical; Name=4; Potential
	Topological domain	147 – 164	18	Extracellular Potential
	Transmembrane	165 – 185	21	Helical; Name=5; Potential
	Topological domain	186 – 226	41	Cytoplasmic Potential
	Transmembrane	227 – 247	21	Helical; Name=6; Potential
	Topological domain	248 – 262	15	Extracellular Potential
	Transmembrane	263 – 283	21	Helical; Name=7; Potential
	Topological domain	284 – 494	211	Cytoplasmic Potential
Natural variations
	Natural variant	5	1	Q → P. Corresponds to variant rs1752428 [ dbSNP | Ensembl ].		VAR_024259
	Natural variant	481	1	V → A. Corresponds to variant rs1752427 [ dbSNP | Ensembl ].		VAR_049402

Sequences

	Sequence		Length	Mass (Da)
	Q8IZ08 [UniParc]. Last modified November 23, 2004. Version 2. Checksum: 439A932E2860D4DF	FASTA	494	51,736
	10 20 30 40 50 60 MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA ALGNLSDASG 70 80 90 100 110 120 GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG AAVAAQALVL LLIFLLSSLG 130 140 150 160 170 180 NCAVMGVIVK HRQLRTVTNA FILSLSLSDL LTALLCLPAA FLDLFTPPGG SAPAAAAGPW 190 200 210 220 230 240 RGFCAASRFF SSCFGIVSTL SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF 250 260 270 280 290 300 SLPWELLGAP RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI 310 320 330 340 350 360 CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL VLLAAARQAQ 370 380 390 400 410 420 TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR NREEGYRTRN VDAFLPSQGP 430 440 450 460 470 480 GLQARSRSRL RNRYANRLGA CNRMSSSNPA SGVAGDVAMW ARKNPVVLFC REGPPEPVTA 490 VTKQPKSEAG DTSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives." Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B. FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-280.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY288418 mRNA. Translation: AAP72127.1. AB065563 Genomic DNA. Translation: BAC05800.1. Sequence problems. BC032831 mRNA. Translation: AAH32831.2. AY255588 mRNA. Translation: AAO85100.1.
IPI	IPI00478110.
RefSeq	NP_072093.2. NM_022571.5.
UniGene	Hs.647573.
3D structure databases
ProteinModelPortal	Q8IZ08.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZ08. 2 interactions.
MINT	MINT-1400777.
STRING	9606.ENSP00000352377.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8IZ08.
Polymorphism databases
DMDM	62900365.
Proteomic databases
PaxDb	Q8IZ08.
PRIDE	Q8IZ08.
Protocols and materials databases
DNASU	64582.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395116; ENSP00000378548; ENSG00000181619. ENST00000481661; ENSP00000432696; ENSG00000181619.
GeneID	64582.
KEGG	hsa:64582.
UCSC	uc010apj.3. human.
Organism-specific databases
CTD	64582.
GeneCards	GC14M059895.
HGNC	HGNC:19991. GPR135.
HPA	HPA045337.
MIM	607970. gene.
neXtProt	NX_Q8IZ08.
PharmGKB	PA134863427.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG282328.
HOGENOM	HOG000001555.
HOVERGEN	HBG051780.
InParanoid	Q8IZ08.
KO	K08427.
OMA	LGNCAVM.
OrthoDB	EOG4VX25G.
PhylomeDB	Q8IZ08.
Gene expression databases
Bgee	Q8IZ08.
CleanEx	HS_GPR135.
Genevestigator	Q8IZ08.
GermOnline	ENSG00000181619. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	64582.
NextBio	66531.
SOURCE	Search...

Entry information

Entry name

GP135_HUMAN

Accession

Primary (citable) accession number: Q8IZ08
Secondary accession number(s): Q7Z604, Q86SM3, Q8NH39

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.