Q8IZ07 (AN13A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 13A

Alternative name(s):
Protein KE03

Gene names

Name:	ANKRD13A
Synonyms:	ANKRD13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	590 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Contains 2 ANK repeats. Contains 3 UIM (ubiquitin-interacting motif) repeats.
Sequence caution	The sequence AAC17109.1 differs from that shown. Reason: Frameshift at positions 343 and 348.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 590	590	Ankyrin repeat domain-containing protein 13A		PRO_0000066909
Regions
	Repeat	40 – 69	30	ANK 1
	Repeat	73 – 102	30	ANK 2
	Repeat	519 – 538	20	UIM 1
	Repeat	549 – 568	20	UIM 2
	Repeat	574 – 590	17	UIM 3
Amino acid modifications
	Modified residue	205	1	Phosphoserine By similarity
Natural variations
	Natural variant	505	1	L → P. Corresponds to variant rs2287174 [ dbSNP | Ensembl ].		VAR_048276
Experimental info
	Sequence conflict	193	1	D → G in AAC17109. Ref.2
	Sequence conflict	296	1	D → G in AAH32833. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8IZ07 [UniParc]. Last modified April 17, 2007. Version 3. Checksum: 25D0B712D1A1B0B9	FASTA	590	67,619
	10 20 30 40 50 60 MSSACDAGDH YPLHLLVWKN DYRQLEKELQ GQNVEAVDPR GRTLLHLAVS LGHLESARVL 70 80 90 100 110 120 LRHKADVTKE NRQGWTVLHE AVSTGDPEMV YTVLQHRDYH NTSMALEGVP ELLQKILEAP 130 140 150 160 170 180 DFYVQMKWEF TSWVPLVSRI CPNDVCRIWK SGAKLRVDIT LLGFENMSWI RGRRSFIFKG 190 200 210 220 230 240 EDNWAELMEV NHDDKVVTTE RFDLSQEMER LTLDLMKPKS REVERRLTSP VINTSLDTKN 250 260 270 280 290 300 IAFERTKSGF WGWRTDKAEV VNGYEAKVYT VNNVNVITKI RTEHLTEEEK KRYKADRNPL 310 320 330 340 350 360 ESLLGTVEHQ FGAQGDLTTE CATANNPTAI TPDEYFNEEF DLKDRDIGRP KELTIRTQKF 370 380 390 400 410 420 KAMLWMCEEF PLSLVEQVIP IIDLMARTSA HFARLRDFIK LEFPPGFPVK IEIPLFHVLN 430 440 450 460 470 480 ARITFGNVNG CSTAEESVSQ NVEGTQADSA SHITNFEVDQ SVFEIPESYY VQDNGRNVHL 490 500 510 520 530 540 QDEDYEIMQF AIQQSLLESS RSQELSGPAS NGGISQTNTY DAQYERAIQE SLLTSTEGLC 550 560 570 580 590 PSALSETSRF DNDLQLAMEL SAKELEEWEL RLQEEEAELQ QVLQLSLTDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"A novel gene from human dendritic cells." Zhao Z., Huang X., Li N., Zhu X., Cao X. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-353. Tissue: Blood.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC032833 mRNA. Translation: AAH32833.2. AF064604 mRNA. Translation: AAC17109.1. Frameshift.
IPI	IPI00217831.
RefSeq	NP_149112.1. NM_033121.1.
UniGene	Hs.528703.
3D structure databases
ProteinModelPortal	Q8IZ07.
SMR	Q8IZ07. Positions 12-95.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZ07. 1 interaction.
MINT	MINT-1191854.
PTM databases
PhosphoSite	Q8IZ07.
Polymorphism databases
DMDM	145559439.
Proteomic databases
PRIDE	Q8IZ07.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261739; ENSP00000261739; ENSG00000076513.
GeneID	88455.
KEGG	hsa:88455.
UCSC	uc001tpx.1. human.
Organism-specific databases
CTD	88455.
GeneCards	GC12P110437.
HGNC	HGNC:21268. ANKRD13A.
HPA	HPA039488.
neXtProt	NX_Q8IZ07.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15111.
GeneTree	ENSGT00410000025381.
HOGENOM	HBG444157.
HOVERGEN	HBG059287.
InParanoid	Q8IZ07.
OMA	VVIRTRT.
OrthoDB	EOG45X7VR.
PhylomeDB	Q8IZ07.
Gene expression databases
ArrayExpress	Q8IZ07.
Bgee	Q8IZ07.
CleanEx	HS_ANKRD13A.
Genevestigator	Q8IZ07.
GermOnline	ENSG00000076513. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR021832. DUF3424. IPR003903. Ubiquitin-int_motif. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 1 hit. PF11904. DUF3424. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. SM00726. UIM. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50330. UIM. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	76216.

Entry information

Entry name

AN13A_HUMAN

Accession

Primary (citable) accession number: Q8IZ07
Secondary accession number(s): O60736

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	April 17, 2007
Last modified:	January 25, 2012
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.