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Protein

Centrosomal protein CEP57L1

Gene

CEP57L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Centrosomal protein which may be required for microtubule attachment to centrosomes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein CEP57L1
Alternative name(s):
Centrosomal protein 57kDa-like protein 1
Centrosomal protein of 57 kDa-related protein
Short name:
Cep57R
Cep57-related protein
Gene namesi
Name:CEP57L1
Synonyms:C6orf182, CEP57R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21561. CEP57L1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980921.

Polymorphism and mutation databases

BioMutaiCEP57L1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Centrosomal protein CEP57L1PRO_0000189534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IYX8.
PaxDbiQ8IYX8.
PeptideAtlasiQ8IYX8.
PRIDEiQ8IYX8.

PTM databases

iPTMnetiQ8IYX8.
PhosphoSiteiQ8IYX8.

Expressioni

Gene expression databases

BgeeiQ8IYX8.
CleanExiHS_C6orf182.
ExpressionAtlasiQ8IYX8. baseline and differential.
GenevisibleiQ8IYX8. HS.

Organism-specific databases

HPAiHPA040378.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6143EBI-10181988,EBI-10249899
ALOX5P099173EBI-10181988,EBI-79934
AP1M1Q9BXS53EBI-10181988,EBI-541426
BYSLQ138955EBI-10181988,EBI-358049
C6orf165Q8IYR03EBI-10181988,EBI-749051
CALCOCO2Q131373EBI-1104570,EBI-739580
CARD9Q9H2573EBI-10181988,EBI-751319
CCDC102BA1A4H13EBI-10181988,EBI-10171570
CCDC136Q96JN2-23EBI-1104570,EBI-10171416
CCDC57Q2TAC23EBI-10181988,EBI-2808286
CDR2Q018503EBI-10181988,EBI-1181367
CEP44Q9C0F13EBI-10181988,EBI-744115
CEP55D3DR373EBI-10181988,EBI-10173536
CEP57L1Q8IYX8-23EBI-1104570,EBI-10181988
CEP63Q96MT83EBI-1104570,EBI-741977
CEP70Q8NHQ13EBI-1104570,EBI-739624
DKFZp451B226Q5HYH73EBI-10181988,EBI-10173842
DYDC1Q8WWB33EBI-10181988,EBI-740680
EXOC8Q8IYI63EBI-10181988,EBI-742102
FAM161AQ3B8203EBI-10181988,EBI-719941
FAM9BQ8IZU03EBI-10181988,EBI-10175124
GADD45GO952573EBI-10181988,EBI-448202
GOLGA1Q928053EBI-10181988,EBI-6164177
GOLGA2Q083793EBI-1104570,EBI-618309
HAUS1Q96CS23EBI-10181988,EBI-2514791
HDDC3Q8N4P33EBI-10181988,EBI-750003
HGSO149643EBI-10181988,EBI-740220
IKZF1Q134223EBI-10181988,EBI-745305
KATNAL1Q9BW623EBI-1104570,EBI-743591
KIFC3Q9BVG83EBI-10181988,EBI-2125614
KLC3Q6P5973EBI-10181988,EBI-1643885
KLC4Q9NSK03EBI-10181988,EBI-949319
KRT13A1A4E93EBI-10181988,EBI-10171552
KRT19P087273EBI-10181988,EBI-742756
KRT31Q153233EBI-1104570,EBI-948001
KRT38O760153EBI-10181988,EBI-1047263
KRT40Q6A1623EBI-1104570,EBI-10171697
LENG1Q96BZ83EBI-10181988,EBI-726510
LMO3Q8TAP43EBI-10181988,EBI-742259
LZTS2Q9BRK43EBI-10181988,EBI-741037
MAGEA1P433553EBI-10181988,EBI-740978
MAGEA2BQ96E033EBI-10181988,EBI-10239285
MDFIQ997503EBI-1104570,EBI-724076
MEOX2A4D1273EBI-10181988,EBI-10172134
MFAP1P550813EBI-10181988,EBI-1048159
MID2Q9UJV3-23EBI-10181988,EBI-10172526
MORF4L1Q9UBU83EBI-10181988,EBI-399246
MTUS2Q5JR593EBI-10181988,EBI-742948
NUP62P371983EBI-10181988,EBI-347978
PKN1Q165123EBI-10181988,EBI-602382
PNMA5Q96PV45EBI-10181988,EBI-10171633
PPLO604373EBI-10181988,EBI-368321
RAD51DO757713EBI-10181988,EBI-1055693
RINT1Q6NUQ13EBI-10181988,EBI-726876
ROPN1Q9HAT03EBI-10181988,EBI-1378139
SNAP47Q5SQN13EBI-10181988,EBI-10244848
SNAPC3Q929663EBI-10181988,EBI-1760638
SPERTQ8NA613EBI-10181988,EBI-741724
TAB3Q8N5C83EBI-10181988,EBI-359964
TCEB3Q142413EBI-10181988,EBI-742350
TFIP11Q9UBB93EBI-1104570,EBI-1105213
TRAF2Q129333EBI-10181988,EBI-355744
TRAPPC2LQ9UL333EBI-10181988,EBI-747601
TRIM54Q9BYV23EBI-10181988,EBI-2130429
TRIP6Q156543EBI-10181988,EBI-742327
TSGA10Q9BZW73EBI-10181988,EBI-744794
TXLNAP402223EBI-10181988,EBI-359793

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130198. 75 interactions.
IntActiQ8IYX8. 72 interactions.
STRINGi9606.ENSP00000352841.

Structurei

3D structure databases

ProteinModelPortaliQ8IYX8.
SMRiQ8IYX8. Positions 319-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 228178Sequence analysisAdd
BLAST
Coiled coili317 – 38468Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the translokin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVGR. Eukaryota.
ENOG410XT4F. LUCA.
GeneTreeiENSGT00530000063695.
InParanoidiQ8IYX8.
KOiK16762.
PhylomeDBiQ8IYX8.
TreeFamiTF329178.

Family and domain databases

InterProiIPR010597. Centrosomal_protein_57kDa.
IPR025913. Cep57_CLD.
IPR024957. Cep57_MT-bd_dom.
[Graphical view]
PANTHERiPTHR19336:SF10. PTHR19336:SF10. 1 hit.
PfamiPF14073. Cep57_CLD. 1 hit.
PF06657. Cep57_MT_bd. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSELMHSIV GSYHKPPERV FVPSFTQNEP SQNCHPANLE VTSPKILHSP
60 70 80 90 100
NSQALILALK TLQEKIHRLE LERTQAEDNL NILSREAAQY KKALENETNE
110 120 130 140 150
RNLAHQELIK QKKDISIQLS SAQSRCTLLE KQLEYTKRMV LNVEREKNMI
160 170 180 190 200
LEQQAQLQRE KEQDQMKLYA KLEKLDVLEK ECFRLTTTQK TAEDKIKHLE
210 220 230 240 250
EKLKEEEHQR KLFQDKASEL QTGLEISKII MSSVSNLKHS KEKKKSSKKT
260 270 280 290 300
KCIKRRPPWQ ICSKFGALPF VAEKMRQHRD PHILQKPFNV TETRCLPKPS
310 320 330 340 350
RTTSWCKAIP PDSEKSISIC DNLSELLMAM QDELDQMSME HQELLKQMKE
360 370 380 390 400
TESHSVCDDI ECELECLLKK MEIKGEQISK LKKHQDSVCK LQQKVQNSKM
410 420 430 440 450
SEASGIQQED SYPKGSKNIK NSPRKCLTDT NLFQKNSSFH PIRVHNLQMK
460
LRRDDIMWEQ
Length:460
Mass (Da):53,649
Last modified:March 1, 2003 - v1
Checksum:i60BFD7F54078A9F5
GO
Isoform 2 (identifier: Q8IYX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-391: CKL → RRL
     392-460: Missing.

Note: No experimental confirmation available. Gene prediction based on partial data.
Show »
Length:391
Mass (Da):45,629
Checksum:iA3E0FB5D1E92F5FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941D → E.
Corresponds to variant rs351733 [ dbSNP | Ensembl ].
VAR_052396

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei389 – 3913CKL → RRL in isoform 2. CuratedVSP_055660
Alternative sequencei392 – 46069Missing in isoform 2. CuratedVSP_055661Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355305 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48364.1.
BC033448 mRNA. Translation: AAH33448.1.
CCDSiCCDS5071.1. [Q8IYX8-1]
CCDS64491.1. [Q8IYX8-2]
RefSeqiNP_001077004.1. NM_001083535.1. [Q8IYX8-1]
NP_001258781.1. NM_001271852.1. [Q8IYX8-1]
NP_001258782.1. NM_001271853.1. [Q8IYX8-2]
NP_776191.1. NM_173830.4. [Q8IYX8-1]
XP_005266995.2. XM_005266938.3. [Q8IYX8-1]
XP_011534063.1. XM_011535761.1. [Q8IYX8-2]
UniGeneiHs.632616.

Genome annotation databases

EnsembliENST00000359793; ENSP00000352841; ENSG00000183137. [Q8IYX8-1]
ENST00000368968; ENSP00000357964; ENSG00000183137. [Q8IYX8-2]
ENST00000517392; ENSP00000427844; ENSG00000183137. [Q8IYX8-1]
GeneIDi285753.
KEGGihsa:285753.
UCSCiuc003psx.5. human. [Q8IYX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355305 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48364.1.
BC033448 mRNA. Translation: AAH33448.1.
CCDSiCCDS5071.1. [Q8IYX8-1]
CCDS64491.1. [Q8IYX8-2]
RefSeqiNP_001077004.1. NM_001083535.1. [Q8IYX8-1]
NP_001258781.1. NM_001271852.1. [Q8IYX8-1]
NP_001258782.1. NM_001271853.1. [Q8IYX8-2]
NP_776191.1. NM_173830.4. [Q8IYX8-1]
XP_005266995.2. XM_005266938.3. [Q8IYX8-1]
XP_011534063.1. XM_011535761.1. [Q8IYX8-2]
UniGeneiHs.632616.

3D structure databases

ProteinModelPortaliQ8IYX8.
SMRiQ8IYX8. Positions 319-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130198. 75 interactions.
IntActiQ8IYX8. 72 interactions.
STRINGi9606.ENSP00000352841.

PTM databases

iPTMnetiQ8IYX8.
PhosphoSiteiQ8IYX8.

Polymorphism and mutation databases

BioMutaiCEP57L1.

Proteomic databases

MaxQBiQ8IYX8.
PaxDbiQ8IYX8.
PeptideAtlasiQ8IYX8.
PRIDEiQ8IYX8.

Protocols and materials databases

DNASUi285753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359793; ENSP00000352841; ENSG00000183137. [Q8IYX8-1]
ENST00000368968; ENSP00000357964; ENSG00000183137. [Q8IYX8-2]
ENST00000517392; ENSP00000427844; ENSG00000183137. [Q8IYX8-1]
GeneIDi285753.
KEGGihsa:285753.
UCSCiuc003psx.5. human. [Q8IYX8-1]

Organism-specific databases

CTDi285753.
GeneCardsiCEP57L1.
H-InvDBHIX0006123.
HGNCiHGNC:21561. CEP57L1.
HPAiHPA040378.
neXtProtiNX_Q8IYX8.
PharmGKBiPA134980921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVGR. Eukaryota.
ENOG410XT4F. LUCA.
GeneTreeiENSGT00530000063695.
InParanoidiQ8IYX8.
KOiK16762.
PhylomeDBiQ8IYX8.
TreeFamiTF329178.

Miscellaneous databases

ChiTaRSiCEP57L1. human.
GenomeRNAii285753.
PROiQ8IYX8.

Gene expression databases

BgeeiQ8IYX8.
CleanExiHS_C6orf182.
ExpressionAtlasiQ8IYX8. baseline and differential.
GenevisibleiQ8IYX8. HS.

Family and domain databases

InterProiIPR010597. Centrosomal_protein_57kDa.
IPR025913. Cep57_CLD.
IPR024957. Cep57_MT-bd_dom.
[Graphical view]
PANTHERiPTHR19336:SF10. PTHR19336:SF10. 1 hit.
PfamiPF14073. Cep57_CLD. 1 hit.
PF06657. Cep57_MT_bd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Urinary bladder.
  4. "Cep57, a multidomain protein with unique microtubule and centrosomal localization domains."
    Momotani K., Khromov A.S., Miyake T., Stukenberg P.T., Somlyo A.V.
    Biochem. J. 412:265-273(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiCE57L_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX8
Secondary accession number(s): G5E992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.