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Protein

Protein FAM154A

Gene

FAM154A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

GO - Biological processi

  • cellular response to cold Source: UniProtKB
  • cold acclimation Source: UniProtKB
  • positive regulation of cilium assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM154A
Gene namesi
Name:FAM154A
Synonyms:C9orf138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28566. FAM154A.

Subcellular locationi

GO - Cellular componenti

  • axonemal microtubule Source: UniProtKB
  • centriole Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • motile primary cilium Source: UniProtKB
  • sperm flagellum Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386652.

Polymorphism and mutation databases

BioMutaiFAM154A.
DMDMi73620045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Protein FAM154APRO_0000089737Add
BLAST

Proteomic databases

PaxDbiQ8IYX7.
PRIDEiQ8IYX7.

PTM databases

PhosphoSiteiQ8IYX7.

Expressioni

Gene expression databases

BgeeiQ8IYX7.
CleanExiHS_FAM154A.
ExpressionAtlasiQ8IYX7. baseline.
GenevisibleiQ8IYX7. HS.

Organism-specific databases

HPAiHPA023899.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-3957636,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi127666. 20 interactions.
IntActiQ8IYX7. 1 interaction.
STRINGi9606.ENSP00000369907.

Structurei

3D structure databases

ProteinModelPortaliQ8IYX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM154 family.Curated

Phylogenomic databases

eggNOGiNOG87688.
GeneTreeiENSGT00390000007252.
HOGENOMiHOG000049249.
HOVERGENiHBG060301.
InParanoidiQ8IYX7.
OMAiPWNQPRR.
OrthoDBiEOG7VMP4T.
PhylomeDBiQ8IYX7.
TreeFamiTF319394.

Family and domain databases

InterProiIPR024963. MAP6/FAM154.
[Graphical view]
PfamiPF05217. STOP. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKCICELC SCGRHHCPHL PTKIYDKTEK PCLLSEYTEN YPFYHSYLPR
60 70 80 90 100
ESFKPRREYQ KGPIPMEGLT TSRRDFGPHK VAPVKVHQYD QFVPSEENMD
110 120 130 140 150
LLTTYKKDYN PYPVCRVDPI KPRDSKYPCS DKMECLPTYK ADYLPWNQPR
160 170 180 190 200
REPLRLEHKY QPASVRFDNR TTHQDDYPIK GLVKTISCKP LAMPKLCNIP
210 220 230 240 250
LEDVTNYKMS YVAHPVEKRF VHEAEKFRPC EIPFESLTTQ KQSYRGLMGE
260 270 280 290 300
PAKSLKPLAR PPGLDMPFCN TTEFRDKYQA WPMPRMFSKA PITYVPPEDR
310 320 330 340 350
MDLLTTVQAH YTCPKGAPAQ SCRPALQIKK CGRFEGSSTT KDDYKQWSSM
360 370 380 390 400
RTEPVKPVPQ LDLPTEPLDC LTTTRAHYVP HLPINTKSCK PHWSGPRGNV
410 420 430 440 450
PVESQTTYTI SFTPKEMGRC LASYPEPPGY TFEEVDALGH RIYKPVSQAG
460 470
SQQSSHLSVD DSENPNQREL EVLA
Length:474
Mass (Da):54,621
Last modified:August 16, 2005 - v2
Checksum:i8D4525BEDE11F5D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271K → E.1 Publication
Corresponds to variant rs7021572 [ dbSNP | Ensembl ].
VAR_023229
Natural varianti63 – 631P → S.1 Publication
Corresponds to variant rs6475273 [ dbSNP | Ensembl ].
VAR_023230
Natural varianti385 – 3851N → S.
Corresponds to variant rs34119945 [ dbSNP | Ensembl ].
VAR_057807

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158150, AL356000 Genomic DNA. Translation: CAH71465.1.
AL356000, AL158150 Genomic DNA. Translation: CAH72135.1.
BC033489 mRNA. Translation: AAH33489.1.
CCDSiCCDS6487.1.
RefSeqiNP_001273978.1. NM_001287049.1.
NP_001273979.1. NM_001287050.1.
NP_714918.2. NM_153707.3.
UniGeneiHs.731593.

Genome annotation databases

EnsembliENST00000380534; ENSP00000369907; ENSG00000155875.
GeneIDi158297.
KEGGihsa:158297.
UCSCiuc003zni.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158150, AL356000 Genomic DNA. Translation: CAH71465.1.
AL356000, AL158150 Genomic DNA. Translation: CAH72135.1.
BC033489 mRNA. Translation: AAH33489.1.
CCDSiCCDS6487.1.
RefSeqiNP_001273978.1. NM_001287049.1.
NP_001273979.1. NM_001287050.1.
NP_714918.2. NM_153707.3.
UniGeneiHs.731593.

3D structure databases

ProteinModelPortaliQ8IYX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127666. 20 interactions.
IntActiQ8IYX7. 1 interaction.
STRINGi9606.ENSP00000369907.

PTM databases

PhosphoSiteiQ8IYX7.

Polymorphism and mutation databases

BioMutaiFAM154A.
DMDMi73620045.

Proteomic databases

PaxDbiQ8IYX7.
PRIDEiQ8IYX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380534; ENSP00000369907; ENSG00000155875.
GeneIDi158297.
KEGGihsa:158297.
UCSCiuc003zni.2. human.

Organism-specific databases

CTDi158297.
GeneCardsiGC09M018920.
HGNCiHGNC:28566. FAM154A.
HPAiHPA023899.
neXtProtiNX_Q8IYX7.
PharmGKBiPA162386652.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87688.
GeneTreeiENSGT00390000007252.
HOGENOMiHOG000049249.
HOVERGENiHBG060301.
InParanoidiQ8IYX7.
OMAiPWNQPRR.
OrthoDBiEOG7VMP4T.
PhylomeDBiQ8IYX7.
TreeFamiTF319394.

Miscellaneous databases

GenomeRNAii158297.
NextBioi87684.
PROiQ8IYX7.

Gene expression databases

BgeeiQ8IYX7.
CleanExiHS_FAM154A.
ExpressionAtlasiQ8IYX7. baseline.
GenevisibleiQ8IYX7. HS.

Family and domain databases

InterProiIPR024963. MAP6/FAM154.
[Graphical view]
PfamiPF05217. STOP. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-27 AND SER-63.
    Tissue: Brain.

Entry informationi

Entry nameiF154A_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX7
Secondary accession number(s): Q5VY58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: June 24, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.