Q8IYX7 (F154A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM154A

Gene names

Name:	FAM154A
Synonyms:	C9orf138

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM154 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Hoxa1	P09022	3	EBI-3957636,EBI-3957603	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Protein FAM154A		PRO_0000089737
Natural variations
	Natural variant	27	1	K → E. Ref.2 Corresponds to variant rs7021572 [ dbSNP | Ensembl ].		VAR_023229
	Natural variant	63	1	P → S. Ref.2 Corresponds to variant rs6475273 [ dbSNP | Ensembl ].		VAR_023230
	Natural variant	385	1	N → S. Corresponds to variant rs34119945 [ dbSNP | Ensembl ].		VAR_057807

Sequences

	Sequence		Length	Mass (Da)
	Q8IYX7 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: 8D4525BEDE11F5D8	FASTA	474	54,621
	10 20 30 40 50 60 MKTKCICELC SCGRHHCPHL PTKIYDKTEK PCLLSEYTEN YPFYHSYLPR ESFKPRREYQ 70 80 90 100 110 120 KGPIPMEGLT TSRRDFGPHK VAPVKVHQYD QFVPSEENMD LLTTYKKDYN PYPVCRVDPI 130 140 150 160 170 180 KPRDSKYPCS DKMECLPTYK ADYLPWNQPR REPLRLEHKY QPASVRFDNR TTHQDDYPIK 190 200 210 220 230 240 GLVKTISCKP LAMPKLCNIP LEDVTNYKMS YVAHPVEKRF VHEAEKFRPC EIPFESLTTQ 250 260 270 280 290 300 KQSYRGLMGE PAKSLKPLAR PPGLDMPFCN TTEFRDKYQA WPMPRMFSKA PITYVPPEDR 310 320 330 340 350 360 MDLLTTVQAH YTCPKGAPAQ SCRPALQIKK CGRFEGSSTT KDDYKQWSSM RTEPVKPVPQ 370 380 390 400 410 420 LDLPTEPLDC LTTTRAHYVP HLPINTKSCK PHWSGPRGNV PVESQTTYTI SFTPKEMGRC 430 440 450 460 470 LASYPEPPGY TFEEVDALGH RIYKPVSQAG SQQSSHLSVD DSENPNQREL EVLA

References

[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-27 AND SER-63. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL158150, AL356000 Genomic DNA. Translation: CAH71465.1. AL356000, AL158150 Genomic DNA. Translation: CAH72135.1. BC033489 mRNA. Translation: AAH33489.1.
IPI	IPI00217912.
RefSeq	NP_714918.2. NM_153707.2.
UniGene	Hs.731593.
3D structure databases
ProteinModelPortal	Q8IYX7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IYX7. 1 interaction.
STRING	9606.ENSP00000369907.
PTM databases
PhosphoSite	Q8IYX7.
Polymorphism databases
DMDM	73620045.
Proteomic databases
PaxDb	Q8IYX7.
PRIDE	Q8IYX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380534; ENSP00000369907; ENSG00000155875.
GeneID	158297.
KEGG	hsa:158297.
UCSC	uc003zni.2. human.
Organism-specific databases
CTD	158297.
GeneCards	GC09M018920.
HGNC	HGNC:28566. FAM154A.
HPA	HPA023899.
neXtProt	NX_Q8IYX7.
PharmGKB	PA162386652.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87688.
HOGENOM	HOG000049249.
HOVERGEN	HBG060301.
InParanoid	Q8IYX7.
OMA	SENPNQR.
OrthoDB	EOG4QJRN0.
PhylomeDB	Q8IYX7.
Gene expression databases
ArrayExpress	Q8IYX7.
Bgee	Q8IYX7.
CleanEx	HS_FAM154A.
Genevestigator	Q8IYX7.
GermOnline	ENSG00000155875. Homo sapiens.
Family and domain databases
InterPro	IPR024963. STOP/FAM154. [Graphical view]
Pfam	PF05217. STOP. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	158297.
NextBio	87684.

Entry information

Entry name

F154A_HUMAN

Accession

Primary (citable) accession number: Q8IYX7
Secondary accession number(s): Q5VY58

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2005
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.