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Q8IYX7

- F154A_HUMAN

UniProt

Q8IYX7 - F154A_HUMAN

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Protein

Protein FAM154A

Gene

FAM154A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM154A
Gene namesi
Name:FAM154A
Synonyms:C9orf138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:28566. FAM154A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Protein FAM154APRO_0000089737Add
BLAST

Proteomic databases

PaxDbiQ8IYX7.
PRIDEiQ8IYX7.

PTM databases

PhosphoSiteiQ8IYX7.

Expressioni

Gene expression databases

BgeeiQ8IYX7.
CleanExiHS_FAM154A.
ExpressionAtlasiQ8IYX7. baseline.
GenevestigatoriQ8IYX7.

Organism-specific databases

HPAiHPA023899.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-3957636,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi127666. 3 interactions.
IntActiQ8IYX7. 1 interaction.
STRINGi9606.ENSP00000369907.

Structurei

3D structure databases

ProteinModelPortaliQ8IYX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM154 family.Curated

Phylogenomic databases

eggNOGiNOG87688.
GeneTreeiENSGT00390000007252.
HOGENOMiHOG000049249.
HOVERGENiHBG060301.
InParanoidiQ8IYX7.
OMAiRMFSKAP.
OrthoDBiEOG7VMP4T.
PhylomeDBiQ8IYX7.
TreeFamiTF319394.

Family and domain databases

InterProiIPR024963. MAP6/FAM154.
[Graphical view]
PfamiPF05217. STOP. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTKCICELC SCGRHHCPHL PTKIYDKTEK PCLLSEYTEN YPFYHSYLPR
60 70 80 90 100
ESFKPRREYQ KGPIPMEGLT TSRRDFGPHK VAPVKVHQYD QFVPSEENMD
110 120 130 140 150
LLTTYKKDYN PYPVCRVDPI KPRDSKYPCS DKMECLPTYK ADYLPWNQPR
160 170 180 190 200
REPLRLEHKY QPASVRFDNR TTHQDDYPIK GLVKTISCKP LAMPKLCNIP
210 220 230 240 250
LEDVTNYKMS YVAHPVEKRF VHEAEKFRPC EIPFESLTTQ KQSYRGLMGE
260 270 280 290 300
PAKSLKPLAR PPGLDMPFCN TTEFRDKYQA WPMPRMFSKA PITYVPPEDR
310 320 330 340 350
MDLLTTVQAH YTCPKGAPAQ SCRPALQIKK CGRFEGSSTT KDDYKQWSSM
360 370 380 390 400
RTEPVKPVPQ LDLPTEPLDC LTTTRAHYVP HLPINTKSCK PHWSGPRGNV
410 420 430 440 450
PVESQTTYTI SFTPKEMGRC LASYPEPPGY TFEEVDALGH RIYKPVSQAG
460 470
SQQSSHLSVD DSENPNQREL EVLA
Length:474
Mass (Da):54,621
Last modified:August 16, 2005 - v2
Checksum:i8D4525BEDE11F5D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271K → E.1 Publication
Corresponds to variant rs7021572 [ dbSNP | Ensembl ].
VAR_023229
Natural varianti63 – 631P → S.1 Publication
Corresponds to variant rs6475273 [ dbSNP | Ensembl ].
VAR_023230
Natural varianti385 – 3851N → S.
Corresponds to variant rs34119945 [ dbSNP | Ensembl ].
VAR_057807

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL158150, AL356000 Genomic DNA. Translation: CAH71465.1.
AL356000, AL158150 Genomic DNA. Translation: CAH72135.1.
BC033489 mRNA. Translation: AAH33489.1.
CCDSiCCDS6487.1.
RefSeqiNP_001273978.1. NM_001287049.1.
NP_001273979.1. NM_001287050.1.
NP_714918.2. NM_153707.3.
UniGeneiHs.731593.

Genome annotation databases

EnsembliENST00000380534; ENSP00000369907; ENSG00000155875.
GeneIDi158297.
KEGGihsa:158297.
UCSCiuc003zni.2. human.

Polymorphism databases

DMDMi73620045.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL158150 , AL356000 Genomic DNA. Translation: CAH71465.1 .
AL356000 , AL158150 Genomic DNA. Translation: CAH72135.1 .
BC033489 mRNA. Translation: AAH33489.1 .
CCDSi CCDS6487.1.
RefSeqi NP_001273978.1. NM_001287049.1.
NP_001273979.1. NM_001287050.1.
NP_714918.2. NM_153707.3.
UniGenei Hs.731593.

3D structure databases

ProteinModelPortali Q8IYX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127666. 3 interactions.
IntActi Q8IYX7. 1 interaction.
STRINGi 9606.ENSP00000369907.

PTM databases

PhosphoSitei Q8IYX7.

Polymorphism databases

DMDMi 73620045.

Proteomic databases

PaxDbi Q8IYX7.
PRIDEi Q8IYX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380534 ; ENSP00000369907 ; ENSG00000155875 .
GeneIDi 158297.
KEGGi hsa:158297.
UCSCi uc003zni.2. human.

Organism-specific databases

CTDi 158297.
GeneCardsi GC09M018920.
HGNCi HGNC:28566. FAM154A.
HPAi HPA023899.
neXtProti NX_Q8IYX7.
PharmGKBi PA162386652.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87688.
GeneTreei ENSGT00390000007252.
HOGENOMi HOG000049249.
HOVERGENi HBG060301.
InParanoidi Q8IYX7.
OMAi RMFSKAP.
OrthoDBi EOG7VMP4T.
PhylomeDBi Q8IYX7.
TreeFami TF319394.

Miscellaneous databases

GenomeRNAii 158297.
NextBioi 87684.
PROi Q8IYX7.

Gene expression databases

Bgeei Q8IYX7.
CleanExi HS_FAM154A.
ExpressionAtlasi Q8IYX7. baseline.
Genevestigatori Q8IYX7.

Family and domain databases

InterProi IPR024963. MAP6/FAM154.
[Graphical view ]
Pfami PF05217. STOP. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-27 AND SER-63.
    Tissue: Brain.

Entry informationi

Entry nameiF154A_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX7
Secondary accession number(s): Q5VY58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3