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Q8IYX7 (F154A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM154A
Gene names
Name:FAM154A
Synonyms:C9orf138
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM154 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Hoxa1P090223EBI-3957636,EBI-3957603From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Protein FAM154A
PRO_0000089737

Natural variations

Natural variant271K → E. Ref.2
Corresponds to variant rs7021572 [ dbSNP | Ensembl ].
VAR_023229
Natural variant631P → S. Ref.2
Corresponds to variant rs6475273 [ dbSNP | Ensembl ].
VAR_023230
Natural variant3851N → S.
Corresponds to variant rs34119945 [ dbSNP | Ensembl ].
VAR_057807

Sequences

Sequence LengthMass (Da)Tools
Q8IYX7 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 8D4525BEDE11F5D8

FASTA47454,621
        10         20         30         40         50         60 
MKTKCICELC SCGRHHCPHL PTKIYDKTEK PCLLSEYTEN YPFYHSYLPR ESFKPRREYQ 

        70         80         90        100        110        120 
KGPIPMEGLT TSRRDFGPHK VAPVKVHQYD QFVPSEENMD LLTTYKKDYN PYPVCRVDPI 

       130        140        150        160        170        180 
KPRDSKYPCS DKMECLPTYK ADYLPWNQPR REPLRLEHKY QPASVRFDNR TTHQDDYPIK 

       190        200        210        220        230        240 
GLVKTISCKP LAMPKLCNIP LEDVTNYKMS YVAHPVEKRF VHEAEKFRPC EIPFESLTTQ 

       250        260        270        280        290        300 
KQSYRGLMGE PAKSLKPLAR PPGLDMPFCN TTEFRDKYQA WPMPRMFSKA PITYVPPEDR 

       310        320        330        340        350        360 
MDLLTTVQAH YTCPKGAPAQ SCRPALQIKK CGRFEGSSTT KDDYKQWSSM RTEPVKPVPQ 

       370        380        390        400        410        420 
LDLPTEPLDC LTTTRAHYVP HLPINTKSCK PHWSGPRGNV PVESQTTYTI SFTPKEMGRC 

       430        440        450        460        470 
LASYPEPPGY TFEEVDALGH RIYKPVSQAG SQQSSHLSVD DSENPNQREL EVLA 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-27 AND SER-63.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL158150, AL356000 Genomic DNA. Translation: CAH71465.1.
AL356000, AL158150 Genomic DNA. Translation: CAH72135.1.
BC033489 mRNA. Translation: AAH33489.1.
RefSeqNP_001273978.1. NM_001287049.1.
NP_001273979.1. NM_001287050.1.
NP_714918.2. NM_153707.3.
UniGeneHs.731593.

3D structure databases

ProteinModelPortalQ8IYX7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127666. 2 interactions.
IntActQ8IYX7. 1 interaction.
STRING9606.ENSP00000369907.

PTM databases

PhosphoSiteQ8IYX7.

Polymorphism databases

DMDM73620045.

Proteomic databases

PaxDbQ8IYX7.
PRIDEQ8IYX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380534; ENSP00000369907; ENSG00000155875.
GeneID158297.
KEGGhsa:158297.
UCSCuc003zni.2. human.

Organism-specific databases

CTD158297.
GeneCardsGC09M018920.
HGNCHGNC:28566. FAM154A.
HPAHPA023899.
neXtProtNX_Q8IYX7.
PharmGKBPA162386652.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87688.
HOGENOMHOG000049249.
HOVERGENHBG060301.
InParanoidQ8IYX7.
OMARMFSKAP.
OrthoDBEOG7VMP4T.
PhylomeDBQ8IYX7.
TreeFamTF319394.

Gene expression databases

ArrayExpressQ8IYX7.
BgeeQ8IYX7.
CleanExHS_FAM154A.
GenevestigatorQ8IYX7.

Family and domain databases

InterProIPR024963. MAP6/FAM154.
[Graphical view]
PfamPF05217. STOP. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi158297.
NextBio87684.
PROQ8IYX7.

Entry information

Entry nameF154A_HUMAN
AccessionPrimary (citable) accession number: Q8IYX7
Secondary accession number(s): Q5VY58
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: March 19, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM