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Q8IYX7

- F154A_HUMAN

UniProt

Q8IYX7 - F154A_HUMAN

Protein

Protein FAM154A

Gene

FAM154A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM154A
    Gene namesi
    Name:FAM154A
    Synonyms:C9orf138
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:28566. FAM154A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162386652.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Protein FAM154APRO_0000089737Add
    BLAST

    Proteomic databases

    PaxDbiQ8IYX7.
    PRIDEiQ8IYX7.

    PTM databases

    PhosphoSiteiQ8IYX7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IYX7.
    BgeeiQ8IYX7.
    CleanExiHS_FAM154A.
    GenevestigatoriQ8IYX7.

    Organism-specific databases

    HPAiHPA023899.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hoxa1P090223EBI-3957636,EBI-3957603From a different organism.

    Protein-protein interaction databases

    BioGridi127666. 2 interactions.
    IntActiQ8IYX7. 1 interaction.
    STRINGi9606.ENSP00000369907.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM154 family.Curated

    Phylogenomic databases

    eggNOGiNOG87688.
    HOGENOMiHOG000049249.
    HOVERGENiHBG060301.
    InParanoidiQ8IYX7.
    OMAiRMFSKAP.
    OrthoDBiEOG7VMP4T.
    PhylomeDBiQ8IYX7.
    TreeFamiTF319394.

    Family and domain databases

    InterProiIPR024963. MAP6/FAM154.
    [Graphical view]
    PfamiPF05217. STOP. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IYX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTKCICELC SCGRHHCPHL PTKIYDKTEK PCLLSEYTEN YPFYHSYLPR    50
    ESFKPRREYQ KGPIPMEGLT TSRRDFGPHK VAPVKVHQYD QFVPSEENMD 100
    LLTTYKKDYN PYPVCRVDPI KPRDSKYPCS DKMECLPTYK ADYLPWNQPR 150
    REPLRLEHKY QPASVRFDNR TTHQDDYPIK GLVKTISCKP LAMPKLCNIP 200
    LEDVTNYKMS YVAHPVEKRF VHEAEKFRPC EIPFESLTTQ KQSYRGLMGE 250
    PAKSLKPLAR PPGLDMPFCN TTEFRDKYQA WPMPRMFSKA PITYVPPEDR 300
    MDLLTTVQAH YTCPKGAPAQ SCRPALQIKK CGRFEGSSTT KDDYKQWSSM 350
    RTEPVKPVPQ LDLPTEPLDC LTTTRAHYVP HLPINTKSCK PHWSGPRGNV 400
    PVESQTTYTI SFTPKEMGRC LASYPEPPGY TFEEVDALGH RIYKPVSQAG 450
    SQQSSHLSVD DSENPNQREL EVLA 474
    Length:474
    Mass (Da):54,621
    Last modified:August 16, 2005 - v2
    Checksum:i8D4525BEDE11F5D8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271K → E.1 Publication
    Corresponds to variant rs7021572 [ dbSNP | Ensembl ].
    VAR_023229
    Natural varianti63 – 631P → S.1 Publication
    Corresponds to variant rs6475273 [ dbSNP | Ensembl ].
    VAR_023230
    Natural varianti385 – 3851N → S.
    Corresponds to variant rs34119945 [ dbSNP | Ensembl ].
    VAR_057807

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL158150, AL356000 Genomic DNA. Translation: CAH71465.1.
    AL356000, AL158150 Genomic DNA. Translation: CAH72135.1.
    BC033489 mRNA. Translation: AAH33489.1.
    CCDSiCCDS6487.1.
    RefSeqiNP_001273978.1. NM_001287049.1.
    NP_001273979.1. NM_001287050.1.
    NP_714918.2. NM_153707.3.
    UniGeneiHs.731593.

    Genome annotation databases

    EnsembliENST00000380534; ENSP00000369907; ENSG00000155875.
    GeneIDi158297.
    KEGGihsa:158297.
    UCSCiuc003zni.2. human.

    Polymorphism databases

    DMDMi73620045.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL158150 , AL356000 Genomic DNA. Translation: CAH71465.1 .
    AL356000 , AL158150 Genomic DNA. Translation: CAH72135.1 .
    BC033489 mRNA. Translation: AAH33489.1 .
    CCDSi CCDS6487.1.
    RefSeqi NP_001273978.1. NM_001287049.1.
    NP_001273979.1. NM_001287050.1.
    NP_714918.2. NM_153707.3.
    UniGenei Hs.731593.

    3D structure databases

    ProteinModelPortali Q8IYX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127666. 2 interactions.
    IntActi Q8IYX7. 1 interaction.
    STRINGi 9606.ENSP00000369907.

    PTM databases

    PhosphoSitei Q8IYX7.

    Polymorphism databases

    DMDMi 73620045.

    Proteomic databases

    PaxDbi Q8IYX7.
    PRIDEi Q8IYX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380534 ; ENSP00000369907 ; ENSG00000155875 .
    GeneIDi 158297.
    KEGGi hsa:158297.
    UCSCi uc003zni.2. human.

    Organism-specific databases

    CTDi 158297.
    GeneCardsi GC09M018920.
    HGNCi HGNC:28566. FAM154A.
    HPAi HPA023899.
    neXtProti NX_Q8IYX7.
    PharmGKBi PA162386652.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87688.
    HOGENOMi HOG000049249.
    HOVERGENi HBG060301.
    InParanoidi Q8IYX7.
    OMAi RMFSKAP.
    OrthoDBi EOG7VMP4T.
    PhylomeDBi Q8IYX7.
    TreeFami TF319394.

    Miscellaneous databases

    GenomeRNAii 158297.
    NextBioi 87684.
    PROi Q8IYX7.

    Gene expression databases

    ArrayExpressi Q8IYX7.
    Bgeei Q8IYX7.
    CleanExi HS_FAM154A.
    Genevestigatori Q8IYX7.

    Family and domain databases

    InterProi IPR024963. MAP6/FAM154.
    [Graphical view ]
    Pfami PF05217. STOP. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-27 AND SER-63.
      Tissue: Brain.

    Entry informationi

    Entry nameiF154A_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYX7
    Secondary accession number(s): Q5VY58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3