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Protein

Dead end protein homolog 1

Gene

DND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).By similarity1 Publication

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • nucleotide binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dead end protein homolog 1
Alternative name(s):
RNA-binding motif, single-stranded-interacting protein 4
Gene namesi
Name:DND1
Synonyms:RBMS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23799. DND1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931157.

Polymorphism and mutation databases

BioMutaiDND1.
DMDMi60389799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Dead end protein homolog 1PRO_0000081568Add
BLAST

Proteomic databases

PaxDbiQ8IYX4.
PRIDEiQ8IYX4.

PTM databases

iPTMnetiQ8IYX4.
PhosphoSiteiQ8IYX4.

Expressioni

Gene expression databases

BgeeiQ8IYX4.
CleanExiHS_DND1.
GenevisibleiQ8IYX4. HS.

Interactioni

Subunit structurei

Interacts with APOBEC3.By similarity

Protein-protein interaction databases

BioGridi131887. 10 interactions.
STRINGi9606.ENSP00000445366.

Structurei

3D structure databases

ProteinModelPortaliQ8IYX4.
SMRiQ8IYX4. Positions 59-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 13679RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini140 – 21374RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IUE0. Eukaryota.
ENOG410YAVC. LUCA.
GeneTreeiENSGT00550000074366.
HOGENOMiHOG000112240.
HOVERGENiHBG051370.
InParanoidiQ8IYX4.
OMAiQSKRECE.
OrthoDBiEOG73JKW2.
PhylomeDBiQ8IYX4.
TreeFamiTF314932.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV
60 70 80 90 100
GSPPPAGSEV FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF
110 120 130 140 150
AYARYSSRRG AQAAIATLHN HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT
160 170 180 190 200
RSALLLALQP LGPGLQEARL LPSPGPAPGQ IALLKFSSHR AAAMAKKALV
210 220 230 240 250
EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG SQLALARDKL
260 270 280 290 300
GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP
310 320 330 340 350
FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM

VKQ
Length:353
Mass (Da):38,687
Last modified:March 1, 2003 - v1
Checksum:i15014AA66BFD4F0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY321065 mRNA. Translation: AAQ63635.1.
BC033496 mRNA. Translation: AAH33496.1.
CCDSiCCDS4236.1.
RefSeqiNP_919225.1. NM_194249.2.
UniGeneiHs.591262.

Genome annotation databases

EnsembliENST00000542735; ENSP00000445366; ENSG00000256453.
GeneIDi373863.
KEGGihsa:373863.
UCSCiuc003lgt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY321065 mRNA. Translation: AAQ63635.1.
BC033496 mRNA. Translation: AAH33496.1.
CCDSiCCDS4236.1.
RefSeqiNP_919225.1. NM_194249.2.
UniGeneiHs.591262.

3D structure databases

ProteinModelPortaliQ8IYX4.
SMRiQ8IYX4. Positions 59-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131887. 10 interactions.
STRINGi9606.ENSP00000445366.

PTM databases

iPTMnetiQ8IYX4.
PhosphoSiteiQ8IYX4.

Polymorphism and mutation databases

BioMutaiDND1.
DMDMi60389799.

Proteomic databases

PaxDbiQ8IYX4.
PRIDEiQ8IYX4.

Protocols and materials databases

DNASUi373863.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000542735; ENSP00000445366; ENSG00000256453.
GeneIDi373863.
KEGGihsa:373863.
UCSCiuc003lgt.4. human.

Organism-specific databases

CTDi373863.
GeneCardsiDND1.
HGNCiHGNC:23799. DND1.
MIMi609385. gene.
neXtProtiNX_Q8IYX4.
PharmGKBiPA134931157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUE0. Eukaryota.
ENOG410YAVC. LUCA.
GeneTreeiENSGT00550000074366.
HOGENOMiHOG000112240.
HOVERGENiHBG051370.
InParanoidiQ8IYX4.
OMAiQSKRECE.
OrthoDBiEOG73JKW2.
PhylomeDBiQ8IYX4.
TreeFamiTF314932.

Miscellaneous databases

GenomeRNAii373863.
NextBioi100136.
PROiQ8IYX4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IYX4.
CleanExiHS_DND1.
GenevisibleiQ8IYX4. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival."
    Weidinger G., Stebler J., Slanchev K., Dumstrei K., Wise C., Lovell-Badge R., Thisse C., Thisse B., Raz E.
    Curr. Biol. 13:1429-1434(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: FUNCTION, RNA-BINDING, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDND1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.