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Q8IYX0 (ZN679_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 679
Gene names
Name:ZNF679
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 9 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Zinc finger protein 679
PRO_0000233999

Regions

Domain16 – 8772KRAB
Zinc finger156 – 17823C2H2-type 1; degenerate
Zinc finger184 – 20623C2H2-type 2; degenerate
Zinc finger212 – 23423C2H2-type 3
Zinc finger240 – 26223C2H2-type 4
Zinc finger268 – 29023C2H2-type 5
Zinc finger296 – 31823C2H2-type 6
Zinc finger324 – 34623C2H2-type 7
Zinc finger352 – 37423C2H2-type 8
Zinc finger380 – 40223C2H2-type 9

Natural variations

Natural variant691E → G.
Corresponds to variant rs12154540 [ dbSNP | Ensembl ].
VAR_033586
Natural variant1201H → R.
Corresponds to variant rs17139320 [ dbSNP | Ensembl ].
VAR_033587
Natural variant2121Y → H.
Corresponds to variant rs1830035 [ dbSNP | Ensembl ].
VAR_033588
Natural variant2231C → S.
Corresponds to variant rs1830036 [ dbSNP | Ensembl ].
VAR_033589

Experimental info

Sequence conflict3281E → K in AAH33523. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8IYX0 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: C687350A4A2BCBC0

FASTA41147,179
        10         20         30         40         50         60 
MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR NLVSLGIAVS 

        70         80         90        100        110        120 
KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE LGIKDSLQKV IPRRYGKSGH 

       130        140        150        160        170        180 
DNLQVKTCKS MGECEVQKGG CNEVNQCLST TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG 

       190        200        210        220        230        240 
KKHFKCKKYG KSFCMVSQLH QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY 

       250        260        270        280        290        300 
RCEECGKAFT WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE 

       310        320        330        340        350        360 
CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK PYKCKECGKA 

       370        380        390        400        410 
FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS MHTGEKPYKC E 

« Hide

References

[1]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC073270 Genomic DNA. No translation available.
BC033523 mRNA. Translation: AAH33523.1.
CCDSCCDS47592.1.
RefSeqNP_699194.2. NM_153363.2.
UniGeneHs.520884.

3D structure databases

ProteinModelPortalQ8IYX0.
SMRQ8IYX0. Positions 6-56, 126-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127961. 2 interactions.
IntActQ8IYX0. 1 interaction.
MINTMINT-1444273.

PTM databases

PhosphoSiteQ8IYX0.

Polymorphism databases

DMDM296453054.

Proteomic databases

PaxDbQ8IYX0.
PRIDEQ8IYX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255746; ENSP00000255746; ENSG00000197123.
ENST00000421025; ENSP00000416809; ENSG00000197123.
GeneID168417.
KEGGhsa:168417.
UCSCuc003tsx.3. human.

Organism-specific databases

CTD168417.
GeneCardsGC07P063688.
HGNCHGNC:28650. ZNF679.
neXtProtNX_Q8IYX0.
PharmGKBPA142670480.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8IYX0.
KOK09228.
OMALANHKSM.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8IYX0.
TreeFamTF342117.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ8IYX0.
CleanExHS_ZNF679.
GenevestigatorQ8IYX0.

Family and domain databases

Gene3D3.30.160.60. 8 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi168417.
NextBio88722.
PROQ8IYX0.

Entry information

Entry nameZN679_HUMAN
AccessionPrimary (citable) accession number: Q8IYX0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM