Q8IYX0 (ZN679_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 679

Gene names

Name:

ZNF679

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	Zinc finger protein 679		PRO_0000233999
Regions
	Domain	16 – 87	72	KRAB
	Zinc finger	156 – 178	23	C2H2-type 1; degenerate
	Zinc finger	184 – 206	23	C2H2-type 2; degenerate
	Zinc finger	212 – 234	23	C2H2-type 3
	Zinc finger	240 – 262	23	C2H2-type 4
	Zinc finger	268 – 290	23	C2H2-type 5
	Zinc finger	296 – 318	23	C2H2-type 6
	Zinc finger	324 – 346	23	C2H2-type 7
	Zinc finger	352 – 374	23	C2H2-type 8
	Zinc finger	380 – 402	23	C2H2-type 9
Natural variations
	Natural variant	69	1	E → G. Corresponds to variant rs12154540 [ dbSNP | Ensembl ].		VAR_033586
	Natural variant	120	1	H → R. Corresponds to variant rs17139320 [ dbSNP | Ensembl ].		VAR_033587
	Natural variant	212	1	Y → H. Corresponds to variant rs1830035 [ dbSNP | Ensembl ].		VAR_033588
	Natural variant	223	1	C → S. Corresponds to variant rs1830036 [ dbSNP | Ensembl ].		VAR_033589
Experimental info
	Sequence conflict	328	1	E → K in AAH33523. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8IYX0 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: C687350A4A2BCBC0	FASTA	411	47,179
	10 20 30 40 50 60 MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR NLVSLGIAVS 70 80 90 100 110 120 KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE LGIKDSLQKV IPRRYGKSGH 130 140 150 160 170 180 DNLQVKTCKS MGECEVQKGG CNEVNQCLST TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG 190 200 210 220 230 240 KKHFKCKKYG KSFCMVSQLH QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY 250 260 270 280 290 300 RCEECGKAFT WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE 310 320 330 340 350 360 CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK PYKCKECGKA 370 380 390 400 410 FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS MHTGEKPYKC E

References

[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC073270 Genomic DNA. No translation available. BC033523 mRNA. Translation: AAH33523.1.
IPI	IPI00472494.
RefSeq	NP_699194.2. NM_153363.2.
UniGene	Hs.520884.
3D structure databases
ProteinModelPortal	Q8IYX0.
SMR	Q8IYX0. Positions 6-56, 153-410.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IYX0. 1 interaction.
MINT	MINT-1444273.
PTM databases
PhosphoSite	Q8IYX0.
Polymorphism databases
DMDM	296453054.
Proteomic databases
PaxDb	Q8IYX0.
PRIDE	Q8IYX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255746; ENSP00000255746; ENSG00000197123. ENST00000421025; ENSP00000416809; ENSG00000197123.
GeneID	168417.
KEGG	hsa:168417.
UCSC	uc003tsx.3. human.
Organism-specific databases
CTD	168417.
GeneCards	GC07P063688.
HGNC	HGNC:28650. ZNF679.
neXtProt	NX_Q8IYX0.
PharmGKB	PA142670480.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q8IYX0.
KO	K09228.
OMA	LANHKSM.
OrthoDB	EOG4XSKRR.
PhylomeDB	Q8IYX0.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q8IYX0.
CleanEx	HS_ZNF679.
Genevestigator	Q8IYX0.
Family and domain databases
Gene3D	3.30.160.60. 8 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 8 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	168417.
NextBio	88722.

Entry information

Entry name

ZN679_HUMAN

Accession

Primary (citable) accession number: Q8IYX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.