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Q8IYX0

- ZN679_HUMAN

UniProt

Q8IYX0 - ZN679_HUMAN

Protein

Zinc finger protein 679

Gene

ZNF679

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri156 – 17823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 679
    Gene namesi
    Name:ZNF679
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:28650. ZNF679.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670480.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Zinc finger protein 679PRO_0000233999Add
    BLAST

    Proteomic databases

    PaxDbiQ8IYX0.
    PRIDEiQ8IYX0.

    PTM databases

    PhosphoSiteiQ8IYX0.

    Expressioni

    Gene expression databases

    BgeeiQ8IYX0.
    CleanExiHS_ZNF679.
    GenevestigatoriQ8IYX0.

    Interactioni

    Protein-protein interaction databases

    BioGridi127961. 2 interactions.
    IntActiQ8IYX0. 1 interaction.
    MINTiMINT-1444273.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYX0.
    SMRiQ8IYX0. Positions 6-56, 126-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 8772KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri156 – 17823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8IYX0.
    KOiK09228.
    OMAiLANHKSM.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8IYX0.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IYX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR    50
    NLVSLGIAVS KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE 100
    LGIKDSLQKV IPRRYGKSGH DNLQVKTCKS MGECEVQKGG CNEVNQCLST 150
    TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG KKHFKCKKYG KSFCMVSQLH 200
    QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY RCEECGKAFT 250
    WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE 300
    CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK 350
    PYKCKECGKA FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS 400
    MHTGEKPYKC E 411
    Length:411
    Mass (Da):47,179
    Last modified:May 18, 2010 - v2
    Checksum:iC687350A4A2BCBC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti328 – 3281E → K in AAH33523. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti69 – 691E → G.
    Corresponds to variant rs12154540 [ dbSNP | Ensembl ].
    VAR_033586
    Natural varianti120 – 1201H → R.
    Corresponds to variant rs17139320 [ dbSNP | Ensembl ].
    VAR_033587
    Natural varianti212 – 2121Y → H.
    Corresponds to variant rs1830035 [ dbSNP | Ensembl ].
    VAR_033588
    Natural varianti223 – 2231C → S.
    Corresponds to variant rs1830036 [ dbSNP | Ensembl ].
    VAR_033589

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073270 Genomic DNA. No translation available.
    BC033523 mRNA. Translation: AAH33523.1.
    CCDSiCCDS47592.1.
    RefSeqiNP_699194.2. NM_153363.2.
    UniGeneiHs.520884.

    Genome annotation databases

    EnsembliENST00000255746; ENSP00000255746; ENSG00000197123.
    ENST00000421025; ENSP00000416809; ENSG00000197123.
    GeneIDi168417.
    KEGGihsa:168417.
    UCSCiuc003tsx.3. human.

    Polymorphism databases

    DMDMi296453054.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073270 Genomic DNA. No translation available.
    BC033523 mRNA. Translation: AAH33523.1 .
    CCDSi CCDS47592.1.
    RefSeqi NP_699194.2. NM_153363.2.
    UniGenei Hs.520884.

    3D structure databases

    ProteinModelPortali Q8IYX0.
    SMRi Q8IYX0. Positions 6-56, 126-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127961. 2 interactions.
    IntActi Q8IYX0. 1 interaction.
    MINTi MINT-1444273.

    PTM databases

    PhosphoSitei Q8IYX0.

    Polymorphism databases

    DMDMi 296453054.

    Proteomic databases

    PaxDbi Q8IYX0.
    PRIDEi Q8IYX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255746 ; ENSP00000255746 ; ENSG00000197123 .
    ENST00000421025 ; ENSP00000416809 ; ENSG00000197123 .
    GeneIDi 168417.
    KEGGi hsa:168417.
    UCSCi uc003tsx.3. human.

    Organism-specific databases

    CTDi 168417.
    GeneCardsi GC07P063688.
    HGNCi HGNC:28650. ZNF679.
    neXtProti NX_Q8IYX0.
    PharmGKBi PA142670480.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8IYX0.
    KOi K09228.
    OMAi LANHKSM.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8IYX0.
    TreeFami TF342117.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 168417.
    NextBioi 88722.
    PROi Q8IYX0.

    Gene expression databases

    Bgeei Q8IYX0.
    CleanExi HS_ZNF679.
    Genevestigatori Q8IYX0.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZN679_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3