Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 679

Gene

ZNF679

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 679
Gene namesi
Name:ZNF679
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197123.9
HGNCiHGNC:28650 ZNF679
neXtProtiNX_Q8IYX0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi168417
OpenTargetsiENSG00000197123
PharmGKBiPA142670480

Polymorphism and mutation databases

BioMutaiZNF679
DMDMi296453054

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339991 – 411Zinc finger protein 679Add BLAST411

Proteomic databases

EPDiQ8IYX0
MaxQBiQ8IYX0
PaxDbiQ8IYX0
PeptideAtlasiQ8IYX0
PRIDEiQ8IYX0
ProteomicsDBi71254

PTM databases

iPTMnetiQ8IYX0
PhosphoSitePlusiQ8IYX0

Expressioni

Gene expression databases

BgeeiENSG00000197123
CleanExiHS_ZNF679

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127961, 4 interactors
IntActiQ8IYX0, 4 interactors
STRINGi9606.ENSP00000255746

Structurei

3D structure databases

ProteinModelPortaliQ8IYX0
SMRiQ8IYX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8IYX0
KOiK09228
OMAiLANHKSM
OrthoDBiEOG091G02KC
PhylomeDBiQ8IYX0
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q8IYX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR
60 70 80 90 100
NLVSLGIAVS KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE
110 120 130 140 150
LGIKDSLQKV IPRRYGKSGH DNLQVKTCKS MGECEVQKGG CNEVNQCLST
160 170 180 190 200
TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG KKHFKCKKYG KSFCMVSQLH
210 220 230 240 250
QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY RCEECGKAFT
260 270 280 290 300
WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE
310 320 330 340 350
CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK
360 370 380 390 400
PYKCKECGKA FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS
410
MHTGEKPYKC E
Length:411
Mass (Da):47,179
Last modified:May 18, 2010 - v2
Checksum:iC687350A4A2BCBC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328E → K in AAH33523 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03358669E → G. Corresponds to variant dbSNP:rs12154540Ensembl.1
Natural variantiVAR_033587120H → R. Corresponds to variant dbSNP:rs17139320Ensembl.1
Natural variantiVAR_033588212Y → H. Corresponds to variant dbSNP:rs1830035Ensembl.1
Natural variantiVAR_033589223C → S. Corresponds to variant dbSNP:rs1830036Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073270 Genomic DNA No translation available.
BC033523 mRNA Translation: AAH33523.1
CCDSiCCDS47592.1
RefSeqiNP_699194.2, NM_153363.2
XP_016867286.1, XM_017011797.1
UniGeneiHs.520884

Genome annotation databases

EnsembliENST00000255746; ENSP00000255746; ENSG00000197123
ENST00000421025; ENSP00000416809; ENSG00000197123
GeneIDi168417
KEGGihsa:168417
UCSCiuc003tsx.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN679_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health