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Q8IYX0

- ZN679_HUMAN

UniProt

Q8IYX0 - ZN679_HUMAN

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Protein

Zinc finger protein 679

Gene

ZNF679

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 679
Gene namesi
Name:ZNF679
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28650. ZNF679.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Zinc finger protein 679PRO_0000233999Add
BLAST

Proteomic databases

PaxDbiQ8IYX0.
PRIDEiQ8IYX0.

PTM databases

PhosphoSiteiQ8IYX0.

Expressioni

Gene expression databases

BgeeiQ8IYX0.
CleanExiHS_ZNF679.
GenevestigatoriQ8IYX0.

Interactioni

Protein-protein interaction databases

BioGridi127961. 2 interactions.
IntActiQ8IYX0. 1 interaction.
MINTiMINT-1444273.

Structurei

3D structure databases

ProteinModelPortaliQ8IYX0.
SMRiQ8IYX0. Positions 6-56, 153-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074383.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IYX0.
KOiK09228.
OMAiLANHKSM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8IYX0.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR
60 70 80 90 100
NLVSLGIAVS KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE
110 120 130 140 150
LGIKDSLQKV IPRRYGKSGH DNLQVKTCKS MGECEVQKGG CNEVNQCLST
160 170 180 190 200
TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG KKHFKCKKYG KSFCMVSQLH
210 220 230 240 250
QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY RCEECGKAFT
260 270 280 290 300
WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE
310 320 330 340 350
CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK
360 370 380 390 400
PYKCKECGKA FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS
410
MHTGEKPYKC E
Length:411
Mass (Da):47,179
Last modified:May 18, 2010 - v2
Checksum:iC687350A4A2BCBC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3281E → K in AAH33523. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691E → G.
Corresponds to variant rs12154540 [ dbSNP | Ensembl ].
VAR_033586
Natural varianti120 – 1201H → R.
Corresponds to variant rs17139320 [ dbSNP | Ensembl ].
VAR_033587
Natural varianti212 – 2121Y → H.
Corresponds to variant rs1830035 [ dbSNP | Ensembl ].
VAR_033588
Natural varianti223 – 2231C → S.
Corresponds to variant rs1830036 [ dbSNP | Ensembl ].
VAR_033589

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073270 Genomic DNA. No translation available.
BC033523 mRNA. Translation: AAH33523.1.
CCDSiCCDS47592.1.
RefSeqiNP_699194.2. NM_153363.2.
UniGeneiHs.520884.

Genome annotation databases

EnsembliENST00000255746; ENSP00000255746; ENSG00000197123.
ENST00000421025; ENSP00000416809; ENSG00000197123.
GeneIDi168417.
KEGGihsa:168417.
UCSCiuc003tsx.3. human.

Polymorphism databases

DMDMi296453054.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073270 Genomic DNA. No translation available.
BC033523 mRNA. Translation: AAH33523.1 .
CCDSi CCDS47592.1.
RefSeqi NP_699194.2. NM_153363.2.
UniGenei Hs.520884.

3D structure databases

ProteinModelPortali Q8IYX0.
SMRi Q8IYX0. Positions 6-56, 153-410.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127961. 2 interactions.
IntActi Q8IYX0. 1 interaction.
MINTi MINT-1444273.

PTM databases

PhosphoSitei Q8IYX0.

Polymorphism databases

DMDMi 296453054.

Proteomic databases

PaxDbi Q8IYX0.
PRIDEi Q8IYX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255746 ; ENSP00000255746 ; ENSG00000197123 .
ENST00000421025 ; ENSP00000416809 ; ENSG00000197123 .
GeneIDi 168417.
KEGGi hsa:168417.
UCSCi uc003tsx.3. human.

Organism-specific databases

CTDi 168417.
GeneCardsi GC07P063688.
HGNCi HGNC:28650. ZNF679.
neXtProti NX_Q8IYX0.
PharmGKBi PA142670480.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00550000074383.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8IYX0.
KOi K09228.
OMAi LANHKSM.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8IYX0.
TreeFami TF342117.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 168417.
NextBioi 88722.
PROi Q8IYX0.

Gene expression databases

Bgeei Q8IYX0.
CleanExi HS_ZNF679.
Genevestigatori Q8IYX0.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN679_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3