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Protein

Zinc finger protein 679

Gene

ZNF679

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 679
Gene namesi
Name:ZNF679
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:28650. ZNF679.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi168417.
OpenTargetsiENSG00000197123.
PharmGKBiPA142670480.

Polymorphism and mutation databases

BioMutaiZNF679.
DMDMi296453054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339991 – 411Zinc finger protein 679Add BLAST411

Proteomic databases

MaxQBiQ8IYX0.
PaxDbiQ8IYX0.
PeptideAtlasiQ8IYX0.
PRIDEiQ8IYX0.

PTM databases

iPTMnetiQ8IYX0.
PhosphoSitePlusiQ8IYX0.

Expressioni

Gene expression databases

BgeeiENSG00000197123.
CleanExiHS_ZNF679.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-745567,EBI-10172150
MDFIQ997503EBI-745567,EBI-724076

Protein-protein interaction databases

BioGridi127961. 3 interactors.
IntActiQ8IYX0. 4 interactors.
MINTiMINT-1444273.
STRINGi9606.ENSP00000255746.

Structurei

3D structure databases

ProteinModelPortaliQ8IYX0.
SMRiQ8IYX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IYX0.
KOiK09228.
OMAiLANHKSM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IYX0.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR
60 70 80 90 100
NLVSLGIAVS KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE
110 120 130 140 150
LGIKDSLQKV IPRRYGKSGH DNLQVKTCKS MGECEVQKGG CNEVNQCLST
160 170 180 190 200
TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG KKHFKCKKYG KSFCMVSQLH
210 220 230 240 250
QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY RCEECGKAFT
260 270 280 290 300
WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE
310 320 330 340 350
CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK
360 370 380 390 400
PYKCKECGKA FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS
410
MHTGEKPYKC E
Length:411
Mass (Da):47,179
Last modified:May 18, 2010 - v2
Checksum:iC687350A4A2BCBC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328E → K in AAH33523 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03358669E → G.Corresponds to variant rs12154540dbSNPEnsembl.1
Natural variantiVAR_033587120H → R.Corresponds to variant rs17139320dbSNPEnsembl.1
Natural variantiVAR_033588212Y → H.Corresponds to variant rs1830035dbSNPEnsembl.1
Natural variantiVAR_033589223C → S.Corresponds to variant rs1830036dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073270 Genomic DNA. No translation available.
BC033523 mRNA. Translation: AAH33523.1.
CCDSiCCDS47592.1.
RefSeqiNP_699194.2. NM_153363.2.
XP_016867286.1. XM_017011797.1.
UniGeneiHs.520884.

Genome annotation databases

EnsembliENST00000255746; ENSP00000255746; ENSG00000197123.
ENST00000421025; ENSP00000416809; ENSG00000197123.
GeneIDi168417.
KEGGihsa:168417.
UCSCiuc003tsx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073270 Genomic DNA. No translation available.
BC033523 mRNA. Translation: AAH33523.1.
CCDSiCCDS47592.1.
RefSeqiNP_699194.2. NM_153363.2.
XP_016867286.1. XM_017011797.1.
UniGeneiHs.520884.

3D structure databases

ProteinModelPortaliQ8IYX0.
SMRiQ8IYX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127961. 3 interactors.
IntActiQ8IYX0. 4 interactors.
MINTiMINT-1444273.
STRINGi9606.ENSP00000255746.

PTM databases

iPTMnetiQ8IYX0.
PhosphoSitePlusiQ8IYX0.

Polymorphism and mutation databases

BioMutaiZNF679.
DMDMi296453054.

Proteomic databases

MaxQBiQ8IYX0.
PaxDbiQ8IYX0.
PeptideAtlasiQ8IYX0.
PRIDEiQ8IYX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255746; ENSP00000255746; ENSG00000197123.
ENST00000421025; ENSP00000416809; ENSG00000197123.
GeneIDi168417.
KEGGihsa:168417.
UCSCiuc003tsx.3. human.

Organism-specific databases

CTDi168417.
DisGeNETi168417.
GeneCardsiZNF679.
HGNCiHGNC:28650. ZNF679.
neXtProtiNX_Q8IYX0.
OpenTargetsiENSG00000197123.
PharmGKBiPA142670480.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IYX0.
KOiK09228.
OMAiLANHKSM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IYX0.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii168417.
PROiQ8IYX0.

Gene expression databases

BgeeiENSG00000197123.
CleanExiHS_ZNF679.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN679_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.