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Protein

ENTH domain-containing protein 1

Gene

ENTHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ENTH domain-containing protein 1
Alternative name(s):
Epsin-2B
Gene namesi
Name:ENTHD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000176177.9
HGNCiHGNC:26352 ENTHD1
neXtProtiNX_Q8IYW4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176177
PharmGKBiPA145148940

Polymorphism and mutation databases

BioMutaiENTHD1
DMDMi74728393

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121791 – 607ENTH domain-containing protein 1Add BLAST607

Proteomic databases

EPDiQ8IYW4
PaxDbiQ8IYW4
PeptideAtlasiQ8IYW4
PRIDEiQ8IYW4
ProteomicsDBi71252

PTM databases

iPTMnetiQ8IYW4
PhosphoSitePlusiQ8IYW4

Expressioni

Gene expression databases

BgeeiENSG00000176177
CleanExiHS_ENTHD1
GenevisibleiQ8IYW4 HS

Organism-specific databases

HPAiHPA019800

Interactioni

Protein-protein interaction databases

BioGridi127283, 24 interactors
STRINGi9606.ENSP00000317431

Structurei

3D structure databases

ProteinModelPortaliQ8IYW4
SMRiQ8IYW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 141ENTHPROSITE-ProRule annotationAdd BLAST133

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili543 – 574Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2056 Eukaryota
ENOG410XSM0 LUCA
GeneTreeiENSGT00550000074611
HOGENOMiHOG000038004
HOVERGENiHBG071423
InParanoidiQ8IYW4
OMAiQVITLLM
OrthoDBiEOG091G05DR
PhylomeDBiQ8IYW4
TreeFamiTF313361

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR013809 ENTH
IPR008942 ENTH_VHS
PfamiView protein in Pfam
PF01417 ENTH, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IYW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRRQVKNF VKNYSDAEIK VREATSNDPW GPSSSLMLDI SDLTFNTISL
60 70 80 90 100
SEIMNMLWHR LNDHGKNWRH VYKSLTLMDY LIKNGSKKVI QHCREGFCNL
110 120 130 140 150
QTLKDFQHID EAGKDQGYYI REKSKQVITL LMDEPLLCKE REVACRTRQR
160 170 180 190 200
TSHSILFSKR QLGSSNSLTA CTSAPTPDIS ASEKKYKLPK FGRLHNKRNV
210 220 230 240 250
CKAGLKQEHC QDVHLPTETM LSQETLPLKI HGWKSTEDLM TFLDDDPELP
260 270 280 290 300
LLATPPSIVS PITCLSEAEE VCNLSGADAV PTLSENSPSG QRDVSLDKRS
310 320 330 340 350
DGIFTNTVTE NLLETPLEKQ SAAEGLKTLT ILPACWSSKE EFISPDLRVS
360 370 380 390 400
KSDSTFHNQA SVETLCLSPS FKIFDRVKEI VINKAYQKPA QSSIQMDDKI
410 420 430 440 450
LKTTTRVSTA SEGASSFSPL SMSSPDLASP EKSAHLLSPI LAGPSFWTLS
460 470 480 490 500
HQQLSSTSFK DEDKTAKLHH SFASRGPVSS DVEENDSLNL LGILPNNSDS
510 520 530 540 550
AKKNISHISS SHWGEFSTQN VDQFIPLSCS GFQSTKDFPQ EPEAKNSISV
560 570 580 590 600
LLREVKRAIA RLHEDLSTVI QELNVINNIL MSMSLNSSQI SQSSQVPQSS

EGSSDQI
Length:607
Mass (Da):67,538
Last modified:March 1, 2003 - v1
Checksum:i0FB7FE674E54D4EF
GO

Sequence cautioni

The sequence BAB71688 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037449109I → T. Corresponds to variant dbSNP:rs17319801Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456452 mRNA Translation: CAG30338.1
Z82206 Genomic DNA No translation available.
AL022353 Genomic DNA No translation available.
AL022319 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60353.1
BC033895 mRNA Translation: AAH33895.1
AK058150 mRNA Translation: BAB71688.1 Different initiation.
CCDSiCCDS13998.1
RefSeqiNP_689725.2, NM_152512.3
XP_006724212.1, XM_006724149.3
UniGeneiHs.474869

Genome annotation databases

EnsembliENST00000325157; ENSP00000317431; ENSG00000176177
GeneIDi150350
KEGGihsa:150350
UCSCiuc003ayg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiENTD1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYW4
Secondary accession number(s): B0QYD5, Q5H9F7, Q96LK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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