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Protein

Ubiquilin-like protein

Gene

UBQLNL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquilin-like protein
Gene namesi
Name:UBQLNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28294. UBQLNL.

Pathology & Biotechi

Organism-specific databases

DisGeNETi143630.
OpenTargetsiENSG00000175518.
PharmGKBiPA162407912.

Polymorphism and mutation databases

BioMutaiUBQLNL.
DMDMi296453003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077911 – 475Ubiquilin-like proteinAdd BLAST475

Proteomic databases

PaxDbiQ8IYU4.
PeptideAtlasiQ8IYU4.
PRIDEiQ8IYU4.

PTM databases

iPTMnetiQ8IYU4.
PhosphoSitePlusiQ8IYU4.

Expressioni

Gene expression databases

BgeeiENSG00000175518.
CleanExiHS_UBQLNL.
GenevisibleiQ8IYU4. HS.

Organism-specific databases

HPAiHPA039112.

Interactioni

Protein-protein interaction databases

IntActiQ8IYU4. 1 interactor.
STRINGi9606.ENSP00000369531.

Structurei

3D structure databases

ProteinModelPortaliQ8IYU4.
SMRiQ8IYU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 105Ubiquitin-likePROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi310 – 315Poly-Pro6

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0010. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00390000005720.
HOGENOMiHOG000234878.
HOVERGENiHBG064537.
InParanoidiQ8IYU4.
KOiK04523.
OMAiVAPYLWG.
OrthoDBiEOG091G06MS.
PhylomeDBiQ8IYU4.
TreeFamiTF314412.

Family and domain databases

InterProiIPR015496. Ubiquilin.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10677. PTHR10677. 1 hit.
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWHAISRTSR MSQSGCPSGL LADKNISSSA TRVIVKTAGN QKDFMVADDI
60 70 80 90 100
SVRQFKEMLL AHFQCQMDQL VLVFMGCLLK DHDTLSQRGI MDGHTIYLVI
110 120 130 140 150
KSKQGSRSLA HSFRDLPTND PCHRDRNTKG NSSRVHQPTG MNQAPVELAH
160 170 180 190 200
FVGSDAPKVH TQNLEVSHPE CKAQMLENPS IQRLLSNMEF MWQFISEHLD
210 220 230 240 250
TQQLMQQNPE VSRLLLDNSE ILLQTLELAR NLAMIQEIMQ IQQPSQNLEY
260 270 280 290 300
PLNPQPYLGL ETMPGGNNAL GQNYADINDQ MLNSMQDPFG GNPFTALLAG
310 320 330 340 350
QVLEQVQSSP PPPPPSQEQQ DQLTQHPATR VIYNSSGGFS SNTSANDTLN
360 370 380 390 400
KVNHTSKANT AMISTKGQSH ICATRQPAWI PALPSIELTQ QLQEEYKDAT
410 420 430 440 450
VSLSSSRQTL KGDLQLSDEQ SSSQITGGMM QLLMNNPYLA AQIMLFTSMP
460 470
QLSEQWRQQL PTFLQQTQIS DLLSA
Length:475
Mass (Da):52,897
Last modified:May 18, 2010 - v3
Checksum:i410A3131A9CE9265
GO
Isoform 2 (identifier: Q8IYU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-341: Missing.

Note: No experimental confirmation available.
Show »
Length:260
Mass (Da):29,004
Checksum:iB5D6A5D11B8A3649
GO

Sequence cautioni

The sequence BAC87218 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351K → E in BAB71398 (PubMed:14702039).Curated1
Sequence conflicti398D → G in BAB71398 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03665292D → V.Corresponds to variant rs7933557dbSNPEnsembl.1
Natural variantiVAR_036653143Q → K.Corresponds to variant rs3802978dbSNPEnsembl.1
Natural variantiVAR_036654171C → R.1 PublicationCorresponds to variant rs2047456dbSNPEnsembl.1
Natural variantiVAR_036655259G → D.Corresponds to variant rs16932225dbSNPEnsembl.1
Natural variantiVAR_036656274Y → H.1 PublicationCorresponds to variant rs2017434dbSNPEnsembl.1
Natural variantiVAR_036657275A → V.2 PublicationsCorresponds to variant rs2017433dbSNPEnsembl.1
Natural variantiVAR_036658379W → G.2 PublicationsCorresponds to variant rs393044dbSNPEnsembl.1
Natural variantiVAR_036659455Q → E.1 PublicationCorresponds to variant rs12223282dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028833127 – 341Missing in isoform 2. 1 PublicationAdd BLAST215

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057255 mRNA. Translation: BAB71398.1.
AK127987 mRNA. Translation: BAC87218.1. Sequence problems.
AC087380 Genomic DNA. No translation available.
BC012183 mRNA. Translation: AAH12183.2.
BC034977 mRNA. Translation: AAH34977.2.
CCDSiCCDS31385.1. [Q8IYU4-1]
RefSeqiNP_659490.4. NM_145053.4. [Q8IYU4-1]
UniGeneiHs.10688.

Genome annotation databases

EnsembliENST00000380184; ENSP00000369531; ENSG00000175518. [Q8IYU4-1]
GeneIDi143630.
KEGGihsa:143630.
UCSCiuc001maz.5. human. [Q8IYU4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057255 mRNA. Translation: BAB71398.1.
AK127987 mRNA. Translation: BAC87218.1. Sequence problems.
AC087380 Genomic DNA. No translation available.
BC012183 mRNA. Translation: AAH12183.2.
BC034977 mRNA. Translation: AAH34977.2.
CCDSiCCDS31385.1. [Q8IYU4-1]
RefSeqiNP_659490.4. NM_145053.4. [Q8IYU4-1]
UniGeneiHs.10688.

3D structure databases

ProteinModelPortaliQ8IYU4.
SMRiQ8IYU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IYU4. 1 interactor.
STRINGi9606.ENSP00000369531.

PTM databases

iPTMnetiQ8IYU4.
PhosphoSitePlusiQ8IYU4.

Polymorphism and mutation databases

BioMutaiUBQLNL.
DMDMi296453003.

Proteomic databases

PaxDbiQ8IYU4.
PeptideAtlasiQ8IYU4.
PRIDEiQ8IYU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380184; ENSP00000369531; ENSG00000175518. [Q8IYU4-1]
GeneIDi143630.
KEGGihsa:143630.
UCSCiuc001maz.5. human. [Q8IYU4-1]

Organism-specific databases

CTDi143630.
DisGeNETi143630.
GeneCardsiUBQLNL.
HGNCiHGNC:28294. UBQLNL.
HPAiHPA039112.
neXtProtiNX_Q8IYU4.
OpenTargetsiENSG00000175518.
PharmGKBiPA162407912.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0010. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00390000005720.
HOGENOMiHOG000234878.
HOVERGENiHBG064537.
InParanoidiQ8IYU4.
KOiK04523.
OMAiVAPYLWG.
OrthoDBiEOG091G06MS.
PhylomeDBiQ8IYU4.
TreeFamiTF314412.

Miscellaneous databases

GenomeRNAii143630.
PROiQ8IYU4.

Gene expression databases

BgeeiENSG00000175518.
CleanExiHS_UBQLNL.
GenevisibleiQ8IYU4. HS.

Family and domain databases

InterProiIPR015496. Ubiquilin.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10677. PTHR10677. 1 hit.
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBQLN_HUMAN
AccessioniPrimary (citable) accession number: Q8IYU4
Secondary accession number(s): Q6ZRU1, Q96EK3, Q96MB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.