##gff-version 3
Q8IYU2	UniProtKB	Chain	1	909	.	.	.	ID=PRO_0000280622;Note=E3 ubiquitin-protein ligase HACE1	
Q8IYU2	UniProtKB	Repeat	64	93	.	.	.	Note=ANK 1	
Q8IYU2	UniProtKB	Repeat	97	126	.	.	.	Note=ANK 2	
Q8IYU2	UniProtKB	Repeat	130	159	.	.	.	Note=ANK 3	
Q8IYU2	UniProtKB	Repeat	163	192	.	.	.	Note=ANK 4	
Q8IYU2	UniProtKB	Repeat	196	226	.	.	.	Note=ANK 5	
Q8IYU2	UniProtKB	Repeat	228	257	.	.	.	Note=ANK 6	
Q8IYU2	UniProtKB	Domain	574	909	.	.	.	Note=HECT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00104	
Q8IYU2	UniProtKB	Region	398	433	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IYU2	UniProtKB	Active site	876	876	.	.	.	Note=Glycyl thioester intermediate	
Q8IYU2	UniProtKB	Alternative sequence	1	591	.	.	.	ID=VSP_023829;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005	
Q8IYU2	UniProtKB	Alternative sequence	1	357	.	.	.	ID=VSP_023830;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10718198;Dbxref=PMID:10718198	
Q8IYU2	UniProtKB	Alternative sequence	358	358	.	.	.	ID=VSP_023831;Note=In isoform 3. K->MMFKKHFCFSQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10718198;Dbxref=PMID:10718198	
Q8IYU2	UniProtKB	Alternative sequence	523	737	.	.	.	ID=VSP_042378;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
Q8IYU2	UniProtKB	Natural variant	17	17	.	.	.	ID=VAR_031180;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17853353,PMID:15489334	
Q8IYU2	UniProtKB	Natural variant	374	374	.	.	.	ID=VAR_031181;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857038,PMID:15489334	
Q8IYU2	UniProtKB	Natural variant	832	832	.	.	.	ID=VAR_076311;Note=In SPPRS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26437029;Dbxref=PMID:26437029	
Q8IYU2	UniProtKB	Mutagenesis	876	876	.	.	.	Note=Loss of E3 ubiquitin ligase activity. C->A%2CS;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15254018,ECO:0000269|PubMed:21988917,ECO:0000269|PubMed:22036506;Dbxref=PMID:15254018,PMID:21988917,PMID:22036506	
Q8IYU2	UniProtKB	Sequence conflict	132	132	.	.	.	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYU2	UniProtKB	Sequence conflict	299	299	.	.	.	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYU2	UniProtKB	Sequence conflict	581	581	.	.	.	Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYU2	UniProtKB	Sequence conflict	875	875	.	.	.	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305