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Protein

Katanin p60 ATPase-containing subunit A-like 2

Gene

KATNAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi294 – 3018ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A-like 2UniRule annotation (EC:3.6.4.3UniRule annotation)
Short name:
Katanin p60 subunit A-like 2UniRule annotation
Alternative name(s):
p60 katanin-like 2UniRule annotation
Gene namesi
Name:KATNAL2UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:25387. KATNAL2.

Subcellular locationi

  • Cytoplasmcytoskeleton UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921461.

Polymorphism and mutation databases

BioMutaiKATNAL2.
DMDMi189028467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Katanin p60 ATPase-containing subunit A-like 2PRO_0000333792Add
BLAST

Proteomic databases

EPDiQ8IYT4.
MaxQBiQ8IYT4.
PaxDbiQ8IYT4.
PeptideAtlasiQ8IYT4.
PRIDEiQ8IYT4.

PTM databases

iPTMnetiQ8IYT4.
PhosphoSiteiQ8IYT4.

Expressioni

Gene expression databases

BgeeiQ8IYT4.
CleanExiHS_KATNAL2.
ExpressionAtlasiQ8IYT4. baseline and differential.
GenevisibleiQ8IYT4. HS.

Organism-specific databases

HPAiHPA040712.
HPA042029.

Interactioni

Protein-protein interaction databases

BioGridi123661. 3 interactions.
IntActiQ8IYT4. 2 interactions.
STRINGi9606.ENSP00000245121.

Structurei

3D structure databases

ProteinModelPortaliQ8IYT4.
SMRiQ8IYT4. Positions 26-57, 189-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5733LisHUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.UniRule annotation
Contains 1 LisH domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0738. Eukaryota.
ENOG410XPN7. LUCA.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225146.
HOVERGENiHBG108053.
InParanoidiQ8IYT4.
KOiK07767.
OMAiQEGYIDT.
PhylomeDBiQ8IYT4.
TreeFamiTF329610.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03025. Katanin_p60_AL2.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027497. Katanin_p60_AL2.
IPR006594. LisH.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSYQTLKF THQAREACEM RTEARRKNLL ILISHYLTQE GYIDTANALE
60 70 80 90 100
QETKLGLRRF EVCDNIDLET ILMEYESYYF VKFQKYPKIV KKSSDTAENN
110 120 130 140 150
LPQRSRGKTR RMMNDSCQNL PKINQQRPRS KTTAGKTGDT KSLNKEHPNQ
160 170 180 190 200
EVVDNTRLES ANFGLHISRI RKDSGEENAH PRRGQIIDFQ GLLTDAIKGA
210 220 230 240 250
TSELALNTFD HNPDPSERLL KPLSAFIGMN SEMRELAAVV SRDIYLHNPN
260 270 280 290 300
IKWNDIIGLD AAKQLVKEAV VYPIRYPQLF TGILSPWKGL LLYGPPGTGK
310 320 330 340 350
TLLAKAVATE CKTTFFNISA STIVSKWRGD SEKLVRVLFE LARYHAPSTI
360 370 380 390 400
FLDELESVMS QRGTASGGEH EGSLRMKTEL LVQMDGLARS EDLVFVLAAS
410 420 430 440 450
NLPWELDCAM LRRLEKRILV DLPSREARQA MIYHWLPPVS KSRALELHTE
460 470 480 490 500
LEYSVLSQET EGYSGSDIKL VCREAAMRPV RKIFDALENH QSESSDLPRI
510 520 530
QLDIVTTADF LDVLTHTKPS AKNLAQRYSD WQREFESV
Length:538
Mass (Da):61,253
Last modified:May 20, 2008 - v3
Checksum:iF966747821008D3F
GO
Isoform 2 (identifier: Q8IYT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:466
Mass (Da):52,781
Checksum:i01B357679285FADE
GO

Sequence cautioni

The sequence BI560635 differs from that shown. Reason: Frameshift at positions 183, 188, 200 and 203. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1802AH → GQ in BI560635 (PubMed:15489334).Curated
Sequence conflicti207 – 2071N → S in BI560635 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti160 – 1601S → N.2 Publications
Corresponds to variant rs7233515 [ dbSNP | Ensembl ].
VAR_043160

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272Missing in isoform 2. 1 PublicationVSP_033523Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012254 Genomic DNA. No translation available.
AC090373 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW62904.1.
BC034999 mRNA. Translation: AAH34999.2.
BI560635 mRNA. No translation available.
DB461284 mRNA. No translation available.
CCDSiCCDS32828.1. [Q8IYT4-2]
RefSeqiNP_112593.2. NM_031303.2. [Q8IYT4-2]
XP_006722617.1. XM_006722554.2. [Q8IYT4-1]
UniGeneiHs.404137.

Genome annotation databases

EnsembliENST00000245121; ENSP00000245121; ENSG00000167216. [Q8IYT4-2]
ENST00000356157; ENSP00000348478; ENSG00000167216. [Q8IYT4-1]
GeneIDi83473.
KEGGihsa:83473.
UCSCiuc002lco.3. human. [Q8IYT4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012254 Genomic DNA. No translation available.
AC090373 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW62904.1.
BC034999 mRNA. Translation: AAH34999.2.
BI560635 mRNA. No translation available.
DB461284 mRNA. No translation available.
CCDSiCCDS32828.1. [Q8IYT4-2]
RefSeqiNP_112593.2. NM_031303.2. [Q8IYT4-2]
XP_006722617.1. XM_006722554.2. [Q8IYT4-1]
UniGeneiHs.404137.

3D structure databases

ProteinModelPortaliQ8IYT4.
SMRiQ8IYT4. Positions 26-57, 189-535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123661. 3 interactions.
IntActiQ8IYT4. 2 interactions.
STRINGi9606.ENSP00000245121.

PTM databases

iPTMnetiQ8IYT4.
PhosphoSiteiQ8IYT4.

Polymorphism and mutation databases

BioMutaiKATNAL2.
DMDMi189028467.

Proteomic databases

EPDiQ8IYT4.
MaxQBiQ8IYT4.
PaxDbiQ8IYT4.
PeptideAtlasiQ8IYT4.
PRIDEiQ8IYT4.

Protocols and materials databases

DNASUi83473.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245121; ENSP00000245121; ENSG00000167216. [Q8IYT4-2]
ENST00000356157; ENSP00000348478; ENSG00000167216. [Q8IYT4-1]
GeneIDi83473.
KEGGihsa:83473.
UCSCiuc002lco.3. human. [Q8IYT4-1]

Organism-specific databases

CTDi83473.
GeneCardsiKATNAL2.
HGNCiHGNC:25387. KATNAL2.
HPAiHPA040712.
HPA042029.
MIMi614697. gene.
neXtProtiNX_Q8IYT4.
PharmGKBiPA134921461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0738. Eukaryota.
ENOG410XPN7. LUCA.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225146.
HOVERGENiHBG108053.
InParanoidiQ8IYT4.
KOiK07767.
OMAiQEGYIDT.
PhylomeDBiQ8IYT4.
TreeFamiTF329610.

Miscellaneous databases

GenomeRNAii83473.
PROiQ8IYT4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IYT4.
CleanExiHS_KATNAL2.
ExpressionAtlasiQ8IYT4. baseline and differential.
GenevisibleiQ8IYT4. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03025. Katanin_p60_AL2.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027497. Katanin_p60_AL2.
IPR006594. LisH.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-160.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-215 (ISOFORM 1), VARIANT ASN-160.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-146 (ISOFORM 1).

Entry informationi

Entry nameiKATL2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 6, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.