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Protein

Katanin p60 ATPase-containing subunit A-like 2

Gene

KATNAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi294 – 301ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A-like 2UniRule annotation (EC:3.6.4.3UniRule annotation)
Short name:
Katanin p60 subunit A-like 2UniRule annotation
Alternative name(s):
p60 katanin-like 2UniRule annotation
Gene namesi
Name:KATNAL2UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000167216.16
HGNCiHGNC:25387 KATNAL2
MIMi614697 gene
neXtProtiNX_Q8IYT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi83473
OpenTargetsiENSG00000167216
PharmGKBiPA134921461

Polymorphism and mutation databases

BioMutaiKATNAL2
DMDMi189028467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003337921 – 538Katanin p60 ATPase-containing subunit A-like 2Add BLAST538

Proteomic databases

EPDiQ8IYT4
MaxQBiQ8IYT4
PaxDbiQ8IYT4
PeptideAtlasiQ8IYT4
PRIDEiQ8IYT4

PTM databases

iPTMnetiQ8IYT4
PhosphoSitePlusiQ8IYT4

Expressioni

Gene expression databases

BgeeiENSG00000167216
CleanExiHS_KATNAL2
ExpressionAtlasiQ8IYT4 baseline and differential
GenevisibleiQ8IYT4 HS

Organism-specific databases

HPAiHPA040712
HPA042029

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356093EBI-1044332,EBI-77797

Protein-protein interaction databases

BioGridi123661, 3 interactors
IntActiQ8IYT4, 57 interactors
STRINGi9606.ENSP00000245121

Structurei

3D structure databases

ProteinModelPortaliQ8IYT4
SMRiQ8IYT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 57LisHUniRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0738 Eukaryota
ENOG410XPN7 LUCA
GeneTreeiENSGT00550000074466
HOGENOMiHOG000225146
HOVERGENiHBG108053
InParanoidiQ8IYT4
KOiK07767
OMAiMKTQGKY
OrthoDBiEOG091G0Q8J
PhylomeDBiQ8IYT4
TreeFamiTF329610

Family and domain databases

HAMAPiMF_03025 Katanin_p60_AL2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027497 Katanin_p60_AL2
IPR006594 LisH
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08513 LisH, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00667 LisH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSYQTLKF THQAREACEM RTEARRKNLL ILISHYLTQE GYIDTANALE
60 70 80 90 100
QETKLGLRRF EVCDNIDLET ILMEYESYYF VKFQKYPKIV KKSSDTAENN
110 120 130 140 150
LPQRSRGKTR RMMNDSCQNL PKINQQRPRS KTTAGKTGDT KSLNKEHPNQ
160 170 180 190 200
EVVDNTRLES ANFGLHISRI RKDSGEENAH PRRGQIIDFQ GLLTDAIKGA
210 220 230 240 250
TSELALNTFD HNPDPSERLL KPLSAFIGMN SEMRELAAVV SRDIYLHNPN
260 270 280 290 300
IKWNDIIGLD AAKQLVKEAV VYPIRYPQLF TGILSPWKGL LLYGPPGTGK
310 320 330 340 350
TLLAKAVATE CKTTFFNISA STIVSKWRGD SEKLVRVLFE LARYHAPSTI
360 370 380 390 400
FLDELESVMS QRGTASGGEH EGSLRMKTEL LVQMDGLARS EDLVFVLAAS
410 420 430 440 450
NLPWELDCAM LRRLEKRILV DLPSREARQA MIYHWLPPVS KSRALELHTE
460 470 480 490 500
LEYSVLSQET EGYSGSDIKL VCREAAMRPV RKIFDALENH QSESSDLPRI
510 520 530
QLDIVTTADF LDVLTHTKPS AKNLAQRYSD WQREFESV
Length:538
Mass (Da):61,253
Last modified:May 20, 2008 - v3
Checksum:iF966747821008D3F
GO
Isoform 2 (identifier: Q8IYT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:466
Mass (Da):52,781
Checksum:i01B357679285FADE
GO

Sequence cautioni

The sequence BI560635 differs from that shown. Reason: Frameshift at positions 183, 188, 200 and 203.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179 – 180AH → GQ in BI560635 (PubMed:15489334).Curated2
Sequence conflicti207N → S in BI560635 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043160160S → N2 PublicationsCorresponds to variant dbSNP:rs7233515Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335231 – 72Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012254 Genomic DNA No translation available.
AC090373 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW62904.1
BC034999 mRNA Translation: AAH34999.2
BI560635 mRNA No translation available.
DB461284 mRNA No translation available.
CCDSiCCDS32828.1 [Q8IYT4-2]
RefSeqiNP_112593.2, NM_031303.2 [Q8IYT4-2]
XP_006722617.1, XM_006722554.3 [Q8IYT4-1]
UniGeneiHs.404137

Genome annotation databases

EnsembliENST00000245121; ENSP00000245121; ENSG00000167216 [Q8IYT4-2]
ENST00000356157; ENSP00000348478; ENSG00000167216 [Q8IYT4-1]
GeneIDi83473
KEGGihsa:83473
UCSCiuc002lco.3 human [Q8IYT4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKATL2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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