Q8IYT4 (KATL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Katanin p60 ATPase-containing subunit A-like 2
Short name=Katanin p60 subunit A-like 2
EC=3.6.4.3

Alternative name(s):
p60 katanin-like 2

Gene names

Name:

KATNAL2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the AAA ATPase family. Contains 1 LisH domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule-severing ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IYT4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IYT4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 538	538	Katanin p60 ATPase-containing subunit A-like 2		PRO_0000333792
Regions
	Domain	25 – 57	33	LisH
	Nucleotide binding	294 – 301	8	ATP Potential
Natural variations
	Alternative sequence	1 – 72	72	Missing in isoform 2.		VSP_033523
	Natural variant	160	1	S → N. Ref.2 Ref.3 Corresponds to variant rs7233515 [ dbSNP | Ensembl ].		VAR_043160

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 20, 2008. Version 3. Checksum: F966747821008D3F	FASTA	538	61,253
	10 20 30 40 50 60 MELSYQTLKF THQAREACEM RTEARRKNLL ILISHYLTQE GYIDTANALE QETKLGLRRF 70 80 90 100 110 120 EVCDNIDLET ILMEYESYYF VKFQKYPKIV KKSSDTAENN LPQRSRGKTR RMMNDSCQNL 130 140 150 160 170 180 PKINQQRPRS KTTAGKTGDT KSLNKEHPNQ EVVDNTRLES ANFGLHISRI RKDSGEENAH 190 200 210 220 230 240 PRRGQIIDFQ GLLTDAIKGA TSELALNTFD HNPDPSERLL KPLSAFIGMN SEMRELAAVV 250 260 270 280 290 300 SRDIYLHNPN IKWNDIIGLD AAKQLVKEAV VYPIRYPQLF TGILSPWKGL LLYGPPGTGK 310 320 330 340 350 360 TLLAKAVATE CKTTFFNISA STIVSKWRGD SEKLVRVLFE LARYHAPSTI FLDELESVMS 370 380 390 400 410 420 QRGTASGGEH EGSLRMKTEL LVQMDGLARS EDLVFVLAAS NLPWELDCAM LRRLEKRILV 430 440 450 460 470 480 DLPSREARQA MIYHWLPPVS KSRALELHTE LEYSVLSQET EGYSGSDIKL VCREAAMRPV 490 500 510 520 530 RKIFDALENH QSESSDLPRI QLDIVTTADF LDVLTHTKPS AKNLAQRYSD WQREFESV
	Isoform 2 [UniParc]. Checksum: 01B357679285FADE	FASTA	466	52,781
	10 20 30 40 50 60 MEYESYYFVK FQKYPKIVKK SSDTAENNLP QRSRGKTRRM MNDSCQNLPK INQQRPRSKT 70 80 90 100 110 120 TAGKTGDTKS LNKEHPNQEV VDNTRLESAN FGLHISRIRK DSGEENAHPR RGQIIDFQGL 130 140 150 160 170 180 LTDAIKGATS ELALNTFDHN PDPSERLLKP LSAFIGMNSE MRELAAVVSR DIYLHNPNIK 190 200 210 220 230 240 WNDIIGLDAA KQLVKEAVVY PIRYPQLFTG ILSPWKGLLL YGPPGTGKTL LAKAVATECK 250 260 270 280 290 300 TTFFNISAST IVSKWRGDSE KLVRVLFELA RYHAPSTIFL DELESVMSQR GTASGGEHEG 310 320 330 340 350 360 SLRMKTELLV QMDGLARSED LVFVLAASNL PWELDCAMLR RLEKRILVDL PSREARQAMI 370 380 390 400 410 420 YHWLPPVSKS RALELHTELE YSVLSQETEG YSGSDIKLVC REAAMRPVRK IFDALENHQS 430 440 450 460 ESSDLPRIQL DIVTTADFLD VLTHTKPSAK NLAQRYSDWQ REFESV

References

[1]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-160.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-160. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC012254 Genomic DNA. No translation available. AC090373 Genomic DNA. No translation available. CH471096 Genomic DNA. Translation: EAW62904.1. BC034999 mRNA. Translation: AAH34999.2.
IPI	IPI00239789. IPI00894474.
RefSeq	NP_112593.2. NM_031303.2.
UniGene	Hs.404137.
3D structure databases
HSSP	HSSP built from PDB template 1XWI based on UniProtKB O75351.
ProteinModelPortal	Q8IYT4.
SMR	Q8IYT4. Positions 244-537.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IYT4. 1 interaction.
STRING	Q8IYT4.
PTM databases
PhosphoSite	Q8IYT4.
Polymorphism databases
DMDM	189028467.
Proteomic databases
PRIDE	Q8IYT4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356157; ENSP00000348478; ENSG00000167216.
GeneID	83473.
KEGG	hsa:83473.
UCSC	uc002lco.1. human.
Organism-specific databases
CTD	83473.
GeneCards	GC18P044526.
HGNC	HGNC:25387. KATNAL2.
neXtProt	NX_Q8IYT4.
PharmGKB	PA134921461.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074466.
HOGENOM	HBG724153.
HOVERGEN	HBG108053.
InParanoid	Q8IYT4.
OrthoDB	EOG4P5K8V.
PhylomeDB	Q8IYT4.
Gene expression databases
ArrayExpress	Q8IYT4.
Bgee	Q8IYT4.
CleanEx	HS_KATNAL2.
Genevestigator	Q8IYT4.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR006594. LisH_dimerisation. IPR013720. LisH_dimerisation_subgr. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF08513. LisH. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00667. LisH. 1 hit. [Graphical view]
PROSITE	PS50896. LISH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	72401.

Entry information

Entry name

KATL2_HUMAN

Accession

Primary (citable) accession number: Q8IYT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.