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Protein

Coiled-coil domain-containing protein 170

Gene

CCDC170

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 170
Gene namesi
Name:CCDC170
Synonyms:C6orf97
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21177. CCDC170.

Pathology & Biotechi

Organism-specific databases

DisGeNETi80129.
OpenTargetsiENSG00000120262.
PharmGKBiPA134876442.

Polymorphism and mutation databases

BioMutaiCCDC170.
DMDMi117949395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552561 – 715Coiled-coil domain-containing protein 170Add BLAST715

Proteomic databases

EPDiQ8IYT3.
PaxDbiQ8IYT3.
PeptideAtlasiQ8IYT3.
PRIDEiQ8IYT3.

PTM databases

iPTMnetiQ8IYT3.
PhosphoSitePlusiQ8IYT3.

Expressioni

Gene expression databases

BgeeiENSG00000120262.
CleanExiHS_C6orf97.
GenevisibleiQ8IYT3. HS.

Organism-specific databases

HPAiHPA027114.
HPA027121.
HPA027185.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNHP519463EBI-2808089,EBI-741406

Protein-protein interaction databases

BioGridi123130. 3 interactors.
IntActiQ8IYT3. 3 interactors.
STRINGi9606.ENSP00000239374.

Structurei

3D structure databases

ProteinModelPortaliQ8IYT3.
SMRiQ8IYT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 286Sequence analysisAdd BLAST257
Coiled coili360 – 418Sequence analysisAdd BLAST59
Coiled coili478 – 656Sequence analysisAdd BLAST179

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG1D. Eukaryota.
ENOG410YFHT. LUCA.
GeneTreeiENSGT00390000012924.
HOGENOMiHOG000111558.
HOVERGENiHBG081105.
InParanoidiQ8IYT3.
OMAiDHLLEVP.
OrthoDBiEOG091G072J.
PhylomeDBiQ8IYT3.
TreeFamiTF325112.

Sequencei

Sequence statusi: Complete.

Q8IYT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDCTSHIA LGAASPAPEE TYDHLSEVPV TREQLNHYRN VAQNARSELA
60 70 80 90 100
ATLVKFECAQ SELQDLRSKM LSKEVSCQEL KAEMESYKEN NARKSSLLTS
110 120 130 140 150
LRDRVQELEE ESAALSTSKI RTEITAHAAI KENQELKKKV VELNEKLQKC
160 170 180 190 200
SKENEENKKQ VSKNCRKHEE FLTQLRDCLD PDERNDKASD EDLILKLRDL
210 220 230 240 250
RKENEFVKGQ IVILEETINV HEMEAKASRE TIMRLASEVN REQKKAASCT
260 270 280 290 300
EEKEKLNQDL LSAVEAKEAL EREVKIFQER LLAGQQVWDA SKQEVSLLKK
310 320 330 340 350
SSSELEKSLK ASQDAVTTSQ SQYFSFREKI AALLRGRLSM TGSTEDTILE
360 370 380 390 400
KIREMDSREE SRDRMVSQLE AQISELVEQL GKESGFHQKA LQRAQKAENM
410 420 430 440 450
LETLQGQLTH LEAELVSGGV LRDNLNFEKQ KYLKFLDQLS QKMKLDQMAA
460 470 480 490 500
ELGFDMRLDV VLARTEQLVR LESNAVIENK TIAHNLQRKL KTQKERLESK
510 520 530 540 550
ELHMSLLRQK IAQLEEEKQA RTALVVERDN AHLTIRNLQK KVERLQKELN
560 570 580 590 600
TCRDLHTELK AKLADTNELK IKTLEQTKAI EDLNKSRDQL EKMKEKAEKK
610 620 630 640 650
LMSVKSELDT TEHEAKENKE RARNMIEVVT SEMKTLKKSL EEAEKREKQL
660 670 680 690 700
ADFREVVSQM LGLNVTSLAL PDYEIIKCLE RLVHSHQHHF VTCACLKDVT
710
TGQERHPQGH LQLLH
Length:715
Mass (Da):82,277
Last modified:October 31, 2006 - v3
Checksum:iB2A332347E0FD1D9
GO

Sequence cautioni

The sequence BAB55025 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH71980 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI10943 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456M → T in BAB15602 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028856269A → V.Corresponds to variant rs12205837dbSNPEnsembl.1
Natural variantiVAR_028857324F → S.1 PublicationCorresponds to variant rs953767dbSNPEnsembl.1
Natural variantiVAR_028858331A → T.1 PublicationCorresponds to variant rs17855718dbSNPEnsembl.1
Natural variantiVAR_061591345E → K.Corresponds to variant rs55868409dbSNPEnsembl.1
Natural variantiVAR_050805479N → K.Corresponds to variant rs35159094dbSNPEnsembl.1
Natural variantiVAR_050806553R → Q.Corresponds to variant rs34430497dbSNPEnsembl.1
Natural variantiVAR_028859604V → I.1 PublicationCorresponds to variant rs6929137dbSNPEnsembl.1
Natural variantiVAR_028860683V → I.2 PublicationsCorresponds to variant rs3734804dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026958 mRNA. Translation: BAB15602.1.
AK027300 mRNA. Translation: BAB55025.1. Different initiation.
AL359494, AL590543 Genomic DNA. Translation: CAH71980.1. Sequence problems.
AL590543, AL359494 Genomic DNA. Translation: CAI10943.1. Sequence problems.
BC060803 mRNA. Translation: AAH60803.1.
CCDSiCCDS43515.1.
RefSeqiNP_079335.2. NM_025059.3.
UniGeneiHs.660044.

Genome annotation databases

EnsembliENST00000239374; ENSP00000239374; ENSG00000120262.
GeneIDi80129.
KEGGihsa:80129.
UCSCiuc003qol.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026958 mRNA. Translation: BAB15602.1.
AK027300 mRNA. Translation: BAB55025.1. Different initiation.
AL359494, AL590543 Genomic DNA. Translation: CAH71980.1. Sequence problems.
AL590543, AL359494 Genomic DNA. Translation: CAI10943.1. Sequence problems.
BC060803 mRNA. Translation: AAH60803.1.
CCDSiCCDS43515.1.
RefSeqiNP_079335.2. NM_025059.3.
UniGeneiHs.660044.

3D structure databases

ProteinModelPortaliQ8IYT3.
SMRiQ8IYT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123130. 3 interactors.
IntActiQ8IYT3. 3 interactors.
STRINGi9606.ENSP00000239374.

PTM databases

iPTMnetiQ8IYT3.
PhosphoSitePlusiQ8IYT3.

Polymorphism and mutation databases

BioMutaiCCDC170.
DMDMi117949395.

Proteomic databases

EPDiQ8IYT3.
PaxDbiQ8IYT3.
PeptideAtlasiQ8IYT3.
PRIDEiQ8IYT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239374; ENSP00000239374; ENSG00000120262.
GeneIDi80129.
KEGGihsa:80129.
UCSCiuc003qol.4. human.

Organism-specific databases

CTDi80129.
DisGeNETi80129.
GeneCardsiCCDC170.
HGNCiHGNC:21177. CCDC170.
HPAiHPA027114.
HPA027121.
HPA027185.
neXtProtiNX_Q8IYT3.
OpenTargetsiENSG00000120262.
PharmGKBiPA134876442.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG1D. Eukaryota.
ENOG410YFHT. LUCA.
GeneTreeiENSGT00390000012924.
HOGENOMiHOG000111558.
HOVERGENiHBG081105.
InParanoidiQ8IYT3.
OMAiDHLLEVP.
OrthoDBiEOG091G072J.
PhylomeDBiQ8IYT3.
TreeFamiTF325112.

Miscellaneous databases

GenomeRNAii80129.
PROiQ8IYT3.

Gene expression databases

BgeeiENSG00000120262.
CleanExiHS_C6orf97.
GenevisibleiQ8IYT3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCC170_HUMAN
AccessioniPrimary (citable) accession number: Q8IYT3
Secondary accession number(s): Q5VXB7
, Q6P9E4, Q96KA9, Q9H5M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.