##gff-version 3
Q8IYT2	UniProtKB	Chain	1	770	.	.	.	ID=PRO_0000326180;Note=Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2	
Q8IYT2	UniProtKB	Domain	109	322	.	.	.	Note=Adrift-type SAM-dependent 2'-O-MTase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00946	
Q8IYT2	UniProtKB	Active site	117	117	.	.	.	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21310715;Dbxref=PMID:21310715	
Q8IYT2	UniProtKB	Active site	235	235	.	.	.	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:21310715;Dbxref=PMID:21310715	
Q8IYT2	UniProtKB	Active site	275	275	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00946,ECO:0000305|PubMed:21310715;Dbxref=PMID:21310715	
Q8IYT2	UniProtKB	Binding site	148	148	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00946	
Q8IYT2	UniProtKB	Binding site	167	167	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00946	
Q8IYT2	UniProtKB	Binding site	235	235	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00946	
Q8IYT2	UniProtKB	Natural variant	60	60	.	.	.	ID=VAR_039998;Note=L->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.3;Dbxref=dbSNP:rs3096380,PMID:14702039	
Q8IYT2	UniProtKB	Natural variant	163	163	.	.	.	ID=VAR_039999;Note=F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17853360,PMID:15489334	
Q8IYT2	UniProtKB	Natural variant	416	416	.	.	.	ID=VAR_040000;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs3803704,PMID:14702039	
Q8IYT2	UniProtKB	Natural variant	608	608	.	.	.	ID=VAR_040001;Note=T->K;Dbxref=dbSNP:rs3096381	
Q8IYT2	UniProtKB	Natural variant	753	753	.	.	.	ID=VAR_040002;Note=F->L;Dbxref=dbSNP:rs16970857	
Q8IYT2	UniProtKB	Mutagenesis	74	74	.	.	.	Note=Strongly reduces mRNA cap binding and catalytic activity of the enzyme. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	77	77	.	.	.	Note=Strongly reduces mRNA cap binding and catalytic activity of the enzyme. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	78	78	.	.	.	Note=Only mildly affects mRNA cap binding and catalytic activity of the enzyme. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	85	85	.	.	.	Note=Strongly reduces mRNA cap binding and catalytic activity of the enzyme. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	86	86	.	.	.	Note=Only mildly affects mRNA cap binding and catalytic activity of the enzyme. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	89	89	.	.	.	Note=Strongly reduces mRNA cap binding and catalytic activity of the enzyme. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	113	113	.	.	.	Note=Only mildly affects mRNA cap binding and catalytic activity of the enzyme. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	117	117	.	.	.	Note=Abolishes catalytic activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21310715;Dbxref=PMID:21310715	
Q8IYT2	UniProtKB	Mutagenesis	142	142	.	.	.	Note=Strongly reduces mRNA cap binding and catalytic activity of the enzyme. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	145	145	.	.	.	Note=Strongly reduces mRNA cap binding and catalytic activity of the enzyme. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Mutagenesis	235	235	.	.	.	Note=Abolishes catalytic activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21310715;Dbxref=PMID:21310715	
Q8IYT2	UniProtKB	Mutagenesis	275	275	.	.	.	Note=Abolishes catalytic activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21310715;Dbxref=PMID:21310715	
Q8IYT2	UniProtKB	Mutagenesis	307	307	.	.	.	Note=Strongly reduces mRNA cap binding and catalytic activity of the enzyme. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24402442;Dbxref=PMID:24402442	
Q8IYT2	UniProtKB	Sequence conflict	27	27	.	.	.	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	53	53	.	.	.	Note=F->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	56	56	.	.	.	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	75	75	.	.	.	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	85	86	.	.	.	Note=WH->LD;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	201	202	.	.	.	Note=YF->HL;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	222	222	.	.	.	Note=F->I;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	317	317	.	.	.	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IYT2	UniProtKB	Sequence conflict	683	683	.	.	.	Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305