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Protein

Biorientation of chromosomes in cell division protein 1-like 2

Gene

BOD1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Biorientation of chromosomes in cell division protein 1-like 2Curated
Alternative name(s):
Biorientation of chromosomes in cell division protein 1 pseudogeneCurated
Protein FAM44CCurated
Gene namesi
Name:BOD1L2Imported
Synonyms:BOD1PImported, FAM44CImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000228075.4
HGNCiHGNC:28505 BOD1L2
neXtProtiNX_Q8IYS8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000228075
PharmGKBiPA166048984

Polymorphism and mutation databases

BioMutaiBOD1L2
DMDMi125987827

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870331 – 172Biorientation of chromosomes in cell division protein 1-like 2Add BLAST172

Proteomic databases

EPDiQ8IYS8
MaxQBiQ8IYS8
PaxDbiQ8IYS8
PeptideAtlasiQ8IYS8
PRIDEiQ8IYS8
ProteomicsDBi71231

PTM databases

iPTMnetiQ8IYS8
PhosphoSitePlusiQ8IYS8

Expressioni

Gene expression databases

BgeeiENSG00000228075
CleanExiHS_FAM44C
GenevisibleiQ8IYS8 HS

Organism-specific databases

HPAiHPA036293

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKAR1BP313214EBI-12118438,EBI-2805516

Protein-protein interaction databases

BioGridi129806, 2 interactors
IntActiQ8IYS8, 5 interactors
STRINGi9606.ENSP00000467843

Structurei

3D structure databases

ProteinModelPortaliQ8IYS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 13Poly-Gly10
Compositional biasi21 – 24Poly-Gly4

Sequence similaritiesi

Belongs to the BOD1 family.Curated

Phylogenomic databases

eggNOGiENOG410KCC4 Eukaryota
ENOG4110P49 LUCA
GeneTreeiENSGT00530000063517
InParanoidiQ8IYS8
OMAiFRRDCKA
OrthoDBiEOG091G0HQM
PhylomeDBiQ8IYS8

Sequencei

Sequence statusi: Complete.

Q8IYS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGGGGGSG GAGPASTRAS GGGGPINPAS LPPGDPQLIA IIVGQLKSRG
60 70 80 90 100
LFDSFRRDCK ADVDTKPAYQ NLSQKADNFV STHLDKQEWN PPANDNQLHD
110 120 130 140 150
GLRQSVVQSG RSEAGVDRIS SQVVDPKLNH IFRPQIEQII HEFLVAQKEA
160 170
AVPALPPEPE GQDPPAPSQD TS
Length:172
Mass (Da):18,075
Last modified:February 6, 2007 - v2
Checksum:i6590AAD1F999A6E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46L → P in BAG54606 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127964 mRNA Translation: BAG54606.1
AC100775 mRNA No translation available.
BC021740 mRNA No translation available.
CCDSiCCDS59322.1
RefSeqiNP_001244893.1, NM_001257964.1
UniGeneiHs.127882

Genome annotation databases

EnsembliENST00000585477; ENSP00000467843; ENSG00000228075
GeneIDi284257
KEGGihsa:284257
UCSCiuc002lgm.4 human

Similar proteinsi

Entry informationi

Entry nameiBD1L2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS8
Secondary accession number(s): B3KXU4, Q8WW13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 6, 2007
Last modified: June 20, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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