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Protein

Biorientation of chromosomes in cell division protein 1-like 2

Gene

BOD1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.By similarity

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Biorientation of chromosomes in cell division protein 1-like 2Curated
Alternative name(s):
Biorientation of chromosomes in cell division protein 1 pseudogeneCurated
Protein FAM44CCurated
Gene namesi
Name:BOD1L2Imported
Synonyms:BOD1PImported, FAM44CImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:28505. BOD1L2.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Chromosomecentromerekinetochore By similarity

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Biorientation of chromosomes in cell division protein 1-like 2PRO_0000187033Add
BLAST

Proteomic databases

PRIDEiQ8IYS8.

PTM databases

PhosphoSiteiQ8IYS8.

Expressioni

Gene expression databases

BgeeiQ8IYS8.
CleanExiHS_FAM44C.
GenevestigatoriQ8IYS8.

Organism-specific databases

HPAiHPA036293.

Structurei

3D structure databases

ProteinModelPortaliQ8IYS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 1310Poly-Gly
Compositional biasi21 – 244Poly-Gly

Sequence similaritiesi

Belongs to the BOD1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063517.
InParanoidiQ8IYS8.
OMAiRRDCKAD.
OrthoDBiEOG7X3QQD.
PhylomeDBiQ8IYS8.

Family and domain databases

InterProiIPR026955. Bod1_like.
[Graphical view]
PANTHERiPTHR31532. PTHR31532. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IYS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGGGGGSG GAGPASTRAS GGGGPINPAS LPPGDPQLIA IIVGQLKSRG
60 70 80 90 100
LFDSFRRDCK ADVDTKPAYQ NLSQKADNFV STHLDKQEWN PPANDNQLHD
110 120 130 140 150
GLRQSVVQSG RSEAGVDRIS SQVVDPKLNH IFRPQIEQII HEFLVAQKEA
160 170
AVPALPPEPE GQDPPAPSQD TS
Length:172
Mass (Da):18,075
Last modified:February 6, 2007 - v2
Checksum:i6590AAD1F999A6E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461L → P in BAG54606 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127964 mRNA. Translation: BAG54606.1.
AC100775 mRNA. No translation available.
BC021740 mRNA. No translation available.
CCDSiCCDS59322.1.
RefSeqiNP_001244893.1. NM_001257964.1.
UniGeneiHs.127882.

Genome annotation databases

EnsembliENST00000585477; ENSP00000467843; ENSG00000228075.
GeneIDi284257.
KEGGihsa:284257.
UCSCiuc002lgm.3. human.

Polymorphism databases

DMDMi125987827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127964 mRNA. Translation: BAG54606.1.
AC100775 mRNA. No translation available.
BC021740 mRNA. No translation available.
CCDSiCCDS59322.1.
RefSeqiNP_001244893.1. NM_001257964.1.
UniGeneiHs.127882.

3D structure databases

ProteinModelPortaliQ8IYS8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8IYS8.

Polymorphism databases

DMDMi125987827.

Proteomic databases

PRIDEiQ8IYS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585477; ENSP00000467843; ENSG00000228075.
GeneIDi284257.
KEGGihsa:284257.
UCSCiuc002lgm.3. human.

Organism-specific databases

CTDi284257.
GeneCardsiGC18P054840.
HGNCiHGNC:28505. BOD1L2.
HPAiHPA036293.
neXtProtiNX_Q8IYS8.
PharmGKBiPA134949651.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063517.
InParanoidiQ8IYS8.
OMAiRRDCKAD.
OrthoDBiEOG7X3QQD.
PhylomeDBiQ8IYS8.

Miscellaneous databases

GenomeRNAii284257.
NextBioi94665.

Gene expression databases

BgeeiQ8IYS8.
CleanExiHS_FAM44C.
GenevestigatoriQ8IYS8.

Family and domain databases

InterProiIPR026955. Bod1_like.
[Graphical view]
PANTHERiPTHR31532. PTHR31532. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiBD1L2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS8
Secondary accession number(s): B3KXU4, Q8WW13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 6, 2007
Last modified: March 4, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.