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Q8IYS5 (OSCAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Osteoclast-associated immunoglobulin-like receptor

Short name=Osteoclast-associated receptor
Short name=hOSCAR
Alternative name(s):
Polymeric immunoglobulin receptor 3
Short name=PIgR-3
Short name=PIgR3
Short name=Poly-Ig receptor 3
Gene names
Name:OSCAR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation By similarity.

Subcellular location

Isoform 1: Secreted Potential.

Isoform 2: Cell membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.

Contains 2 Ig-like (immunoglobulin-like) domains.

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IYS5-1)

Also known as: OSCAR-S1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IYS5-2)

Also known as: OSCAR-M1;

The sequence of this isoform differs from the canonical sequence as follows:
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP
Isoform 3 (identifier: Q8IYS5-3)

Also known as: OSCAR-M2;

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP
Isoform 4 (identifier: Q8IYS5-4)

Also known as: OSCAR-S2;

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP
Isoform 5 (identifier: Q8IYS5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     129-134: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: Q8IYS5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV
Note: No experimental confirmation available.
Isoform 6 (identifier: Q8IYS5-6)

Also known as: OSCAR-M3;

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 282264Osteoclast-associated immunoglobulin-like receptor
PRO_0000310951

Regions

Domain22 – 11695Ig-like 1
Domain126 – 21994Ig-like 2

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Disulfide bond53 ↔ 100 By similarity

Natural variations

Alternative sequence13 – 2513WPLCH…TPSVP → FP in isoform 4 and isoform 6.
VSP_029352
Alternative sequence241V → VAIIV in isoform 3 and isoform 7.
VSP_029353
Alternative sequence129 – 1346Missing in isoform 5.
VSP_029354
Alternative sequence219 – 28264GEGPE…SDPGV → DSGSSDYTRGNLVRLGLAGL VLISLGALVTFDWRSQNRAP AGIRP in isoform 2, isoform 3 and isoform 6.
VSP_029355
Natural variant971I → S. Ref.1 Ref.3 Ref.4 Ref.6
Corresponds to variant rs1657535 [ dbSNP | Ensembl ].
VAR_037108
Natural variant2291S → Y.
Corresponds to variant rs8106130 [ dbSNP | Ensembl ].
VAR_047393

Experimental info

Sequence conflict1581S → N in AAM19095. Ref.1
Sequence conflict1941S → G in BAC03586. Ref.4
Sequence conflict1941S → G in AX746784. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (OSCAR-S1) [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: 1C0A86B90DA6F5CD

FASTA28230,481
        10         20         30         40         50         60 
MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT LRCRAPQPAW 

        70         80         90        100        110        120 
RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC CYRRPDWGPG VWSQPSDVLE 

       130        140        150        160        170        180 
LLVTEELPRP SLVALPGPVV GPGANVSLRC AGRLRNMSFV LYREGVAAPL QYRHSAQPWA 

       190        200        210        220        230        240 
DFTLLGARAP GTYSCYYHTP SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP 

       250        260        270        280 
SDPGAQAPSL SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GV 

« Hide

Isoform 2 (OSCAR-M1) [UniParc].

Checksum: A8657336B9DD1237
Show »

FASTA26328,832
Isoform 3 (OSCAR-M2) [UniParc].

Checksum: AA9C139695285E4A
Show »

FASTA26729,229
Isoform 4 (OSCAR-S2) [UniParc].

Checksum: 45660528C75F9A8A
Show »

FASTA27129,278
Isoform 5 [UniParc].

Checksum: 74AF3F9451D97806
Show »

FASTA27629,857
Isoform 7 [UniParc].

Checksum: 6F3E049373829FCA
Show »

FASTA28630,877
Isoform 6 (OSCAR-M3) [UniParc].

Checksum: CE0BFD7C3FB9DF53
Show »

FASTA25227,629

References

« Hide 'large scale' references
[1]"Novel PIGR2."
Zhang W., Li N., Wan T., Cao X.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT SER-97.
[2]"A novel member of the leukocyte receptor complex regulates osteoclast differentiation."
Kim N., Takami M., Rho J., Josien R., Choi Y.
J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6).
[3]"Full-length cDNA sequences."
Isogai T., Sugiyama T., Otsuki T., Wakamatsu A., Sato H., Ishii S., Yamamoto J., Isono Y., Hio Y., Otsuka K., Nagai K., Irie R., Tamechika I., Seki N., Yoshikawa T., Otsuka M., Nagahari K., Masuho Y.
Patent number EP1308459, 20-JUN-2003
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 5), VARIANT SER-97.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANT SER-97.
Tissue: Macrophage.
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-97.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF251702 mRNA. Translation: AAM19095.1.
AF391162 mRNA. Translation: AAL68495.1.
AF391163 mRNA. Translation: AAL68496.1.
AF391164 mRNA. Translation: AAL68497.1.
AF474152 mRNA. Translation: AAQ05766.1.
AF474153 mRNA. Translation: AAQ05767.1.
AX746784 mRNA. No translation available.
AK091111 mRNA. Translation: BAC03586.1.
AK130199 mRNA. No translation available.
AC012314 Genomic DNA. No translation available.
BC035023 mRNA. Translation: AAH35023.1.
CCDSCCDS12873.1. [Q8IYS5-3]
CCDS12874.1. [Q8IYS5-6]
CCDS12875.1. [Q8IYS5-2]
CCDS12876.1. [Q8IYS5-7]
CCDS62789.1. [Q8IYS5-4]
RefSeqNP_001269278.1. NM_001282349.1.
NP_001269279.1. NM_001282350.1.
NP_570127.3. NM_130771.4.
NP_573398.2. NM_133168.4.
NP_573399.2. NM_133169.4.
NP_996554.2. NM_206818.2.
UniGeneHs.347655.

3D structure databases

ProteinModelPortalQ8IYS5.
SMRQ8IYS5. Positions 31-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8IYS5. 2 interactions.
STRING9606.ENSP00000352671.

Polymorphism databases

DMDM311033418.

Proteomic databases

PaxDbQ8IYS5.
PRIDEQ8IYS5.

Protocols and materials databases

DNASU126014.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000284648; ENSP00000365808; ENSG00000170909. [Q8IYS5-1]
ENST00000351806; ENSP00000304523; ENSG00000170909. [Q8IYS5-6]
ENST00000356532; ENSP00000348927; ENSG00000170909. [Q8IYS5-3]
ENST00000358375; ENSP00000351145; ENSG00000170909. [Q8IYS5-2]
ENST00000359649; ENSP00000352671; ENSG00000170909. [Q8IYS5-7]
ENST00000391761; ENSP00000375641; ENSG00000170909. [Q8IYS5-4]
ENST00000570944; ENSP00000460784; ENSG00000273074. [Q8IYS5-6]
ENST00000571211; ENSP00000460281; ENSG00000273074. [Q8IYS5-1]
ENST00000571840; ENSP00000460942; ENSG00000273074. [Q8IYS5-2]
ENST00000572943; ENSP00000459649; ENSG00000273074. [Q8IYS5-7]
ENST00000573655; ENSP00000460337; ENSG00000273074. [Q8IYS5-4]
ENST00000576430; ENSP00000460314; ENSG00000273074. [Q8IYS5-3]
ENST00000604323; ENSP00000474338; ENSG00000271658.
ENST00000605761; ENSP00000474934; ENSG00000271658.
ENST00000607900; ENSP00000476765; ENSG00000273222. [Q8IYS5-7]
ENST00000607958; ENSP00000477076; ENSG00000272833. [Q8IYS5-3]
ENST00000608046; ENSP00000476884; ENSG00000273239. [Q8IYS5-2]
ENST00000608076; ENSP00000476719; ENSG00000273222. [Q8IYS5-4]
ENST00000608212; ENSP00000476590; ENSG00000273380. [Q8IYS5-7]
ENST00000608225; ENSP00000477166; ENSG00000273239. [Q8IYS5-4]
ENST00000608234; ENSP00000476274; ENSG00000273380. [Q8IYS5-1]
ENST00000608356; ENSP00000476716; ENSG00000272833. [Q8IYS5-7]
ENST00000608387; ENSP00000476279; ENSG00000273239. [Q8IYS5-3]
ENST00000608401; ENSP00000477266; ENSG00000272919. [Q8IYS5-4]
ENST00000608411; ENSP00000476550; ENSG00000273268. [Q8IYS5-7]
ENST00000608460; ENSP00000477479; ENSG00000272919. [Q8IYS5-1]
ENST00000608530; ENSP00000476762; ENSG00000273380. [Q8IYS5-4]
ENST00000608668; ENSP00000476822; ENSG00000273268. [Q8IYS5-1]
ENST00000608702; ENSP00000477379; ENSG00000272833. [Q8IYS5-6]
ENST00000608755; ENSP00000477431; ENSG00000273222. [Q8IYS5-2]
ENST00000608808; ENSP00000476357; ENSG00000273239. [Q8IYS5-6]
ENST00000608863; ENSP00000476548; ENSG00000273268. [Q8IYS5-4]
ENST00000608865; ENSP00000476747; ENSG00000272891. [Q8IYS5-3]
ENST00000608899; ENSP00000476900; ENSG00000272891. [Q8IYS5-6]
ENST00000608914; ENSP00000476936; ENSG00000273239. [Q8IYS5-7]
ENST00000608976; ENSP00000476949; ENSG00000272833. [Q8IYS5-2]
ENST00000609186; ENSP00000476982; ENSG00000272891. [Q8IYS5-7]
ENST00000609236; ENSP00000476962; ENSG00000272919. [Q8IYS5-2]
ENST00000609255; ENSP00000477422; ENSG00000273239. [Q8IYS5-1]
ENST00000609283; ENSP00000477158; ENSG00000273268. [Q8IYS5-2]
ENST00000609294; ENSP00000476484; ENSG00000272891. [Q8IYS5-1]
ENST00000609339; ENSP00000477388; ENSG00000273222. [Q8IYS5-6]
ENST00000609355; ENSP00000477104; ENSG00000273380. [Q8IYS5-3]
ENST00000609408; ENSP00000477286; ENSG00000273268. [Q8IYS5-6]
ENST00000609419; ENSP00000476381; ENSG00000272833. [Q8IYS5-4]
ENST00000609460; ENSP00000476505; ENSG00000272833. [Q8IYS5-1]
ENST00000609479; ENSP00000476476; ENSG00000272919. [Q8IYS5-7]
ENST00000609533; ENSP00000476635; ENSG00000272891. [Q8IYS5-4]
ENST00000609563; ENSP00000477407; ENSG00000272919. [Q8IYS5-3]
ENST00000609730; ENSP00000476683; ENSG00000273268. [Q8IYS5-3]
ENST00000609804; ENSP00000477465; ENSG00000273222. [Q8IYS5-1]
ENST00000609851; ENSP00000476490; ENSG00000272891. [Q8IYS5-2]
ENST00000609888; ENSP00000476995; ENSG00000273380. [Q8IYS5-6]
ENST00000609892; ENSP00000476679; ENSG00000272919. [Q8IYS5-6]
ENST00000610053; ENSP00000476571; ENSG00000273380. [Q8IYS5-2]
ENST00000610147; ENSP00000477452; ENSG00000273222. [Q8IYS5-3]
GeneID126014.
KEGGhsa:126014.
UCSCuc002qcy.3. human. [Q8IYS5-3]
uc002qcz.3. human. [Q8IYS5-2]
uc002qda.3. human. [Q8IYS5-7]
uc002qdb.3. human. [Q8IYS5-6]
uc002qdc.3. human. [Q8IYS5-4]
uc002qdd.3. human. [Q8IYS5-1]

Organism-specific databases

CTD126014.
GeneCardsGC19M054597.
HGNCHGNC:29960. OSCAR.
MIM606862. gene.
neXtProtNX_Q8IYS5.
PharmGKBPA162398474.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276170.
HOVERGENHBG108217.
InParanoidQ8IYS5.
KOK14377.
OMAQIQESSE.
PhylomeDBQ8IYS5.
TreeFamTF336644.

Gene expression databases

ArrayExpressQ8IYS5.
BgeeQ8IYS5.
CleanExHS_OSCAR.
GenevestigatorQ8IYS5.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOSCAR_(gene).
GenomeRNAi126014.
NextBio81631.
PROQ8IYS5.
SOURCESearch...

Entry information

Entry nameOSCAR_HUMAN
AccessionPrimary (citable) accession number: Q8IYS5
Secondary accession number(s): B7WNS2 expand/collapse secondary AC list , Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM