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Protein

Osteoclast-associated immunoglobulin-like receptor

Gene

OSCAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-associated immunoglobulin-like receptor
Short name:
Osteoclast-associated receptor
Short name:
hOSCAR
Alternative name(s):
Polymeric immunoglobulin receptor 3
Short name:
PIgR-3
Short name:
PIgR3
Short name:
Poly-Ig receptor 3
Gene namesi
Name:OSCAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29960. OSCAR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi126014.
OpenTargetsiENSG00000273511.
ENSG00000274703.
ENSG00000275551.
ENSG00000275644.
ENSG00000275736.
ENSG00000276982.
ENSG00000277088.
ENSG00000278378.
ENSG00000278533.
PharmGKBiPA162398474.

Polymorphism and mutation databases

DMDMi311033418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031095119 – 282Osteoclast-associated immunoglobulin-like receptorAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi53 ↔ 100By similarity
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IYS5.
PeptideAtlasiQ8IYS5.
PRIDEiQ8IYS5.

Expressioni

Gene expression databases

BgeeiENSG00000170909.
CleanExiHS_OSCAR.
ExpressionAtlasiQ8IYS5. baseline and differential.
GenevisibleiQ8IYS5. HS.

Organism-specific databases

HPAiHPA062740.

Interactioni

Protein-protein interaction databases

IntActiQ8IYS5. 2 interactors.

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 39Combined sources6
Beta strandi41 – 43Combined sources3
Beta strandi49 – 65Combined sources17
Beta strandi73 – 87Combined sources15
Helixi92 – 94Combined sources3
Beta strandi96 – 103Combined sources8
Helixi105 – 107Combined sources3
Beta strandi119 – 123Combined sources5
Beta strandi125 – 127Combined sources3
Beta strandi131 – 134Combined sources4
Beta strandi146 – 151Combined sources6
Beta strandi158 – 163Combined sources6
Beta strandi166 – 174Combined sources9
Beta strandi176 – 184Combined sources9
Turni186 – 188Combined sources3
Beta strandi191 – 198Combined sources8
Beta strandi200 – 203Combined sources4
Beta strandi213 – 215Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CJ8X-ray2.02A31-215[»]
5CJBX-ray2.40A31-215[»]
5EIQX-ray2.01A28-215[»]
5EIVX-ray2.41A/B26-215[»]
ProteinModelPortaliQ8IYS5.
SMRiQ8IYS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 116Ig-like 1Add BLAST95
Domaini126 – 219Ig-like 2Add BLAST94

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
HOVERGENiHBG108217.
InParanoidiQ8IYS5.
KOiK14377.
OrthoDBiEOG091G020P.
PhylomeDBiQ8IYS5.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYS5-1) [UniParc]FASTAAdd to basket
Also known as: OSCAR-S1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT
60 70 80 90 100
LRCRAPQPAW RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC
110 120 130 140 150
CYRRPDWGPG VWSQPSDVLE LLVTEELPRP SLVALPGPVV GPGANVSLRC
160 170 180 190 200
AGRLRNMSFV LYREGVAAPL QYRHSAQPWA DFTLLGARAP GTYSCYYHTP
210 220 230 240 250
SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP SDPGAQAPSL
260 270 280
SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GV
Length:282
Mass (Da):30,481
Last modified:November 2, 2010 - v3
Checksum:i1C0A86B90DA6F5CD
GO
Isoform 2 (identifier: Q8IYS5-2) [UniParc]FASTAAdd to basket
Also known as: OSCAR-M1

The sequence of this isoform differs from the canonical sequence as follows:
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Show »
Length:263
Mass (Da):28,832
Checksum:iA8657336B9DD1237
GO
Isoform 3 (identifier: Q8IYS5-3) [UniParc]FASTAAdd to basket
Also known as: OSCAR-M2

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Show »
Length:267
Mass (Da):29,229
Checksum:iAA9C139695285E4A
GO
Isoform 4 (identifier: Q8IYS5-4) [UniParc]FASTAAdd to basket
Also known as: OSCAR-S2

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP

Show »
Length:271
Mass (Da):29,278
Checksum:i45660528C75F9A8A
GO
Isoform 5 (identifier: Q8IYS5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-134: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):29,857
Checksum:i74AF3F9451D97806
GO
Isoform 7 (identifier: Q8IYS5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):30,877
Checksum:i6F3E049373829FCA
GO
Isoform 6 (identifier: Q8IYS5-6) [UniParc]FASTAAdd to basket
Also known as: OSCAR-M3

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):27,629
Checksum:iCE0BFD7C3FB9DF53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158S → N in AAM19095 (Ref. 1) Curated1
Sequence conflicti194S → G in BAC03586 (PubMed:14702039).Curated1
Sequence conflicti194S → G in AX746784 (PubMed:15057824).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03710897I → S.4 PublicationsCorresponds to variant rs1657535dbSNPEnsembl.1
Natural variantiVAR_047393229S → Y.Corresponds to variant rs8106130dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02935213 – 25WPLCH…TPSVP → FP in isoform 4 and isoform 6. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_02935324V → VAIIV in isoform 3 and isoform 7. 2 Publications1
Alternative sequenceiVSP_029354129 – 134Missing in isoform 5. 1 Publication6
Alternative sequenceiVSP_029355219 – 282GEGPE…SDPGV → DSGSSDYTRGNLVRLGLAGL VLISLGALVTFDWRSQNRAP AGIRP in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251702 mRNA. Translation: AAM19095.1.
AF391162 mRNA. Translation: AAL68495.1.
AF391163 mRNA. Translation: AAL68496.1.
AF391164 mRNA. Translation: AAL68497.1.
AF474152 mRNA. Translation: AAQ05766.1.
AF474153 mRNA. Translation: AAQ05767.1.
AX746784 mRNA. No translation available.
AK091111 mRNA. Translation: BAC03586.1.
AK130199 mRNA. No translation available.
AC012314 Genomic DNA. No translation available.
BC035023 mRNA. Translation: AAH35023.1.
CCDSiCCDS12873.1. [Q8IYS5-3]
CCDS12874.1. [Q8IYS5-6]
CCDS12875.1. [Q8IYS5-2]
CCDS12876.1. [Q8IYS5-7]
CCDS62789.1. [Q8IYS5-4]
CCDS74444.1. [Q8IYS5-1]
RefSeqiNP_001269278.1. NM_001282349.1.
NP_001269279.1. NM_001282350.1.
NP_570127.3. NM_130771.4.
NP_573398.2. NM_133168.4.
NP_573399.2. NM_133169.4.
NP_996554.2. NM_206818.2.
UniGeneiHs.347655.

Genome annotation databases

EnsembliENST00000284648; ENSP00000365808; ENSG00000170909.
ENST00000391761; ENSP00000375641; ENSG00000170909.
ENST00000610577; ENSP00000478594; ENSG00000276982. [Q8IYS5-7]
ENST00000610915; ENSP00000479317; ENSG00000277088. [Q8IYS5-4]
ENST00000610985; ENSP00000484755; ENSG00000274703. [Q8IYS5-7]
ENST00000611143; ENSP00000477994; ENSG00000278533. [Q8IYS5-3]
ENST00000611480; ENSP00000480193; ENSG00000275551. [Q8IYS5-1]
ENST00000611535; ENSP00000483744; ENSG00000275736. [Q8IYS5-2]
ENST00000611715; ENSP00000478382; ENSG00000278533. [Q8IYS5-4]
ENST00000611719; ENSP00000478099; ENSG00000275644. [Q8IYS5-4]
ENST00000611918; ENSP00000482460; ENSG00000276982. [Q8IYS5-4]
ENST00000611987; ENSP00000478027; ENSG00000276982. [Q8IYS5-3]
ENST00000612289; ENSP00000482414; ENSG00000277088. [Q8IYS5-1]
ENST00000612406; ENSP00000478224; ENSG00000273511. [Q8IYS5-7]
ENST00000612953; ENSP00000479954; ENSG00000275644. [Q8IYS5-7]
ENST00000613426; ENSP00000480900; ENSG00000275736. [Q8IYS5-1]
ENST00000613814; ENSP00000484125; ENSG00000275736. [Q8IYS5-4]
ENST00000614003; ENSP00000481647; ENSG00000274703. [Q8IYS5-1]
ENST00000614380; ENSP00000482734; ENSG00000277088. [Q8IYS5-7]
ENST00000615074; ENSP00000477845; ENSG00000275736. [Q8IYS5-7]
ENST00000615546; ENSP00000482402; ENSG00000275551. [Q8IYS5-4]
ENST00000616215; ENSP00000479628; ENSG00000170909.
ENST00000616227; ENSP00000479849; ENSG00000275736. [Q8IYS5-7]
ENST00000616232; ENSP00000484567; ENSG00000274703. [Q8IYS5-4]
ENST00000616461; ENSP00000482610; ENSG00000278533. [Q8IYS5-7]
ENST00000616758; ENSP00000481785; ENSG00000278533. [Q8IYS5-1]
ENST00000617187; ENSP00000481805; ENSG00000275551. [Q8IYS5-7]
ENST00000617210; ENSP00000482359; ENSG00000278378. [Q8IYS5-3]
ENST00000617622; ENSP00000480863; ENSG00000273511. [Q8IYS5-1]
ENST00000617834; ENSP00000481147; ENSG00000275551. [Q8IYS5-3]
ENST00000617993; ENSP00000481261; ENSG00000278378. [Q8IYS5-7]
ENST00000618710; ENSP00000484323; ENSG00000278378. [Q8IYS5-1]
ENST00000619170; ENSP00000482545; ENSG00000273511. [Q8IYS5-3]
ENST00000619287; ENSP00000484977; ENSG00000275736. [Q8IYS5-6]
ENST00000619631; ENSP00000484878; ENSG00000273511. [Q8IYS5-4]
ENST00000620283; ENSP00000483090; ENSG00000274703. [Q8IYS5-3]
ENST00000620647; ENSP00000478216; ENSG00000275644. [Q8IYS5-1]
ENST00000621284; ENSP00000477825; ENSG00000275736. [Q8IYS5-4]
ENST00000621290; ENSP00000482791; ENSG00000275736. [Q8IYS5-3]
ENST00000621328; ENSP00000482997; ENSG00000275644. [Q8IYS5-3]
ENST00000621506; ENSP00000480424; ENSG00000278378. [Q8IYS5-4]
ENST00000621788; ENSP00000481926; ENSG00000275736. [Q8IYS5-3]
ENST00000622288; ENSP00000484602; ENSG00000277088. [Q8IYS5-3]
ENST00000622326; ENSP00000481257; ENSG00000276982. [Q8IYS5-1]
GeneIDi126014.
KEGGihsa:126014.
UCSCiuc002qdc.5. human. [Q8IYS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251702 mRNA. Translation: AAM19095.1.
AF391162 mRNA. Translation: AAL68495.1.
AF391163 mRNA. Translation: AAL68496.1.
AF391164 mRNA. Translation: AAL68497.1.
AF474152 mRNA. Translation: AAQ05766.1.
AF474153 mRNA. Translation: AAQ05767.1.
AX746784 mRNA. No translation available.
AK091111 mRNA. Translation: BAC03586.1.
AK130199 mRNA. No translation available.
AC012314 Genomic DNA. No translation available.
BC035023 mRNA. Translation: AAH35023.1.
CCDSiCCDS12873.1. [Q8IYS5-3]
CCDS12874.1. [Q8IYS5-6]
CCDS12875.1. [Q8IYS5-2]
CCDS12876.1. [Q8IYS5-7]
CCDS62789.1. [Q8IYS5-4]
CCDS74444.1. [Q8IYS5-1]
RefSeqiNP_001269278.1. NM_001282349.1.
NP_001269279.1. NM_001282350.1.
NP_570127.3. NM_130771.4.
NP_573398.2. NM_133168.4.
NP_573399.2. NM_133169.4.
NP_996554.2. NM_206818.2.
UniGeneiHs.347655.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CJ8X-ray2.02A31-215[»]
5CJBX-ray2.40A31-215[»]
5EIQX-ray2.01A28-215[»]
5EIVX-ray2.41A/B26-215[»]
ProteinModelPortaliQ8IYS5.
SMRiQ8IYS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IYS5. 2 interactors.

Polymorphism and mutation databases

DMDMi311033418.

Proteomic databases

PaxDbiQ8IYS5.
PeptideAtlasiQ8IYS5.
PRIDEiQ8IYS5.

Protocols and materials databases

DNASUi126014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284648; ENSP00000365808; ENSG00000170909.
ENST00000391761; ENSP00000375641; ENSG00000170909.
ENST00000610577; ENSP00000478594; ENSG00000276982. [Q8IYS5-7]
ENST00000610915; ENSP00000479317; ENSG00000277088. [Q8IYS5-4]
ENST00000610985; ENSP00000484755; ENSG00000274703. [Q8IYS5-7]
ENST00000611143; ENSP00000477994; ENSG00000278533. [Q8IYS5-3]
ENST00000611480; ENSP00000480193; ENSG00000275551. [Q8IYS5-1]
ENST00000611535; ENSP00000483744; ENSG00000275736. [Q8IYS5-2]
ENST00000611715; ENSP00000478382; ENSG00000278533. [Q8IYS5-4]
ENST00000611719; ENSP00000478099; ENSG00000275644. [Q8IYS5-4]
ENST00000611918; ENSP00000482460; ENSG00000276982. [Q8IYS5-4]
ENST00000611987; ENSP00000478027; ENSG00000276982. [Q8IYS5-3]
ENST00000612289; ENSP00000482414; ENSG00000277088. [Q8IYS5-1]
ENST00000612406; ENSP00000478224; ENSG00000273511. [Q8IYS5-7]
ENST00000612953; ENSP00000479954; ENSG00000275644. [Q8IYS5-7]
ENST00000613426; ENSP00000480900; ENSG00000275736. [Q8IYS5-1]
ENST00000613814; ENSP00000484125; ENSG00000275736. [Q8IYS5-4]
ENST00000614003; ENSP00000481647; ENSG00000274703. [Q8IYS5-1]
ENST00000614380; ENSP00000482734; ENSG00000277088. [Q8IYS5-7]
ENST00000615074; ENSP00000477845; ENSG00000275736. [Q8IYS5-7]
ENST00000615546; ENSP00000482402; ENSG00000275551. [Q8IYS5-4]
ENST00000616215; ENSP00000479628; ENSG00000170909.
ENST00000616227; ENSP00000479849; ENSG00000275736. [Q8IYS5-7]
ENST00000616232; ENSP00000484567; ENSG00000274703. [Q8IYS5-4]
ENST00000616461; ENSP00000482610; ENSG00000278533. [Q8IYS5-7]
ENST00000616758; ENSP00000481785; ENSG00000278533. [Q8IYS5-1]
ENST00000617187; ENSP00000481805; ENSG00000275551. [Q8IYS5-7]
ENST00000617210; ENSP00000482359; ENSG00000278378. [Q8IYS5-3]
ENST00000617622; ENSP00000480863; ENSG00000273511. [Q8IYS5-1]
ENST00000617834; ENSP00000481147; ENSG00000275551. [Q8IYS5-3]
ENST00000617993; ENSP00000481261; ENSG00000278378. [Q8IYS5-7]
ENST00000618710; ENSP00000484323; ENSG00000278378. [Q8IYS5-1]
ENST00000619170; ENSP00000482545; ENSG00000273511. [Q8IYS5-3]
ENST00000619287; ENSP00000484977; ENSG00000275736. [Q8IYS5-6]
ENST00000619631; ENSP00000484878; ENSG00000273511. [Q8IYS5-4]
ENST00000620283; ENSP00000483090; ENSG00000274703. [Q8IYS5-3]
ENST00000620647; ENSP00000478216; ENSG00000275644. [Q8IYS5-1]
ENST00000621284; ENSP00000477825; ENSG00000275736. [Q8IYS5-4]
ENST00000621290; ENSP00000482791; ENSG00000275736. [Q8IYS5-3]
ENST00000621328; ENSP00000482997; ENSG00000275644. [Q8IYS5-3]
ENST00000621506; ENSP00000480424; ENSG00000278378. [Q8IYS5-4]
ENST00000621788; ENSP00000481926; ENSG00000275736. [Q8IYS5-3]
ENST00000622288; ENSP00000484602; ENSG00000277088. [Q8IYS5-3]
ENST00000622326; ENSP00000481257; ENSG00000276982. [Q8IYS5-1]
GeneIDi126014.
KEGGihsa:126014.
UCSCiuc002qdc.5. human. [Q8IYS5-1]

Organism-specific databases

CTDi126014.
DisGeNETi126014.
GeneCardsiOSCAR.
HGNCiHGNC:29960. OSCAR.
HPAiHPA062740.
MIMi606862. gene.
neXtProtiNX_Q8IYS5.
OpenTargetsiENSG00000273511.
ENSG00000274703.
ENSG00000275551.
ENSG00000275644.
ENSG00000275736.
ENSG00000276982.
ENSG00000277088.
ENSG00000278378.
ENSG00000278533.
PharmGKBiPA162398474.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
HOVERGENiHBG108217.
InParanoidiQ8IYS5.
KOiK14377.
OrthoDBiEOG091G020P.
PhylomeDBiQ8IYS5.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

GeneWikiiOSCAR_(gene).
GenomeRNAii126014.
PROiQ8IYS5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170909.
CleanExiHS_OSCAR.
ExpressionAtlasiQ8IYS5. baseline and differential.
GenevisibleiQ8IYS5. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiOSCAR_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS5
Secondary accession number(s): B7WNS2
, Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.