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Q8IYS5

- OSCAR_HUMAN

UniProt

Q8IYS5 - OSCAR_HUMAN

Protein

Osteoclast-associated immunoglobulin-like receptor

Gene

OSCAR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.By similarity

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteoclast-associated immunoglobulin-like receptor
    Short name:
    Osteoclast-associated receptor
    Short name:
    hOSCAR
    Alternative name(s):
    Polymeric immunoglobulin receptor 3
    Short name:
    PIgR-3
    Short name:
    PIgR3
    Short name:
    Poly-Ig receptor 3
    Gene namesi
    Name:OSCAR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29960. OSCAR.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162398474.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 282264Osteoclast-associated immunoglobulin-like receptorPRO_0000310951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi53 ↔ 100By similarity
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IYS5.
    PRIDEiQ8IYS5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IYS5.
    BgeeiQ8IYS5.
    CleanExiHS_OSCAR.
    GenevestigatoriQ8IYS5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8IYS5. 2 interactions.
    STRINGi9606.ENSP00000352671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYS5.
    SMRiQ8IYS5. Positions 31-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 11695Ig-like 1Add
    BLAST
    Domaini126 – 21994Ig-like 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276170.
    HOVERGENiHBG108217.
    InParanoidiQ8IYS5.
    KOiK14377.
    OMAiQIQESSE.
    PhylomeDBiQ8IYS5.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IYS5-1) [UniParc]FASTAAdd to Basket

    Also known as: OSCAR-S1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT    50
    LRCRAPQPAW RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC 100
    CYRRPDWGPG VWSQPSDVLE LLVTEELPRP SLVALPGPVV GPGANVSLRC 150
    AGRLRNMSFV LYREGVAAPL QYRHSAQPWA DFTLLGARAP GTYSCYYHTP 200
    SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP SDPGAQAPSL 250
    SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GV 282
    Length:282
    Mass (Da):30,481
    Last modified:November 2, 2010 - v3
    Checksum:i1C0A86B90DA6F5CD
    GO
    Isoform 2 (identifier: Q8IYS5-2) [UniParc]FASTAAdd to Basket

    Also known as: OSCAR-M1

    The sequence of this isoform differs from the canonical sequence as follows:
         219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

    Show »
    Length:263
    Mass (Da):28,832
    Checksum:iA8657336B9DD1237
    GO
    Isoform 3 (identifier: Q8IYS5-3) [UniParc]FASTAAdd to Basket

    Also known as: OSCAR-M2

    The sequence of this isoform differs from the canonical sequence as follows:
         24-24: V → VAIIV
         219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

    Show »
    Length:267
    Mass (Da):29,229
    Checksum:iAA9C139695285E4A
    GO
    Isoform 4 (identifier: Q8IYS5-4) [UniParc]FASTAAdd to Basket

    Also known as: OSCAR-S2

    The sequence of this isoform differs from the canonical sequence as follows:
         13-25: WPLCHTDITPSVP → FP

    Show »
    Length:271
    Mass (Da):29,278
    Checksum:i45660528C75F9A8A
    GO
    Isoform 5 (identifier: Q8IYS5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         129-134: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:276
    Mass (Da):29,857
    Checksum:i74AF3F9451D97806
    GO
    Isoform 7 (identifier: Q8IYS5-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-24: V → VAIIV

    Note: No experimental confirmation available.

    Show »
    Length:286
    Mass (Da):30,877
    Checksum:i6F3E049373829FCA
    GO
    Isoform 6 (identifier: Q8IYS5-6) [UniParc]FASTAAdd to Basket

    Also known as: OSCAR-M3

    The sequence of this isoform differs from the canonical sequence as follows:
         13-25: WPLCHTDITPSVP → FP
         219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

    Note: No experimental confirmation available.

    Show »
    Length:252
    Mass (Da):27,629
    Checksum:iCE0BFD7C3FB9DF53
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1581S → N in AAM19095. 1 PublicationCurated
    Sequence conflicti194 – 1941S → G in BAC03586. (PubMed:14702039)Curated
    Sequence conflicti194 – 1941S → G in AX746784. (PubMed:15057824)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971I → S.4 Publications
    Corresponds to variant rs1657535 [ dbSNP | Ensembl ].
    VAR_037108
    Natural varianti229 – 2291S → Y.
    Corresponds to variant rs8106130 [ dbSNP | Ensembl ].
    VAR_047393

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei13 – 2513WPLCH…TPSVP → FP in isoform 4 and isoform 6. 1 PublicationVSP_029352Add
    BLAST
    Alternative sequencei24 – 241V → VAIIV in isoform 3 and isoform 7. 2 PublicationsVSP_029353
    Alternative sequencei129 – 1346Missing in isoform 5. 1 PublicationVSP_029354
    Alternative sequencei219 – 28264GEGPE…SDPGV → DSGSSDYTRGNLVRLGLAGL VLISLGALVTFDWRSQNRAP AGIRP in isoform 2, isoform 3 and isoform 6. 2 PublicationsVSP_029355Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251702 mRNA. Translation: AAM19095.1.
    AF391162 mRNA. Translation: AAL68495.1.
    AF391163 mRNA. Translation: AAL68496.1.
    AF391164 mRNA. Translation: AAL68497.1.
    AF474152 mRNA. Translation: AAQ05766.1.
    AF474153 mRNA. Translation: AAQ05767.1.
    AX746784 mRNA. No translation available.
    AK091111 mRNA. Translation: BAC03586.1.
    AK130199 mRNA. No translation available.
    AC012314 Genomic DNA. No translation available.
    BC035023 mRNA. Translation: AAH35023.1.
    CCDSiCCDS12873.1. [Q8IYS5-3]
    CCDS12874.1. [Q8IYS5-6]
    CCDS12875.1. [Q8IYS5-2]
    CCDS12876.1. [Q8IYS5-7]
    CCDS62789.1. [Q8IYS5-4]
    RefSeqiNP_001269278.1. NM_001282349.1.
    NP_001269279.1. NM_001282350.1.
    NP_570127.3. NM_130771.4.
    NP_573398.2. NM_133168.4.
    NP_573399.2. NM_133169.4.
    NP_996554.2. NM_206818.2.
    UniGeneiHs.347655.

    Genome annotation databases

    EnsembliENST00000284648; ENSP00000365808; ENSG00000170909. [Q8IYS5-1]
    ENST00000351806; ENSP00000304523; ENSG00000170909. [Q8IYS5-6]
    ENST00000356532; ENSP00000348927; ENSG00000170909. [Q8IYS5-3]
    ENST00000358375; ENSP00000351145; ENSG00000170909. [Q8IYS5-2]
    ENST00000359649; ENSP00000352671; ENSG00000170909. [Q8IYS5-7]
    ENST00000391761; ENSP00000375641; ENSG00000170909. [Q8IYS5-4]
    GeneIDi126014.
    KEGGihsa:126014.
    UCSCiuc002qcy.3. human. [Q8IYS5-3]
    uc002qcz.3. human. [Q8IYS5-2]
    uc002qda.3. human. [Q8IYS5-7]
    uc002qdb.3. human. [Q8IYS5-6]
    uc002qdc.3. human. [Q8IYS5-4]
    uc002qdd.3. human. [Q8IYS5-1]

    Polymorphism databases

    DMDMi311033418.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251702 mRNA. Translation: AAM19095.1 .
    AF391162 mRNA. Translation: AAL68495.1 .
    AF391163 mRNA. Translation: AAL68496.1 .
    AF391164 mRNA. Translation: AAL68497.1 .
    AF474152 mRNA. Translation: AAQ05766.1 .
    AF474153 mRNA. Translation: AAQ05767.1 .
    AX746784 mRNA. No translation available.
    AK091111 mRNA. Translation: BAC03586.1 .
    AK130199 mRNA. No translation available.
    AC012314 Genomic DNA. No translation available.
    BC035023 mRNA. Translation: AAH35023.1 .
    CCDSi CCDS12873.1. [Q8IYS5-3 ]
    CCDS12874.1. [Q8IYS5-6 ]
    CCDS12875.1. [Q8IYS5-2 ]
    CCDS12876.1. [Q8IYS5-7 ]
    CCDS62789.1. [Q8IYS5-4 ]
    RefSeqi NP_001269278.1. NM_001282349.1.
    NP_001269279.1. NM_001282350.1.
    NP_570127.3. NM_130771.4.
    NP_573398.2. NM_133168.4.
    NP_573399.2. NM_133169.4.
    NP_996554.2. NM_206818.2.
    UniGenei Hs.347655.

    3D structure databases

    ProteinModelPortali Q8IYS5.
    SMRi Q8IYS5. Positions 31-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IYS5. 2 interactions.
    STRINGi 9606.ENSP00000352671.

    Polymorphism databases

    DMDMi 311033418.

    Proteomic databases

    PaxDbi Q8IYS5.
    PRIDEi Q8IYS5.

    Protocols and materials databases

    DNASUi 126014.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284648 ; ENSP00000365808 ; ENSG00000170909 . [Q8IYS5-1 ]
    ENST00000351806 ; ENSP00000304523 ; ENSG00000170909 . [Q8IYS5-6 ]
    ENST00000356532 ; ENSP00000348927 ; ENSG00000170909 . [Q8IYS5-3 ]
    ENST00000358375 ; ENSP00000351145 ; ENSG00000170909 . [Q8IYS5-2 ]
    ENST00000359649 ; ENSP00000352671 ; ENSG00000170909 . [Q8IYS5-7 ]
    ENST00000391761 ; ENSP00000375641 ; ENSG00000170909 . [Q8IYS5-4 ]
    GeneIDi 126014.
    KEGGi hsa:126014.
    UCSCi uc002qcy.3. human. [Q8IYS5-3 ]
    uc002qcz.3. human. [Q8IYS5-2 ]
    uc002qda.3. human. [Q8IYS5-7 ]
    uc002qdb.3. human. [Q8IYS5-6 ]
    uc002qdc.3. human. [Q8IYS5-4 ]
    uc002qdd.3. human. [Q8IYS5-1 ]

    Organism-specific databases

    CTDi 126014.
    GeneCardsi GC19M054597.
    HGNCi HGNC:29960. OSCAR.
    MIMi 606862. gene.
    neXtProti NX_Q8IYS5.
    PharmGKBi PA162398474.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276170.
    HOVERGENi HBG108217.
    InParanoidi Q8IYS5.
    KOi K14377.
    OMAi QIQESSE.
    PhylomeDBi Q8IYS5.
    TreeFami TF336644.

    Miscellaneous databases

    GeneWikii OSCAR_(gene).
    GenomeRNAii 126014.
    NextBioi 81631.
    PROi Q8IYS5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IYS5.
    Bgeei Q8IYS5.
    CleanExi HS_OSCAR.
    Genevestigatori Q8IYS5.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel PIGR2."
      Zhang W., Li N., Wan T., Cao X.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT SER-97.
    2. "A novel member of the leukocyte receptor complex regulates osteoclast differentiation."
      Kim N., Takami M., Rho J., Josien R., Choi Y.
      J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6).
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 5), VARIANT SER-97.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANT SER-97.
      Tissue: Macrophage.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-97.
      Tissue: Testis.

    Entry informationi

    Entry nameiOSCAR_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYS5
    Secondary accession number(s): B7WNS2
    , Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3