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Q8IYS5

- OSCAR_HUMAN

UniProt

Q8IYS5 - OSCAR_HUMAN

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Protein

Osteoclast-associated immunoglobulin-like receptor

Gene

OSCAR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-associated immunoglobulin-like receptor
Short name:
Osteoclast-associated receptor
Short name:
hOSCAR
Alternative name(s):
Polymeric immunoglobulin receptor 3
Short name:
PIgR-3
Short name:
PIgR3
Short name:
Poly-Ig receptor 3
Gene namesi
Name:OSCAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29960. OSCAR.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 282264Osteoclast-associated immunoglobulin-like receptorPRO_0000310951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi53 ↔ 100By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IYS5.
PRIDEiQ8IYS5.

Expressioni

Gene expression databases

BgeeiQ8IYS5.
CleanExiHS_OSCAR.
GenevestigatoriQ8IYS5.

Interactioni

Protein-protein interaction databases

IntActiQ8IYS5. 2 interactions.
STRINGi9606.ENSP00000352671.

Structurei

3D structure databases

ProteinModelPortaliQ8IYS5.
SMRiQ8IYS5. Positions 31-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11695Ig-like 1Add
BLAST
Domaini126 – 21994Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276170.
GeneTreeiENSGT00760000119033.
HOVERGENiHBG108217.
InParanoidiQ8IYS5.
KOiK14377.
OMAiQIQESSE.
PhylomeDBiQ8IYS5.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IYS5-1) [UniParc]FASTAAdd to Basket

Also known as: OSCAR-S1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT
60 70 80 90 100
LRCRAPQPAW RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC
110 120 130 140 150
CYRRPDWGPG VWSQPSDVLE LLVTEELPRP SLVALPGPVV GPGANVSLRC
160 170 180 190 200
AGRLRNMSFV LYREGVAAPL QYRHSAQPWA DFTLLGARAP GTYSCYYHTP
210 220 230 240 250
SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP SDPGAQAPSL
260 270 280
SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GV
Length:282
Mass (Da):30,481
Last modified:November 2, 2010 - v3
Checksum:i1C0A86B90DA6F5CD
GO
Isoform 2 (identifier: Q8IYS5-2) [UniParc]FASTAAdd to Basket

Also known as: OSCAR-M1

The sequence of this isoform differs from the canonical sequence as follows:
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Show »
Length:263
Mass (Da):28,832
Checksum:iA8657336B9DD1237
GO
Isoform 3 (identifier: Q8IYS5-3) [UniParc]FASTAAdd to Basket

Also known as: OSCAR-M2

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Show »
Length:267
Mass (Da):29,229
Checksum:iAA9C139695285E4A
GO
Isoform 4 (identifier: Q8IYS5-4) [UniParc]FASTAAdd to Basket

Also known as: OSCAR-S2

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP

Show »
Length:271
Mass (Da):29,278
Checksum:i45660528C75F9A8A
GO
Isoform 5 (identifier: Q8IYS5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-134: Missing.

Note: No experimental confirmation available.

Show »
Length:276
Mass (Da):29,857
Checksum:i74AF3F9451D97806
GO
Isoform 7 (identifier: Q8IYS5-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV

Note: No experimental confirmation available.

Show »
Length:286
Mass (Da):30,877
Checksum:i6F3E049373829FCA
GO
Isoform 6 (identifier: Q8IYS5-6) [UniParc]FASTAAdd to Basket

Also known as: OSCAR-M3

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Note: No experimental confirmation available.

Show »
Length:252
Mass (Da):27,629
Checksum:iCE0BFD7C3FB9DF53
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581S → N in AAM19095. 1 PublicationCurated
Sequence conflicti194 – 1941S → G in BAC03586. (PubMed:14702039)Curated
Sequence conflicti194 – 1941S → G in AX746784. (PubMed:15057824)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971I → S.4 Publications
Corresponds to variant rs1657535 [ dbSNP | Ensembl ].
VAR_037108
Natural varianti229 – 2291S → Y.
Corresponds to variant rs8106130 [ dbSNP | Ensembl ].
VAR_047393

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei13 – 2513WPLCH…TPSVP → FP in isoform 4 and isoform 6. 1 PublicationVSP_029352Add
BLAST
Alternative sequencei24 – 241V → VAIIV in isoform 3 and isoform 7. 2 PublicationsVSP_029353
Alternative sequencei129 – 1346Missing in isoform 5. 1 PublicationVSP_029354
Alternative sequencei219 – 28264GEGPE…SDPGV → DSGSSDYTRGNLVRLGLAGL VLISLGALVTFDWRSQNRAP AGIRP in isoform 2, isoform 3 and isoform 6. 2 PublicationsVSP_029355Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251702 mRNA. Translation: AAM19095.1.
AF391162 mRNA. Translation: AAL68495.1.
AF391163 mRNA. Translation: AAL68496.1.
AF391164 mRNA. Translation: AAL68497.1.
AF474152 mRNA. Translation: AAQ05766.1.
AF474153 mRNA. Translation: AAQ05767.1.
AX746784 mRNA. No translation available.
AK091111 mRNA. Translation: BAC03586.1.
AK130199 mRNA. No translation available.
AC012314 Genomic DNA. No translation available.
BC035023 mRNA. Translation: AAH35023.1.
CCDSiCCDS12873.1. [Q8IYS5-3]
CCDS12874.1. [Q8IYS5-6]
CCDS12875.1. [Q8IYS5-2]
CCDS12876.1. [Q8IYS5-7]
CCDS62789.1. [Q8IYS5-4]
CCDS74444.1. [Q8IYS5-1]
RefSeqiNP_001269278.1. NM_001282349.1.
NP_001269279.1. NM_001282350.1.
NP_570127.3. NM_130771.4.
NP_573398.2. NM_133168.4.
NP_573399.2. NM_133169.4.
NP_996554.2. NM_206818.2.
UniGeneiHs.347655.

Genome annotation databases

EnsembliENST00000284648; ENSP00000365808; ENSG00000170909.
ENST00000391761; ENSP00000375641; ENSG00000170909.
ENST00000611535; ENSP00000483744; ENSG00000275736. [Q8IYS5-2]
ENST00000613426; ENSP00000480900; ENSG00000275736. [Q8IYS5-1]
ENST00000613814; ENSP00000484125; ENSG00000275736. [Q8IYS5-4]
ENST00000615074; ENSP00000477845; ENSG00000275736. [Q8IYS5-7]
ENST00000616215; ENSP00000479628; ENSG00000170909.
ENST00000616227; ENSP00000479849; ENSG00000275736. [Q8IYS5-7]
ENST00000619287; ENSP00000484977; ENSG00000275736. [Q8IYS5-6]
ENST00000621284; ENSP00000477825; ENSG00000275736. [Q8IYS5-4]
ENST00000621290; ENSP00000482791; ENSG00000275736. [Q8IYS5-3]
ENST00000621788; ENSP00000481926; ENSG00000275736. [Q8IYS5-3]
GeneIDi126014.
KEGGihsa:126014.
UCSCiuc002qcy.3. human. [Q8IYS5-3]
uc002qcz.3. human. [Q8IYS5-2]
uc002qda.3. human. [Q8IYS5-7]
uc002qdb.3. human. [Q8IYS5-6]
uc002qdc.3. human. [Q8IYS5-4]
uc002qdd.3. human. [Q8IYS5-1]

Polymorphism databases

DMDMi311033418.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251702 mRNA. Translation: AAM19095.1 .
AF391162 mRNA. Translation: AAL68495.1 .
AF391163 mRNA. Translation: AAL68496.1 .
AF391164 mRNA. Translation: AAL68497.1 .
AF474152 mRNA. Translation: AAQ05766.1 .
AF474153 mRNA. Translation: AAQ05767.1 .
AX746784 mRNA. No translation available.
AK091111 mRNA. Translation: BAC03586.1 .
AK130199 mRNA. No translation available.
AC012314 Genomic DNA. No translation available.
BC035023 mRNA. Translation: AAH35023.1 .
CCDSi CCDS12873.1. [Q8IYS5-3 ]
CCDS12874.1. [Q8IYS5-6 ]
CCDS12875.1. [Q8IYS5-2 ]
CCDS12876.1. [Q8IYS5-7 ]
CCDS62789.1. [Q8IYS5-4 ]
CCDS74444.1. [Q8IYS5-1 ]
RefSeqi NP_001269278.1. NM_001282349.1.
NP_001269279.1. NM_001282350.1.
NP_570127.3. NM_130771.4.
NP_573398.2. NM_133168.4.
NP_573399.2. NM_133169.4.
NP_996554.2. NM_206818.2.
UniGenei Hs.347655.

3D structure databases

ProteinModelPortali Q8IYS5.
SMRi Q8IYS5. Positions 31-238.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8IYS5. 2 interactions.
STRINGi 9606.ENSP00000352671.

Polymorphism databases

DMDMi 311033418.

Proteomic databases

PaxDbi Q8IYS5.
PRIDEi Q8IYS5.

Protocols and materials databases

DNASUi 126014.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000284648 ; ENSP00000365808 ; ENSG00000170909 .
ENST00000391761 ; ENSP00000375641 ; ENSG00000170909 .
ENST00000611535 ; ENSP00000483744 ; ENSG00000275736 . [Q8IYS5-2 ]
ENST00000613426 ; ENSP00000480900 ; ENSG00000275736 . [Q8IYS5-1 ]
ENST00000613814 ; ENSP00000484125 ; ENSG00000275736 . [Q8IYS5-4 ]
ENST00000615074 ; ENSP00000477845 ; ENSG00000275736 . [Q8IYS5-7 ]
ENST00000616215 ; ENSP00000479628 ; ENSG00000170909 .
ENST00000616227 ; ENSP00000479849 ; ENSG00000275736 . [Q8IYS5-7 ]
ENST00000619287 ; ENSP00000484977 ; ENSG00000275736 . [Q8IYS5-6 ]
ENST00000621284 ; ENSP00000477825 ; ENSG00000275736 . [Q8IYS5-4 ]
ENST00000621290 ; ENSP00000482791 ; ENSG00000275736 . [Q8IYS5-3 ]
ENST00000621788 ; ENSP00000481926 ; ENSG00000275736 . [Q8IYS5-3 ]
GeneIDi 126014.
KEGGi hsa:126014.
UCSCi uc002qcy.3. human. [Q8IYS5-3 ]
uc002qcz.3. human. [Q8IYS5-2 ]
uc002qda.3. human. [Q8IYS5-7 ]
uc002qdb.3. human. [Q8IYS5-6 ]
uc002qdc.3. human. [Q8IYS5-4 ]
uc002qdd.3. human. [Q8IYS5-1 ]

Organism-specific databases

CTDi 126014.
GeneCardsi GC19M054597.
HGNCi HGNC:29960. OSCAR.
MIMi 606862. gene.
neXtProti NX_Q8IYS5.
PharmGKBi PA162398474.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276170.
GeneTreei ENSGT00760000119033.
HOVERGENi HBG108217.
InParanoidi Q8IYS5.
KOi K14377.
OMAi QIQESSE.
PhylomeDBi Q8IYS5.
TreeFami TF336644.

Miscellaneous databases

GeneWikii OSCAR_(gene).
GenomeRNAii 126014.
NextBioi 81631.
PROi Q8IYS5.
SOURCEi Search...

Gene expression databases

Bgeei Q8IYS5.
CleanExi HS_OSCAR.
Genevestigatori Q8IYS5.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel PIGR2."
    Zhang W., Li N., Wan T., Cao X.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT SER-97.
  2. "A novel member of the leukocyte receptor complex regulates osteoclast differentiation."
    Kim N., Takami M., Rho J., Josien R., Choi Y.
    J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6).
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 5), VARIANT SER-97.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANT SER-97.
    Tissue: Macrophage.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-97.
    Tissue: Testis.

Entry informationi

Entry nameiOSCAR_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS5
Secondary accession number(s): B7WNS2
, Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3