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Protein

Peptidase M20 domain-containing protein 2

Gene

PM20D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • dipeptidase activity Source: MGI

GO - Biological processi

  • proteolysis Source: MGI
  • regulation of cellular protein metabolic process Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiM20.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase M20 domain-containing protein 2
Alternative name(s):
Aminoacylase-1-like protein 2
Gene namesi
Name:PM20D2
Synonyms:ACY1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21408. PM20D2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399803.

Polymorphism and mutation databases

DMDMi121944459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Peptidase M20 domain-containing protein 2PRO_0000286340Add
BLAST

Proteomic databases

EPDiQ8IYS1.
MaxQBiQ8IYS1.
PaxDbiQ8IYS1.
PRIDEiQ8IYS1.

PTM databases

iPTMnetiQ8IYS1.
PhosphoSiteiQ8IYS1.

Expressioni

Gene expression databases

BgeeiQ8IYS1.
CleanExiHS_PM20D2.
GenevisibleiQ8IYS1. HS.

Organism-specific databases

HPAiHPA030325.
HPA030326.
HPA030327.

Interactioni

Protein-protein interaction databases

BioGridi126427. 15 interactions.
IntActiQ8IYS1. 1 interaction.
STRINGi9606.ENSP00000275072.

Structurei

3D structure databases

ProteinModelPortaliQ8IYS1.
SMRiQ8IYS1. Positions 41-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

eggNOGiENOG410IFYV. Eukaryota.
COG1473. LUCA.
GeneTreeiENSGT00390000003365.
HOGENOMiHOG000251261.
HOVERGENiHBG095598.
InParanoidiQ8IYS1.
OMAiFFECEPP.
OrthoDBiEOG7H4DTD.
PhylomeDBiQ8IYS1.
TreeFamiTF332656.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
InterProiIPR017144. Pept_M20A_amidohydro_pred.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037226. Amidohydrolase_ACY1L2_prd. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IYS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPGGERPVE GGACNGRSEL ELLKLRSAEC IDEAAERLGA LSRAIWSQPE
60 70 80 90 100
LAYEEHHAHR VLTHFFEREP PAASWAVQPH YQLPTAFRAE WEPPEARAPS
110 120 130 140 150
ATPRPLHLGF LCEYDALPGI GHACGHNLIA EVGAAAALGV RGALEGLPRP
160 170 180 190 200
PPPVKVVVLG TPAEEDGGGK IDLIEAGAFT NLDVVFMAHP SQENAAYLPD
210 220 230 240 250
MAEHDVTVKY YGKASHSASY PWEGLNALDA AVLAYNNLSV FRQQMKPTWR
260 270 280 290 300
VHGIIKNGGV KPNIIPSYSE LIYYFRAPSM KELQVLTKKA EDCFRAAALA
310 320 330 340 350
SGCTVEIKGG AHDYYNVLPN KSLWKAYMEN GRKLGIEFIS EDTMLNGPSG
360 370 380 390 400
STDFGNVSFV VPGIHPYFHI GSNALNHTEQ YTEAAGSQEA QFYTLRTAKA
410 420 430
LAMTALDVIF KPELLEGIRE DFKLKLQEEQ FVNAVE
Length:436
Mass (Da):47,776
Last modified:August 30, 2005 - v2
Checksum:iBC387E3CD2B29A94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711I → V in AAH45583 (PubMed:15489334).Curated
Sequence conflicti189 – 1891H → N in AAH45583 (PubMed:15489334).Curated
Sequence conflicti434 – 4341A → V in AAH45583 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti333 – 3331K → E.
Corresponds to variant rs10944433 [ dbSNP | Ensembl ].
VAR_032081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302464 mRNA. Translation: BAG63754.1.
AL353135 Genomic DNA. Translation: CAI16248.1.
CH471051 Genomic DNA. Translation: EAW48559.1.
BC035036 mRNA. Translation: AAH35036.2.
BC045583 mRNA. Translation: AAH45583.1.
BX640865 mRNA. Translation: CAE45925.1.
CCDSiCCDS34499.1.
RefSeqiNP_001010853.1. NM_001010853.2.
UniGeneiHs.356247.

Genome annotation databases

EnsembliENST00000275072; ENSP00000275072; ENSG00000146281.
GeneIDi135293.
KEGGihsa:135293.
UCSCiuc003pmz.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302464 mRNA. Translation: BAG63754.1.
AL353135 Genomic DNA. Translation: CAI16248.1.
CH471051 Genomic DNA. Translation: EAW48559.1.
BC035036 mRNA. Translation: AAH35036.2.
BC045583 mRNA. Translation: AAH45583.1.
BX640865 mRNA. Translation: CAE45925.1.
CCDSiCCDS34499.1.
RefSeqiNP_001010853.1. NM_001010853.2.
UniGeneiHs.356247.

3D structure databases

ProteinModelPortaliQ8IYS1.
SMRiQ8IYS1. Positions 41-421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126427. 15 interactions.
IntActiQ8IYS1. 1 interaction.
STRINGi9606.ENSP00000275072.

Protein family/group databases

MEROPSiM20.021.

PTM databases

iPTMnetiQ8IYS1.
PhosphoSiteiQ8IYS1.

Polymorphism and mutation databases

DMDMi121944459.

Proteomic databases

EPDiQ8IYS1.
MaxQBiQ8IYS1.
PaxDbiQ8IYS1.
PRIDEiQ8IYS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275072; ENSP00000275072; ENSG00000146281.
GeneIDi135293.
KEGGihsa:135293.
UCSCiuc003pmz.6. human.

Organism-specific databases

CTDi135293.
GeneCardsiPM20D2.
H-InvDBHIX0006063.
HGNCiHGNC:21408. PM20D2.
HPAiHPA030325.
HPA030326.
HPA030327.
MIMi615913. gene.
neXtProtiNX_Q8IYS1.
PharmGKBiPA162399803.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFYV. Eukaryota.
COG1473. LUCA.
GeneTreeiENSGT00390000003365.
HOGENOMiHOG000251261.
HOVERGENiHBG095598.
InParanoidiQ8IYS1.
OMAiFFECEPP.
OrthoDBiEOG7H4DTD.
PhylomeDBiQ8IYS1.
TreeFamiTF332656.

Miscellaneous databases

GenomeRNAii135293.
PROiQ8IYS1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IYS1.
CleanExiHS_PM20D2.
GenevisibleiQ8IYS1. HS.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
InterProiIPR017144. Pept_M20A_amidohydro_pred.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037226. Amidohydrolase_ACY1L2_prd. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 371-436.
    Tissue: Salivary gland.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiP20D2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS1
Secondary accession number(s): B4DYJ2
, Q5T7J9, Q6MZV2, Q86XD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: August 30, 2005
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.