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Protein

GRAM domain-containing protein 1C

Gene

GRAMD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GRAM domain-containing protein 1C
Gene namesi
Name:GRAMD1C
ORF Names:UNQ2543/PRO6095
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25252. GRAMD1C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178075.
PharmGKBiPA142671709.

Polymorphism and mutation databases

BioMutaiGRAMD1C.
DMDMi147645434.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874511 – 662GRAM domain-containing protein 1CAdd BLAST662

Proteomic databases

PaxDbiQ8IYS0.
PeptideAtlasiQ8IYS0.
PRIDEiQ8IYS0.

PTM databases

iPTMnetiQ8IYS0.
PhosphoSitePlusiQ8IYS0.

Expressioni

Gene expression databases

BgeeiENSG00000178075.
CleanExiHS_GRAMD1C.
ExpressionAtlasiQ8IYS0. baseline and differential.
GenevisibleiQ8IYS0. HS.

Organism-specific databases

HPAiHPA012316.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CD151P485095EBI-7054335,EBI-10210332

Protein-protein interaction databases

BioGridi120137. 8 interactors.
IntActiQ8IYS0. 2 interactors.
MINTiMINT-4781532.
STRINGi9606.ENSP00000350881.

Structurei

3D structure databases

ProteinModelPortaliQ8IYS0.
SMRiQ8IYS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 136GRAMAdd BLAST68
Domaini326 – 497VAStPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Contains 1 GRAM domain.Curated
Contains 1 VASt domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1032. Eukaryota.
ENOG410XRQQ. LUCA.
GeneTreeiENSGT00580000081380.
HOGENOMiHOG000294164.
HOVERGENiHBG062004.
InParanoidiQ8IYS0.
OMAiKIEHAAQ.
OrthoDBiEOG091G051I.
PhylomeDBiQ8IYS0.
TreeFamiTF327695.

Family and domain databases

InterProiIPR031968. DUF4782.
IPR004182. GRAM.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF02893. GRAM. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
PROSITEiPS51778. VAST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGAPTVRQV MNEGDSSLAT DLQEDVEENP SPTVEENNVV VKKQGPNLHN
60 70 80 90 100
WSGDWSFWIS SSTYKDRNEE YRRQFTHLPD TERLIADYAC ALQRDILLQG
110 120 130 140 150
RLYLSENWLC FYSNIFRWET TISIALKNIT FMTKEKTARL IPNAIQIVTE
160 170 180 190 200
SEKFFFTSFG ARDRSYLSIF RLWQNVLLDK SLTRQEFWQL LQQNYGTELG
210 220 230 240 250
LNAEEMENLS LSIEDVQPRS PGRSSLDDSG ERDEKLSKSI SFTSESISRV
260 270 280 290 300
SETESFDGNS SKGGLGKEES QNEKQTKKSL LPTLEKKLTR VPSKSLDLNK
310 320 330 340 350
NEYLSLDKSS TSDSVDEENV PEKDLHGRLF INRIFHISAD RMFELLFTSS
360 370 380 390 400
RFMQKFASSR NIIDVVSTPW TAELGGDQLR TMTYTIVLNS PLTGKCTAAT
410 420 430 440 450
EKQTLYKESR EARFYLVDSE VLTHDVPYHD YFYTVNRYCI IRSSKQKCRL
460 470 480 490 500
RVSTDLKYRK QPWGLVKSLI EKNSWSSLED YFKQLESDLL IEESVLNQAI
510 520 530 540 550
EDPGKLTGLR RRRRTFNRTA ETVPKLSSQH SSGDVGLGAK GDITGKKKEM
560 570 580 590 600
ENYNVTLIVV MSIFVLLLVL LNVTLFLKLS KIEHAAQSFY RLRLQEEKSL
610 620 630 640 650
NLASDMVSRA ETIQKNKDQA HRLKGVLRDS IVMLEQLKSS LIMLQKTFDL
660
LNKNKTGMAV ES
Length:662
Mass (Da):76,035
Last modified:May 15, 2007 - v2
Checksum:i1A0F5471FA1F7CD3
GO
Isoform 2 (identifier: Q8IYS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-205: Missing.

Show »
Length:457
Mass (Da):52,015
Checksum:i3F73F0C7AF4370ED
GO

Sequence cautioni

The sequence AAH28972 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti503 – 506PGKL → AVHH in AAH28972 (PubMed:15489334).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032302644L → P.1 PublicationCorresponds to variant rs17853381dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254771 – 205Missing in isoform 2. 2 PublicationsAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358725 mRNA. Translation: AAQ89087.1.
AK292846 mRNA. Translation: BAF85535.1.
AK292964 mRNA. Translation: BAF85653.1.
AK304142 mRNA. Translation: BAH14115.1.
CH471052 Genomic DNA. Translation: EAW79621.1.
CH471052 Genomic DNA. Translation: EAW79622.1.
BC028972 mRNA. Translation: AAH28972.1. Different initiation.
BC035040 mRNA. Translation: AAH35040.1.
AL133661 mRNA. Translation: CAB63774.2.
BX648633 mRNA. Translation: CAH10770.1.
CCDSiCCDS33826.1. [Q8IYS0-1]
CCDS54625.1. [Q8IYS0-2]
PIRiT43471.
RefSeqiNP_001165576.1. NM_001172105.1. [Q8IYS0-2]
NP_060047.3. NM_017577.4. [Q8IYS0-1]
XP_011511233.1. XM_011512931.1. [Q8IYS0-2]
UniGeneiHs.24583.

Genome annotation databases

EnsembliENST00000358160; ENSP00000350881; ENSG00000178075. [Q8IYS0-1]
ENST00000440446; ENSP00000408135; ENSG00000178075. [Q8IYS0-2]
GeneIDi54762.
KEGGihsa:54762.
UCSCiuc003eaq.5. human. [Q8IYS0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358725 mRNA. Translation: AAQ89087.1.
AK292846 mRNA. Translation: BAF85535.1.
AK292964 mRNA. Translation: BAF85653.1.
AK304142 mRNA. Translation: BAH14115.1.
CH471052 Genomic DNA. Translation: EAW79621.1.
CH471052 Genomic DNA. Translation: EAW79622.1.
BC028972 mRNA. Translation: AAH28972.1. Different initiation.
BC035040 mRNA. Translation: AAH35040.1.
AL133661 mRNA. Translation: CAB63774.2.
BX648633 mRNA. Translation: CAH10770.1.
CCDSiCCDS33826.1. [Q8IYS0-1]
CCDS54625.1. [Q8IYS0-2]
PIRiT43471.
RefSeqiNP_001165576.1. NM_001172105.1. [Q8IYS0-2]
NP_060047.3. NM_017577.4. [Q8IYS0-1]
XP_011511233.1. XM_011512931.1. [Q8IYS0-2]
UniGeneiHs.24583.

3D structure databases

ProteinModelPortaliQ8IYS0.
SMRiQ8IYS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120137. 8 interactors.
IntActiQ8IYS0. 2 interactors.
MINTiMINT-4781532.
STRINGi9606.ENSP00000350881.

PTM databases

iPTMnetiQ8IYS0.
PhosphoSitePlusiQ8IYS0.

Polymorphism and mutation databases

BioMutaiGRAMD1C.
DMDMi147645434.

Proteomic databases

PaxDbiQ8IYS0.
PeptideAtlasiQ8IYS0.
PRIDEiQ8IYS0.

Protocols and materials databases

DNASUi54762.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358160; ENSP00000350881; ENSG00000178075. [Q8IYS0-1]
ENST00000440446; ENSP00000408135; ENSG00000178075. [Q8IYS0-2]
GeneIDi54762.
KEGGihsa:54762.
UCSCiuc003eaq.5. human. [Q8IYS0-1]

Organism-specific databases

CTDi54762.
GeneCardsiGRAMD1C.
HGNCiHGNC:25252. GRAMD1C.
HPAiHPA012316.
neXtProtiNX_Q8IYS0.
OpenTargetsiENSG00000178075.
PharmGKBiPA142671709.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1032. Eukaryota.
ENOG410XRQQ. LUCA.
GeneTreeiENSGT00580000081380.
HOGENOMiHOG000294164.
HOVERGENiHBG062004.
InParanoidiQ8IYS0.
OMAiKIEHAAQ.
OrthoDBiEOG091G051I.
PhylomeDBiQ8IYS0.
TreeFamiTF327695.

Miscellaneous databases

ChiTaRSiGRAMD1C. human.
GenomeRNAii54762.
PROiQ8IYS0.

Gene expression databases

BgeeiENSG00000178075.
CleanExiHS_GRAMD1C.
ExpressionAtlasiQ8IYS0. baseline and differential.
GenevisibleiQ8IYS0. HS.

Family and domain databases

InterProiIPR031968. DUF4782.
IPR004182. GRAM.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF02893. GRAM. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
PROSITEiPS51778. VAST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRM1C_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS0
Secondary accession number(s): A8K9Y1
, A8KA99, Q6AW94, Q6UWN1, Q8N6S0, Q9UF46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.