Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GRAM domain-containing protein 1C

Gene

GRAMD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GRAM domain-containing protein 1C
Gene namesi
Name:GRAMD1C
ORF Names:UNQ2543/PRO6095
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000178075.19
HGNCiHGNC:25252 GRAMD1C
neXtProtiNX_Q8IYS0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178075
PharmGKBiPA142671709

Polymorphism and mutation databases

BioMutaiGRAMD1C
DMDMi147645434

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874511 – 662GRAM domain-containing protein 1CAdd BLAST662

Proteomic databases

EPDiQ8IYS0
PaxDbiQ8IYS0
PeptideAtlasiQ8IYS0
PRIDEiQ8IYS0

PTM databases

iPTMnetiQ8IYS0
PhosphoSitePlusiQ8IYS0

Expressioni

Gene expression databases

BgeeiENSG00000178075
CleanExiHS_GRAMD1C
ExpressionAtlasiQ8IYS0 baseline and differential
GenevisibleiQ8IYS0 HS

Organism-specific databases

HPAiHPA012316

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CD151P485098EBI-7054335,EBI-10210332

Protein-protein interaction databases

BioGridi120137, 9 interactors
IntActiQ8IYS0, 3 interactors
MINTiQ8IYS0
STRINGi9606.ENSP00000350881

Structurei

3D structure databases

ProteinModelPortaliQ8IYS0
SMRiQ8IYS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 136GRAMAdd BLAST68
Domaini326 – 497VAStPROSITE-ProRule annotationAdd BLAST172

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1032 Eukaryota
ENOG410XRQQ LUCA
GeneTreeiENSGT00580000081380
HOGENOMiHOG000294164
HOVERGENiHBG062004
InParanoidiQ8IYS0
OMAiFTSSRFM
OrthoDBiEOG091G051I
PhylomeDBiQ8IYS0
TreeFamiTF327695

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR031968 VASt
PfamiView protein in Pfam
PF16016 DUF4782, 1 hit
PF02893 GRAM, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
PROSITEiView protein in PROSITE
PS51778 VAST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGAPTVRQV MNEGDSSLAT DLQEDVEENP SPTVEENNVV VKKQGPNLHN
60 70 80 90 100
WSGDWSFWIS SSTYKDRNEE YRRQFTHLPD TERLIADYAC ALQRDILLQG
110 120 130 140 150
RLYLSENWLC FYSNIFRWET TISIALKNIT FMTKEKTARL IPNAIQIVTE
160 170 180 190 200
SEKFFFTSFG ARDRSYLSIF RLWQNVLLDK SLTRQEFWQL LQQNYGTELG
210 220 230 240 250
LNAEEMENLS LSIEDVQPRS PGRSSLDDSG ERDEKLSKSI SFTSESISRV
260 270 280 290 300
SETESFDGNS SKGGLGKEES QNEKQTKKSL LPTLEKKLTR VPSKSLDLNK
310 320 330 340 350
NEYLSLDKSS TSDSVDEENV PEKDLHGRLF INRIFHISAD RMFELLFTSS
360 370 380 390 400
RFMQKFASSR NIIDVVSTPW TAELGGDQLR TMTYTIVLNS PLTGKCTAAT
410 420 430 440 450
EKQTLYKESR EARFYLVDSE VLTHDVPYHD YFYTVNRYCI IRSSKQKCRL
460 470 480 490 500
RVSTDLKYRK QPWGLVKSLI EKNSWSSLED YFKQLESDLL IEESVLNQAI
510 520 530 540 550
EDPGKLTGLR RRRRTFNRTA ETVPKLSSQH SSGDVGLGAK GDITGKKKEM
560 570 580 590 600
ENYNVTLIVV MSIFVLLLVL LNVTLFLKLS KIEHAAQSFY RLRLQEEKSL
610 620 630 640 650
NLASDMVSRA ETIQKNKDQA HRLKGVLRDS IVMLEQLKSS LIMLQKTFDL
660
LNKNKTGMAV ES
Length:662
Mass (Da):76,035
Last modified:May 15, 2007 - v2
Checksum:i1A0F5471FA1F7CD3
GO
Isoform 2 (identifier: Q8IYS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-205: Missing.

Show »
Length:457
Mass (Da):52,015
Checksum:i3F73F0C7AF4370ED
GO

Sequence cautioni

The sequence AAH28972 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti503 – 506PGKL → AVHH in AAH28972 (PubMed:15489334).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032302644L → P1 PublicationCorresponds to variant dbSNP:rs17853381Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254771 – 205Missing in isoform 2. 2 PublicationsAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358725 mRNA Translation: AAQ89087.1
AK292846 mRNA Translation: BAF85535.1
AK292964 mRNA Translation: BAF85653.1
AK304142 mRNA Translation: BAH14115.1
CH471052 Genomic DNA Translation: EAW79621.1
CH471052 Genomic DNA Translation: EAW79622.1
BC028972 mRNA Translation: AAH28972.1 Different initiation.
BC035040 mRNA Translation: AAH35040.1
AL133661 mRNA Translation: CAB63774.2
BX648633 mRNA Translation: CAH10770.1
CCDSiCCDS33826.1 [Q8IYS0-1]
CCDS54625.1 [Q8IYS0-2]
PIRiT43471
RefSeqiNP_001165576.1, NM_001172105.1 [Q8IYS0-2]
NP_060047.3, NM_017577.4 [Q8IYS0-1]
XP_011511233.1, XM_011512931.1 [Q8IYS0-2]
UniGeneiHs.24583

Genome annotation databases

EnsembliENST00000358160; ENSP00000350881; ENSG00000178075 [Q8IYS0-1]
ENST00000440446; ENSP00000408135; ENSG00000178075 [Q8IYS0-2]
GeneIDi54762
KEGGihsa:54762
UCSCiuc003eaq.5 human [Q8IYS0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRM1C_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS0
Secondary accession number(s): A8K9Y1
, A8KA99, Q6AW94, Q6UWN1, Q8N6S0, Q9UF46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health