Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SET and MYND domain-containing protein 4

Gene

SMYD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei427S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei573S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei595S-adenosyl-L-methioninePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 335MYND-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SET and MYND domain-containing protein 4 (EC:2.1.1.-)
Gene namesi
Name:SMYD4
Synonyms:KIAA1936
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000186532.11
HGNCiHGNC:21067 SMYD4
neXtProtiNX_Q8IYR2

Pathology & Biotechi

Organism-specific databases

DisGeNETi114826
OpenTargetsiENSG00000186532
PharmGKBiPA134925431

Polymorphism and mutation databases

BioMutaiSMYD4
DMDMi296452956

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277841 – 804SET and MYND domain-containing protein 4Add BLAST804

Proteomic databases

EPDiQ8IYR2
MaxQBiQ8IYR2
PaxDbiQ8IYR2
PeptideAtlasiQ8IYR2
PRIDEiQ8IYR2

PTM databases

iPTMnetiQ8IYR2
PhosphoSitePlusiQ8IYR2

Expressioni

Gene expression databases

BgeeiENSG00000186532
CleanExiHS_SMYD4
ExpressionAtlasiQ8IYR2 baseline and differential
GenevisibleiQ8IYR2 HS

Organism-specific databases

HPAiHPA030059

Interactioni

Protein-protein interaction databases

BioGridi125376, 4 interactors
IntActiQ8IYR2, 1 interactor
STRINGi9606.ENSP00000304360

Structurei

3D structure databases

ProteinModelPortaliQ8IYR2
SMRiQ8IYR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 574SETPROSITE-ProRule annotationAdd BLAST342

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 114S-adenosyl-L-methionine bindingBy similarity3
Regioni539 – 540S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 335MYND-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00730000111079
HOGENOMiHOG000118355
HOVERGENiHBG082493
InParanoidiQ8IYR2
OMAiCSYAKYC
OrthoDBiEOG091G0BCB
PhylomeDBiQ8IYR2
TreeFamiTF106441

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR001214 SET_dom
IPR011990 TPR-like_helical_dom_sf
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IYR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPVDEWKS YLLQKWASLP TSVQVTISTA ETLRDIFLHS SSLLQPEDEL
60 70 80 90 100
FLKRLSKGYL VGKDSDAPLF YREEGNKKFQ EKDYTGAAVL YSKGVSHSRP
110 120 130 140 150
NTEDMSLCHA NRSAALFHLG QYETCLKDIN RAQTHGYPER LQPKIMLRKA
160 170 180 190 200
ECLVALGRLQ EASQTISDLE RNFTATPALA DVLPQTLQRN LHRLKMKMQE
210 220 230 240 250
KDSLTESFPA ALAKTLEDAA LREENEQLSN ASSSIGLCVD PLKGRCLVAT
260 270 280 290 300
KDILPGELLV QEDAFVSVLN PGELPPPHHG LDSKWDTRVT NGDLYCHRCL
310 320 330 340 350
KHTLATVPCD GCSYAKYCSQ ECLQQAWELY HRTECPLGGL LLTLGVFCHI
360 370 380 390 400
ALRLTLLVGF EDVRKIITKL CDKISNKDIC LPESNNQVKT LNYGLGESEK
410 420 430 440 450
NGNIVETPIP GCDINGKYEN NYNAVFNLLP HTENHSPEHK FLCALCVSAL
460 470 480 490 500
CRQLEAASLQ AIPTERIVNS SQLKAAVTPE LCPDVTIWGV AMLRHMLQLQ
510 520 530 540 550
CNAQAMTTIQ HTGPKGSIVT DSRQVRLATG IFPVISLLNH SCSPNTSVSF
560 570 580 590 600
ISTVATIRAS QRIRKGQEIL HCYGPHKSRM GVAERQQKLR SQYFFDCACP
610 620 630 640 650
ACQTEAHRMA AGPRWEAFCC NSCGAPMQGD DVLRCGSRSC AESAVSRDHL
660 670 680 690 700
VSRLQDLQQQ VRVAQKLLRD GELERAVQRL SGCQRDAESF LWAEHAVVGE
710 720 730 740 750
IADGLARACA ALGDWQKSAT HLQRSLYVVE VRHGPSSVEM GHELFKLAQI
760 770 780 790 800
FFNGFAVPEA LSTIQKAEEV LSLHCGPWDD EIQELQKMKS CLLDLPPTPV

GPAL
Length:804
Mass (Da):89,225
Last modified:May 18, 2010 - v3
Checksum:i982F8BFEF40A49A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326A → V in AAH35077 (PubMed:15489334).Curated1
Sequence conflicti511H → R in BAC04538 (PubMed:14702039).Curated1
Sequence conflicti514P → S in BAC04538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057495101N → D. Corresponds to variant dbSNP:rs9907701Ensembl.1
Natural variantiVAR_025626131R → I2 PublicationsCorresponds to variant dbSNP:rs7224496Ensembl.1
Natural variantiVAR_057496236G → S. Corresponds to variant dbSNP:rs9913923Ensembl.1
Natural variantiVAR_057497374I → M. Corresponds to variant dbSNP:rs9890631Ensembl.1
Natural variantiVAR_057498382P → R. Corresponds to variant dbSNP:rs3809875Ensembl.1
Natural variantiVAR_025628562R → W1 PublicationCorresponds to variant dbSNP:rs11549830Ensembl.1
Natural variantiVAR_064755601A → P Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_025627727Y → C3 PublicationsCorresponds to variant dbSNP:rs9902398Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057769 mRNA Translation: BAB71564.1
AK095369 mRNA Translation: BAC04538.1
BC035077 mRNA Translation: AAH35077.1
AB067523 mRNA Translation: BAB67829.1
CCDSiCCDS11013.1
RefSeqiNP_443160.2, NM_052928.2
UniGeneiHs.514602

Genome annotation databases

EnsembliENST00000305513; ENSP00000304360; ENSG00000186532
GeneIDi114826
KEGGihsa:114826
UCSCiuc002ftm.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSMYD4_HUMAN
AccessioniPrimary (citable) accession number: Q8IYR2
Secondary accession number(s): Q8N1P2
, Q8NAT0, Q96LV4, Q96PV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health