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Protein

Cilia- and flagella-associated protein 206

Gene

CFAP206

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate cilium motility through its role in the assembly of the axonemal radial spokes.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

BioCyciZFISH:G66-31108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 206Curated
Gene namesi
Name:CFAP206Imported
Synonyms:C6orf165Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21405. CFAP206.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213204.
ENSG00000272514.
PharmGKBiPA134983540.

Polymorphism and mutation databases

BioMutaiC6orf165.
DMDMi34395551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895531 – 622Cilia- and flagella-associated protein 206Add BLAST622

Proteomic databases

PaxDbiQ8IYR0.
PeptideAtlasiQ8IYR0.
PRIDEiQ8IYR0.

PTM databases

iPTMnetiQ8IYR0.
PhosphoSitePlusiQ8IYR0.

Expressioni

Gene expression databases

BgeeiENSG00000213204.
CleanExiHS_C6orf165.
ExpressionAtlasiQ8IYR0. baseline and differential.
GenevisibleiQ8IYR0. HS.

Organism-specific databases

HPAiHPA044891.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-35EBI-749051,EBI-10173507
AESQ081173EBI-749051,EBI-717810
APIPQ96GX93EBI-749051,EBI-359248
BANPQ8N9N53EBI-749051,EBI-744695
C1orf94Q6P1W54EBI-749051,EBI-946029
CEP57L1Q8IYX8-23EBI-749051,EBI-10181988
GFAPP141363EBI-749051,EBI-744302
GLYR1Q49A263EBI-749051,EBI-2804292
GPRASP2Q96D093EBI-749051,EBI-473189
GSE1Q146873EBI-749051,EBI-372619
KLHL3Q8N4I83EBI-749051,EBI-10230467
KRT31Q153233EBI-749051,EBI-948001
KRT40Q6A1625EBI-749051,EBI-10171697
LZTS2Q9BRK43EBI-749051,EBI-741037
ROCK1Q134643EBI-749051,EBI-876651
SAMD3Q8N6K73EBI-749051,EBI-748741
SOX30O949934EBI-749051,EBI-742973
TCF12Q990813EBI-749051,EBI-722877
TFIP11Q9UBB93EBI-749051,EBI-1105213
TMCC2Q7Z6C63EBI-749051,EBI-10177480
UBXN11Q5T1244EBI-749051,EBI-746004
USHBP1Q8N6Y03EBI-749051,EBI-739895

Protein-protein interaction databases

BioGridi127543. 28 interactors.
IntActiQ8IYR0. 49 interactors.
MINTiMINT-1479566.
STRINGi9606.ENSP00000358575.

Structurei

3D structure databases

ProteinModelPortaliQ8IYR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CFAP206 family.Curated

Phylogenomic databases

eggNOGiENOG410IH8G. Eukaryota.
ENOG410XS92. LUCA.
GeneTreeiENSGT00390000016036.
HOGENOMiHOG000031483.
HOVERGENiHBG050916.
InParanoidiQ8IYR0.
OMAiDPRNGFN.
OrthoDBiEOG091G061G.
PhylomeDBiQ8IYR0.
TreeFamiTF323439.

Family and domain databases

InterProiIPR021897. DUF3508.
[Graphical view]
PANTHERiPTHR21442:SF0. PTHR21442:SF0. 1 hit.
PfamiPF12018. DUF3508. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPTQAESVI RSIIREIGQE CAAHGEIVSE TLIAFMVKAV VLDPSNGFNM
60 70 80 90 100
DRTLMKSDVQ NLVKLCMTRL LDTKNPSLDT IKMQVYFDMN YTNRVEFLEE
110 120 130 140 150
HHRVLESRLG SVTREITDNR ACAKEELESL YRKIISYVLL RSGLGSPTDI
160 170 180 190 200
KTVREVTAAL QSVFPQAELG TFLTLSKKDK ERQLKELTMI VTGIRLFNRD
210 220 230 240 250
CGKGGEGIDD LPAVLHVAIP ATMQHIDYQL ETARSQVYRY TAILEKAAND
260 270 280 290 300
PLMRAELQPY MLKEALYNIR QYEVFLQIIL SDIITGAQEV EMMTKQLGAH
310 320 330 340 350
LEQLKMTIKS KIAVPTSQVF PIFIALSTLW TSLQDETIVV GVLSNLFTHI
360 370 380 390 400
QPFLGAHELY FPERVMQCHL NGATVKTDVC RMKEHMEDRV NVADFRKLEW
410 420 430 440 450
LFPETTANFD KLLIQYRGFC AYTFAATDGL LLPGNPAIGI LKYKEKYYTF
460 470 480 490 500
NSKDAAYSFA ENPEHYIDIV REKAKKNTEL IQLLELHQQF ETFIPYSQMR
510 520 530 540 550
DADKHYIKPI TKCESSTQTN THILPPTIVR SYEWNEWELR RKAIKLANLR
560 570 580 590 600
QKVTHSVQTD LSHLRRENCS QVYPPKDTST QSMREDSTGV PRPQIYLAGL
610 620
RGGKSEITDE VKVNLTRDVD ET
Length:622
Mass (Da):71,193
Last modified:August 29, 2003 - v2
Checksum:iEC3818B8596C0B1E
GO

Sequence cautioni

The sequence BAC04234 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti489Q → R in BAF85273 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033679154R → K.Corresponds to variant rs13219364dbSNPEnsembl.1
Natural variantiVAR_033680170G → A.Corresponds to variant rs16879281dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093830 mRNA. Translation: BAC04234.1. Sequence problems.
AK292584 mRNA. Translation: BAF85273.1.
AL049697 Genomic DNA. Translation: CAD92567.1.
CH471051 Genomic DNA. Translation: EAW48594.1.
CH471051 Genomic DNA. Translation: EAW48596.1.
CH471051 Genomic DNA. Translation: EAW48598.1.
BC035083 mRNA. Translation: AAH35083.2.
CCDSiCCDS34498.1.
RefSeqiNP_001026913.1. NM_001031743.2.
UniGeneiHs.82921.

Genome annotation databases

EnsembliENST00000369562; ENSP00000358575; ENSG00000272514.
GeneIDi154313.
KEGGihsa:154313.
UCSCiuc003plv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093830 mRNA. Translation: BAC04234.1. Sequence problems.
AK292584 mRNA. Translation: BAF85273.1.
AL049697 Genomic DNA. Translation: CAD92567.1.
CH471051 Genomic DNA. Translation: EAW48594.1.
CH471051 Genomic DNA. Translation: EAW48596.1.
CH471051 Genomic DNA. Translation: EAW48598.1.
BC035083 mRNA. Translation: AAH35083.2.
CCDSiCCDS34498.1.
RefSeqiNP_001026913.1. NM_001031743.2.
UniGeneiHs.82921.

3D structure databases

ProteinModelPortaliQ8IYR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127543. 28 interactors.
IntActiQ8IYR0. 49 interactors.
MINTiMINT-1479566.
STRINGi9606.ENSP00000358575.

PTM databases

iPTMnetiQ8IYR0.
PhosphoSitePlusiQ8IYR0.

Polymorphism and mutation databases

BioMutaiC6orf165.
DMDMi34395551.

Proteomic databases

PaxDbiQ8IYR0.
PeptideAtlasiQ8IYR0.
PRIDEiQ8IYR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369562; ENSP00000358575; ENSG00000272514.
GeneIDi154313.
KEGGihsa:154313.
UCSCiuc003plv.4. human.

Organism-specific databases

CTDi154313.
GeneCardsiC6orf165.
HGNCiHGNC:21405. CFAP206.
HPAiHPA044891.
neXtProtiNX_Q8IYR0.
OpenTargetsiENSG00000213204.
ENSG00000272514.
PharmGKBiPA134983540.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH8G. Eukaryota.
ENOG410XS92. LUCA.
GeneTreeiENSGT00390000016036.
HOGENOMiHOG000031483.
HOVERGENiHBG050916.
InParanoidiQ8IYR0.
OMAiDPRNGFN.
OrthoDBiEOG091G061G.
PhylomeDBiQ8IYR0.
TreeFamiTF323439.

Enzyme and pathway databases

BioCyciZFISH:G66-31108-MONOMER.

Miscellaneous databases

ChiTaRSiC6orf165. human.
GenomeRNAii154313.
PROiQ8IYR0.

Gene expression databases

BgeeiENSG00000213204.
CleanExiHS_C6orf165.
ExpressionAtlasiQ8IYR0. baseline and differential.
GenevisibleiQ8IYR0. HS.

Family and domain databases

InterProiIPR021897. DUF3508.
[Graphical view]
PANTHERiPTHR21442:SF0. PTHR21442:SF0. 1 hit.
PfamiPF12018. DUF3508. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCF206_HUMAN
AccessioniPrimary (citable) accession number: Q8IYR0
Secondary accession number(s): A8K969, E1P507, Q8N9U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.