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Protein

Importin subunit alpha

Gene

KPNA3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in nuclear protein import.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transportUniRule annotation, Transport

Enzyme and pathway databases

SignaLinkiQ8IYQ9.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alphaUniRule annotation
Gene namesi
Name:KPNA3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30187.

PTM / Processingi

Proteomic databases

PaxDbiQ8IYQ9.
PeptideAtlasiQ8IYQ9.
PRIDEiQ8IYQ9.

Expressioni

Gene expression databases

GenevisibleiQ8IYQ9. HS.

Interactioni

Protein-protein interaction databases

IntActiQ8IYQ9. 15 interactors.
MINTiMINT-5005388.
STRINGi9606.ENSP00000261667.

Structurei

3D structure databases

ProteinModelPortaliQ8IYQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58IBBInterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the importin alpha family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
HOVERGENiHBG001846.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
PS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN
60 70 80 90 100
VPQEESLEDS DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS
110 120 130 140 150
SDRNPPIDDL IKSGILPILV KCLERDDNPS LQFEAAWALT NIASGTSAQT
160 170 180 190 200
QDIVQSNAVP LFLRLLRSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV
210 220 230 240 250
VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV QEILPALCVL
260 270 280 290 300
IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV
310 320 330 340 350
QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FQNLLSHPKE KINKEAVWFL
360 370 380 390 400
SNITAGNQQQ VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR
410 420 430 440 450
KDQVEYLVQQ DVIPPFCNLL SVKDSQVVQV VLDGLKNILI MAGDEASTIA
460 470 480 490 500
EIIEECGGLE KIEVLQQHEN EDIYKLAFEI IDQYFSGDDI DEDPCLIPEA
510 520
TQGGTYNFDP TANLQTKEFN F
Length:521
Mass (Da):57,901
Last modified:March 1, 2003 - v1
Checksum:i454E099FEDD26567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035090 mRNA. Translation: AAH35090.1.
RefSeqiNP_002258.2. NM_002267.3.
UniGeneiHs.527919.

Genome annotation databases

GeneIDi3839.
KEGGihsa:3839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035090 mRNA. Translation: AAH35090.1.
RefSeqiNP_002258.2. NM_002267.3.
UniGeneiHs.527919.

3D structure databases

ProteinModelPortaliQ8IYQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IYQ9. 15 interactors.
MINTiMINT-5005388.
STRINGi9606.ENSP00000261667.

Proteomic databases

PaxDbiQ8IYQ9.
PeptideAtlasiQ8IYQ9.
PRIDEiQ8IYQ9.

Protocols and materials databases

DNASUi3839.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3839.
KEGGihsa:3839.

Organism-specific databases

CTDi3839.
PharmGKBiPA30187.

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
HOVERGENiHBG001846.

Enzyme and pathway databases

SignaLinkiQ8IYQ9.

Miscellaneous databases

ChiTaRSiKPNA3. human.
GenomeRNAii3839.

Gene expression databases

GenevisibleiQ8IYQ9. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
PS51214. IBB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IYQ9_HUMAN
AccessioniPrimary (citable) accession number: Q8IYQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.