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Q8IYQ7

- THNS1_HUMAN

UniProt

Q8IYQ7 - THNS1_HUMAN

Protein

Threonine synthase-like 1

Gene

THNSL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.By similarity

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase-like 1
    Short name:
    TSH1
    Gene namesi
    Name:THNSL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:26160. THNSL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrion Source: HPA
    3. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134906927.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 743743Threonine synthase-like 1PRO_0000185646Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811N6-acetyllysine1 Publication
    Modified residuei351 – 3511N6-(pyridoxal phosphate)lysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8IYQ7.
    PaxDbiQ8IYQ7.
    PeptideAtlasiQ8IYQ7.
    PRIDEiQ8IYQ7.

    PTM databases

    PhosphoSiteiQ8IYQ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IYQ7.
    BgeeiQ8IYQ7.
    CleanExiHS_THNSL1.
    GenevestigatoriQ8IYQ7.

    Organism-specific databases

    HPAiHPA037585.
    HPA044875.

    Interactioni

    Protein-protein interaction databases

    BioGridi122980. 3 interactions.
    IntActiQ8IYQ7. 1 interaction.
    STRINGi9606.ENSP00000365534.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYQ7.
    SMRiQ8IYQ7. Positions 42-223, 251-682.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0703.
    HOGENOMiHOG000065776.
    HOVERGENiHBG055015.
    InParanoidiQ8IYQ7.
    OMAiCSKIAPV.
    OrthoDBiEOG7QZG93.
    PhylomeDBiQ8IYQ7.
    TreeFamiTF329641.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.90.1380.10. 1 hit.
    HAMAPiMF_00109. Shikimate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF01202. SKI. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    PRINTSiPR01100. SHIKIMTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8IYQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHFNRCHHL KKITQKCFSS IHVKTDKHAQ RFLSRTFALA ELRKSWYSTH    50
    SLVGDKNIIL MGPPGAGKTT VGRIIGQKLG CCVIDVDDDI LEKTWNMSVS 100
    EKLQDVGNEQ FLEEEGKAVL NFSASGSVIS LTGSNPMHDA SMWHLKKNGI 150
    IVYLDVPLLD LICRLKLMKT DRIVGQNSGT SMKDLLKFRR QYYKKWYDAR 200
    VFCESGASPE EVADKVLNAI KRYQDVDSET FISTRHVWPE DCEQKVSAKF 250
    FSEAVIEGLA SDGGLFVPAK EFPKLSCGEW KSLVGATYVE RAQILLERCI 300
    HPADIPAARL GEMIETAYGE NFACSKIAPV RHLSGNQFIL ELFHGPTGSF 350
    KDLSLQLMPH IFAHCIPPSC NYMILVATSG DTGSAVLNGF SRLNKNDKQR 400
    IAVVAFFPEN GVSDFQKAQI IGSQRENGWA VGVESDFDFC QTAIKRIFND 450
    SDFTGFLTVE YGTILSSANS INWGRLLPQV VYHASAYLDL VSQGFISFGS 500
    PVDVCIPTGN FGNILAAVYA KMMGIPIRKF ICASNQNHVL TDFIKTGHYD 550
    LRERKLAQTF SPSIDILKSS NLERHLHLMA NKDGQLMTEL FNRLESQHHF 600
    QIEKALVEKL QQDFVADWCS EGECLAAINS TYNTSGYILD PHTAVAKVVA 650
    DRVQDKTCPV IISSTAHYSK FAPAIMQALK IKEINETSSS QLYLLGSYNA 700
    LPPLHEALLE RTKQQEKMEY QVCAADMNVL KSHVEQLVQN QFI 743
    Length:743
    Mass (Da):83,070
    Last modified:April 12, 2005 - v2
    Checksum:i0C166A57EF34A682
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941T → N in AAH35132. (PubMed:15489334)Curated
    Sequence conflicti705 – 7051H → R in AAH35132. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541L → P.
    Corresponds to variant rs35827877 [ dbSNP | Ensembl ].
    VAR_052545
    Natural varianti239 – 2391P → R.
    Corresponds to variant rs41279890 [ dbSNP | Ensembl ].
    VAR_061893
    Natural varianti248 – 2481A → E.
    Corresponds to variant rs34929144 [ dbSNP | Ensembl ].
    VAR_052546
    Natural varianti399 – 3991Q → R.
    Corresponds to variant rs41279894 [ dbSNP | Ensembl ].
    VAR_058869

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125249 mRNA. Translation: BAG54173.1.
    AL512598 Genomic DNA. Translation: CAH70791.1.
    CH471072 Genomic DNA. Translation: EAW86113.1.
    CH471072 Genomic DNA. Translation: EAW86114.1.
    BC035132 mRNA. Translation: AAH35132.1.
    CCDSiCCDS7147.1.
    RefSeqiNP_079114.3. NM_024838.4.
    XP_005252654.1. XM_005252597.1.
    UniGeneiHs.645274.

    Genome annotation databases

    EnsembliENST00000376356; ENSP00000365534; ENSG00000185875.
    ENST00000524413; ENSP00000434887; ENSG00000185875.
    GeneIDi79896.
    KEGGihsa:79896.
    UCSCiuc001isi.4. human.

    Polymorphism databases

    DMDMi62511212.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125249 mRNA. Translation: BAG54173.1 .
    AL512598 Genomic DNA. Translation: CAH70791.1 .
    CH471072 Genomic DNA. Translation: EAW86113.1 .
    CH471072 Genomic DNA. Translation: EAW86114.1 .
    BC035132 mRNA. Translation: AAH35132.1 .
    CCDSi CCDS7147.1.
    RefSeqi NP_079114.3. NM_024838.4.
    XP_005252654.1. XM_005252597.1.
    UniGenei Hs.645274.

    3D structure databases

    ProteinModelPortali Q8IYQ7.
    SMRi Q8IYQ7. Positions 42-223, 251-682.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122980. 3 interactions.
    IntActi Q8IYQ7. 1 interaction.
    STRINGi 9606.ENSP00000365534.

    Chemistry

    DrugBanki DB00156. L-Threonine.
    DB00114. Pyridoxal Phosphate.

    PTM databases

    PhosphoSitei Q8IYQ7.

    Polymorphism databases

    DMDMi 62511212.

    Proteomic databases

    MaxQBi Q8IYQ7.
    PaxDbi Q8IYQ7.
    PeptideAtlasi Q8IYQ7.
    PRIDEi Q8IYQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376356 ; ENSP00000365534 ; ENSG00000185875 .
    ENST00000524413 ; ENSP00000434887 ; ENSG00000185875 .
    GeneIDi 79896.
    KEGGi hsa:79896.
    UCSCi uc001isi.4. human.

    Organism-specific databases

    CTDi 79896.
    GeneCardsi GC10P025345.
    HGNCi HGNC:26160. THNSL1.
    HPAi HPA037585.
    HPA044875.
    MIMi 611260. gene.
    neXtProti NX_Q8IYQ7.
    PharmGKBi PA134906927.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0703.
    HOGENOMi HOG000065776.
    HOVERGENi HBG055015.
    InParanoidi Q8IYQ7.
    OMAi CSKIAPV.
    OrthoDBi EOG7QZG93.
    PhylomeDBi Q8IYQ7.
    TreeFami TF329641.

    Miscellaneous databases

    GenomeRNAii 79896.
    NextBioi 69730.
    PROi Q8IYQ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IYQ7.
    Bgeei Q8IYQ7.
    CleanExi HS_THNSL1.
    Genevestigatori Q8IYQ7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.90.1380.10. 1 hit.
    HAMAPi MF_00109. Shikimate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF01202. SKI. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01100. SHIKIMTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTHNS1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYQ7
    Secondary accession number(s): B3KWL1, D3DRV3, Q5VV21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3