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Protein

Palmitoyltransferase ZDHHC23

Gene

ZDHHC23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri259 – 30951DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC23 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 23
Short name:
DHHC-23
Short name:
zDHHC23
Gene namesi
Name:ZDHHC23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28654. ZDHHC23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10619HelicalSequence analysisAdd
BLAST
Transmembranei110 – 13223HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960347.

Polymorphism and mutation databases

BioMutaiZDHHC23.
DMDMi215274191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Palmitoyltransferase ZDHHC23PRO_0000212912Add
BLAST

Proteomic databases

MaxQBiQ8IYP9.
PaxDbiQ8IYP9.
PRIDEiQ8IYP9.

PTM databases

iPTMnetiQ8IYP9.
PhosphoSiteiQ8IYP9.

Expressioni

Gene expression databases

BgeeiQ8IYP9.
CleanExiHS_ZDHHC23.
ExpressionAtlasiQ8IYP9. baseline and differential.
GenevisibleiQ8IYP9. HS.

Organism-specific databases

HPAiHPA016808.

Interactioni

Subunit structurei

Interacts with NOS1.By similarity

Protein-protein interaction databases

BioGridi129056. 6 interactions.
STRINGi9606.ENSP00000330485.

Structurei

3D structure databases

ProteinModelPortaliQ8IYP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri259 – 30951DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000290638.
HOVERGENiHBG055654.
InParanoidiQ8IYP9.
KOiK18932.
OrthoDBiEOG78D7M8.
PhylomeDBiQ8IYP9.
TreeFamiTF354316.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKGSMKPV KKKKTEEPEL EPLCCCEYID RNGEKNHVAT CLCDCQDLDE
60 70 80 90 100
GCDRWITCKS LQPETCERIM DTISDRLRIP WLRGAKKVNI SIIPPLVLLP
110 120 130 140 150
VFLHVASWHF LLGVVVLTSL PVLALWYYYL THRRKEQTLF FLSLGLFSLG
160 170 180 190 200
YMYYVFLQEV VPKGRVGPVQ LAVLTCGLFL ILLALHRAKK NPGYLSNPAS
210 220 230 240 250
GDRSLSSSQL ECLSRKGQEK TKGFPGADMS GSLNNRTTKD DPKGSSKMPA
260 270 280 290 300
GSPTKAKEDW CAKCQLVRPA RAWHCRICGI CVRRMDHHCV WINSCVGESN
310 320 330 340 350
HQAFILALLI FLLTSVYGIT LTLDTICRDR SVFTALFYCP GVYANYSSAL
360 370 380 390 400
SFTCVWYSVI ITAGMAYIFL IQLINISYNV TEREVQQALR QKTGRRLLCG

LIVDTGLLG
Length:409
Mass (Da):45,983
Last modified:November 25, 2008 - v3
Checksum:i6AD65E37DA8F34AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321H → N.1 Publication
Corresponds to variant rs17853401 [ dbSNP | Ensembl ].
VAR_047389
Natural varianti221 – 2211T → A.1 Publication
Corresponds to variant rs17853402 [ dbSNP | Ensembl ].
VAR_047390
Natural varianti247 – 2471K → R.1 Publication
Corresponds to variant rs11921691 [ dbSNP | Ensembl ].
VAR_047391
Natural varianti274 – 2741H → R.1 Publication
Corresponds to variant rs17857054 [ dbSNP | Ensembl ].
VAR_047392

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128687 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79617.1.
CH471052 Genomic DNA. Translation: EAW79618.1.
BC035230 mRNA. Translation: AAH35230.2.
CCDSiCCDS33827.1.
RefSeqiNP_775841.2. NM_173570.4.
XP_005247326.1. XM_005247269.1.
UniGeneiHs.21902.

Genome annotation databases

EnsembliENST00000330212; ENSP00000330485; ENSG00000184307.
GeneIDi254887.
KEGGihsa:254887.
UCSCiuc003eau.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128687 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79617.1.
CH471052 Genomic DNA. Translation: EAW79618.1.
BC035230 mRNA. Translation: AAH35230.2.
CCDSiCCDS33827.1.
RefSeqiNP_775841.2. NM_173570.4.
XP_005247326.1. XM_005247269.1.
UniGeneiHs.21902.

3D structure databases

ProteinModelPortaliQ8IYP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129056. 6 interactions.
STRINGi9606.ENSP00000330485.

PTM databases

iPTMnetiQ8IYP9.
PhosphoSiteiQ8IYP9.

Polymorphism and mutation databases

BioMutaiZDHHC23.
DMDMi215274191.

Proteomic databases

MaxQBiQ8IYP9.
PaxDbiQ8IYP9.
PRIDEiQ8IYP9.

Protocols and materials databases

DNASUi254887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330212; ENSP00000330485; ENSG00000184307.
GeneIDi254887.
KEGGihsa:254887.
UCSCiuc003eau.4. human.

Organism-specific databases

CTDi254887.
GeneCardsiZDHHC23.
HGNCiHGNC:28654. ZDHHC23.
HPAiHPA016808.
neXtProtiNX_Q8IYP9.
PharmGKBiPA134960347.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000290638.
HOVERGENiHBG055654.
InParanoidiQ8IYP9.
KOiK18932.
OrthoDBiEOG78D7M8.
PhylomeDBiQ8IYP9.
TreeFamiTF354316.

Miscellaneous databases

GenomeRNAii254887.
PROiQ8IYP9.

Gene expression databases

BgeeiQ8IYP9.
CleanExiHS_ZDHHC23.
ExpressionAtlasiQ8IYP9. baseline and differential.
GenevisibleiQ8IYP9. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-247.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-132; ALA-221 AND ARG-274.
    Tissue: Testis.
  4. "Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels."
    Tian L., McClafferty H., Knaus H.G., Ruth P., Shipston M.J.
    J. Biol. Chem. 287:14718-14725(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiZDH23_HUMAN
AccessioniPrimary (citable) accession number: Q8IYP9
Secondary accession number(s): D3DN76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 25, 2008
Last modified: June 8, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.