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Q8IYP2

- PRS58_HUMAN

UniProt

Q8IYP2 - PRS58_HUMAN

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Protein

Serine protease 58

Gene

PRSS58

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561Charge relay systemBy similarity
Active sitei101 – 1011Charge relay systemBy similarity
Active sitei195 – 1951Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.085.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 58 (EC:3.4.21.4)
Alternative name(s):
Trypsin-X3
Gene namesi
Name:PRSS58
Synonyms:TRY1, TRYX3
ORF Names:UNQ2540/PRO6090
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:39125. PRSS58.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 241224Serine protease 58PRO_0000317763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 57PROSITE-ProRule annotation
Disulfide bondi133 ↔ 201PROSITE-ProRule annotation
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi165 ↔ 180PROSITE-ProRule annotation
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi191 ↔ 215PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IYP2.
PRIDEiQ8IYP2.

PTM databases

PhosphoSiteiQ8IYP2.

Expressioni

Gene expression databases

BgeeiQ8IYP2.
GenevestigatoriQ8IYP2.

Structurei

3D structure databases

ProteinModelPortaliQ8IYP2.
SMRiQ8IYP2. Positions 22-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 239222Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG289695.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8IYP2.
OMAiVSTWAYN.
OrthoDBiEOG7TBC32.
PhylomeDBiQ8IYP2.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IYP2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFILLWALL NLTVALAFNP DYTVSSTPPY LVYLKSDYLP CAGVLIHPLW
60 70 80 90 100
VITAAHCNLP KLRVILGVTI PADSNEKHLQ VIGYEKMIHH PHFSVTSIDH
110 120 130 140 150
DIMLIKLKTE AELNDYVKLA NLPYQTISEN TMCSVSTWSY NVCDIYKEPD
160 170 180 190 200
SLQTVNISVI SKPQCRDAYK TYNITENMLC VGIVPGRRQP CKEVSAAPAI
210 220 230 240
CNGMLQGILS FADGCVLRAD VGIYAKIFYY IPWIENVIQN N
Length:241
Mass (Da):27,085
Last modified:March 1, 2003 - v1
Checksum:i964829EE2BAD60AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122940 mRNA. Translation: BAG53808.1.
DQ384426 Genomic DNA. Translation: ABD48876.1.
DQ384427 Genomic DNA. Translation: ABD48877.1.
DQ384428 Genomic DNA. Translation: ABD48878.1.
DQ384429 Genomic DNA. Translation: ABD48879.1.
DQ384431 Genomic DNA. Translation: ABD48880.1.
AY358487 mRNA. Translation: AAQ88851.1.
CH236959 Genomic DNA. Translation: EAL23772.1.
CH471198 Genomic DNA. Translation: EAW51980.1.
CH471198 Genomic DNA. Translation: EAW51981.1.
BC035384 mRNA. Translation: AAH35384.1.
CCDSiCCDS5871.1.
RefSeqiNP_001001317.1. NM_001001317.3.
UniGeneiHs.98609.

Genome annotation databases

EnsembliENST00000547058; ENSP00000447588; ENSG00000258223.
ENST00000552471; ENSP00000446916; ENSG00000258223.
GeneIDi136541.
KEGGihsa:136541.
UCSCiuc003vxb.3. human.

Polymorphism databases

DMDMi74759717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122940 mRNA. Translation: BAG53808.1 .
DQ384426 Genomic DNA. Translation: ABD48876.1 .
DQ384427 Genomic DNA. Translation: ABD48877.1 .
DQ384428 Genomic DNA. Translation: ABD48878.1 .
DQ384429 Genomic DNA. Translation: ABD48879.1 .
DQ384431 Genomic DNA. Translation: ABD48880.1 .
AY358487 mRNA. Translation: AAQ88851.1 .
CH236959 Genomic DNA. Translation: EAL23772.1 .
CH471198 Genomic DNA. Translation: EAW51980.1 .
CH471198 Genomic DNA. Translation: EAW51981.1 .
BC035384 mRNA. Translation: AAH35384.1 .
CCDSi CCDS5871.1.
RefSeqi NP_001001317.1. NM_001001317.3.
UniGenei Hs.98609.

3D structure databases

ProteinModelPortali Q8IYP2.
SMRi Q8IYP2. Positions 22-241.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.085.

PTM databases

PhosphoSitei Q8IYP2.

Polymorphism databases

DMDMi 74759717.

Proteomic databases

PaxDbi Q8IYP2.
PRIDEi Q8IYP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000547058 ; ENSP00000447588 ; ENSG00000258223 .
ENST00000552471 ; ENSP00000446916 ; ENSG00000258223 .
GeneIDi 136541.
KEGGi hsa:136541.
UCSCi uc003vxb.3. human.

Organism-specific databases

CTDi 136541.
GeneCardsi GC07M141952.
HGNCi HGNC:39125. PRSS58.
neXtProti NX_Q8IYP2.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289695.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q8IYP2.
OMAi VSTWAYN.
OrthoDBi EOG7TBC32.
PhylomeDBi Q8IYP2.
TreeFami TF331065.

Miscellaneous databases

GenomeRNAii 136541.
NextBioi 83595.
PROi Q8IYP2.

Gene expression databases

Bgeei Q8IYP2.
Genevestigatori Q8IYP2.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPRS58_HUMAN
AccessioniPrimary (citable) accession number: Q8IYP2
Secondary accession number(s): B3KVJ6, D3DXD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3