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Q8IYP2

- PRS58_HUMAN

UniProt

Q8IYP2 - PRS58_HUMAN

Protein

Serine protease 58

Gene

PRSS58

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561Charge relay systemBy similarity
    Active sitei101 – 1011Charge relay systemBy similarity
    Active sitei195 – 1951Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.085.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine protease 58 (EC:3.4.21.4)
    Alternative name(s):
    Trypsin-X3
    Gene namesi
    Name:PRSS58
    Synonyms:TRY1, TRYX3
    ORF Names:UNQ2540/PRO6090
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:39125. PRSS58.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 241224Serine protease 58PRO_0000317763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 57PROSITE-ProRule annotation
    Disulfide bondi133 ↔ 201PROSITE-ProRule annotation
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi165 ↔ 180PROSITE-ProRule annotation
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi191 ↔ 215PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IYP2.
    PRIDEiQ8IYP2.

    PTM databases

    PhosphoSiteiQ8IYP2.

    Expressioni

    Gene expression databases

    BgeeiQ8IYP2.
    GenevestigatoriQ8IYP2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYP2.
    SMRiQ8IYP2. Positions 22-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 239222Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG289695.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ8IYP2.
    OMAiVSTWAYN.
    OrthoDBiEOG7TBC32.
    PhylomeDBiQ8IYP2.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IYP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFILLWALL NLTVALAFNP DYTVSSTPPY LVYLKSDYLP CAGVLIHPLW    50
    VITAAHCNLP KLRVILGVTI PADSNEKHLQ VIGYEKMIHH PHFSVTSIDH 100
    DIMLIKLKTE AELNDYVKLA NLPYQTISEN TMCSVSTWSY NVCDIYKEPD 150
    SLQTVNISVI SKPQCRDAYK TYNITENMLC VGIVPGRRQP CKEVSAAPAI 200
    CNGMLQGILS FADGCVLRAD VGIYAKIFYY IPWIENVIQN N 241
    Length:241
    Mass (Da):27,085
    Last modified:March 1, 2003 - v1
    Checksum:i964829EE2BAD60AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122940 mRNA. Translation: BAG53808.1.
    DQ384426 Genomic DNA. Translation: ABD48876.1.
    DQ384427 Genomic DNA. Translation: ABD48877.1.
    DQ384428 Genomic DNA. Translation: ABD48878.1.
    DQ384429 Genomic DNA. Translation: ABD48879.1.
    DQ384431 Genomic DNA. Translation: ABD48880.1.
    AY358487 mRNA. Translation: AAQ88851.1.
    CH236959 Genomic DNA. Translation: EAL23772.1.
    CH471198 Genomic DNA. Translation: EAW51980.1.
    CH471198 Genomic DNA. Translation: EAW51981.1.
    BC035384 mRNA. Translation: AAH35384.1.
    CCDSiCCDS5871.1.
    RefSeqiNP_001001317.1. NM_001001317.3.
    UniGeneiHs.98609.

    Genome annotation databases

    EnsembliENST00000547058; ENSP00000447588; ENSG00000258223.
    ENST00000552471; ENSP00000446916; ENSG00000258223.
    GeneIDi136541.
    KEGGihsa:136541.
    UCSCiuc003vxb.3. human.

    Polymorphism databases

    DMDMi74759717.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122940 mRNA. Translation: BAG53808.1 .
    DQ384426 Genomic DNA. Translation: ABD48876.1 .
    DQ384427 Genomic DNA. Translation: ABD48877.1 .
    DQ384428 Genomic DNA. Translation: ABD48878.1 .
    DQ384429 Genomic DNA. Translation: ABD48879.1 .
    DQ384431 Genomic DNA. Translation: ABD48880.1 .
    AY358487 mRNA. Translation: AAQ88851.1 .
    CH236959 Genomic DNA. Translation: EAL23772.1 .
    CH471198 Genomic DNA. Translation: EAW51980.1 .
    CH471198 Genomic DNA. Translation: EAW51981.1 .
    BC035384 mRNA. Translation: AAH35384.1 .
    CCDSi CCDS5871.1.
    RefSeqi NP_001001317.1. NM_001001317.3.
    UniGenei Hs.98609.

    3D structure databases

    ProteinModelPortali Q8IYP2.
    SMRi Q8IYP2. Positions 22-241.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.085.

    PTM databases

    PhosphoSitei Q8IYP2.

    Polymorphism databases

    DMDMi 74759717.

    Proteomic databases

    PaxDbi Q8IYP2.
    PRIDEi Q8IYP2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000547058 ; ENSP00000447588 ; ENSG00000258223 .
    ENST00000552471 ; ENSP00000446916 ; ENSG00000258223 .
    GeneIDi 136541.
    KEGGi hsa:136541.
    UCSCi uc003vxb.3. human.

    Organism-specific databases

    CTDi 136541.
    GeneCardsi GC07M141952.
    HGNCi HGNC:39125. PRSS58.
    neXtProti NX_Q8IYP2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289695.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q8IYP2.
    OMAi VSTWAYN.
    OrthoDBi EOG7TBC32.
    PhylomeDBi Q8IYP2.
    TreeFami TF331065.

    Miscellaneous databases

    GenomeRNAii 136541.
    NextBioi 83595.
    PROi Q8IYP2.

    Gene expression databases

    Bgeei Q8IYP2.
    Genevestigatori Q8IYP2.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPRS58_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYP2
    Secondary accession number(s): B3KVJ6, D3DXD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3