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Protein

Serine protease 58

Gene

PRSS58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Charge relay systemBy similarity1
Active sitei101Charge relay systemBy similarity1
Active sitei195Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:HS15954-MONOMER.

Protein family/group databases

MEROPSiS01.085.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 58 (EC:3.4.21.4)
Alternative name(s):
Trypsin-X3
Gene namesi
Name:PRSS58
Synonyms:TRY1, TRYX3
ORF Names:UNQ2540/PRO6090
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:39125. PRSS58.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi136541.
OpenTargetsiENSG00000258223.
ENSG00000276785.

Polymorphism and mutation databases

BioMutaiPRSS58.
DMDMi74759717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000031776318 – 241Serine protease 58Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 57PROSITE-ProRule annotation
Disulfide bondi133 ↔ 201PROSITE-ProRule annotation
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi165 ↔ 180PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi191 ↔ 215PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IYP2.
PeptideAtlasiQ8IYP2.
PRIDEiQ8IYP2.

PTM databases

iPTMnetiQ8IYP2.
PhosphoSitePlusiQ8IYP2.

Expressioni

Gene expression databases

BgeeiENSG00000258223.
GenevisibleiQ8IYP2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000446916.

Structurei

3D structure databases

ProteinModelPortaliQ8IYP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 239Peptidase S1PROSITE-ProRule annotationAdd BLAST222

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00770000120601.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8IYP2.
OMAiTWAYNLC.
OrthoDBiEOG091G0MM8.
PhylomeDBiQ8IYP2.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IYP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFILLWALL NLTVALAFNP DYTVSSTPPY LVYLKSDYLP CAGVLIHPLW
60 70 80 90 100
VITAAHCNLP KLRVILGVTI PADSNEKHLQ VIGYEKMIHH PHFSVTSIDH
110 120 130 140 150
DIMLIKLKTE AELNDYVKLA NLPYQTISEN TMCSVSTWSY NVCDIYKEPD
160 170 180 190 200
SLQTVNISVI SKPQCRDAYK TYNITENMLC VGIVPGRRQP CKEVSAAPAI
210 220 230 240
CNGMLQGILS FADGCVLRAD VGIYAKIFYY IPWIENVIQN N
Length:241
Mass (Da):27,085
Last modified:March 1, 2003 - v1
Checksum:i964829EE2BAD60AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122940 mRNA. Translation: BAG53808.1.
DQ384426 Genomic DNA. Translation: ABD48876.1.
DQ384427 Genomic DNA. Translation: ABD48877.1.
DQ384428 Genomic DNA. Translation: ABD48878.1.
DQ384429 Genomic DNA. Translation: ABD48879.1.
DQ384431 Genomic DNA. Translation: ABD48880.1.
AY358487 mRNA. Translation: AAQ88851.1.
CH236959 Genomic DNA. Translation: EAL23772.1.
CH471198 Genomic DNA. Translation: EAW51980.1.
CH471198 Genomic DNA. Translation: EAW51981.1.
BC035384 mRNA. Translation: AAH35384.1.
CCDSiCCDS5871.1.
RefSeqiNP_001001317.1. NM_001001317.4.
UniGeneiHs.98609.

Genome annotation databases

EnsembliENST00000547058; ENSP00000447588; ENSG00000258223.
ENST00000552471; ENSP00000446916; ENSG00000258223.
ENST00000621886; ENSP00000478535; ENSG00000276785.
ENST00000622880; ENSP00000479165; ENSG00000276785.
GeneIDi136541.
KEGGihsa:136541.
UCSCiuc003vxb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122940 mRNA. Translation: BAG53808.1.
DQ384426 Genomic DNA. Translation: ABD48876.1.
DQ384427 Genomic DNA. Translation: ABD48877.1.
DQ384428 Genomic DNA. Translation: ABD48878.1.
DQ384429 Genomic DNA. Translation: ABD48879.1.
DQ384431 Genomic DNA. Translation: ABD48880.1.
AY358487 mRNA. Translation: AAQ88851.1.
CH236959 Genomic DNA. Translation: EAL23772.1.
CH471198 Genomic DNA. Translation: EAW51980.1.
CH471198 Genomic DNA. Translation: EAW51981.1.
BC035384 mRNA. Translation: AAH35384.1.
CCDSiCCDS5871.1.
RefSeqiNP_001001317.1. NM_001001317.4.
UniGeneiHs.98609.

3D structure databases

ProteinModelPortaliQ8IYP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000446916.

Protein family/group databases

MEROPSiS01.085.

PTM databases

iPTMnetiQ8IYP2.
PhosphoSitePlusiQ8IYP2.

Polymorphism and mutation databases

BioMutaiPRSS58.
DMDMi74759717.

Proteomic databases

PaxDbiQ8IYP2.
PeptideAtlasiQ8IYP2.
PRIDEiQ8IYP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000547058; ENSP00000447588; ENSG00000258223.
ENST00000552471; ENSP00000446916; ENSG00000258223.
ENST00000621886; ENSP00000478535; ENSG00000276785.
ENST00000622880; ENSP00000479165; ENSG00000276785.
GeneIDi136541.
KEGGihsa:136541.
UCSCiuc003vxb.4. human.

Organism-specific databases

CTDi136541.
DisGeNETi136541.
GeneCardsiPRSS58.
HGNCiHGNC:39125. PRSS58.
neXtProtiNX_Q8IYP2.
OpenTargetsiENSG00000258223.
ENSG00000276785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00770000120601.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8IYP2.
OMAiTWAYNLC.
OrthoDBiEOG091G0MM8.
PhylomeDBiQ8IYP2.
TreeFamiTF331065.

Enzyme and pathway databases

BioCyciZFISH:HS15954-MONOMER.

Miscellaneous databases

GenomeRNAii136541.
PROiQ8IYP2.

Gene expression databases

BgeeiENSG00000258223.
GenevisibleiQ8IYP2. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRS58_HUMAN
AccessioniPrimary (citable) accession number: Q8IYP2
Secondary accession number(s): B3KVJ6, D3DXD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.