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Protein

Transcription elongation factor A protein-like 8

Gene

TCEAL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 8
Short name:
TCEA-like protein 8
Alternative name(s):
Transcription elongation factor S-II protein-like 8
Gene namesi
Name:TCEAL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28683. TCEAL8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991274.

Polymorphism and mutation databases

BioMutaiTCEAL8.
DMDMi74762496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Transcription elongation factor A protein-like 8PRO_0000239216Add
BLAST

Proteomic databases

EPDiQ8IYN2.
MaxQBiQ8IYN2.
PaxDbiQ8IYN2.
PRIDEiQ8IYN2.

PTM databases

iPTMnetiQ8IYN2.
PhosphoSiteiQ8IYN2.

Expressioni

Gene expression databases

BgeeiQ8IYN2.
CleanExiHS_TCEAL8.
ExpressionAtlasiQ8IYN2. baseline and differential.
GenevisibleiQ8IYN2. HS.

Organism-specific databases

HPAiHPA059115.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124770. 4 interactions.
IntActiQ8IYN2. 1 interaction.
STRINGi9606.ENSP00000353093.

Structurei

3D structure databases

ProteinModelPortaliQ8IYN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili73 – 10028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JBTZ. Eukaryota.
ENOG4111DNR. LUCA.
GeneTreeiENSGT00730000111091.
HOGENOMiHOG000231343.
HOVERGENiHBG098559.
InParanoidiQ8IYN2.
OMAiSCDENEG.
OrthoDBiEOG7G4QH8.
PhylomeDBiQ8IYN2.
TreeFamiTF336871.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKSCEENEG KPQNMPKAEE DRPLEDVPQE AEGNPQPSEE GVSQEAEGNP
60 70 80 90 100
RGGPNQPGQG FKEDTPVRHL DPEEMIRGVD ELERLREEIR RVRNKFVMMH
110
WKQRHSRSRP YPVCFRP
Length:117
Mass (Da):13,616
Last modified:March 1, 2003 - v1
Checksum:i8BCFC0CAC699C7A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035573 mRNA. Translation: AAH35573.1.
Z68694 Genomic DNA. Translation: CAI41979.1.
CCDSiCCDS14504.1.
RefSeqiNP_001006685.1. NM_001006684.1.
NP_699164.1. NM_153333.2.
UniGeneiHs.389734.

Genome annotation databases

EnsembliENST00000360000; ENSP00000353093; ENSG00000180964.
ENST00000372685; ENSP00000361770; ENSG00000180964.
GeneIDi90843.
KEGGihsa:90843.
UCSCiuc004ejx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035573 mRNA. Translation: AAH35573.1.
Z68694 Genomic DNA. Translation: CAI41979.1.
CCDSiCCDS14504.1.
RefSeqiNP_001006685.1. NM_001006684.1.
NP_699164.1. NM_153333.2.
UniGeneiHs.389734.

3D structure databases

ProteinModelPortaliQ8IYN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124770. 4 interactions.
IntActiQ8IYN2. 1 interaction.
STRINGi9606.ENSP00000353093.

PTM databases

iPTMnetiQ8IYN2.
PhosphoSiteiQ8IYN2.

Polymorphism and mutation databases

BioMutaiTCEAL8.
DMDMi74762496.

Proteomic databases

EPDiQ8IYN2.
MaxQBiQ8IYN2.
PaxDbiQ8IYN2.
PRIDEiQ8IYN2.

Protocols and materials databases

DNASUi90843.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360000; ENSP00000353093; ENSG00000180964.
ENST00000372685; ENSP00000361770; ENSG00000180964.
GeneIDi90843.
KEGGihsa:90843.
UCSCiuc004ejx.4. human.

Organism-specific databases

CTDi90843.
GeneCardsiTCEAL8.
HGNCiHGNC:28683. TCEAL8.
HPAiHPA059115.
neXtProtiNX_Q8IYN2.
PharmGKBiPA134991274.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBTZ. Eukaryota.
ENOG4111DNR. LUCA.
GeneTreeiENSGT00730000111091.
HOGENOMiHOG000231343.
HOVERGENiHBG098559.
InParanoidiQ8IYN2.
OMAiSCDENEG.
OrthoDBiEOG7G4QH8.
PhylomeDBiQ8IYN2.
TreeFamiTF336871.

Miscellaneous databases

GenomeRNAii90843.
PROiQ8IYN2.

Gene expression databases

BgeeiQ8IYN2.
CleanExiHS_TCEAL8.
ExpressionAtlasiQ8IYN2. baseline and differential.
GenevisibleiQ8IYN2. HS.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTCAL8_HUMAN
AccessioniPrimary (citable) accession number: Q8IYN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.