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Protein

Zinc finger protein 100

Gene

ZNF100

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri177 – 19923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 100
Gene namesi
Name:ZNF100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12880. ZNF100.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37469.

Polymorphism and mutation databases

BioMutaiZNF100.
DMDMi296453037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Zinc finger protein 100PRO_0000047405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei525 – 5251PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYN0.
MaxQBiQ8IYN0.
PaxDbiQ8IYN0.
PeptideAtlasiQ8IYN0.
PRIDEiQ8IYN0.

PTM databases

iPTMnetiQ8IYN0.
PhosphoSiteiQ8IYN0.

Expressioni

Gene expression databases

BgeeiQ8IYN0.
CleanExiHS_ZNF100.
ExpressionAtlasiQ8IYN0. baseline and differential.
GenevisibleiQ8IYN0. HS.

Organism-specific databases

HPAiHPA059135.

Interactioni

Protein-protein interaction databases

BioGridi127858. 4 interactions.
IntActiQ8IYN0. 1 interaction.
STRINGi9606.ENSP00000351042.

Structurei

3D structure databases

ProteinModelPortaliQ8IYN0.
SMRiQ8IYN0. Positions 177-537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10773KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri177 – 19923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IYN0.
KOiK09228.
OMAiCEVHKED.
PhylomeDBiQ8IYN0.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ
60 70 80 90 100
CLDSAQQGLY RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH
110 120 130 140 150
EMVAKPPVIC SHFPQDLWAE QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK
160 170 180 190 200
SVDECKVHKE HDNKLNQCLI TTQSNIFQCD PSAKVFHTFS NSNRHKIRHT
210 220 230 240 250
RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK AFNWFSTLTT
260 270 280 290 300
HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR
310 320 330 340 350
SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC
360 370 380 390 400
GKAFNQSSTL TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF
410 420 430 440 450
YKCEECGKGF NWSSALTKHK RIHTGEKPYK CEECGKAFNE SSNLTTHKMI
460 470 480 490 500
HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT GEKPYKCEEC GKAFNRSSTL
510 520 530 540
TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL QM
Length:542
Mass (Da):62,745
Last modified:May 18, 2010 - v2
Checksum:i9755C6215FC44C87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti411 – 4122NW → WN no nucleotide entry (PubMed:1740334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81M → V.
Corresponds to variant rs12974842 [ dbSNP | Ensembl ].
VAR_057395
Natural varianti389 – 3891T → I.2 Publications
Corresponds to variant rs7246400 [ dbSNP | Ensembl ].
VAR_060422

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092364 Genomic DNA. No translation available.
BC035579 mRNA. Translation: AAH35579.1.
CCDSiCCDS42538.1.
PIRiE42075.
RefSeqiNP_775802.2. NM_173531.3.
UniGeneiHs.365142.

Genome annotation databases

EnsembliENST00000358296; ENSP00000351042; ENSG00000197020.
ENST00000614218; ENSP00000483779; ENSG00000274746.
GeneIDi163227.
KEGGihsa:163227.
UCSCiuc002nqi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092364 Genomic DNA. No translation available.
BC035579 mRNA. Translation: AAH35579.1.
CCDSiCCDS42538.1.
PIRiE42075.
RefSeqiNP_775802.2. NM_173531.3.
UniGeneiHs.365142.

3D structure databases

ProteinModelPortaliQ8IYN0.
SMRiQ8IYN0. Positions 177-537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127858. 4 interactions.
IntActiQ8IYN0. 1 interaction.
STRINGi9606.ENSP00000351042.

PTM databases

iPTMnetiQ8IYN0.
PhosphoSiteiQ8IYN0.

Polymorphism and mutation databases

BioMutaiZNF100.
DMDMi296453037.

Proteomic databases

EPDiQ8IYN0.
MaxQBiQ8IYN0.
PaxDbiQ8IYN0.
PeptideAtlasiQ8IYN0.
PRIDEiQ8IYN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358296; ENSP00000351042; ENSG00000197020.
ENST00000614218; ENSP00000483779; ENSG00000274746.
GeneIDi163227.
KEGGihsa:163227.
UCSCiuc002nqi.4. human.

Organism-specific databases

CTDi163227.
GeneCardsiZNF100.
HGNCiHGNC:12880. ZNF100.
HPAiHPA059135.
MIMi603982. gene.
neXtProtiNX_Q8IYN0.
PharmGKBiPA37469.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IYN0.
KOiK09228.
OMAiCEVHKED.
PhylomeDBiQ8IYN0.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF100. human.
GenomeRNAii163227.
PROiQ8IYN0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IYN0.
CleanExiHS_ZNF100.
ExpressionAtlasiQ8IYN0. baseline and differential.
GenevisibleiQ8IYN0. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-389.
    Tissue: Testis.
  3. "High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered."
    Hoovers J.M.N., Mannens M., John R., Bliek J., van Heyningen V., Porteous D.J., Leschot N.J., Westerveld A., Little P.F.R.
    Genomics 12:254-263(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-437, VARIANT ILE-389.

Entry informationi

Entry nameiZN100_HUMAN
AccessioniPrimary (citable) accession number: Q8IYN0
Secondary accession number(s): Q7M4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.