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Protein

Schlafen family member 12

Gene

SLFN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 12
Gene namesi
Name:SLFN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25500. SLFN12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596359.

Polymorphism and mutation databases

BioMutaiSLFN12.
DMDMi143585256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Schlafen family member 12PRO_0000282984Add
BLAST

Proteomic databases

PaxDbiQ8IYM2.
PeptideAtlasiQ8IYM2.
PRIDEiQ8IYM2.

PTM databases

iPTMnetiQ8IYM2.
PhosphoSiteiQ8IYM2.

Expressioni

Gene expression databases

BgeeiENSG00000172123.
CleanExiHS_SLFN12.
ExpressionAtlasiQ8IYM2. baseline and differential.
GenevisibleiQ8IYM2. HS.

Organism-specific databases

HPAiHPA022523.

Interactioni

Protein-protein interaction databases

BioGridi120416. 3 interactions.
IntActiQ8IYM2. 4 interactions.
MINTiMINT-8417717.
STRINGi9606.ENSP00000302077.

Structurei

3D structure databases

ProteinModelPortaliQ8IYM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family.Curated

Phylogenomic databases

eggNOGiENOG410JAUV. Eukaryota.
ENOG4111BZ2. LUCA.
GeneTreeiENSGT00410000025651.
HOGENOMiHOG000133056.
HOVERGENiHBG057499.
InParanoidiQ8IYM2.
OMAiCRKLFLQ.
OrthoDBiEOG091G0916.
PhylomeDBiQ8IYM2.
TreeFamiTF337168.

Family and domain databases

InterProiIPR029684. Schlafen.
IPR007421. Schlafen_AAA_dom.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PfamiPF04326. AlbA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISVDLETN YAELVLDVGR VTLGENSRKK MKDCKLRKKQ NESVSRAMCA
60 70 80 90 100
LLNSGGGVIK AEIENEDYSY TKDGIGLDLE NSFSNILLFV PEYLDFMQNG
110 120 130 140 150
NYFLIFVKSW SLNTSGLRIT TLSSNLYKRD ITSAKVMNAT AALEFLKDMK
160 170 180 190 200
KTRGRLYLRP ELLAKRPCVD IQEENNMKAL AGVFFDRTEL DRKEKLTFTE
210 220 230 240 250
STHVEIKNFS TEKLLQRIKE ILPQYVSAFA NTDGGYLFIG LNEDKEIIGF
260 270 280 290 300
KAEMSDLDDL EREIEKSIRK MPVHHFCMEK KKINYSCKFL GVYDKGSLCG
310 320 330 340 350
YVCALRVERF CCAVFAKEPD SWHVKDNRVM QLTRKEWIQF MVEAEPKFSS
360 370 380 390 400
SYEEVISQIN TSLPAPHSWP LLEWQRQRHH CPGLSGRITY TPENLCRKLF
410 420 430 440 450
LQHEGLKQLI CEEMDSVRKG SLIFSRSWSV DLGLQENHKV LCDALLISQD
460 470 480 490 500
SPPVLYTFHM VQDEEFKGYS TQTALTLKQK LAKIGGYTKK VCVMTKIFYL
510 520 530 540 550
SPEGMTSCQY DLRSQVIYPE SYYFTRRKYL LKALFKALKR LKSLRDQFSF
560 570
AENLYQIIGI DCFQKNDKKM FKSCRRLT
Length:578
Mass (Da):66,972
Last modified:April 3, 2007 - v2
Checksum:i858DEC808A50E753
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611T → A in BAA91512 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431S → R.1 Publication
Corresponds to variant rs1849733 [ dbSNP | Ensembl ].
VAR_031447
Natural varianti168 – 1681C → R.1 Publication
Corresponds to variant rs2586514 [ dbSNP | Ensembl ].
VAR_031448
Natural varianti448 – 4481S → P.
Corresponds to variant rs12946189 [ dbSNP | Ensembl ].
VAR_053877

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001122 mRNA. Translation: BAA91512.1.
AK291826 mRNA. Translation: BAF84515.1.
BC035605 mRNA. Translation: AAH35605.1.
CCDSiCCDS11295.1.
RefSeqiNP_001275938.1. NM_001289009.1.
NP_060512.3. NM_018042.4.
XP_005258052.1. XM_005257995.4.
XP_011523269.1. XM_011524967.2.
UniGeneiHs.663548.

Genome annotation databases

EnsembliENST00000304905; ENSP00000302077; ENSG00000172123.
ENST00000394562; ENSP00000378063; ENSG00000172123.
ENST00000452764; ENSP00000394903; ENSG00000172123.
GeneIDi55106.
KEGGihsa:55106.
UCSCiuc002hji.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001122 mRNA. Translation: BAA91512.1.
AK291826 mRNA. Translation: BAF84515.1.
BC035605 mRNA. Translation: AAH35605.1.
CCDSiCCDS11295.1.
RefSeqiNP_001275938.1. NM_001289009.1.
NP_060512.3. NM_018042.4.
XP_005258052.1. XM_005257995.4.
XP_011523269.1. XM_011524967.2.
UniGeneiHs.663548.

3D structure databases

ProteinModelPortaliQ8IYM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120416. 3 interactions.
IntActiQ8IYM2. 4 interactions.
MINTiMINT-8417717.
STRINGi9606.ENSP00000302077.

PTM databases

iPTMnetiQ8IYM2.
PhosphoSiteiQ8IYM2.

Polymorphism and mutation databases

BioMutaiSLFN12.
DMDMi143585256.

Proteomic databases

PaxDbiQ8IYM2.
PeptideAtlasiQ8IYM2.
PRIDEiQ8IYM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304905; ENSP00000302077; ENSG00000172123.
ENST00000394562; ENSP00000378063; ENSG00000172123.
ENST00000452764; ENSP00000394903; ENSG00000172123.
GeneIDi55106.
KEGGihsa:55106.
UCSCiuc002hji.6. human.

Organism-specific databases

CTDi55106.
GeneCardsiSLFN12.
HGNCiHGNC:25500. SLFN12.
HPAiHPA022523.
MIMi614955. gene.
neXtProtiNX_Q8IYM2.
PharmGKBiPA144596359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAUV. Eukaryota.
ENOG4111BZ2. LUCA.
GeneTreeiENSGT00410000025651.
HOGENOMiHOG000133056.
HOVERGENiHBG057499.
InParanoidiQ8IYM2.
OMAiCRKLFLQ.
OrthoDBiEOG091G0916.
PhylomeDBiQ8IYM2.
TreeFamiTF337168.

Miscellaneous databases

GenomeRNAii55106.
PROiQ8IYM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172123.
CleanExiHS_SLFN12.
ExpressionAtlasiQ8IYM2. baseline and differential.
GenevisibleiQ8IYM2. HS.

Family and domain databases

InterProiIPR029684. Schlafen.
IPR007421. Schlafen_AAA_dom.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PfamiPF04326. AlbA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLN12_HUMAN
AccessioniPrimary (citable) accession number: Q8IYM2
Secondary accession number(s): A8K711, Q9NP47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.