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Protein

Psychosine receptor

Gene

GPR65

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: BHF-UCL

GO - Biological processi

  • actin cytoskeleton reorganization Source: BHF-UCL
  • activation of GTPase activity Source: BHF-UCL
  • apoptotic process Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • immune response Source: ProtInc
  • multicellular organism development Source: ProtInc
  • positive regulation of cAMP biosynthetic process Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: GO_Central
  • positive regulation of Rho protein signal transduction Source: GO_Central
  • positive regulation of stress fiber assembly Source: BHF-UCL
  • response to acidic pH Source: BHF-UCL

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Psychosine receptor
Alternative name(s):
G-protein coupled receptor 65
T-cell death-associated gene 8 protein
Gene namesi
Name:GPR65
Synonyms:TDAG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000140030.5.
HGNCiHGNC:4517. GPR65.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 50CytoplasmicSequence analysisAdd BLAST14
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 89ExtracellularSequence analysisAdd BLAST18
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 129CytoplasmicSequence analysisAdd BLAST19
Transmembranei130 – 150Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini151 – 180ExtracellularSequence analysisAdd BLAST30
Transmembranei181 – 201Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini202 – 227CytoplasmicSequence analysisAdd BLAST26
Transmembranei228 – 248Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini249 – 273ExtracellularSequence analysisAdd BLAST25
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 337CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8477.
OpenTargetsiENSG00000140030.
PharmGKBiPA28909.

Chemistry databases

ChEMBLiCHEMBL3714081.

Polymorphism and mutation databases

BioMutaiGPR65.
DMDMi37537957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700871 – 337Psychosine receptorAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 170PROSITE-ProRule annotation
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IYL9.
PeptideAtlasiQ8IYL9.
PRIDEiQ8IYL9.

PTM databases

iPTMnetiQ8IYL9.
PhosphoSitePlusiQ8IYL9.

Expressioni

Tissue specificityi

Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000140030.
CleanExiHS_GPR65.
ExpressionAtlasiQ8IYL9. baseline and differential.
GenevisibleiQ8IYL9. HS.

Organism-specific databases

HPAiHPA054454.

Interactioni

Protein-protein interaction databases

IntActiQ8IYL9. 1 interactor.
STRINGi9606.ENSP00000267549.

Structurei

3D structure databases

ProteinModelPortaliQ8IYL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00900000140916.
HOGENOMiHOG000004801.
HOVERGENiHBG101118.
InParanoidiQ8IYL9.
KOiK08416.
OMAiCTGYAIP.
OrthoDBiEOG091G0BK0.
PhylomeDBiQ8IYL9.
TreeFamiTF331803.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005464. Psych_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01649. PSYCHOSINER.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IYL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTCIEEQH DLDHYLFPIV YIFVIIVSIP ANIGSLCVSF LQAKKESELG
60 70 80 90 100
IYLFSLSLSD LLYALTLPLW IDYTWNKDNW TFSPALCKGS AFLMYMNFYS
110 120 130 140 150
STAFLTCIAV DRYLAVVYPL KFFFLRTRRF ALMVSLSIWI LETIFNAVML
160 170 180 190 200
WEDETVVEYC DAEKSNFTLC YDKYPLEKWQ INLNLFRTCT GYAIPLVTIL
210 220 230 240 250
ICNRKVYQAV RHNKATENKE KKRIIKLLVS ITVTFVLCFT PFHVMLLIRC
260 270 280 290 300
ILEHAVNFED HSNSGKRTYT MYRITVALTS LNCVADPILY CFVTETGRYD
310 320 330
MWNILKFCTG RCNTSQRQRK RILSVSTKDT MELEVLE
Length:337
Mass (Da):39,333
Last modified:March 1, 2003 - v1
Checksum:iCFDBF217291C0FA2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43A → P in AAC31794 (PubMed:9655242).Curated1
Sequence conflicti97N → K in AAC31794 (PubMed:9655242).Curated1
Sequence conflicti130F → I in AAC31794 (PubMed:9655242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022064231I → L. Corresponds to variant dbSNP:rs3742704Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95218 Genomic DNA. Translation: AAC31794.1.
AL157955 Genomic DNA. No translation available.
BC035633 mRNA. Translation: AAH35633.1.
BC071715 mRNA. Translation: AAH71715.1.
CCDSiCCDS9879.1.
RefSeqiNP_003599.2. NM_003608.3.
UniGeneiHs.443243.

Genome annotation databases

EnsembliENST00000267549; ENSP00000267549; ENSG00000140030.
GeneIDi8477.
KEGGihsa:8477.
UCSCiuc001xvv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPSYR_HUMAN
AccessioniPrimary (citable) accession number: Q8IYL9
Secondary accession number(s): O75819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families