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Q8IYL9

- PSYR_HUMAN

UniProt

Q8IYL9 - PSYR_HUMAN

Protein

Psychosine receptor

Gene

GPR65

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: BHF-UCL

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: BHF-UCL
    2. activation of Rho GTPase activity Source: BHF-UCL
    3. apoptotic process Source: ProtInc
    4. G-protein coupled receptor signaling pathway Source: BHF-UCL
    5. immune response Source: ProtInc
    6. multicellular organismal development Source: ProtInc
    7. positive regulation of cAMP biosynthetic process Source: BHF-UCL
    8. positive regulation of stress fiber assembly Source: BHF-UCL
    9. response to acidic pH Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Psychosine receptor
    Alternative name(s):
    G-protein coupled receptor 65
    T-cell death-associated gene 8 protein
    Gene namesi
    Name:GPR65
    Synonyms:TDAG8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:4517. GPR65.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28909.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Psychosine receptorPRO_0000070087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi87 ↔ 170PROSITE-ProRule annotation
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IYL9.
    PRIDEiQ8IYL9.

    PTM databases

    PhosphoSiteiQ8IYL9.

    Expressioni

    Tissue specificityi

    Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.2 Publications

    Gene expression databases

    ArrayExpressiQ8IYL9.
    BgeeiQ8IYL9.
    CleanExiHS_GPR65.
    GenevestigatoriQ8IYL9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8IYL9. 1 interaction.
    STRINGi9606.ENSP00000267549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYL9.
    SMRiQ8IYL9. Positions 16-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini37 – 5014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini72 – 8918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini151 – 18030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini202 – 22726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini249 – 27325ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini295 – 33743CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149070.
    HOGENOMiHOG000004801.
    HOVERGENiHBG101118.
    InParanoidiQ8IYL9.
    KOiK08416.
    OMAiCYDKYPL.
    OrthoDBiEOG7B31N7.
    PhylomeDBiQ8IYL9.
    TreeFamiTF331803.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005464. Psych_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01649. PSYCHOSINER.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IYL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSTCIEEQH DLDHYLFPIV YIFVIIVSIP ANIGSLCVSF LQAKKESELG    50
    IYLFSLSLSD LLYALTLPLW IDYTWNKDNW TFSPALCKGS AFLMYMNFYS 100
    STAFLTCIAV DRYLAVVYPL KFFFLRTRRF ALMVSLSIWI LETIFNAVML 150
    WEDETVVEYC DAEKSNFTLC YDKYPLEKWQ INLNLFRTCT GYAIPLVTIL 200
    ICNRKVYQAV RHNKATENKE KKRIIKLLVS ITVTFVLCFT PFHVMLLIRC 250
    ILEHAVNFED HSNSGKRTYT MYRITVALTS LNCVADPILY CFVTETGRYD 300
    MWNILKFCTG RCNTSQRQRK RILSVSTKDT MELEVLE 337
    Length:337
    Mass (Da):39,333
    Last modified:March 1, 2003 - v1
    Checksum:iCFDBF217291C0FA2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431A → P in AAC31794. (PubMed:9655242)Curated
    Sequence conflicti97 – 971N → K in AAC31794. (PubMed:9655242)Curated
    Sequence conflicti130 – 1301F → I in AAC31794. (PubMed:9655242)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti231 – 2311I → L.
    Corresponds to variant rs3742704 [ dbSNP | Ensembl ].
    VAR_022064

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95218 Genomic DNA. Translation: AAC31794.1.
    AL157955 Genomic DNA. No translation available.
    BC035633 mRNA. Translation: AAH35633.1.
    BC071715 mRNA. Translation: AAH71715.1.
    CCDSiCCDS9879.1.
    RefSeqiNP_003599.2. NM_003608.3.
    UniGeneiHs.443243.

    Genome annotation databases

    EnsembliENST00000267549; ENSP00000267549; ENSG00000140030.
    GeneIDi8477.
    KEGGihsa:8477.
    UCSCiuc001xvv.3. human.

    Polymorphism databases

    DMDMi37537957.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95218 Genomic DNA. Translation: AAC31794.1 .
    AL157955 Genomic DNA. No translation available.
    BC035633 mRNA. Translation: AAH35633.1 .
    BC071715 mRNA. Translation: AAH71715.1 .
    CCDSi CCDS9879.1.
    RefSeqi NP_003599.2. NM_003608.3.
    UniGenei Hs.443243.

    3D structure databases

    ProteinModelPortali Q8IYL9.
    SMRi Q8IYL9. Positions 16-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IYL9. 1 interaction.
    STRINGi 9606.ENSP00000267549.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IYL9.

    Polymorphism databases

    DMDMi 37537957.

    Proteomic databases

    PaxDbi Q8IYL9.
    PRIDEi Q8IYL9.

    Protocols and materials databases

    DNASUi 8477.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267549 ; ENSP00000267549 ; ENSG00000140030 .
    GeneIDi 8477.
    KEGGi hsa:8477.
    UCSCi uc001xvv.3. human.

    Organism-specific databases

    CTDi 8477.
    GeneCardsi GC14P088471.
    HGNCi HGNC:4517. GPR65.
    MIMi 604620. gene.
    neXtProti NX_Q8IYL9.
    PharmGKBi PA28909.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149070.
    HOGENOMi HOG000004801.
    HOVERGENi HBG101118.
    InParanoidi Q8IYL9.
    KOi K08416.
    OMAi CYDKYPL.
    OrthoDBi EOG7B31N7.
    PhylomeDBi Q8IYL9.
    TreeFami TF331803.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii GPR65.
    GenomeRNAii 8477.
    NextBioi 31721.
    PROi Q8IYL9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IYL9.
    Bgeei Q8IYL9.
    CleanExi HS_GPR65.
    Genevestigatori Q8IYL9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005464. Psych_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01649. PSYCHOSINER.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene."
      Kyaw H., Zeng Z., Su K., Fan P., Shell B.K., Carter K.C., Li Y.
      DNA Cell Biol. 17:493-500(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood and Brain.
    4. "Identification of a molecular target of psychosine and its role in globoid cell formation."
      Im D.-S., Heise C.E., Nguyen T., O'Dowd B.F., Lynch K.R.
      J. Cell Biol. 153:429-434(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPSYR_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYL9
    Secondary accession number(s): O75819
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3