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Q8IYL9 (PSYR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Psychosine receptor
Alternative name(s):
G-protein coupled receptor 65
T-cell death-associated gene 8 protein
Gene names
Name:GPR65
Synonyms:TDAG8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes. Ref.1 Ref.4

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Psychosine receptor
PRO_0000070087

Regions

Topological domain1 – 1515Extracellular Potential
Transmembrane16 – 3621Helical; Name=1; Potential
Topological domain37 – 5014Cytoplasmic Potential
Transmembrane51 – 7121Helical; Name=2; Potential
Topological domain72 – 8918Extracellular Potential
Transmembrane90 – 11021Helical; Name=3; Potential
Topological domain111 – 12919Cytoplasmic Potential
Transmembrane130 – 15021Helical; Name=4; Potential
Topological domain151 – 18030Extracellular Potential
Transmembrane181 – 20121Helical; Name=5; Potential
Topological domain202 – 22726Cytoplasmic Potential
Transmembrane228 – 24821Helical; Name=6; Potential
Topological domain249 – 27325Extracellular Potential
Transmembrane274 – 29421Helical; Name=7; Potential
Topological domain295 – 33743Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1661N-linked (GlcNAc...) Potential
Disulfide bond87 ↔ 170 By similarity

Natural variations

Natural variant2311I → L.
Corresponds to variant rs3742704 [ dbSNP | Ensembl ].
VAR_022064

Experimental info

Sequence conflict431A → P in AAC31794. Ref.1
Sequence conflict971N → K in AAC31794. Ref.1
Sequence conflict1301F → I in AAC31794. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8IYL9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CFDBF217291C0FA2

FASTA33739,333
        10         20         30         40         50         60 
MNSTCIEEQH DLDHYLFPIV YIFVIIVSIP ANIGSLCVSF LQAKKESELG IYLFSLSLSD 

        70         80         90        100        110        120 
LLYALTLPLW IDYTWNKDNW TFSPALCKGS AFLMYMNFYS STAFLTCIAV DRYLAVVYPL 

       130        140        150        160        170        180 
KFFFLRTRRF ALMVSLSIWI LETIFNAVML WEDETVVEYC DAEKSNFTLC YDKYPLEKWQ 

       190        200        210        220        230        240 
INLNLFRTCT GYAIPLVTIL ICNRKVYQAV RHNKATENKE KKRIIKLLVS ITVTFVLCFT 

       250        260        270        280        290        300 
PFHVMLLIRC ILEHAVNFED HSNSGKRTYT MYRITVALTS LNCVADPILY CFVTETGRYD 

       310        320        330 
MWNILKFCTG RCNTSQRQRK RILSVSTKDT MELEVLE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene."
Kyaw H., Zeng Z., Su K., Fan P., Shell B.K., Carter K.C., Li Y.
DNA Cell Biol. 17:493-500(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood and Brain.
[4]"Identification of a molecular target of psychosine and its role in globoid cell formation."
Im D.-S., Heise C.E., Nguyen T., O'Dowd B.F., Lynch K.R.
J. Cell Biol. 153:429-434(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U95218 Genomic DNA. Translation: AAC31794.1.
AL157955 Genomic DNA. No translation available.
BC035633 mRNA. Translation: AAH35633.1.
BC071715 mRNA. Translation: AAH71715.1.
CCDSCCDS9879.1.
RefSeqNP_003599.2. NM_003608.3.
UniGeneHs.443243.

3D structure databases

ProteinModelPortalQ8IYL9.
SMRQ8IYL9. Positions 16-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8IYL9. 1 interaction.
STRING9606.ENSP00000267549.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8IYL9.

Polymorphism databases

DMDM37537957.

Proteomic databases

PaxDbQ8IYL9.
PRIDEQ8IYL9.

Protocols and materials databases

DNASU8477.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267549; ENSP00000267549; ENSG00000140030.
GeneID8477.
KEGGhsa:8477.
UCSCuc001xvv.3. human.

Organism-specific databases

CTD8477.
GeneCardsGC14P088471.
HGNCHGNC:4517. GPR65.
MIM604620. gene.
neXtProtNX_Q8IYL9.
PharmGKBPA28909.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149070.
HOGENOMHOG000004801.
HOVERGENHBG101118.
InParanoidQ8IYL9.
KOK08416.
OMACYDKYPL.
OrthoDBEOG7B31N7.
PhylomeDBQ8IYL9.
TreeFamTF331803.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ8IYL9.
BgeeQ8IYL9.
CleanExHS_GPR65.
GenevestigatorQ8IYL9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005464. Psych_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01649. PSYCHOSINER.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR65.
GenomeRNAi8477.
NextBio31721.
PROQ8IYL9.
SOURCESearch...

Entry information

Entry namePSYR_HUMAN
AccessionPrimary (citable) accession number: Q8IYL9
Secondary accession number(s): O75819
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries